AR033857A1 - Cepas de levaduras que producen esteroides de forma autonoma. - Google Patents
Cepas de levaduras que producen esteroides de forma autonoma.Info
- Publication number
- AR033857A1 AR033857A1 ARP020100328A ARP020100328A AR033857A1 AR 033857 A1 AR033857 A1 AR 033857A1 AR P020100328 A ARP020100328 A AR P020100328A AR P020100328 A ARP020100328 A AR P020100328A AR 033857 A1 AR033857 A1 AR 033857A1
- Authority
- AR
- Argentina
- Prior art keywords
- strains
- steroids
- leaves
- endogenous gene
- yeast
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
- C12Y114/15—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen (1.14.15)
- C12Y114/15004—Steroid 11-beta-monooxygenase (1.14.15.4)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/16—Yeasts; Culture media therefor
- C12N1/18—Baker's yeast; Brewer's yeast
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P33/00—Preparation of steroids
- C12P33/005—Degradation of the lateral chains at position 17
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P33/00—Preparation of steroids
- C12P33/06—Hydroxylating
- C12P33/08—Hydroxylating at 11 position
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P33/00—Preparation of steroids
- C12P33/12—Acting on D ring
- C12P33/16—Acting at 17 position
- C12P33/18—Hydroxylating at 17 position
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
- C12Y114/15—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen (1.14.15)
- C12Y114/15006—Cholesterol monooxygenase (side-chain-cleaving) (1.14.15.6), i.e. cytochrome P450scc
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
- C12Y114/99—Miscellaneous (1.14.99)
- C12Y114/99009—Steroid 17-alpha-monooxygenase (1.14.99.9), i.e. cytochrome-P450-steroid-17-alpha-hydroxylase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
- C12Y114/99—Miscellaneous (1.14.99)
- C12Y114/9901—Steroid 21-monooxygenase (1.14.99.10), i.e. steroid cytochrome P450 21-hydroxylase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y118/00—Oxidoreductases acting on iron-sulfur proteins as donors (1.18)
- C12Y118/01—Oxidoreductases acting on iron-sulfur proteins as donors (1.18) with NAD+ or NADP+ as acceptor (1.18.1)
- C12Y118/01002—Ferredoxin-NADP+ reductase (1.18.1.2)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychology (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Transplantation (AREA)
- Botany (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Steroid Compounds (AREA)
Abstract
Se refiere a cepas de levaduras modificadas genéticamente y que producen esteroides de manera autónoma, a partir de una fuente de carbono simple. También se refiere a un procedimiento de producción de esteroides a partir de tales cepas de levadura y a las composiciones farmacéuticas que contienen dichas cepas de levadura. Los esteroides producidos por las cepas modificadas genéticamente están comprendidas en el grupo constituido por la 17a-hidroxi pregnenolona, el cortisol la cortexolona, la 17a-hidroxi progesterona, y los derivados de éstos esteroides. A su vez, dichas cepas de levaduras presentan al menos una modificación genética elegida del grupo constituido por disrupción o inactivación de un gen endógeno, la modificación del promotor de un gen endógeno, la duplicación de un gen endógeno, la introducción de al menos de un gen heterólogo en un bloque de expresión, en una o varias copias, de forma episómica o cromosómica, y se trata particularmente de las cepas CDR07 Mat-a o TGY260, presentadas en el CNCM el 24 de enero de 2001 bajo los números de orden respectivo I-2616 e I-2615, o de una cepa obtenida después de cruzamiento de CDR07 Mat-a y TGY260, y eventualmente esporulación y transformación con un plásmido de levadura, particularmente la cepa UCY2 o UCY4.