CY1668A - 3-substituted-2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents - Google Patents

3-substituted-2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents

Info

Publication number
CY1668A
CY1668A CY1668A CY166893A CY1668A CY 1668 A CY1668 A CY 1668A CY 1668 A CY1668 A CY 1668A CY 166893 A CY166893 A CY 166893A CY 1668 A CY1668 A CY 1668A
Authority
CY
Cyprus
Prior art keywords
alkyl
optionally substituted
oxindole
carboxamides
analgesic
Prior art date
Application number
CY1668A
Other languages
English (en)
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of CY1668A publication Critical patent/CY1668A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CY1668A 1984-03-19 1993-05-14 3-substituted-2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents CY1668A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US59065984A 1984-03-19 1984-03-19
US06/684,634 US4556672A (en) 1984-03-19 1984-12-21 3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents

Publications (1)

Publication Number Publication Date
CY1668A true CY1668A (en) 1993-05-14

Family

ID=27080909

Family Applications (1)

Application Number Title Priority Date Filing Date
CY1668A CY1668A (en) 1984-03-19 1993-05-14 3-substituted-2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents

Country Status (36)

Country Link
US (1) US4556672A (enExample)
EP (1) EP0156603B1 (enExample)
JP (1) JPH04235165A (enExample)
KR (1) KR860001873B1 (enExample)
AT (1) ATE45731T1 (enExample)
AU (1) AU549927B2 (enExample)
BG (1) BG60347B2 (enExample)
CA (2) CA1251441A (enExample)
CS (1) CS249539B2 (enExample)
CY (1) CY1668A (enExample)
DE (1) DE3572481D1 (enExample)
DK (1) DK162090C (enExample)
EG (1) EG17795A (enExample)
ES (1) ES8603408A1 (enExample)
FI (2) FI82042C (enExample)
GR (1) GR850668B (enExample)
HK (1) HK78392A (enExample)
HU (1) HU196178B (enExample)
IE (1) IE57743B1 (enExample)
IL (3) IL85130A (enExample)
LV (1) LV5618A3 (enExample)
MA (1) MA20380A1 (enExample)
MY (1) MY101987A (enExample)
NL (1) NL940025I2 (enExample)
NO (1) NO165799C (enExample)
NZ (2) NZ211486A (enExample)
OA (1) OA07966A (enExample)
PH (2) PH21323A (enExample)
PL (1) PL145951B1 (enExample)
PT (1) PT80117B (enExample)
RO (1) RO90952B (enExample)
SI (1) SI8510440A8 (enExample)
SU (1) SU1445556A3 (enExample)
UA (1) UA6343A1 (enExample)
YU (1) YU43870B (enExample)
ZW (1) ZW4785A1 (enExample)

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ATE67185T1 (de) * 1985-07-09 1991-09-15 Pfizer Substituierte oxindol-3-carboxamine als entzuendungshemmendes und schmerzstillendes mittel.
US4678802A (en) * 1985-07-09 1987-07-07 Pfizer Inc. 1-acylcarbamoyloxindole-3-carboxamides as antiinflammatory agents
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WO1988005656A1 (en) * 1987-02-02 1988-08-11 Pfizer Inc. Anhydrous, crystalline sodium salt of 5-chloro-3-(2-thenoyl)-2-oxindole-1-carboxamide
US4885370A (en) * 1987-03-11 1989-12-05 Pfizer Inc. Synthetic method for indol-2(3H)-ones
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US4853409A (en) * 1988-04-13 1989-08-01 Pfizer Inc. 3-substituted-2-oxindole-1-carboxamides for suppressing T-cell function
US4861794A (en) * 1988-04-13 1989-08-29 Pfizer Inc. 3-substituted-2-oxindole-1-carboxamides as inhibitors of interleukin-1 biosynthesis
US5118703A (en) * 1988-10-18 1992-06-02 Pfizer Inc. Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamides
DE68923673T2 (de) * 1988-10-18 1996-01-18 Pfizer Prodrogen von antiinflammatorischen 3-Acyl-2-oxindol-1-carboxamiden.
HU215112B (hu) * 1989-01-10 1998-12-28 Pfizer Inc. Eljárás gyulladáscsökkentő 1-heteroaril-3-acil-2-oxindol-származékok előállítására
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IL95880A (en) * 1989-10-13 1995-12-31 Pfizer Use of 3-Transformed History of 2-Oxindole for the Preparation of Pharmaceuticals for Inhibition of Interlaukio-1 Biosynthesis
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US5008283A (en) * 1990-03-19 1991-04-16 Pfizer Inc. Use of tenidap to inhibit activation of collagenase and to inhibit the activity of myeloperoxidase
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US5122534A (en) * 1991-02-08 1992-06-16 Pfizer Inc. Use of tenidap to reduce total serum cholesterol, ldl cholesterol and triglycerides
DE4111306C2 (de) * 1991-04-08 1994-06-01 Mack Chem Pharm Pharmazeutische Zubereitungen, die ein 2-Oxindol-l-carboxamid-derivat enthalten und zur Injektion bestimmt sind
DE4111305C2 (de) * 1991-04-08 1994-12-01 Mack Chem Pharm Pharmazeutische Zubereitung zur rektalen Applikation, die ein 2-Oxindol-l-carboxamid-derivat enthält
US5210212A (en) * 1991-06-25 1993-05-11 Pfizer Inc Process for 5-fluoro-6-chlorooxindole
US5166401A (en) * 1991-06-25 1992-11-24 Pfizer Inc Intermediates for 5-fluoro-6-chlorooxindole
TW438798B (en) * 1992-10-07 2001-06-07 Pfizer 3-substituted 2-oxindole-1-carboxamide pharmaceutical compositions
US5288743A (en) * 1992-11-20 1994-02-22 Abbott Laboratories Indole carboxylate derivatives which inhibit leukotriene biosynthesis
US5298522A (en) * 1993-01-22 1994-03-29 Pfizer Inc. 6-chloro-5-fluoro-3-(2-thenoyl)-2-oxindole-1-carboxamide as an analgesic and anti-inflammatory agent while maintaining a normal urine protein/creatinine ratio
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US5270331A (en) * 1993-01-26 1993-12-14 Pfizer, Inc. Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamides
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JP4202250B2 (ja) 2001-07-25 2008-12-24 バイオマリン ファーマシューティカル インコーポレイテッド 血液脳関門輸送を調節するための組成物および方法
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DK3395372T3 (da) 2009-02-20 2022-04-19 Enhanx Biopharm Inc System til afgivelse af glutathion-baseret medikament
CN110075069A (zh) 2009-05-06 2019-08-02 实验室护肤股份有限公司 包含活性剂-磷酸钙颗粒复合物的皮肤递送组合物及其应用
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Also Published As

