DK135884A - 1,4-dihydropyridin-forbindelser og farmaceutisk acceptable syreadditionssalte deraf og deres anvendelse som anti-ischaemiske og antihypertensive midler - Google Patents
1,4-dihydropyridin-forbindelser og farmaceutisk acceptable syreadditionssalte deraf og deres anvendelse som anti-ischaemiske og antihypertensive midler Download PDFInfo
- Publication number
- DK135884A DK135884A DK135884A DK135884A DK135884A DK 135884 A DK135884 A DK 135884A DK 135884 A DK135884 A DK 135884A DK 135884 A DK135884 A DK 135884A DK 135884 A DK135884 A DK 135884A
- Authority
- DK
- Denmark
- Prior art keywords
- ischaemic
- acid addition
- addition salts
- acceptable acid
- pharmaceutical acceptable
- Prior art date
Links
- YNGDWRXWKFWCJY-UHFFFAOYSA-N 1,4-Dihydropyridine Chemical class C1C=CNC=C1 YNGDWRXWKFWCJY-UHFFFAOYSA-N 0.000 title 1
- 239000002253 acid Substances 0.000 title 1
- 230000002253 anti-ischaemic effect Effects 0.000 title 1
- 229940030600 antihypertensive agent Drugs 0.000 title 1
- 239000002220 antihypertensive agent Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB838306666A GB8306666D0 (en) | 1983-03-10 | 1983-03-10 | Therapeutic agents |
| GB8306666 | 1983-03-10 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK135884D0 DK135884D0 (da) | 1984-02-29 |
| DK135884A true DK135884A (da) | 1984-09-11 |
| DK168378B1 DK168378B1 (da) | 1994-03-21 |
Family
ID=10539350
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK135884A DK168378B1 (da) | 1983-03-10 | 1984-02-29 | 1,4-Dihydropyridin-forbindelser og farmaceutiske præparater indeholdende disse samt forbindelserne til anvendelse ved behandling af cardiovaskulære tilstande |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US4590195A (da) |
| EP (1) | EP0119050B1 (da) |
| JP (1) | JPS59175466A (da) |
| KR (1) | KR840008147A (da) |
| AU (1) | AU546634B2 (da) |
| DE (1) | DE3477379D1 (da) |
| DK (1) | DK168378B1 (da) |
| ES (3) | ES530379A0 (da) |
| FI (1) | FI840955A7 (da) |
| GB (1) | GB8306666D0 (da) |
| GR (1) | GR81872B (da) |
| HU (1) | HU191220B (da) |
| IE (1) | IE57116B1 (da) |
| IL (1) | IL71187A0 (da) |
| PH (1) | PH20692A (da) |
| PL (2) | PL246574A1 (da) |
| PT (1) | PT78219B (da) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8421039D0 (en) * | 1984-08-17 | 1984-09-19 | Wyeth John & Brother Ltd | Heterocyclic compounds |
| GB8501395D0 (en) * | 1985-01-19 | 1985-02-20 | Pfizer Ltd | Dihydropyridine anti-ischaemic & anti-hypertensive agents |
| WO1987000836A1 (en) * | 1985-08-06 | 1987-02-12 | Boehringer Biochemia Robin S.P.A. | Pharmaceutically active 2-thiomethyl-substituted-1,4-dihydropyridines |
| IT1204421B (it) * | 1986-06-27 | 1989-03-01 | Boehringer Biochemia Srl | 2-(aminoalchiltio)metil-1,4-diidropiridine,un metodo per la loro preparazione e composizioni farmaceutiche che le contengono |
| IT1201454B (it) * | 1985-08-19 | 1989-02-02 | Boehringer Biochemia Srl | 1,4-diidropiridine-2-sostituite |
| GB8527698D0 (en) * | 1985-11-09 | 1985-12-11 | Pfizer Ltd | Dihydropyridine antiischaemic & antihypertensive agents |
