MY101987A - 3-substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammattory agents - Google Patents
3-substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammattory agentsInfo
- Publication number
- MY101987A MY101987A MYPI87001358A MYPI19871358A MY101987A MY 101987 A MY101987 A MY 101987A MY PI87001358 A MYPI87001358 A MY PI87001358A MY PI19871358 A MYPI19871358 A MY PI19871358A MY 101987 A MY101987 A MY 101987A
- Authority
- MY
- Malaysia
- Prior art keywords
- oxindole
- analgesic
- agents
- inflammattory
- carboxamides
- Prior art date
Links
- UYINJAQCJCYCGO-UHFFFAOYSA-N 2-oxo-3h-indole-1-carboxamide Chemical class C1=CC=C2N(C(=O)N)C(=O)CC2=C1 UYINJAQCJCYCGO-UHFFFAOYSA-N 0.000 title abstract 2
- 230000000202 analgesic effect Effects 0.000 title abstract 2
- 102000003820 Lipoxygenases Human genes 0.000 abstract 2
- 108090000128 Lipoxygenases Proteins 0.000 abstract 2
- 102000004005 Prostaglandin-endoperoxide synthases Human genes 0.000 abstract 2
- 108090000459 Prostaglandin-endoperoxide synthases Proteins 0.000 abstract 2
- 208000017667 Chronic Disease Diseases 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 208000014674 injury Diseases 0.000 abstract 1
- 201000008482 osteoarthritis Diseases 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
- 238000001356 surgical procedure Methods 0.000 abstract 1
- 230000008733 trauma Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pain & Pain Management (AREA)
- Public Health (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US59065984A | 1984-03-19 | 1984-03-19 | |
| US06/684,634 US4556672A (en) | 1984-03-19 | 1984-12-21 | 3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents |
| EP85301808A EP0156603B1 (en) | 1984-03-19 | 1985-03-15 | 3-substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MY101987A true MY101987A (en) | 1992-02-29 |
Family
ID=27080909
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MYPI87001358A MY101987A (en) | 1984-03-19 | 1987-08-17 | 3-substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammattory agents |
Country Status (36)
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE63543T1 (de) * | 1984-02-07 | 1991-06-15 | Pfizer | 2-oxindolzwischenprodukte. |
| US4686224A (en) * | 1984-10-31 | 1987-08-11 | Pfizer Inc. | Oxindole antiinflammatory agents |
| DE3681358D1 (de) * | 1985-07-09 | 1991-10-17 | Pfizer | Substituierte oxindol-3-carboxamine als entzuendungshemmendes und schmerzstillendes mittel. |
| US4678802A (en) * | 1985-07-09 | 1987-07-07 | Pfizer Inc. | 1-acylcarbamoyloxindole-3-carboxamides as antiinflammatory agents |
| GB8623819D0 (en) * | 1986-10-03 | 1986-11-05 | Glaxo Group Ltd | Heterocyclic compounds |
| UA25898A1 (uk) * | 1987-02-02 | 1999-02-26 | Пфайзер Інк. | Спосіб одержаhhя кристалічhої hатрієвої солі 5-хлор-3-(2-теhоїл)-2-оксііhдол-1-карбоксаміду |
| US4761485A (en) * | 1987-03-11 | 1988-08-02 | Pfizer Inc. | Synthetic method for indol-2(3H)-ones |
| US4885370A (en) * | 1987-03-11 | 1989-12-05 | Pfizer Inc. | Synthetic method for indol-2(3H)-ones |
| GB8720693D0 (en) * | 1987-09-03 | 1987-10-07 | Glaxo Group Ltd | Chemical compounds |
| DE3803775A1 (de) * | 1988-02-09 | 1989-08-17 | Boehringer Mannheim Gmbh | Neue substituierte lactame, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten |
| US4861794A (en) * | 1988-04-13 | 1989-08-29 | Pfizer Inc. | 3-substituted-2-oxindole-1-carboxamides as inhibitors of interleukin-1 biosynthesis |
