ES8507111A1 - Un procedimiento para la preparacion de compuestos de 1,4-dihidropiridina. - Google Patents
Un procedimiento para la preparacion de compuestos de 1,4-dihidropiridina.Info
- Publication number
- ES8507111A1 ES8507111A1 ES537268A ES537268A ES8507111A1 ES 8507111 A1 ES8507111 A1 ES 8507111A1 ES 537268 A ES537268 A ES 537268A ES 537268 A ES537268 A ES 537268A ES 8507111 A1 ES8507111 A1 ES 8507111A1
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- aryl
- ischaemic
- nhco
- heterocyclic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- YNGDWRXWKFWCJY-UHFFFAOYSA-N 1,4-Dihydropyridine Chemical compound C1C=CNC=C1 YNGDWRXWKFWCJY-UHFFFAOYSA-N 0.000 title abstract 2
- 230000002253 anti-ischaemic effect Effects 0.000 title abstract 2
- 229940030600 antihypertensive agent Drugs 0.000 title abstract 2
- 239000002220 antihypertensive agent Substances 0.000 title abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 12
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- 125000004200 2-methoxyethyl group Chemical group [H]C([H])([H])OC([H])([H])C([H])([H])* 0.000 abstract 1
- 101100134922 Gallus gallus COR5 gene Proteins 0.000 abstract 1
- -1 SO2N(C1-C4 alkyl)2 Inorganic materials 0.000 abstract 1
- 229910006074 SO2NH2 Inorganic materials 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000006367 bivalent amino carbonyl group Chemical group [H]N([*:1])C([*:2])=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000000717 hydrazino group Chemical group [H]N([*])N([H])[H] 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000565 sulfonamide group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE COMPUESTOS DE 1,4-DIHIDROPIRINA.CONSISTE EN: HACER REACCIONAR A UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III), DURANTE VARIAS HORAS, CALENTADO A REFLUJO EN METANOL, PARA OBTENER UN COMPUESTO DE FORMULA (I) Y SUS SALES DE ADICION DE ACIDOS FARMACEUTICAMENTE ACEPTABLES. SIENDO; R ARILO O HETEROARILO; R1 Y R2, ALQUILO DE C 1 A 4 O 2-METOXIETILO; R3, H, ALQUILO DE C 1 A 4, CH2CO2 (ALQUILO DE C 1 A 4) Y OTROS Y OTROS; R4-C(FNR6)R7; R6, H, CN, CO2 (ALQUILO C 1 A 4) Y OTROS; R7, NH2, NHCO (ALQUILO DE C 1 A 4), NH (ALQUILO DE C 1 A 4) Y OTROS; R10, SCH3 NH2 Y OTROS Y N, 2, 3 O 4.SE UTILIZAN COMO ANTI-ISQUEMICOS Y ANTI-HIPERTENSIVOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB838306666A GB8306666D0 (en) | 1983-03-10 | 1983-03-10 | Therapeutic agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES537268A0 ES537268A0 (es) | 1985-08-16 |
| ES8507111A1 true ES8507111A1 (es) | 1985-08-16 |
Family
ID=10539350
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES530379A Granted ES530379A0 (es) | 1983-03-10 | 1984-03-08 | Un procedimiento para la preparacion de compuestos de 1, 4-dihidropiridina. |
| ES537268A Expired ES8507111A1 (es) | 1983-03-10 | 1984-10-31 | Un procedimiento para la preparacion de compuestos de 1,4-dihidropiridina. |
| ES537269A Expired ES8507112A1 (es) | 1983-03-10 | 1984-10-31 | Un procedimiento para la prpeparacion de compuestos de 1,4-dihidropiridina. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES530379A Granted ES530379A0 (es) | 1983-03-10 | 1984-03-08 | Un procedimiento para la preparacion de compuestos de 1, 4-dihidropiridina. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES537269A Expired ES8507112A1 (es) | 1983-03-10 | 1984-10-31 | Un procedimiento para la prpeparacion de compuestos de 1,4-dihidropiridina. |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US4590195A (es) |
| EP (1) | EP0119050B1 (es) |
| JP (1) | JPS59175466A (es) |
| KR (1) | KR840008147A (es) |
| AU (1) | AU546634B2 (es) |
| DE (1) | DE3477379D1 (es) |
| DK (1) | DK168378B1 (es) |