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0101294A FR2820145B1 (fr) | 2001-01-31 | 2001-01-31 | Souche de levure produisant des steroides de facon autonome |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR033857A1 true AR033857A1 (es) | 2004-01-07 |
Family
ID=8859443
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP020100328A AR033857A1 (es) | 2001-01-31 | 2002-01-30 | Cepas de levaduras que producen esteroides de forma autonoma. |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US7670829B2 (es) |
| EP (1) | EP1385980B1 (es) |
| JP (1) | JP4620932B2 (es) |
| KR (1) | KR100882150B1 (es) |
| AR (1) | AR033857A1 (es) |
| AT (1) | ATE486134T1 (es) |
| BR (1) | BRPI0206809B8 (es) |
| CA (1) | CA2435096C (es) |
| CY (1) | CY1111099T1 (es) |
| DE (1) | DE60238114D1 (es) |
| DK (1) | DK1385980T3 (es) |
| ES (1) | ES2354603T3 (es) |
| FR (1) | FR2820145B1 (es) |
| IL (2) | IL157118A0 (es) |
| MX (1) | MXPA03006031A (es) |
| NO (1) | NO333769B1 (es) |
| NZ (1) | NZ526381A (es) |
| PT (1) | PT1385980E (es) |
| WO (1) | WO2002061109A2 (es) |
| ZA (1) | ZA200305772B (es) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2812884B1 (fr) | 2000-08-08 | 2002-11-08 | Aventis Pharma Sa | Levures modifiees et utilisations, notamment pour la production de derives steroidiens |
| US20060177416A1 (en) | 2003-10-14 | 2006-08-10 | Medivas, Llc | Polymer particle delivery compositions and methods of use |
| FR2820145B1 (fr) | 2001-01-31 | 2004-01-23 | Aventis Pharma Sa | Souche de levure produisant des steroides de facon autonome |
| FR2869914B1 (fr) | 2004-05-06 | 2012-11-09 | Aventis Pharma Sa | Souches de levure produisant du cholesterol et leurs applications |
| GB0512707D0 (en) * | 2005-06-22 | 2005-07-27 | Delta Biotechnology Ltd | Gene expression technique |
| JP5192384B2 (ja) | 2005-09-22 | 2013-05-08 | メディバス エルエルシー | ビス−（α−アミノ）−ジオール−ジエステル含有ポリ（エステルアミド）およびポリ（エステルウレタン）組成物および使用の方法 |
| JP5178520B2 (ja) * | 2005-09-22 | 2013-04-10 | メディバス エルエルシー | 固体ポリマー送達組成物およびその使用法 |
| JP2009524584A (ja) * | 2005-12-07 | 2009-07-02 | メディバス エルエルシー | ポリマー−生物製剤送達組成物を構築するための方法 |
| EP2021141A4 (en) * | 2006-05-09 | 2013-07-03 | Medivas Llc | BIODEGRADABLE WATER SOLUBLE POLYMERS |
| WO2009015143A1 (en) * | 2007-07-24 | 2009-01-29 | Medivas, Llc | Biodegradable cationic polymer gene transfer compositions and methods of use |
| JP2012500207A (ja) * | 2008-08-13 | 2012-01-05 | メディバス エルエルシー | Ａａｂｂ−ポリ（デプシペプチド）生分解性ポリマー及び使用方法 |
| CN102272304B (zh) | 2009-01-07 | 2013-10-23 | 三菱化学株式会社 | 切断固醇侧链的酶蛋白质及其应用 |
| FR2961218A1 (fr) | 2010-06-10 | 2011-12-16 | Sanofi Aventis | Methode de detection de composes modulateurs du metabolisme du cholesterol |
| KR200458070Y1 (ko) * | 2010-06-21 | 2012-01-19 | 주광진 | 양치 기능이 부가된 젖꼭지 |
| WO2012095816A1 (en) | 2011-01-14 | 2012-07-19 | Sanofi | Method for detecting the biological activity of alpha-synuclein |
| FR2976949B1 (fr) * | 2011-06-21 | 2015-08-28 | Sanofi Sa | Procede de preparation de levures genetiquement transformees capables de produire une molecule d'interet a haut titre |
