CY1110605T1 - Διαδικασια για την παρασκευη ενωσεων πυριμιδινης - Google Patents
Διαδικασια για την παρασκευη ενωσεων πυριμιδινηςInfo
- Publication number
- CY1110605T1 CY1110605T1 CY20101100025T CY101100025T CY1110605T1 CY 1110605 T1 CY1110605 T1 CY 1110605T1 CY 20101100025 T CY20101100025 T CY 20101100025T CY 101100025 T CY101100025 T CY 101100025T CY 1110605 T1 CY1110605 T1 CY 1110605T1
- Authority
- CY
- Cyprus
- Prior art keywords
- compound
- formula
- preparation
- alkyl
- group
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 3
- WCFAPJDPAPDDAQ-UHFFFAOYSA-N 1,2-dihydropyrimidine Chemical compound C1NC=CC=N1 WCFAPJDPAPDDAQ-UHFFFAOYSA-N 0.000 abstract 2
- 125000003341 7 membered heterocyclic group Chemical group 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 125000006575 electron-withdrawing group Chemical group 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/20—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D239/22—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
- C07C69/716—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0229243A GB0229243D0 (en) | 2002-12-16 | 2002-12-16 | Compounds and process |
| GB0303589A GB0303589D0 (en) | 2003-02-17 | 2003-02-17 | Compounds and process |
| GB0318515A GB0318515D0 (en) | 2003-08-07 | 2003-08-07 | Compounds and process |
| EP03780362A EP1578731B1 (en) | 2002-12-16 | 2003-12-09 | Process for the preparation of pyrimidine compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1110605T1 true CY1110605T1 (el) | 2015-04-29 |
Family
ID=32600665
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20101100025T CY1110605T1 (el) | 2002-12-16 | 2010-01-11 | Διαδικασια για την παρασκευη ενωσεων πυριμιδινης |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US7524955B2 (enExample) |
| EP (2) | EP1578731B1 (enExample) |
| JP (2) | JP4579821B2 (enExample) |
| KR (1) | KR101060215B1 (enExample) |
| AR (1) | AR042355A1 (enExample) |
| AT (1) | ATE448209T1 (enExample) |
| AU (1) | AU2003288443B2 (enExample) |
| BR (1) | BR0317313A (enExample) |
| CA (1) | CA2509344C (enExample) |
| CY (1) | CY1110605T1 (enExample) |
| DE (1) | DE60330050D1 (enExample) |
| DK (1) | DK1578731T3 (enExample) |
| ES (1) | ES2335279T3 (enExample) |
| IL (1) | IL168884A (enExample) |
| MX (1) | MXPA05006425A (enExample) |
| MY (1) | MY138051A (enExample) |
| NO (2) | NO330983B1 (enExample) |
| NZ (1) | NZ540722A (enExample) |
| PT (1) | PT1578731E (enExample) |
| SI (1) | SI1578731T1 (enExample) |
| TW (1) | TWI322145B (enExample) |
| WO (1) | WO2004054986A2 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0011120D0 (en) | 2000-05-09 | 2000-06-28 | Avecia Ltd | Process |
| NL1015744C2 (nl) | 2000-07-19 | 2002-01-22 | Dsm Nv | Werkwijze voor de bereiding van 2-(6-gesubstitueerde-1,3-dioxan-4-yl) azijnzuurderivaten. |
| CN1301977C (zh) * | 2001-07-13 | 2007-02-28 | 阿斯特拉曾尼卡英国有限公司 | 氨基嘧啶化合物的制备方法 |
| EP1323717A1 (en) | 2001-12-27 | 2003-07-02 | Dsm N.V. | Process for the preparation of 2-(6-Substituted-1,3-Dioxane-4-yL) acetic acid derivatives |
| KR20030092446A (ko) * | 2002-05-29 | 2003-12-06 | 주식회사 한국토종약초연구소 | 씨형 간염 활성 억제를 갖는 조릿대 추출물을 포함하는조성물 |
| EP1375493A1 (en) | 2002-06-17 | 2004-01-02 | Dsm N.V. | Process for the preparation of an dioxane acetic acid ester |
| GB0218781D0 (en) | 2002-08-13 | 2002-09-18 | Astrazeneca Ab | Chemical process |
| JP4579821B2 (ja) | 2002-12-16 | 2010-11-10 | アストラゼネカ・ユーケイ・リミテッド | ピリミジン化合物を製造するための方法 |
| GB0312896D0 (en) * | 2003-06-05 | 2003-07-09 | Astrazeneca Ab | Chemical process |
| UY28501A1 (es) | 2003-09-10 | 2005-04-29 | Astrazeneca Uk Ltd | Compuestos químicos |
| GB0324791D0 (en) * | 2003-10-24 | 2003-11-26 | Astrazeneca Ab | Chemical process |
