MX18021A - Pro-farmacos de la 3-acil-2-oxindol-1-carboxamidasanti-inflamatorias - Google Patents
Pro-farmacos de la 3-acil-2-oxindol-1-carboxamidasanti-inflamatoriasInfo
- Publication number
- MX18021A MX18021A MX1802188A MX1802188A MX18021A MX 18021 A MX18021 A MX 18021A MX 1802188 A MX1802188 A MX 1802188A MX 1802188 A MX1802188 A MX 1802188A MX 18021 A MX18021 A MX 18021A
- Authority
- MX
- Mexico
- Prior art keywords
- inflammatorias
- carboxamidasanti
- oxindol
- acil
- pro
- Prior art date
Links
- 229940002612 prodrug Drugs 0.000 title 1
- 239000000651 prodrug Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Rheumatology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US1988/003658 WO1990004393A1 (en) | 1988-10-18 | 1988-10-18 | Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX18021A true MX18021A (es) | 1993-11-01 |
Family
ID=22208957
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX1802188A MX18021A (es) | 1988-10-18 | 1988-10-18 | Pro-farmacos de la 3-acil-2-oxindol-1-carboxamidasanti-inflamatorias |
Country Status (33)
| Country | Link |
|---|---|
| US (1) | US5118703A (es) |
| JP (1) | JPH07597B2 (es) |
| KR (1) | KR910007237B1 (es) |
| CN (1) | CN1022241C (es) |
| AP (1) | AP118A (es) |
| AR (1) | AR246519A1 (es) |
| AT (1) | ATE125794T1 (es) |
| AU (1) | AU606819B2 (es) |
| BG (1) | BG50834A3 (es) |
| CA (1) | CA1339558C (es) |
| CZ (1) | CZ278983B6 (es) |
| DD (1) | DD285604A5 (es) |
| DK (1) | DK514989A (es) |
| EG (1) | EG19887A (es) |
| FI (1) | FI95253C (es) |
| HU (1) | HU208421B (es) |
| IE (1) | IE66586B1 (es) |
| IL (1) | IL91960A (es) |
| IS (1) | IS1598B (es) |
| MA (1) | MA21657A1 (es) |
| MX (1) | MX18021A (es) |
| MY (1) | MY104238A (es) |
| NO (1) | NO178027C (es) |
| NZ (1) | NZ231044A (es) |
| OA (1) | OA09140A (es) |
| PH (1) | PH27554A (es) |
| PL (2) | PL163112B1 (es) |
| PT (1) | PT92000B (es) |
| RO (1) | RO109195B1 (es) |
| RU (1) | RU2036905C1 (es) |
| SK (1) | SK278175B6 (es) |
| WO (1) | WO1990004393A1 (es) |
| YU (1) | YU48070B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5059693A (en) * | 1989-10-06 | 1991-10-22 | Pfizer Inc. | Process for making 3-aroyl-2-oxindole-1-carboxamides |
| WO1994012505A1 (en) * | 1992-11-23 | 1994-06-09 | Pfizer Inc. | Regioselective synthesis of 4-chloro-2-thiophenecarboxylic acid |
| US5270331A (en) * | 1993-01-26 | 1993-12-14 | Pfizer, Inc. | Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamides |
| DE69305999T2 (de) * | 1993-02-09 | 1997-03-06 | Pfizer Inc., New York, N.Y. | Oxindol 1-[n-(alkoxycarbonyl)]carboxamide und 1-[n-carboxamido]carboxamide als antiinflammatorische wirkstoffe |
| US5449788A (en) * | 1994-01-28 | 1995-09-12 | Catalytica, Inc. | Process for preparing 2-oxindole-1-carboxamides |
| CN1094819C (zh) * | 1997-04-30 | 2002-11-27 | 大兴株式会社 | 环状坯料之制造装置 |
| EP0984012A3 (en) * | 1998-08-31 | 2001-01-10 | Pfizer Products Inc. | Nitric oxide releasing oxindole prodrugs with analgesic and anti-inflammatory properties |
| JP2003512396A (ja) * | 1999-10-26 | 2003-04-02 | ザ・ユニバーシティ・オブ・テキサス・サウスウエスタン・メディカル・センター | インドリン化合物を投与することを含む脱毛症の処置方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL96047C (es) * | 1956-06-08 | |||
| US3564009A (en) * | 1966-01-13 | 1971-02-16 | Sumitomo Chemical Co | Process for producing 1-acylindole derivatives |
| BE756447A (fr) * | 1969-10-15 | 1971-03-22 | Pfizer | Oxindolecarboxamides |