| US9873765B2 (en) | 2011-06-23 | 2018-01-23 | Dsm Ip Assets, B.V. | Biodegradable polyesteramide copolymers for drug delivery |
| US9963549B2 (en) | 2011-06-23 | 2018-05-08 | Dsm Ip Assets, B.V. | Biodegradable polyesteramide copolymers for drug delivery |
| RU2684714C2 (ru) * | 2013-06-17 | 2019-04-11 | Санофи | Цельноклеточная система для биокатализа монооксигеназ цитохрома p450 |
| EP3233067B1 (en) | 2014-12-18 | 2019-11-06 | DSM IP Assets B.V. | Drug delivery system for delivery of acid sensitive drugs |
| EP3130680A1 (en) | 2015-08-11 | 2017-02-15 | Universitat de Girona | Method for the detection, follow up and/or classification of intestinal diseases |
| WO2017048316A1 (en) * | 2015-09-18 | 2017-03-23 | President And Fellows Of Harvard College | Small molecule biosensors |
| CN108866142B (zh) * | 2017-05-10 | 2022-08-16 | 中国科学院分子植物科学卓越创新中心 | 细胞色素p450、烟酰胺腺嘌呤二核苷酸-细胞色素p450还原酶及其应用 |
| CN110903993A (zh) * | 2019-12-20 | 2020-03-24 | 河北兰升生物科技有限公司 | 一种产生菜籽甾醇的酿酒酵母工程菌及其构建方法和应用 |
| CN114456964B (zh) * | 2022-03-15 | 2023-02-03 | 陕西海斯夫生物工程有限公司 | 一种高产豆甾醇的重组解脂亚罗酵母、其构建方法、用于产豆甾醇的发酵培养基及应用 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6447380A (en) * | 1987-08-19 | 1989-02-21 | Agency Ind Science Techn | Steroid-oxidizing yeast strain |
| PT90484B (pt) * | 1988-05-06 | 1994-08-31 | Roussel Uclaf | Processo para a oxidacao bioquimica de esteroides e para a preparacao por engenharia genetica de celulas para esse fim |
| EP0340878B1 (en) | 1988-05-06 | 2001-05-16 | Aventis Pharma S.A. | Process for the biochemical oxidation of steroids and genetically engineered cells to be used therefor |
| JPH0231680A (ja) | 1988-07-22 | 1990-02-01 | Agency Of Ind Science & Technol | チトクロムＰ４５０ｃ↓２↓１産生酵母菌株 |
| CN1042567A (zh) * | 1988-09-23 | 1990-05-30 | 吉斯特-布罗卡迪斯公司 | 类固醇多步氧化方法和所用的遗传工程细胞 |
| JPH02249488A (ja) | 1989-03-22 | 1990-10-05 | Sumitomo Chem Co Ltd | チトクロムＰ４５０↓ｃ↓２↓１と酵母ＮＡＤＰＨ‐チトクロムＰ４５０還元酵素の融合酸化酵素、該酵素をコードする遺伝子および該酵素の製造方法 |
| JP2645130B2 (ja) | 1989-03-31 | 1997-08-25 | 日清製粉株式会社 | ステロイド誘導体 |
| FR2678611B1 (fr) | 1991-07-04 | 1995-01-20 | Roussel Uclaf | Nouveaux esters pyrethrinouides de l'alcool 1,3,4,5,6,7-hexahydro 1,3-dioxo-2h-isoindol-2-yl-methylique, leur procede de preparation et leur application comme pesticides. |
| JP3363197B2 (ja) | 1992-06-18 | 2003-01-08 | 麒麟麦酒株式会社 | アルコールアセチルトランスフェラーゼ遺伝子およびその利用 |
| US5547868A (en) | 1993-06-09 | 1996-08-20 | Regents Of The University Of California | Cholesterol disposal fusion enzymes |
| IL116872A (en) * | 1995-02-15 | 2004-12-15 | Aventis Pharma Sa | Delta 5,7-Strol Reductase from Arbidopsis Thaliana |
| DE19505578A1 (de) | 1995-02-18 | 1996-08-22 | Sel Alcatel Ag | Optisches Übertragungssystem für Kabelfernsehsignale und Video- und Telekommunikationssignale |
| JP4093598B2 (ja) | 1995-03-14 | 2008-06-04 | 大関株式会社 | 新規なアルコールアセチルトランスフェラーゼ遺伝子 |
| JP3171560B2 (ja) * | 1996-05-21 | 2001-05-28 | 仁 苅野 | ヘテロポリ酸触媒 |
| DE19744212B4 (de) | 1997-09-30 | 2006-01-19 | Schering Ag | Verfahren zur Herstellung von Ergosterol und dessen Zwischenprodukten mittels rekombinanter Hefen |
| US6303302B1 (en) | 1997-11-19 | 2001-10-16 | The Whitehead Institute For Biomedical Research | Regulation of fungal gene expression |
| FR2774393B1 (fr) | 1998-02-05 | 2000-03-24 | Hoechst Marion Roussel Inc | Souches de levure ayant le gene atf2 interrompu et leurs applications |