| ES (3) | ES530379A0 (es) |
| FI (1) | FI840955A (es) |
| GB (1) | GB8306666D0 (es) |
| GR (1) | GR81872B (es) |
| HU (1) | HU191220B (es) |
| IE (1) | IE57116B1 (es) |
| IL (1) | IL71187A0 (es) |
| PH (1) | PH20692A (es) |
| PL (2) | PL252773A1 (es) |
| PT (1) | PT78219B (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8421039D0 (en) * | 1984-08-17 | 1984-09-19 | Wyeth John & Brother Ltd | Heterocyclic compounds |
| GB8501395D0 (en) * | 1985-01-19 | 1985-02-20 | Pfizer Ltd | Dihydropyridine anti-ischaemic & anti-hypertensive agents |
| IT1204421B (it) * | 1986-06-27 | 1989-03-01 | Boehringer Biochemia Srl | 2-(aminoalchiltio)metil-1,4-diidropiridine,un metodo per la loro preparazione e composizioni farmaceutiche che le contengono |
| EP0233228A1 (en) * | 1985-08-06 | 1987-08-26 | Boehringer Mannheim Italia S.P.A. | Pharmaceutically active 2-thiomethyl-substituted-1,4-dihydropyridines |
| IT1201454B (it) * | 1985-08-19 | 1989-02-02 | Boehringer Biochemia Srl | 1,4-diidropiridine-2-sostituite |
| GB8527698D0 (en) * | 1985-11-09 | 1985-12-11 | Pfizer Ltd | Dihydropyridine antiischaemic & antihypertensive agents |
| EP0225175A3 (en) * | 1985-11-28 | 1988-12-28 | FISONS plc | Dihydropyridine derivatives, processes for their preparation and pharmaceutical compositions thereof |
| DE3621104A1 (de) * | 1986-06-24 | 1988-01-07 | Heumann Pharma Gmbh & Co | 1,4-dihydropyridinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| IT1197012B (it) * | 1986-07-29 | 1988-11-25 | Boehringer Biochemia Srl | 2-(aciltio) metil diidropiridine, un processo per la loro preparazione e composizioni farmaceutiche che le contengono |
| FR2602231B1 (fr) * | 1986-08-04 | 1988-10-28 | Adir | Nouveaux derives de la dihydro-1,4 pyridine, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent |
| IT1213555B (it) * | 1986-12-11 | 1989-12-20 | Boehringer Biochemia Srl | 2 metiltiometildiidropiridine, un processo per laloro preparazione e composizioni farmaceutiche che le contengono. |
| IT1215381B (it) * | 1987-03-12 | 1990-02-08 | Boehringer Biochemia Srl | Farmaceutiche che le contengono. carbonil- e solfonil- derivati di 2-(aminoalchiltio)metil-1,4-diidropiridine, un metodo per la loro preparazione e composizioni |
| GB8710493D0 (en) * | 1987-05-02 | 1987-06-03 | Pfizer Ltd | Dihydropyridines |
| NZ229828A (en) * | 1988-08-09 | 1992-03-26 | Squibb & Sons Inc | Aryl cyanoguanidine derivatives and pharmaceutical compositions |
| US5278169A (en) * | 1988-08-09 | 1994-01-11 | E. R. Squibb & Sons, Inc. | Method of treating or prevention of fibrillation of the heart |
| IE960442L (en) * | 1988-12-27 | 1990-06-27 | Takeda Chemical Industries Ltd | Guanidine derivatives, their production and insecticides |
| AT5874U1 (de) | 2000-12-29 | 2003-01-27 | Bioorg Bv | Pharmazeutische zubereitungen enthaltend amlodipinmaleat |
| US20070135488A1 (en) * | 2002-04-13 | 2007-06-14 | Chung You S | Amlodipine nicotinate and process for the preparation thereof |
| CA2501534A1 (en) * | 2002-10-07 | 2004-04-22 | Artesian Therapeutics, Inc. | Dihydropyridine compounds having simultaneous ability to block l-type calcium channels and to inhibit phosphodiesterase type 3 activity |
| US20070066619A1 (en) * | 2002-10-07 | 2007-03-22 | Artesian Therapeutics, Inc. | Compounds having simultaneous ability to block L-type calcium channels and to inhibit phosphodiesterase type 3 activity |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3974278A (en) * | 1973-07-12 | 1976-08-10 | Bayer Aktiengesellschaft | 1,4-Dihydropyridine esters |
| US4177278A (en) * | 1977-04-05 | 1979-12-04 | Bayer Aktiengesellschaft | 2-Alkyleneaminodihydropyridines compounds, their production and their medicinal use |
