CY1113174T1 - Στελεχη ζυμων που παραγουν χοληστερολη και οι εφαρμογες τους - Google Patents

Στελεχη ζυμων που παραγουν χοληστερολη και οι εφαρμογες τους

Info

Publication number
CY1113174T1
CY1113174T1 CY20121100926T CY121100926T CY1113174T1 CY 1113174 T1 CY1113174 T1 CY 1113174T1 CY 20121100926 T CY20121100926 T CY 20121100926T CY 121100926 T CY121100926 T CY 121100926T CY 1113174 T1 CY1113174 T1 CY 1113174T1
Authority
CY
Cyprus
Prior art keywords
cholesterol
applications
yeast strain
fungi
producing yeast
Prior art date
Application number
CY20121100926T
Other languages
English (en)
Inventor
Denis Pompon
Bruno Dumas
Roberto Spagnoli
Original Assignee
Aventis Pharma S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma S.A. filed Critical Aventis Pharma S.A.
Publication of CY1113174T1 publication Critical patent/CY1113174T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0493—Steroids, e.g. cholesterol, testosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Biomedical Technology (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Η παρούσα εφεύρεση αφορά την παραγωγή χοληστερόλης στους οργανισμούς του βασιλείου των μυκήτων (Fungi). Πιο δυγκεκριμένα, η εφεύρεση αφορά τους γενετικά τροποποιημένους μύκητες οι οποίοι παράγουν αυτόνομα χοληστερόλη από μια πηγή απλού άνθρακα. Η εφεύρεση αφορά επίσης τη χρήση μυκήτων σύμφωνα με την εφεύρεση για την παραγωγή μη ιχνηθετημένης και ιχνηθετημένης χοληστερόλης.
CY20121100926T 2004-05-06 2012-10-04 Στελεχη ζυμων που παραγουν χοληστερολη και οι εφαρμογες τους CY1113174T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0404890A FR2869914B1 (fr) 2004-05-06 2004-05-06 Souches de levure produisant du cholesterol et leurs applications
EP05763706A EP1745123B1 (fr) 2004-05-06 2005-05-02 Souches de levure produisant du cholesterol et leurs applications

Publications (1)

Publication Number Publication Date
CY1113174T1 true CY1113174T1 (el) 2016-04-13

Family

ID=34946597

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20121100926T CY1113174T1 (el) 2004-05-06 2012-10-04 Στελεχη ζυμων που παραγουν χοληστερολη και οι εφαρμογες τους
CY20181100308T CY1120394T1 (el) 2004-05-06 2018-03-13 Στελεχη ζυμων που παραγουν χοληστερολη και οι εφαρμογες τους

Family Applications After (1)

Application Number Title Priority Date Filing Date
CY20181100308T CY1120394T1 (el) 2004-05-06 2018-03-13 Στελεχη ζυμων που παραγουν χοληστερολη και οι εφαρμογες τους

Country Status (31)