| US3923996A (en) * | 1972-07-31 | 1975-12-02 | Sandoz Ag | 3-Substituted-oxindoles in compositions and methods of treating obesity |
| IE53102B1 (en) * | 1981-05-12 | 1988-06-22 | Ici Plc | Pharmaceutical spiro-succinimide derivatives |
| DE3268971D1 (en) * | 1981-10-06 | 1986-03-20 | Ici Plc | Biochemical process |
| US4556672A (en) * | 1984-03-19 | 1985-12-03 | Pfizer Inc. | 3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents |
| US4752609A (en) * | 1985-06-20 | 1988-06-21 | Pfizer Inc. | Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds |
| US5036099A (en) * | 1987-02-02 | 1991-07-30 | Pfizer Inc. | Anhydrous, crystalline sodium salt of 5-chloro-3-(2-thenoyl)-2-oxindole-1-carboxamide |
| EP0365194B1 (en) * | 1988-10-18 | 1995-08-02 | Pfizer Inc. | Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamides |
| US5047554A (en) * | 1989-04-18 | 1991-09-10 | Pfizer Inc. | 3-substituted-2-oxindole derivatives |
| US5059693A (en) * | 1989-10-06 | 1991-10-22 | Pfizer Inc. | Process for making 3-aroyl-2-oxindole-1-carboxamides |
-
1988
- 1988-10-18 WO PCT/US1988/003658 patent/WO1990004393A1/en active IP Right Grant
- 1988-10-18 US US07/675,883 patent/US5118703A/en not_active Expired - Lifetime
- 1988-10-18 HU HU886740A patent/HU208421B/hu not_active IP Right Cessation
- 1988-10-18 SK SK5906-89A patent/SK278175B6/sk unknown
- 1988-10-18 RO RO147347A patent/RO109195B1/ro unknown
- 1988-10-18 MX MX1802188A patent/MX18021A/es unknown
-
1989
- 1989-09-20 IS IS3509A patent/IS1598B/is unknown
- 1989-09-28 CA CA000614317A patent/CA1339558C/en not_active Expired - Fee Related
- 1989-10-04 PH PH39329A patent/PH27554A/en unknown
- 1989-10-09 AT AT89310319T patent/ATE125794T1/de active
- 1989-10-12 IL IL9196089A patent/IL91960A/xx not_active IP Right Cessation
- 1989-10-16 PT PT92000A patent/PT92000B/pt not_active IP Right Cessation
- 1989-10-16 BG BG090022A patent/BG50834A3/xx unknown
- 1989-10-16 AP APAP/P/1989/000141A patent/AP118A/en active
- 1989-10-16 MY MYPI89001415A patent/MY104238A/en unknown
- 1989-10-16 YU YU200589A patent/YU48070B/sh unknown
- 1989-10-17 AU AU42956/89A patent/AU606819B2/en not_active Ceased
- 1989-10-17 NZ NZ231044A patent/NZ231044A/en unknown
- 1989-10-17 PL PL89296831A patent/PL163112B1/pl unknown
- 1989-10-17 DK DK514989A patent/DK514989A/da not_active Application Discontinuation
- 1989-10-17 CN CN89107943A patent/CN1022241C/zh not_active Expired - Fee Related
- 1989-10-17 DD DD89333653A patent/DD285604A5/de not_active IP Right Cessation
- 1989-10-17 MA MA21909A patent/MA21657A1/fr unknown
- 1989-10-17 KR KR1019890014914A patent/KR910007237B1/ko not_active IP Right Cessation
- 1989-10-17 AR AR89315179A patent/AR246519A1/es active
- 1989-10-17 IE IE333289A patent/IE66586B1/en not_active IP Right Cessation
- 1989-10-17 OA OA59665A patent/OA09140A/xx unknown
- 1989-10-17 JP JP1270174A patent/JPH07597B2/ja not_active Expired - Lifetime
- 1989-10-17 PL PL89281871A patent/PL162316B1/pl unknown
- 1989-10-18 CZ CS895906A patent/CZ278983B6/cs not_active IP Right Cessation
- 1989-10-18 EG EG49689A patent/EG19887A/xx active
-
1991
- 1991-04-17 FI FI911855A patent/FI95253C/fi not_active IP Right Cessation
- 1991-04-17 NO NO911512A patent/NO178027C/no unknown
- 1991-04-17 RU SU914895525A patent/RU2036905C1/ru active
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