KR101060215B1 - 피리미딘 화합물의 제조 방법 - Google Patents

피리미딘 화합물의 제조 방법 Download PDF

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Publication number
KR101060215B1
KR101060215B1 KR1020057010964A KR20057010964A KR101060215B1 KR 101060215 B1 KR101060215 B1 KR 101060215B1 KR 1020057010964 A KR1020057010964 A KR 1020057010964A KR 20057010964 A KR20057010964 A KR 20057010964A KR 101060215 B1 KR101060215 B1 KR 101060215B1
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KR
South Korea
Prior art keywords
group
formula
compound
alkyl
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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KR1020057010964A
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English (en)
Korean (ko)
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KR20050085674A (ko
Inventor
리 뉴튼
마크 베일리
Original Assignee
아스트라제네카 유케이 리미티드
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Priority claimed from GB0229243A external-priority patent/GB0229243D0/en
Priority claimed from GB0303589A external-priority patent/GB0303589D0/en
Priority claimed from GB0318515A external-priority patent/GB0318515D0/en
Application filed by 아스트라제네카 유케이 리미티드 filed Critical 아스트라제네카 유케이 리미티드
Publication of KR20050085674A publication Critical patent/KR20050085674A/ko
Application granted granted Critical
Publication of KR101060215B1 publication Critical patent/KR101060215B1/ko
Anticipated expiration legal-status Critical
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/20—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D239/22—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/716—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
KR1020057010964A 2002-12-16 2003-12-09 피리미딘 화합물의 제조 방법 Expired - Fee Related KR101060215B1 (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GB0229243A GB0229243D0 (en) 2002-12-16 2002-12-16 Compounds and process
GB0229243.1 2002-12-16
GB0303589.6 2003-02-17
GB0303589A GB0303589D0 (en) 2003-02-17 2003-02-17 Compounds and process
GB0318515A GB0318515D0 (en) 2003-08-07 2003-08-07 Compounds and process
GB0318515.4 2003-08-07
PCT/GB2003/005359 WO2004054986A2 (en) 2002-12-16 2003-12-09 Process for the preparation of pyrimidine compounds

Publications (2)

Publication Number Publication Date
KR20050085674A KR20050085674A (ko) 2005-08-29
KR101060215B1 true KR101060215B1 (ko) 2011-08-29

Family

ID=32600665

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020057010964A Expired - Fee Related KR101060215B1 (ko) 2002-12-16 2003-12-09 피리미딘 화합물의 제조 방법

Country Status (22)

Country Link
US (2) US7524955B2 (enExample)
EP (2) EP1578731B1 (enExample)
JP (2) JP4579821B2 (enExample)
KR (1) KR101060215B1 (enExample)
AR (1) AR042355A1 (enExample)
AT (1) ATE448209T1 (enExample)
AU (1) AU2003288443B2 (enExample)
BR (1) BR0317313A (enExample)
CA (1) CA2509344C (enExample)
CY (1) CY1110605T1 (enExample)
DE (1) DE60330050D1 (enExample)
DK (1) DK1578731T3 (enExample)
ES (1) ES2335279T3 (enExample)
IL (1) IL168884A (enExample)
MX (1) MXPA05006425A (enExample)
MY (1) MY138051A (enExample)
NO (2) NO330983B1 (enExample)
NZ (1) NZ540722A (enExample)
PT (1) PT1578731E (enExample)
SI (1) SI1578731T1 (enExample)
TW (1) TWI322145B (enExample)
WO (1) WO2004054986A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20030092446A (ko) * 2002-05-29 2003-12-06 주식회사 한국토종약초연구소 씨형 간염 활성 억제를 갖는 조릿대 추출물을 포함하는조성물