Country Link
US (2) US8211676B2 (el)
EP (2) EP1745123B1 (el)
JP (2) JP5053838B2 (el)
KR (1) KR101252304B1 (el)
CN (1) CN1981029B (el)
AR (1) AR048938A1 (el)
AU (1) AU2005252401B2 (el)
BR (1) BRPI0509598B8 (el)
CA (1) CA2562773C (el)
CY (2) CY1113174T1 (el)
DK (2) DK2354218T3 (el)
ES (2) ES2390588T3 (el)
FR (1) FR2869914B1 (el)
HK (1) HK1107117A1 (el)
HR (2) HRP20120806T1 (el)
HU (1) HUE036218T2 (el)
IL (2) IL178741A (el)
LT (1) LT2354218T (el)
MA (1) MA28570B1 (el)
ME (1) ME01455B (el)
MX (1) MXPA06012840A (el)
NO (2) NO341207B1 (el)
NZ (1) NZ551057A (el)
PL (2) PL1745123T3 (el)
PT (2) PT1745123E (el)
RS (2) RS56952B1 (el)
RU (1) RU2397245C2 (el)
SG (3) SG150408A1 (el)
SI (1) SI2354218T1 (el)
WO (1) WO2005121315A1 (el)
ZA (1) ZA200609162B (el)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100612398B1 (ko) * 2000-11-14 2006-08-16 바이탈 헬스 사이언시즈 피티와이 리미티드 포스페이트 유도체의 착체
FR2869914B1 (fr) * 2004-05-06 2012-11-09 Aventis Pharma Sa Souches de levure produisant du cholesterol et leurs applications
DE102009022772A1 (de) * 2009-05-21 2010-11-25 Organobalance Gmbh Mikroorganismus zur Expression eines humanen Membranproteins
KR101861387B1 (ko) 2009-12-03 2018-05-25 디에스엠 아이피 어셋츠 비.브이. 효모에 의한 비효모 스테롤의 제조
FR2961218A1 (fr) * 2010-06-10 2011-12-16 Sanofi Aventis Methode de detection de composes modulateurs du metabolisme du cholesterol
WO2012095816A1 (en) 2011-01-14 2012-07-19 Sanofi Method for detecting the biological activity of alpha-synuclein
FR2976949B1 (fr) * 2011-06-21 2015-08-28 Sanofi Sa Procede de preparation de levures genetiquement transformees capables de produire une molecule d'interet a haut titre
US20130316462A1 (en) * 2012-05-25 2013-11-28 Health Diagnostic Laboratory, Inc. Rapid and high-throughput analysis of sterols/stanols or derivatives thereof
CN107075551B (zh) * 2014-01-17 2020-09-01 协和发酵生化株式会社 7-脱氢胆固醇和维生素d3的制造法
WO2016056610A1 (ja) * 2014-10-08 2016-04-14 協和発酵バイオ株式会社 ７デヒドロコレステロール及びビタミンｄ３の製造法
CN104805027B (zh) * 2015-05-27 2018-04-27 天津大学 一种重组耶氏解脂酵母菌株及其构建方法和应用
EP3394282B1 (en) * 2015-12-23 2023-06-07 DSM IP Assets B.V. Production of sterols in modified yeast
CN106754993B (zh) * 2017-02-17 2020-06-30 天津大学 一种基因、重组酿酒酵母菌株及其构建方法与应用
JP6909466B2 (ja) * 2017-07-25 2021-07-28 大陽日酸株式会社 標識代謝物の製造方法、代謝物の定量方法、及び標識代謝物製造キット
CN112626159B (zh) * 2021-01-07 2022-08-05 华东理工大学 利用工程酿酒酵母高效生产胆固醇的发酵培养基及其制备方法
CN114577925B (zh) * 2021-12-29 2024-02-02 西南大学 一种水样中粪甾醇类物质快速检测方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB613778A (en) 1946-07-02 1948-12-02 United Domestic Ind Ltd Improvements in or relating to the production of cholesterol
GB646227A (en) 1948-02-27 1950-11-15 Organon Labor Ltd Process for isolation of cholesterol from wool wax alcohols
US2650929A (en) 1948-02-27 1953-09-01 Hewett Colin Leslie Process for isolation of cholesterol from wool wax alcohols
GB690879A (en) 1950-07-21 1953-04-29 Organon Labor Ltd Process for the isolation of cholesterol from wool-wax alcohols
US2688623A (en) 1950-07-21 1954-09-07 Organon Labor Ltd Process for the isolation of cholesterol from wool-wax alcohols
CN1017820B (zh) * 1988-12-01 1992-08-12 韦斯普里米森本亚克 地下空间特别是矿区的排水方法
US5460949A (en) * 1990-11-15 1995-10-24 Amoco Corporation Method and composition for increasing the accumulation of squalene and specific sterols in yeast
IL116872A (en) * 1995-02-15 2004-12-15 Aventis Pharma Sa Delta 5,7-Strol Reductase from Arbidopsis Thaliana
FR2774393B1 (fr) 1998-02-05 2000-03-24 Hoechst Marion Roussel Inc Souches de levure ayant le gene atf2 interrompu et leurs applications
FR2820145B1 (fr) 2001-01-31 2004-01-23 Aventis Pharma Sa Souche de levure produisant des steroides de facon autonome
JP2004141125A (ja) * 2002-08-28 2004-05-20 Mitsubishi Chemicals Corp 代謝工学的に改変されている真菌類およびそれを用いるステロール類の製造法
FR2869914B1 (fr) * 2004-05-06 2012-11-09 Aventis Pharma Sa Souches de levure produisant du cholesterol et leurs applications