| FR2799206A1 (fr) | 1999-10-05 | 2001-04-06 | Transgene Sa | Procede de production de steroides modifies par fermentation de levures |
| FR2812884B1 (fr) | 2000-08-08 | 2002-11-08 | Aventis Pharma Sa | Levures modifiees et utilisations, notamment pour la production de derives steroidiens |
| FR2820145B1 (fr) | 2001-01-31 | 2004-01-23 | Aventis Pharma Sa | Souche de levure produisant des steroides de facon autonome |
-
2001
- 2001-01-31 FR FR0101294A patent/FR2820145B1/fr not_active Expired - Lifetime
-
2002
- 2002-01-29 WO PCT/FR2002/000348 patent/WO2002061109A2/fr active IP Right Grant
- 2002-01-29 PT PT02708406T patent/PT1385980E/pt unknown
- 2002-01-29 DE DE60238114T patent/DE60238114D1/de not_active Expired - Lifetime
- 2002-01-29 JP JP2002561663A patent/JP4620932B2/ja not_active Expired - Lifetime
- 2002-01-29 NZ NZ526381A patent/NZ526381A/en not_active IP Right Cessation
- 2002-01-29 IL IL15711802A patent/IL157118A0/xx unknown
- 2002-01-29 MX MXPA03006031A patent/MXPA03006031A/es active IP Right Grant
- 2002-01-29 ES ES02708406T patent/ES2354603T3/es not_active Expired - Lifetime
- 2002-01-29 KR KR1020037010173A patent/KR100882150B1/ko active IP Right Grant
- 2002-01-29 DK DK02708406.0T patent/DK1385980T3/da active
- 2002-01-29 BR BR0206809-5 patent/BRPI0206809B8/pt not_active IP Right Cessation
- 2002-01-29 AT AT02708406T patent/ATE486134T1/de active
- 2002-01-29 EP EP02708406A patent/EP1385980B1/fr not_active Expired - Lifetime
- 2002-01-29 CA CA2435096A patent/CA2435096C/en not_active Expired - Lifetime
- 2002-01-29 US US10/470,673 patent/US7670829B2/en not_active Expired - Lifetime
- 2002-01-30 AR ARP020100328A patent/AR033857A1/es active IP Right Grant
-
2003
- 2003-07-17 NO NO20033242A patent/NO333769B1/no not_active IP Right Cessation
- 2003-07-25 ZA ZA200305772A patent/ZA200305772B/en unknown
- 2003-07-27 IL IL157118A patent/IL157118A/en unknown
-
2010
- 2010-01-07 US US12/683,642 patent/US7977065B2/en not_active Expired - Fee Related
-
2011
- 2011-01-12 CY CY20111100036T patent/CY1111099T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1385980B1 (fr) | 2010-10-27 |
| US20100112634A1 (en) | 2010-05-06 |
| NO20033242L (no) | 2003-09-04 |
| ES2354603T3 (es) | 2011-03-16 |
| CA2435096A1 (en) | 2002-08-08 |
| BRPI0206809B1 (pt) | 2020-04-22 |
| KR20030082580A (ko) | 2003-10-22 |
| WO2002061109A3 (fr) | 2003-11-27 |
| FR2820145B1 (fr) | 2004-01-23 |
| FR2820145A1 (fr) | 2002-08-02 |
| DK1385980T3 (da) | 2011-02-21 |
| BR0206809A (pt) | 2004-02-03 |
| CY1111099T1 (el) | 2015-06-11 |
| JP4620932B2 (ja) | 2011-01-26 |
| BRPI0206809B8 (pt) | 2021-05-25 |
| JP2004528827A (ja) | 2004-09-24 |
| EP1385980A2 (fr) | 2004-02-04 |
| US7977065B2 (en) | 2011-07-12 |
| IL157118A0 (en) | 2004-02-08 |
| US7670829B2 (en) | 2010-03-02 |
| MXPA03006031A (es) | 2005-02-14 |
| IL157118A (en) | 2010-11-30 |
| DE60238114D1 (de) | 2010-12-09 |
| KR100882150B1 (ko) | 2009-02-06 |
| NZ526381A (en) | 2005-07-29 |
| PT1385980E (pt) | 2011-01-14 |
| ZA200305772B (en) | 2004-07-26 |
| NO333769B1 (no) | 2013-09-16 |
| CA2435096C (en) | 2012-11-13 |
| ATE486134T1 (de) | 2010-11-15 |
| US20040137556A1 (en) | 2004-07-15 |
| WO2002061109A2 (fr) | 2002-08-08 |
| NO20033242D0 (no) | 2003-07-17 |
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