| US4853409A (en) * | 1988-04-13 | 1989-08-01 | Pfizer Inc. | 3-substituted-2-oxindole-1-carboxamides for suppressing T-cell function |
| US5118703A (en) * | 1988-10-18 | 1992-06-02 | Pfizer Inc. | Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamides |
| EP0365194B1 (en) * | 1988-10-18 | 1995-08-02 | Pfizer Inc. | Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamides |
| WO1990008145A1 (en) * | 1989-01-10 | 1990-07-26 | Pfizer Inc. | Anti-inflammatory 1-heteroaryl-3-acyl-2-oxindoles |
| US5300655A (en) * | 1989-04-18 | 1994-04-05 | Pfizer Inc. | 2-carboxy-thiophene derivatives |
| US5047554A (en) * | 1989-04-18 | 1991-09-10 | Pfizer Inc. | 3-substituted-2-oxindole derivatives |
| US5059693A (en) * | 1989-10-06 | 1991-10-22 | Pfizer Inc. | Process for making 3-aroyl-2-oxindole-1-carboxamides |
| IL95880A (en) * | 1989-10-13 | 1995-12-31 | Pfizer | Use of 3-Transformed History of 2-Oxindole for the Preparation of Pharmaceuticals for Inhibition of Interlaukio-1 Biosynthesis |
| WO1991009598A1 (en) * | 1990-01-05 | 1991-07-11 | Pfizer Inc. | Azaoxindole derivatives |
| US5008283A (en) * | 1990-03-19 | 1991-04-16 | Pfizer Inc. | Use of tenidap to inhibit activation of collagenase and to inhibit the activity of myeloperoxidase |
| US5006547A (en) * | 1990-03-19 | 1991-04-09 | Pfizer Inc. | Tenidap as an inhibitor of the release of elastase by neutrophils |
| US5064851A (en) * | 1990-07-24 | 1991-11-12 | Pfizer Inc. | 3-(1-substituted-pyrazoyl)-2-oxindole derivatives, compositions and use |
| US5095031A (en) * | 1990-08-20 | 1992-03-10 | Abbott Laboratories | Indole derivatives which inhibit leukotriene biosynthesis |
| US5122534A (en) * | 1991-02-08 | 1992-06-16 | Pfizer Inc. | Use of tenidap to reduce total serum cholesterol, ldl cholesterol and triglycerides |
| DE4111305C2 (de) * | 1991-04-08 | 1994-12-01 | Mack Chem Pharm | Pharmazeutische Zubereitung zur rektalen Applikation, die ein 2-Oxindol-l-carboxamid-derivat enthält |
| DE4111306C2 (de) * | 1991-04-08 | 1994-06-01 | Mack Chem Pharm | Pharmazeutische Zubereitungen, die ein 2-Oxindol-l-carboxamid-derivat enthalten und zur Injektion bestimmt sind |
| US5166401A (en) * | 1991-06-25 | 1992-11-24 | Pfizer Inc | Intermediates for 5-fluoro-6-chlorooxindole |
| US5210212A (en) * | 1991-06-25 | 1993-05-11 | Pfizer Inc | Process for 5-fluoro-6-chlorooxindole |
| TW438798B (en) * | 1992-10-07 | 2001-06-07 | Pfizer | 3-substituted 2-oxindole-1-carboxamide pharmaceutical compositions |
| US5288743A (en) * | 1992-11-20 | 1994-02-22 | Abbott Laboratories | Indole carboxylate derivatives which inhibit leukotriene biosynthesis |
| AU671533B2 (en) * | 1993-01-22 | 1996-08-29 | Pfizer Inc. | Lysine salt of 6-chloro-5-fluoro-3-(2 6-chloro-5-fluoro-3-(2-thenoyl)-2-oxindole-1-carboxamide |
| US5298522A (en) * | 1993-01-22 | 1994-03-29 | Pfizer Inc. | 6-chloro-5-fluoro-3-(2-thenoyl)-2-oxindole-1-carboxamide as an analgesic and anti-inflammatory agent while maintaining a normal urine protein/creatinine ratio |
| US5270331A (en) * | 1993-01-26 | 1993-12-14 | Pfizer, Inc. | Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamides |
| US5607959A (en) * | 1993-02-09 | 1997-03-04 | Pfizer Inc. | Oxindole 1-[N-(alkoxycarbonyl) ] carboxamides and 1-(N-carboxamido) carboxamides as antiinflammatory agents |
| ES2076106B1 (es) * | 1993-08-26 | 1996-06-16 | Pfizer | Composiciones farmaceuticas a base de 2-oxindol-1-carboxamidas 3-sustituidas |