Also Published As

Publication number Publication date
US8211676B2 (en) 2012-07-03
IL178741A0 (en) 2007-02-11
CY1120394T1 (el) 2019-07-10
FR2869914B1 (fr) 2012-11-09
SG150408A1 (en) 2009-03-30
MA28570B1 (fr) 2007-05-02
ES2662971T3 (es) 2018-04-10
HUE036218T2 (hu) 2018-06-28
NO20171396A1 (no) 2007-01-18
KR101252304B1 (ko) 2013-04-08
NO20065402L (no) 2007-01-18
EP2354218A3 (fr) 2012-01-18
BRPI0509598B1 (pt) 2016-12-06
SG10201501156WA (en) 2015-04-29
CN1981029B (zh) 2010-06-16
NZ551057A (en) 2009-09-25
AU2005252401B2 (en) 2012-04-05
US20090239837A1 (en) 2009-09-24
RU2397245C2 (ru) 2010-08-20
CA2562773A1 (fr) 2005-12-22
JP2007535960A (ja) 2007-12-13
PT1745123E (pt) 2012-10-03
EP1745123A1 (fr) 2007-01-24
ME01455B (me) 2014-04-20
RS56952B1 (sr) 2018-05-31
SG185179A1 (en) 2012-11-29
EP1745123B1 (fr) 2012-07-11
AU2005252401A1 (en) 2005-12-22
HK1107117A1 (en) 2008-03-28
LT2354218T (lt) 2018-03-26
AR048938A1 (es) 2006-06-14
ES2390588T3 (es) 2012-11-14
US8685705B2 (en) 2014-04-01
WO2005121315A1 (fr) 2005-12-22
KR20070007902A (ko) 2007-01-16
IL238365A0 (en) 2015-06-30
HRP20120806T1 (hr) 2012-11-30
NO341207B1 (no) 2017-09-11
CA2562773C (fr) 2016-12-20
NO343427B1 (no) 2019-03-04
RS52444B (en) 2013-02-28
HRP20180433T1 (hr) 2018-04-20
DK1745123T3 (da) 2012-10-22
CN1981029A (zh) 2007-06-13
PT2354218T (pt) 2018-03-15
ZA200609162B (en) 2009-03-25
DK2354218T3 (en) 2018-03-26
US20120276586A1 (en) 2012-11-01
IL238365B (en) 2018-12-31
IL178741A (en) 2015-07-30
PL2354218T3 (pl) 2018-05-30
RU2006143060A (ru) 2008-06-20
EP2354218B1 (fr) 2017-12-13
JP5053838B2 (ja) 2012-10-24
SI2354218T1 (en) 2018-04-30
JP2012105651A (ja) 2012-06-07
BRPI0509598B8 (pt) 2021-05-25
JP5670310B2 (ja) 2015-02-18
PL1745123T3 (pl) 2012-12-31
MXPA06012840A (es) 2007-02-15
BRPI0509598A (pt) 2007-10-16
FR2869914A1 (fr) 2005-11-11
EP2354218A2 (fr) 2011-08-10

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