Publication number Publication date
YU44085A (en) 1988-02-29
ATE45731T1 (de) 1989-09-15
ES541372A0 (es) 1985-12-16
DK121385D0 (da) 1985-03-18
EP0156603A2 (en) 1985-10-02
PL145951B1 (en) 1988-12-31
NO165799C (no) 1991-04-10
AU549927B2 (en) 1986-02-20
BG60347B2 (bg) 1994-09-30
EP0156603A3 (en) 1986-02-12
IL74631A (en) 1988-07-31
CA1288422C (en) 1991-09-03
EG17795A (en) 1990-08-30
SU1445556A3 (ru) 1988-12-15
FI894540A0 (fi) 1989-09-26
NZ211486A (en) 1988-10-28
FI851069A0 (fi) 1985-03-18
FI82042C (fi) 1991-01-10
ZW4785A1 (en) 1985-06-19
IL74631A0 (en) 1985-06-30
HK78392A (en) 1992-10-23
FI894540L (fi) 1989-09-26
YU43870B (en) 1989-12-31
CA1251441A (en) 1989-03-21
PL252434A1 (en) 1985-12-03
FI82449C (fi) 1991-03-11
IE57743B1 (en) 1993-03-24
KR860001873B1 (ko) 1986-10-24
RO90952B (ro) 1987-03-01
UA6343A1 (uk) 1994-12-29
LV5618A3 (lv) 1994-05-10
FI82449B (fi) 1990-11-30
DK162090C (da) 1992-02-24
NZ224134A (en) 1988-10-28
GR850668B (enExample) 1985-07-16
FI82042B (fi) 1990-09-28
ES8603408A1 (es) 1985-12-16
JPH04235165A (ja) 1992-08-24
RO90952A (ro) 1987-02-27
PH21470A (en) 1987-10-28
DE3572481D1 (en) 1989-09-28
OA07966A (fr) 1987-01-31
PT80117B (pt) 1987-10-20
HU196178B (en) 1988-10-28
NL940025I2 (nl) 2000-01-03
PT80117A (en) 1985-04-01
MA20380A1 (fr) 1985-10-01
US4556672A (en) 1985-12-03
NO165799B (no) 1991-01-02
HUT37398A (en) 1985-12-28
IL85130A0 (en) 1988-06-30
CS249539B2 (en) 1987-03-12
DK162090B (da) 1991-09-16
PH21323A (en) 1987-09-28
NO851054L (no) 1985-09-20
KR850006173A (ko) 1985-10-02
SI8510440A8 (sl) 1996-06-30
JPH0561269B2 (enExample) 1993-09-06
EP0156603B1 (en) 1989-08-23
AU4005985A (en) 1985-09-26
FI851069L (fi) 1985-09-20
IE850684L (en) 1985-09-19
MY101987A (en) 1992-02-29
IL85130A (en) 1988-07-31
DK121385A (da) 1985-09-20
NL940025I1 (nl) 1995-02-01

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