| GB0428328D0 (en) * | 2004-12-24 | 2005-02-02 | Astrazeneca Uk Ltd | Chemical process |
| GB0514078D0 (en) * | 2005-07-08 | 2005-08-17 | Astrazeneca Uk Ltd | Chemical process |
| US8153791B2 (en) | 2005-12-21 | 2012-04-10 | Janssen Pharmaceutica N.V. | Substituted pyrimidinyl oxime kinase inhibitors |
| WO2007109783A2 (en) * | 2006-03-23 | 2007-09-27 | Janssen Pharmaceutica, N.V. | Substituted pyrimidine kinase inhibitors |
| TW200831469A (en) * | 2006-12-01 | 2008-08-01 | Astrazeneca Uk Ltd | Chemical process |
| US8328569B2 (en) | 2010-05-21 | 2012-12-11 | Cooper Technologies Company | Adapter for coupling a deadbreak bushing to a deadbreak arrestor elbow |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3278001A (en) * | 1965-02-02 | 1966-10-11 | Charles C Andrews | Bearing assembly for auger conveyors |
| US4698340A (en) | 1984-07-19 | 1987-10-06 | Fujisawa Pharmaceutical Co., Ltd. | Pyrimidine derivatives, processes for preparation thereof and composition containing the same |
| US4689414A (en) * | 1986-02-24 | 1987-08-25 | E. R. Squibb & Sons, Inc. | 2-(substituted imino)-6-aryl-3,6-dihydro-4-substituted-1,5(2H)-pyrimidinecarboxylic acids and analogs |
| WO1990003973A1 (en) | 1988-10-06 | 1990-04-19 | Sandoz Ag | Pyrimidinyl-substituted hydroxyacids, lactones and esters and pharmaceutical compositions containing them |
| FR2665159B1 (fr) | 1990-07-24 | 1992-11-13 | Rhone Poulenc Sante | Nouveaux derives de la pyridine et de la quinoleine, leur preparation et les compositions pharmaceutiques qui les contiennent. |
| JP2648897B2 (ja) * | 1991-07-01 | 1997-09-03 | 塩野義製薬株式会社 | ピリミジン誘導体 |
| WO1993008823A1 (en) | 1991-11-06 | 1993-05-13 | Tanabe Seiyaku Co., Ltd. | Guanidinyl and related cell adhesion modulation compounds |
| JP3197971B2 (ja) | 1993-03-01 | 2001-08-13 | 塩野義製薬株式会社 | ５−カルボアルコキシピリミジン誘導体の合成方法 |
| US5593992A (en) * | 1993-07-16 | 1997-01-14 | Smithkline Beecham Corporation | Compounds |
| NZ264063A (en) | 1993-08-13 | 1995-11-27 | Nihon Nohyaku Co Ltd | N-(2-phenylpyrid-3-yl)- and n-(4-phenylpyrimidin-5-yl)-n'-phenylurea derivatives and pharmaceutical compositions |
| JP3200070B2 (ja) | 1994-11-16 | 2001-08-20 | シナプティック・ファーマスーティカル・コーポレーション | ジヒドロピリミジン類およびその使用 |
| DE19517186A1 (de) * | 1995-05-11 | 1996-11-14 | Bayer Ag | Verfahren zur Herstellung substituierter 2-Fluor-pyrimidine |
| FR2741620B1 (fr) | 1995-11-28 | 1997-12-26 | Oreal | Procede de preparation de composes a groupement beta-hydroxy -delta-lactone analogues de la (+) compactine et de la (+) mevinoline |
| US6278001B1 (en) | 1995-11-28 | 2001-08-21 | L'oréal | Method for preparing (+) compactin and (+) mevinolin analog compounds having a β-hydroxy-δ-lactone grouping |
| CZ184098A3 (cs) | 1995-12-14 | 1998-11-11 | Merck And Co., Inc. | Způsob výroby dihydropyrimidinonů |
| US5958934A (en) | 1996-05-23 | 1999-09-28 | Syntex (U.S.A.) Inc. | Aryl pyrimidine derivatives and uses thereof |
| SE9702563D0 (sv) | 1997-07-02 | 1997-07-02 | Astra Ab | Compounds |
| AU8680598A (en) | 1997-08-05 | 1999-03-01 | Merck & Co., Inc. | Alpha 1a adrenergic receptor antagonist |
| GB9903472D0 (en) * | 1999-02-17 | 1999-04-07 | Zeneca Ltd | Chemical process |
| AU5568400A (en) * | 1999-06-23 | 2001-01-09 | Ajinomoto Co., Inc. | Novel dihydropyrimidine derivatives |
| AU6266600A (en) | 1999-07-13 | 2001-01-30 | Lonza A.G. | Process for preparing 2-amino-4-(4-fluorphenyl)-6-alkylpyrimidine-5-carboxylate |
| GB0003305D0 (en) | 2000-02-15 | 2000-04-05 | Zeneca Ltd | Pyrimidine derivatives |
| WO2001072706A1 (en) | 2000-03-28 | 2001-10-04 | Biocon India Limited | Synthesis of [r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid hemi calcium salt (atorvastatin) |