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GB0011120D0 (en) 2000-05-09 2000-06-28 Avecia Ltd Process
NL1015744C2 (nl) 2000-07-19 2002-01-22 Dsm Nv Werkwijze voor de bereiding van 2-(6-gesubstitueerde-1,3-dioxan-4-yl) azijnzuurderivaten.
CN1301977C (zh) * 2001-07-13 2007-02-28 阿斯特拉曾尼卡英国有限公司 氨基嘧啶化合物的制备方法
EP1323717A1 (en) 2001-12-27 2003-07-02 Dsm N.V. Process for the preparation of 2-(6-Substituted-1,3-Dioxane-4-yL) acetic acid derivatives
EP1375493A1 (en) 2002-06-17 2004-01-02 Dsm N.V. Process for the preparation of an dioxane acetic acid ester
GB0218781D0 (en) 2002-08-13 2002-09-18 Astrazeneca Ab Chemical process
JP4579821B2 (ja) 2002-12-16 2010-11-10 アストラゼネカ・ユーケイ・リミテッド ピリミジン化合物を製造するための方法
GB0312896D0 (en) * 2003-06-05 2003-07-09 Astrazeneca Ab Chemical process
UY28501A1 (es) 2003-09-10 2005-04-29 Astrazeneca Uk Ltd Compuestos químicos
GB0324791D0 (en) * 2003-10-24 2003-11-26 Astrazeneca Ab Chemical process
GB0428328D0 (en) * 2004-12-24 2005-02-02 Astrazeneca Uk Ltd Chemical process
GB0514078D0 (en) * 2005-07-08 2005-08-17 Astrazeneca Uk Ltd Chemical process
US8153791B2 (en) 2005-12-21 2012-04-10 Janssen Pharmaceutica N.V. Substituted pyrimidinyl oxime kinase inhibitors
WO2007109783A2 (en) * 2006-03-23 2007-09-27 Janssen Pharmaceutica, N.V. Substituted pyrimidine kinase inhibitors
TW200831469A (en) * 2006-12-01 2008-08-01 Astrazeneca Uk Ltd Chemical process
US8328569B2 (en) 2010-05-21 2012-12-11 Cooper Technologies Company Adapter for coupling a deadbreak bushing to a deadbreak arrestor elbow

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WO1990003973A1 (en) 1988-10-06 1990-04-19 Sandoz Ag Pyrimidinyl-substituted hydroxyacids, lactones and esters and pharmaceutical compositions containing them

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US4689414A (en) * 1986-02-24 1987-08-25 E. R. Squibb & Sons, Inc. 2-(substituted imino)-6-aryl-3,6-dihydro-4-substituted-1,5(2H)-pyrimidinecarboxylic acids and analogs
FR2665159B1 (fr) 1990-07-24 1992-11-13 Rhone Poulenc Sante Nouveaux derives de la pyridine et de la quinoleine, leur preparation et les compositions pharmaceutiques qui les contiennent.
JP2648897B2 (ja) * 1991-07-01 1997-09-03 塩野義製薬株式会社 ピリミジン誘導体
WO1993008823A1 (en) 1991-11-06 1993-05-13 Tanabe Seiyaku Co., Ltd. Guanidinyl and related cell adhesion modulation compounds
JP3197971B2 (ja) 1993-03-01 2001-08-13 塩野義製薬株式会社 ５−カルボアルコキシピリミジン誘導体の合成方法
US5593992A (en) * 1993-07-16 1997-01-14 Smithkline Beecham Corporation Compounds
NZ264063A (en) 1993-08-13 1995-11-27 Nihon Nohyaku Co Ltd N-(2-phenylpyrid-3-yl)- and n-(4-phenylpyrimidin-5-yl)-n'-phenylurea derivatives and pharmaceutical compositions
JP3200070B2 (ja) 1994-11-16 2001-08-20 シナプティック・ファーマスーティカル・コーポレーション ジヒドロピリミジン類およびその使用
DE19517186A1 (de) * 1995-05-11 1996-11-14 Bayer Ag Verfahren zur Herstellung substituierter 2-Fluor-pyrimidine
FR2741620B1 (fr) 1995-11-28 1997-12-26 Oreal Procede de preparation de composes a groupement beta-hydroxy -delta-lactone analogues de la (+) compactine et de la (+) mevinoline
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CZ184098A3 (cs) 1995-12-14 1998-11-11 Merck And Co., Inc. Způsob výroby dihydropyrimidinonů
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NL1015744C2 (nl) 2000-07-19 2002-01-22 Dsm Nv Werkwijze voor de bereiding van 2-(6-gesubstitueerde-1,3-dioxan-4-yl) azijnzuurderivaten.
CN1301977C (zh) 2001-07-13 2007-02-28 阿斯特拉曾尼卡英国有限公司 氨基嘧啶化合物的制备方法
EP1323717A1 (en) 2001-12-27 2003-07-02 Dsm N.V. Process for the preparation of 2-(6-Substituted-1,3-Dioxane-4-yL) acetic acid derivatives
KR100511533B1 (ko) 2002-04-09 2005-08-31 임광민 키랄 중간체, 그의 제조방법 및 그를 이용한 HMG-CoA환원저해제의 제조방법
EP1375493A1 (en) 2002-06-17 2004-01-02 Dsm N.V. Process for the preparation of an dioxane acetic acid ester
GB0218781D0 (en) 2002-08-13 2002-09-18 Astrazeneca Ab Chemical process
JP4579821B2 (ja) 2002-12-16 2010-11-10 アストラゼネカ・ユーケイ・リミテッド ピリミジン化合物を製造するための方法
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Publication number Priority date Publication date Assignee Title
WO1990003973A1 (en) 1988-10-06 1990-04-19 Sandoz Ag Pyrimidinyl-substituted hydroxyacids, lactones and esters and pharmaceutical compositions containing them