| JPS5547656A (en) * | 1978-09-29 | 1980-04-04 | Dainippon Pharmaceut Co Ltd | 2-(2-substituted aminoethyl)-1,4-dihydropyridine derivative and its derivative |
| SE7910521L (sv) * | 1979-12-20 | 1981-06-21 | Haessle Ab | Nya 2-metyl-6-substituerade-4-(2,3-disubstituerad fenyl)-1,4-dihydropyridin-3,5-diestrar med hypotesiva egenskaper, samt forfarande for deras framstellning, och farmaceutiska beredningar innehallande desamma |
| DE3022030A1 (de) * | 1980-06-12 | 1981-12-17 | Bayer Ag, 5090 Leverkusen | 4-thiazol- bzw. 4-imidazol-substituierte, 1,4-dihydropyridine, verfahren zu deren herstellung sowie diese enthaltende arzneimittel |
| CS228917B2 (en) * | 1981-03-14 | 1984-05-14 | Pfizer | Method of preparing substituted derivatives of 1,4-dihydropyridine |
| DK161312C (da) * | 1982-03-11 | 1991-12-09 | Pfizer | Analogifremgangsmaade til fremstilling af 2-aminoalkoxymethyl-4-phenyl-6-methyl-1,4-dihydropyridin-3,5-dicarboxylsyreestere eller syreadditionssalte deraf samt phthalimidoderivater til anvendelse som udgangsmateriale ved fremgangsmaaden |
| US4568677A (en) * | 1983-07-23 | 1986-02-04 | Pfizer Inc. | 2-(4-Pyrimidone alkoxyalkyl) dihydropyridine anti-ischaemic and antihypertensive agents |
-
1983
- 1983-03-10 GB GB838306666A patent/GB8306666D0/en active Pending
-
1984
- 1984-02-29 DK DK135884A patent/DK168378B1/da not_active IP Right Cessation
- 1984-03-05 US US06/586,514 patent/US4590195A/en not_active Expired - Lifetime
- 1984-03-06 DE DE8484301452T patent/DE3477379D1/de not_active Expired
- 1984-03-06 EP EP84301452A patent/EP0119050B1/en not_active Expired
- 1984-03-06 PH PH30346A patent/PH20692A/en unknown
- 1984-03-08 GR GR74031A patent/GR81872B/el unknown
- 1984-03-08 ES ES530379A patent/ES530379A0/es active Granted
- 1984-03-08 FI FI840955A patent/FI840955A/fi not_active Application Discontinuation
- 1984-03-08 PL PL25277384A patent/PL252773A1/xx unknown
- 1984-03-08 IL IL71187A patent/IL71187A0/xx unknown
- 1984-03-08 PT PT78219A patent/PT78219B/pt not_active IP Right Cessation
- 1984-03-08 PL PL24657484A patent/PL246574A1/xx unknown
- 1984-03-09 AU AU25464/84A patent/AU546634B2/en not_active Ceased
- 1984-03-09 KR KR1019840001209A patent/KR840008147A/ko not_active Application Discontinuation
- 1984-03-09 HU HU84964A patent/HU191220B/hu unknown
- 1984-03-09 IE IE585/84A patent/IE57116B1/en not_active IP Right Cessation
- 1984-03-10 JP JP59046375A patent/JPS59175466A/ja active Pending
- 1984-10-31 ES ES537268A patent/ES8507111A1/es not_active Expired
- 1984-10-31 ES ES537269A patent/ES8507112A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| KR840008147A (ko) | 1984-12-13 |
| DE3477379D1 (en) | 1989-04-27 |
| ES537268A0 (es) | 1985-08-16 |
| GB8306666D0 (en) | 1983-04-13 |
| PL252773A1 (en) | 1985-11-19 |
| EP0119050A3 (en) | 1987-07-01 |
| PL246574A1 (en) | 1985-08-13 |
| AU546634B2 (en) | 1985-09-12 |
| JPS59175466A (ja) | 1984-10-04 |
| EP0119050B1 (en) | 1989-03-22 |
| ES8506275A1 (es) | 1985-07-01 |
| ES530379A0 (es) | 1985-07-01 |
| ES537269A0 (es) | 1985-08-16 |
| FI840955A0 (fi) | 1984-03-08 |
| ES8507112A1 (es) | 1985-08-16 |
| PT78219B (en) | 1986-08-12 |
| DK135884D0 (da) | 1984-02-29 |
| AU2546484A (en) | 1984-09-13 |
| FI840955A (fi) | 1984-09-11 |
| IE57116B1 (en) | 1992-05-06 |
| GR81872B (es) | 1984-12-12 |
| DK168378B1 (da) | 1994-03-21 |
| US4590195A (en) | 1986-05-20 |
| IL71187A0 (en) | 1984-06-29 |
| EP0119050A2 (en) | 1984-09-19 |
| PT78219A (en) | 1984-04-01 |
| IE840585L (en) | 1984-09-10 |
| PH20692A (en) | 1987-03-24 |
| DK135884A (da) | 1984-09-11 |
| HU191220B (en) | 1987-01-28 |
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