| US5449788A (en) * | 1994-01-28 | 1995-09-12 | Catalytica, Inc. | Process for preparing 2-oxindole-1-carboxamides |
| EP0679396A1 (en) * | 1994-03-02 | 1995-11-02 | Pfizer Inc. | Use of 3-substituted-2-oxidole-1-carboxamides for the manufacture of a medicament in the treatment and prevention of ischemia induced myocardial injury and cytokine mediated myocardial injury |
| US6469181B1 (en) | 1995-01-30 | 2002-10-22 | Catalytica, Inc. | Process for preparing 2-oxindoles and N-hydroxy-2-oxindoles |
| US5545656A (en) * | 1995-04-05 | 1996-08-13 | Pfizer Inc. | 2-Oxidole-1-carboxamide pharmaceutical agents for the treatment of alzheimer's disease |
| US6043232A (en) * | 1997-07-23 | 2000-03-28 | Nitromed, Inc. | Nitroso esters of beta-oxo-amides and aryl propionic acid derivatives of non-steroidal antiinflammatory drugs |
| US5703073A (en) * | 1995-04-19 | 1997-12-30 | Nitromed, Inc. | Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs |
| US6051588A (en) * | 1995-04-19 | 2000-04-18 | Nitromed Inc | Nitroso esters of β-oxo-amides and aryl propionic acid derivatives of non-steroidal antiinflammatory drugs |
| AU7503496A (en) * | 1995-12-19 | 1997-07-14 | Pfizer Inc. | Stable, long acting salts of indole derivatives for the treatment of joint diseases |
| HUP9600855A3 (en) * | 1996-04-03 | 1998-04-28 | Egyt Gyogyszervegyeszeti Gyar | Process for producing tenidap |
| EP0826685A1 (en) * | 1996-08-21 | 1998-03-04 | Pfizer Inc. | Stable, long acting salts of carboxamides for the treatment of joint disease |
| EP1126838A4 (en) * | 1998-10-30 | 2005-02-16 | Nitromed Inc | NITROSIS AND NITROSYAL NON-STEROID ANTI-INFLAMMATORY COMPOUNDS, COMPOSITIONS AND METHODS OF USE |
| ES2301255T3 (es) | 1998-12-17 | 2008-06-16 | F. Hoffmann-La Roche Ag | 4,5-pirazinaxindoles como inhibidores de proteinoquinasas. |
| US6153634A (en) | 1998-12-17 | 2000-11-28 | Hoffmann-La Roche Inc. | 4,5-azolo-oxindoles |
| DE69906152T2 (de) | 1998-12-17 | 2004-02-12 | F. Hoffmann-La Roche Ag | 4-alkenyl (und alkinyl)oxoindole als inhibitoren cyclinabhängiger kinasen, insbesondere cdk2 |
| KR20010101266A (ko) | 1998-12-17 | 2001-11-14 | 프리돌린 클라우스너, 롤란드 비. 보레르 | Ｊｎｋ 단백질 키나제의 억제제로서의 4-아릴옥신돌 |
| IT1308633B1 (it) | 1999-03-02 | 2002-01-09 | Nicox Sa | Nitrossiderivati. |
| JP2003512396A (ja) * | 1999-10-26 | 2003-04-02 | ザ・ユニバーシティ・オブ・テキサス・サウスウエスタン・メディカル・センター | インドリン化合物を投与することを含む脱毛症の処置方法 |
| US6313310B1 (en) | 1999-12-15 | 2001-11-06 | Hoffmann-La Roche Inc. | 4-and 5-alkynyloxindoles and 4-and 5-alkenyloxindoles |
| IT1318674B1 (it) * | 2000-08-08 | 2003-08-27 | Nicox Sa | Faramaci per l'incontinenza. |
| IT1318673B1 (it) * | 2000-08-08 | 2003-08-27 | Nicox Sa | Farmaci per le disfunzioni sessuali. |
| CA2450073C (en) | 2001-07-25 | 2017-08-29 | Biomarin Pharmaceutical Inc. | Compositions and methods for modulating blood-brain barrier transport |
| EP2671508B1 (en) | 2005-04-28 | 2020-09-16 | Proteus Digital Health, Inc. | Pharma-informatics system |
| JP2010503710A (ja) | 2006-09-18 | 2010-02-04 | ラプトール ファーマシューティカル インコーポレイテッド | 受容体関連タンパク質（ｒａｐ）結合体の投与による肝障害の処置 |
| ES2919563T3 (es) | 2009-02-20 | 2022-07-27 | Enhanx Biopharm Inc | Sistema de administración de medicamentos a base de glutatión |
| KR20180114970A (ko) | 2009-05-06 | 2018-10-19 | 라보라토리 스킨 케어, 인크. | 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법 |
| US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
| CN102911105B (zh) * | 2012-11-12 | 2013-12-04 | 辽宁科技大学 | 一种3-芳酰基吲哚化合物的合成方法 |