| GB0011120D0 (en) | 2000-05-09 | 2000-06-28 | Avecia Ltd | Process |
| GB0011163D0 (en) | 2000-05-10 | 2000-06-28 | Astrazeneca Ab | Chemical compound |
| NL1015744C2 (nl) | 2000-07-19 | 2002-01-22 | Dsm Nv | Werkwijze voor de bereiding van 2-(6-gesubstitueerde-1,3-dioxan-4-yl) azijnzuurderivaten. |
| CN1301977C (zh) | 2001-07-13 | 2007-02-28 | 阿斯特拉曾尼卡英国有限公司 | 氨基嘧啶化合物的制备方法 |
| EP1323717A1 (en) | 2001-12-27 | 2003-07-02 | Dsm N.V. | Process for the preparation of 2-(6-Substituted-1,3-Dioxane-4-yL) acetic acid derivatives |
| KR100511533B1 (ko) | 2002-04-09 | 2005-08-31 | 임광민 | 키랄 중간체, 그의 제조방법 및 그를 이용한 HMG-CoA환원저해제의 제조방법 |
| EP1375493A1 (en) | 2002-06-17 | 2004-01-02 | Dsm N.V. | Process for the preparation of an dioxane acetic acid ester |
| GB0218781D0 (en) | 2002-08-13 | 2002-09-18 | Astrazeneca Ab | Chemical process |
| JP4579821B2 (ja) | 2002-12-16 | 2010-11-10 | アストラゼネカ・ユーケイ・リミテッド | ピリミジン化合物を製造するための方法 |
| WO2004103977A2 (en) | 2003-05-21 | 2004-12-02 | Ciba Specialty Chemicals Holding Inc. | Process for the preparation of pyrimidine derivatives |
| GB0312896D0 (en) | 2003-06-05 | 2003-07-09 | Astrazeneca Ab | Chemical process |
| UY28501A1 (es) | 2003-09-10 | 2005-04-29 | Astrazeneca Uk Ltd | Compuestos químicos |
| GB0321827D0 (en) | 2003-09-18 | 2003-10-15 | Astrazeneca Uk Ltd | Chemical compounds |
| GB0324791D0 (en) | 2003-10-24 | 2003-11-26 | Astrazeneca Ab | Chemical process |
| US20050159615A1 (en) | 2003-12-24 | 2005-07-21 | Entire Interest. | Process for preparation of statins with high syn to anti ratio |
| GB0428328D0 (en) | 2004-12-24 | 2005-02-02 | Astrazeneca Uk Ltd | Chemical process |
-
2003
- 2003-12-09 JP JP2005502458A patent/JP4579821B2/ja not_active Expired - Fee Related
- 2003-12-09 NZ NZ540722A patent/NZ540722A/en not_active IP Right Cessation
- 2003-12-09 MX MXPA05006425A patent/MXPA05006425A/es active IP Right Grant
- 2003-12-09 CA CA2509344A patent/CA2509344C/en not_active Expired - Fee Related
- 2003-12-09 KR KR1020057010964A patent/KR101060215B1/ko not_active Expired - Fee Related
- 2003-12-09 DE DE60330050T patent/DE60330050D1/de not_active Expired - Lifetime
- 2003-12-09 DK DK03780362.4T patent/DK1578731T3/da active
- 2003-12-09 SI SI200331722T patent/SI1578731T1/sl unknown
- 2003-12-09 AU AU2003288443A patent/AU2003288443B2/en not_active Ceased
- 2003-12-09 WO PCT/GB2003/005359 patent/WO2004054986A2/en not_active Ceased
- 2003-12-09 BR BR0317313-5A patent/BR0317313A/pt not_active IP Right Cessation
- 2003-12-09 AT AT03780362T patent/ATE448209T1/de active
- 2003-12-09 EP EP03780362A patent/EP1578731B1/en not_active Expired - Lifetime
- 2003-12-09 PT PT03780362T patent/PT1578731E/pt unknown
- 2003-12-09 EP EP09159247A patent/EP2088142A3/en not_active Ceased
- 2003-12-09 US US10/537,723 patent/US7524955B2/en not_active Expired - Fee Related
- 2003-12-09 ES ES03780362T patent/ES2335279T3/es not_active Expired - Lifetime
- 2003-12-10 AR ARP030104541A patent/AR042355A1/es unknown
- 2003-12-12 MY MYPI20034768A patent/MY138051A/en unknown
- 2003-12-16 TW TW092135557A patent/TWI322145B/zh not_active IP Right Cessation
-
2005
- 2005-05-30 IL IL168884A patent/IL168884A/en not_active IP Right Cessation
- 2005-06-08 NO NO20052781A patent/NO330983B1/no not_active IP Right Cessation
-
2009
- 2009-03-16 US US12/404,575 patent/US8273878B2/en not_active Expired - Fee Related
-
2010
- 2010-01-11 CY CY20101100025T patent/CY1110605T1/el unknown
- 2010-06-23 JP JP2010142779A patent/JP5318037B2/ja not_active Expired - Fee Related
-
2011
- 2011-03-10 NO NO20110366A patent/NO20110366L/no not_active Application Discontinuation
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