CY1111099T1 - Στελεχη ζυμης τα οποια παραγουν στεροειδη με αυτονομο τροπο - Google Patents

Στελεχη ζυμης τα οποια παραγουν στεροειδη με αυτονομο τροπο

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Publication number
CY1111099T1
CY1111099T1 CY20111100036T CY111100036T CY1111099T1 CY 1111099 T1 CY1111099 T1 CY 1111099T1 CY 20111100036 T CY20111100036 T CY 20111100036T CY 111100036 T CY111100036 T CY 111100036T CY 1111099 T1 CY1111099 T1 CY 1111099T1
Authority
CY
Cyprus
Prior art keywords
yeast
executives
steroids
autonomous way
producing steroids
Prior art date
Application number
CY20111100036T
Other languages
English (en)
Inventor
Roberto Spagnoli
Tilman Achstetter
Gilles Cauet
Eric Degryse
Bruno Dumas
Denis Pompon
Jacques Winter
Original Assignee
Aventis Pharma S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma S.A. filed Critical Aventis Pharma S.A.
Publication of CY1111099T1 publication Critical patent/CY1111099T1/el

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/15—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen (1.14.15)
    • C12Y114/15004—Steroid 11-beta-monooxygenase (1.14.15.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/16—Yeasts; Culture media therefor
    • C12N1/18—Baker's yeast; Brewer's yeast
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/005—Degradation of the lateral chains at position 17
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/06—Hydroxylating
    • C12P33/08—Hydroxylating at 11 position
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/12—Acting on D ring
    • C12P33/16—Acting at 17 position
    • C12P33/18—Hydroxylating at 17 position
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/15—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen (1.14.15)
    • C12Y114/15006—Cholesterol monooxygenase (side-chain-cleaving) (1.14.15.6), i.e. cytochrome P450scc
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/99—Miscellaneous (1.14.99)
    • C12Y114/99009—Steroid 17-alpha-monooxygenase (1.14.99.9), i.e. cytochrome-P450-steroid-17-alpha-hydroxylase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/99—Miscellaneous (1.14.99)
    • C12Y114/9901—Steroid 21-monooxygenase (1.14.99.10), i.e. steroid cytochrome P450 21-hydroxylase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y118/00—Oxidoreductases acting on iron-sulfur proteins as donors (1.18)
    • C12Y118/01—Oxidoreductases acting on iron-sulfur proteins as donors (1.18) with NAD+ or NADP+ as acceptor (1.18.1)
    • C12Y118/01002—Ferredoxin-NADP+ reductase (1.18.1.2)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Transplantation (AREA)
  • Botany (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)

Abstract

Η παρούσα εφεύρεση αφορά σε στελέχη ζυμών γενετικά τροποποιημένα τα οποία παράγουν με αυτόνομο τρόπο, από μια πηγή απλού άνθρακα, στεροειδή. Η εφεύρεση αφορά επίσης σε μια διαδικασία παραγωγής στεροειδών από τέτοιου είδους στελέχη ζύμης.
CY20111100036T 2001-01-31 2011-01-12 Στελεχη ζυμης τα οποια παραγουν στεροειδη με αυτονομο τροπο CY1111099T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0101294A FR2820145B1 (fr) 2001-01-31 2001-01-31 Souche de levure produisant des steroides de facon autonome
EP02708406A EP1385980B1 (fr) 2001-01-31 2002-01-29 Souches de levures produisant des steroides de facon autonome

Publications (1)

Publication Number Publication Date
CY1111099T1 true CY1111099T1 (el) 2015-06-11

Family

ID=8859443

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20111100036T CY1111099T1 (el) 2001-01-31 2011-01-12 Στελεχη ζυμης τα οποια παραγουν στεροειδη με αυτονομο τροπο

Country Status (20)

Country Link
US (2) US7670829B2 (el)
EP (1) EP1385980B1 (el)
JP (1) JP4620932B2 (el)
KR (1) KR100882150B1 (el)
AR (1) AR033857A1 (el)
AT (1) ATE486134T1 (el)
BR (1) BRPI0206809B8 (el)
CA (1) CA2435096C (el)
CY (1) CY1111099T1 (el)
DE (1) DE60238114D1 (el)
DK (1) DK1385980T3 (el)
ES (1) ES2354603T3 (el)
FR (1) FR2820145B1 (el)
IL (2) IL157118A0 (el)
MX (1) MXPA03006031A (el)
NO (1) NO333769B1 (el)
NZ (1) NZ526381A (el)
PT (1) PT1385980E (el)
WO (1) WO2002061109A2 (el)
ZA (1) ZA200305772B (el)