| EP3277275A4 (en) * | 2015-03-31 | 2018-07-11 | Monsanto Technology LLC | Processes for the preparation of 2-thiophenecarbonyl chloride |
| US10537552B2 (en) | 2015-05-05 | 2020-01-21 | Carafe Drug Innovation, Llc | Substituted 5-hydroxyoxindoles and their use as analgesics and fever reducers |
| CN109195961A (zh) | 2016-03-24 | 2019-01-11 | 孟山都技术公司 | 用于制备杂芳基羧酸的方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL125443C (enExample) * | 1963-06-06 | |||
| US3462450A (en) * | 1966-06-29 | 1969-08-19 | Merck & Co Inc | Chemical compounds |
| GB1158532A (en) * | 1967-01-05 | 1969-07-16 | Centre Nat Rech Scient | 2-Oxoindoline-3-Carboxylic Acids and Esters thereof |
| US3519592A (en) * | 1967-04-18 | 1970-07-07 | Smithkline Corp | Indole compounds |
| US3631177A (en) * | 1967-04-18 | 1971-12-28 | Smith Kline French Lab | 3-phenacyl-2-oxoindolines |
| BE714717A (enExample) * | 1967-05-12 | 1968-09-30 | ||
| FR7337M (enExample) * | 1968-01-11 | 1969-10-13 | ||
| BE756447A (fr) * | 1969-10-15 | 1971-03-22 | Pfizer | Oxindolecarboxamides |
| US3767653A (en) * | 1971-06-28 | 1973-10-23 | Squibb & Sons Inc | Thiazines |
| US3749731A (en) * | 1971-07-08 | 1973-07-31 | Warner Lambert Co | 2-oxo-n-(2-thiazolyl)-3-indoline-carboxamide |
| DE2306374A1 (de) * | 1973-02-09 | 1974-08-15 | Bayer Ag | Neue 3-substituierte 2-oxo-4-hydroxy1,2,3,4-tetrahydrochinazolin-4-carbonsaeureamide |
| US4012394A (en) * | 1973-02-16 | 1977-03-15 | Labaz | Indole derivatives |
| DE2314242A1 (de) * | 1973-03-22 | 1974-09-26 | Bayer Ag | Neue 3-substituierte 2-oxo-4-hydroxy1,2,3,4-tetrahydrochinazolin-4-carbonsaeurehydrazide |
| US3975531A (en) * | 1973-10-02 | 1976-08-17 | A. H. Robins Company, Incorporated | 4-(5- And 7-)benzoylindolin-2-ones and pharmaceutical uses thereof |
-
1984
- 1984-12-21 US US06/684,634 patent/US4556672A/en not_active Expired - Lifetime
-
1985
- 1985-03-15 CA CA000476605A patent/CA1251441A/en not_active Expired
- 1985-03-15 AT AT85301808T patent/ATE45731T1/de not_active IP Right Cessation
- 1985-03-15 EP EP85301808A patent/EP0156603B1/en not_active Expired
- 1985-03-15 GR GR850668A patent/GR850668B/el unknown
- 1985-03-15 IE IE684/85A patent/IE57743B1/en not_active IP Right Cessation
- 1985-03-15 PT PT80117A patent/PT80117B/pt unknown
- 1985-03-15 DE DE8585301808T patent/DE3572481D1/de not_active Expired
- 1985-03-17 EG EG174/85A patent/EG17795A/xx active
- 1985-03-18 IL IL74631A patent/IL74631A/xx not_active IP Right Cessation
- 1985-03-18 NO NO851054A patent/NO165799C/no not_active IP Right Cessation
- 1985-03-18 PL PL1985252434A patent/PL145951B1/pl unknown
- 1985-03-18 ES ES541372A patent/ES541372A0/es active Granted
- 1985-03-18 BG BG069278A patent/BG60347B2/bg unknown
- 1985-03-18 MA MA20604A patent/MA20380A1/fr unknown
- 1985-03-18 DK DK121385A patent/DK162090C/da not_active IP Right Cessation
- 1985-03-18 FI FI851069A patent/FI82042C/fi not_active IP Right Cessation
- 1985-03-18 ZW ZW47/85A patent/ZW4785A1/xx unknown
- 1985-03-18 SU SU853869754A patent/SU1445556A3/ru active
- 1985-03-18 IL IL85130A patent/IL85130A/xx not_active IP Right Cessation
- 1985-03-18 HU HU85992A patent/HU196178B/hu unknown
- 1985-03-18 KR KR1019850001746A patent/KR860001873B1/ko not_active Expired
- 1985-03-18 PH PH32001A patent/PH21323A/en unknown
- 1985-03-18 UA UA3869754A patent/UA6343A1/uk unknown
- 1985-03-18 NZ NZ211486A patent/NZ211486A/xx unknown
- 1985-03-18 NZ NZ224134A patent/NZ224134A/xx unknown