Non-Patent Citations (2)

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Title
Bioorganic & Medicinal Chemistry Letters, 10(1), pp.49-51(2000.01.03.)
Monatshefte fur Chemie, 106(6), pp.1479-1493(1975)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20030092446A (ko) * 2002-05-29 2003-12-06 주식회사 한국토종약초연구소 씨형 간염 활성 억제를 갖는 조릿대 추출물을 포함하는조성물

Also Published As

Publication number Publication date
JP4579821B2 (ja) 2010-11-10
NO20110366L (no) 2005-07-07
US7524955B2 (en) 2009-04-28
CY1110605T1 (el) 2015-04-29
SI1578731T1 (sl) 2010-02-26
AR042355A1 (es) 2005-06-15
PT1578731E (pt) 2010-01-12
KR20050085674A (ko) 2005-08-29
AU2003288443A1 (en) 2004-07-09
DK1578731T3 (da) 2010-02-15
NZ540722A (en) 2008-03-28
JP5318037B2 (ja) 2013-10-16
JP2010248222A (ja) 2010-11-04
HK1080477A1 (en) 2006-04-28
EP1578731A2 (en) 2005-09-28
NO330983B1 (no) 2011-08-29
US8273878B2 (en) 2012-09-25
NO20052781L (no) 2005-07-07
ES2335279T3 (es) 2010-03-24
EP2088142A3 (en) 2010-04-21
WO2004054986A2 (en) 2004-07-01
IL168884A (en) 2011-01-31
MY138051A (en) 2009-04-30
US20090264654A1 (en) 2009-10-22
MXPA05006425A (es) 2005-08-19
EP2088142A2 (en) 2009-08-12
WO2004054986A3 (en) 2004-12-02
TW200418809A (en) 2004-10-01
ATE448209T1 (de) 2009-11-15
CA2509344C (en) 2011-10-04
BR0317313A (pt) 2005-11-08
JP2006515600A (ja) 2006-06-01
DE60330050D1 (de) 2009-12-24
US20060052604A1 (en) 2006-03-09
EP1578731B1 (en) 2009-11-11
WO2004054986A8 (en) 2005-07-21
TWI322145B (en) 2010-03-21
CA2509344A1 (en) 2004-07-01
AU2003288443B2 (en) 2007-10-25

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