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FR2812884B1 (fr) 2000-08-08 2002-11-08 Aventis Pharma Sa Levures modifiees et utilisations, notamment pour la production de derives steroidiens
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FR2820145B1 (fr) 2001-01-31 2004-01-23 Aventis Pharma Sa Souche de levure produisant des steroides de facon autonome
FR2869914B1 (fr) 2004-05-06 2012-11-09 Aventis Pharma Sa Souches de levure produisant du cholesterol et leurs applications
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EP1933881B1 (en) * 2005-09-22 2019-03-13 Medivas, LLC Solid polymer delivery compositions and methods for use thereof
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EP2178944A1 (en) * 2007-07-24 2010-04-28 Medivas, LLC Biodegradable cationic polymer gene transfer compositions and methods of use
WO2010019716A1 (en) * 2008-08-13 2010-02-18 Medivas, Llc Aabb-poly(depsipeptide) biodegradable polymers and methods of use
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FR2961218A1 (fr) 2010-06-10 2011-12-16 Sanofi Aventis Methode de detection de composes modulateurs du metabolisme du cholesterol
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WO2012095816A1 (en) 2011-01-14 2012-07-19 Sanofi Method for detecting the biological activity of alpha-synuclein
FR2976949B1 (fr) * 2011-06-21 2015-08-28 Sanofi Sa Procede de preparation de levures genetiquement transformees capables de produire une molecule d'interet a haut titre
US9873765B2 (en) 2011-06-23 2018-01-23 Dsm Ip Assets, B.V. Biodegradable polyesteramide copolymers for drug delivery
EP3159368A1 (en) 2011-06-23 2017-04-26 DSM IP Assets B.V. New biodegradable polyesteramide copolymers for drug delivery
EP3011045B1 (en) * 2013-06-17 2019-10-16 Sanofi Whole-cell system for cytochrome p450 monooxygenases biocatalysis
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CN114456964B (zh) * 2022-03-15 2023-02-03 陕西海斯夫生物工程有限公司 一种高产豆甾醇的重组解脂亚罗酵母、其构建方法、用于产豆甾醇的发酵培养基及应用

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FR2820145B1 (fr) 2001-01-31 2004-01-23 Aventis Pharma Sa Souche de levure produisant des steroides de facon autonome

Also Published As

Publication number Publication date
NO20033242D0 (no) 2003-07-17
JP4620932B2 (ja) 2011-01-26
WO2002061109A2 (fr) 2002-08-08
CA2435096C (en) 2012-11-13
KR20030082580A (ko) 2003-10-22
ATE486134T1 (de) 2010-11-15
CA2435096A1 (en) 2002-08-08
NZ526381A (en) 2005-07-29
BR0206809A (pt) 2004-02-03
EP1385980B1 (fr) 2010-10-27
NO333769B1 (no) 2013-09-16
MXPA03006031A (es) 2005-02-14
US7670829B2 (en) 2010-03-02
IL157118A0 (en) 2004-02-08
NO20033242L (no) 2003-09-04
FR2820145B1 (fr) 2004-01-23
BRPI0206809B8 (pt) 2021-05-25
DK1385980T3 (da) 2011-02-21
FR2820145A1 (fr) 2002-08-02
IL157118A (en) 2010-11-30
PT1385980E (pt) 2011-01-14
US20100112634A1 (en) 2010-05-06
ES2354603T3 (es) 2011-03-16
AR033857A1 (es) 2004-01-07
BRPI0206809B1 (pt) 2020-04-22
ZA200305772B (en) 2004-07-26
US7977065B2 (en) 2011-07-12
JP2004528827A (ja) 2004-09-24
US20040137556A1 (en) 2004-07-15
EP1385980A2 (fr) 2004-02-04
DE60238114D1 (de) 2010-12-09
WO2002061109A3 (fr) 2003-11-27
KR100882150B1 (ko) 2009-02-06

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