- 1985-03-18 AU AU40059/85A patent/AU549927B2/en not_active Expired
- 1985-03-19 CS CS851920A patent/CS249539B2/cs unknown
- 1985-03-19 YU YU440/85A patent/YU43870B/xx unknown
- 1985-03-19 OA OA58541A patent/OA07966A/xx unknown
- 1985-03-19 RO RO118055A patent/RO90952B/ro unknown
- 1985-03-19 SI SI8510440A patent/SI8510440A8/sl unknown
-
1986
- 1986-02-21 PH PH33439A patent/PH21470A/en unknown
-
1987
- 1987-08-17 MY MYPI87001358A patent/MY101987A/en unknown
-
1988
- 1988-01-19 IL IL85130A patent/IL85130A0/xx unknown
- 1988-07-07 CA CA000571475A patent/CA1288422C/en not_active Expired - Lifetime
-
1989
- 1989-09-26 FI FI894540A patent/FI82449C/fi not_active IP Right Cessation
-
1991
- 1991-06-04 JP JP3132826A patent/JPH04235165A/ja active Granted
-
1992
- 1992-10-15 HK HK783/92A patent/HK78392A/en not_active IP Right Cessation
-
1993
- 1993-05-14 CY CY1668A patent/CY1668A/xx unknown
- 1993-11-11 LV LV931200A patent/LV5618A3/xx unknown
-
1994
- 1994-12-15 NL NL940025C patent/NL940025I2/nl unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU573160B2 (en) | Treatment of tissue degenerative inflammatory disease | |
| AU584124B2 (en) | Diarylacetylenes, their preparation and their use | |
| ZA964759B (en) | Antithrombotic petidoyl heterocycles. | |
| PT83902B (en) | Inhibition of the 5-lipoxygenase pathway | |
| AU4297685A (en) | Compositions for the allevation, treatment and diagnosis of arthritic disease and related conditions | |
| EP0153831A3 (en) | Instruments for use in the surgical replacement of ligaments | |
| EP0137457A3 (en) | Trace-labeled conjugates of metallothionein and target-seeking biologically active molecules | |
| MD1838F2 (en) | 5,6-dichlorbenzimidazole derivatives, process for obtaining thereof, pharmaceutical composition and method of treatment or prevention of herpetic viral infections | |
| EP0668750A4 (en) | PEDICULAR SCREW AND INSTRUMENTS FOR REAR SPINE CORRECTION. | |
| BG103190A (en) | Substituted pyrimidine derivatives and their pharmaceutical application | |
| AU6546890A (en) | Isoxazole-4-carboxamides and hydroxyalkylidene-cyanoacetamides, drugs containing these compounds and use of such drugs | |
| AU8956382A (en) | Endoscope assembly and surgical instrument for use therewith | |
| NZ319090A (en) | (Methylsulfonyl)phenyl-2-(5H)-furanones as COX-2 inhibitors | |
| AU3717395A (en) | Compositions for the treatment of skin disorders | |
| AU2740797A (en) | Androstene derivatives | |
| GR79637B (enExample) | ||
| MY106202A (en) | Saccharin derivatives useful as proteolytic enzyme inhibitors and preparation thereof. | |
| TR199802537T2 (xx) | Peptit t�revleri. | |
| DK100487A (da) | Hidtil ukendte carbonsyrederivater, fremgangsmaade til deres fremstilling, deres anvendelse samt laegemidler indeholdende disse forbindelser | |
| DK254386A (da) | Pyridinderivater, fremgangsmaade til fremstilling heraf og praeparaterindeholdende disse forbindelser | |
| FR2611274B1 (fr) | Ensemble pour la detection du sida, procede de determination des risques de sida et composition therapeutique contre cette maladie | |
| FI853624L (fi) | 1-substituerade tetralinderivat, deras framstaellning och anvaendning. | |
| CA2294090A1 (en) | Method and product using sturgeon notochord for alleviating the symptoms of arthritis | |
| MX9403088A (es) | Composiciones farmaceuticas que contienen deriva- dos de indol y metodos de uso. | |
| AU550675B2 (en) | Pharmaceutical compositions for the treatment of skin |