| EP0225175A3 (en) * | 1985-11-28 | 1988-12-28 | FISONS plc | Dihydropyridine derivatives, processes for their preparation and pharmaceutical compositions thereof |
| DE3621104A1 (de) * | 1986-06-24 | 1988-01-07 | Heumann Pharma Gmbh & Co | 1,4-dihydropyridinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| IT1197012B (it) * | 1986-07-29 | 1988-11-25 | Boehringer Biochemia Srl | 2-(aciltio) metil diidropiridine, un processo per la loro preparazione e composizioni farmaceutiche che le contengono |
| FR2602231B1 (fr) * | 1986-08-04 | 1988-10-28 | Adir | Nouveaux derives de la dihydro-1,4 pyridine, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent |
| IT1213555B (it) * | 1986-12-11 | 1989-12-20 | Boehringer Biochemia Srl | 2 metiltiometildiidropiridine, un processo per laloro preparazione e composizioni farmaceutiche che le contengono. |
| IT1215381B (it) * | 1987-03-12 | 1990-02-08 | Boehringer Biochemia Srl | Farmaceutiche che le contengono. carbonil- e solfonil- derivati di 2-(aminoalchiltio)metil-1,4-diidropiridine, un metodo per la loro preparazione e composizioni |
| GB8710493D0 (en) * | 1987-05-02 | 1987-06-03 | Pfizer Ltd | Dihydropyridines |
| US5278169A (en) * | 1988-08-09 | 1994-01-11 | E. R. Squibb & Sons, Inc. | Method of treating or prevention of fibrillation of the heart |
| NZ229828A (en) * | 1988-08-09 | 1992-03-26 | Squibb & Sons Inc | Aryl cyanoguanidine derivatives and pharmaceutical compositions |
| IE960441L (en) * | 1988-12-27 | 1990-06-27 | Takeda Chemical Industries Ltd | Guanidine derivatives, their production and insecticides |
| AT5874U1 (de) | 2000-12-29 | 2003-01-27 | Bioorg Bv | Pharmazeutische zubereitungen enthaltend amlodipinmaleat |
| US20070135488A1 (en) * | 2002-04-13 | 2007-06-14 | Chung You S | Amlodipine nicotinate and process for the preparation thereof |
| US20070066619A1 (en) * | 2002-10-07 | 2007-03-22 | Artesian Therapeutics, Inc. | Compounds having simultaneous ability to block L-type calcium channels and to inhibit phosphodiesterase type 3 activity |
| JP2006504738A (ja) * | 2002-10-07 | 2006-02-09 | アルテシアン セラピューティック，インコーポレイティド | Ｌ型カルシウムチャンネルを遮断し、かつホスホジエステラーゼ３型活性を阻害する同時能力を有するジヒドロピリジン化合物 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3974278A (en) * | 1973-07-12 | 1976-08-10 | Bayer Aktiengesellschaft | 1,4-Dihydropyridine esters |
| US4177278A (en) * | 1977-04-05 | 1979-12-04 | Bayer Aktiengesellschaft | 2-Alkyleneaminodihydropyridines compounds, their production and their medicinal use |
| JPS5547656A (en) * | 1978-09-29 | 1980-04-04 | Dainippon Pharmaceut Co Ltd | 2-(2-substituted aminoethyl)-1,4-dihydropyridine derivative and its derivative |
| SE7910521L (sv) * | 1979-12-20 | 1981-06-21 | Haessle Ab | Nya 2-metyl-6-substituerade-4-(2,3-disubstituerad fenyl)-1,4-dihydropyridin-3,5-diestrar med hypotesiva egenskaper, samt forfarande for deras framstellning, och farmaceutiska beredningar innehallande desamma |
| DE3022030A1 (de) * | 1980-06-12 | 1981-12-17 | Bayer Ag, 5090 Leverkusen | 4-thiazol- bzw. 4-imidazol-substituierte, 1,4-dihydropyridine, verfahren zu deren herstellung sowie diese enthaltende arzneimittel |
| CS228917B2 (en) * | 1981-03-14 | 1984-05-14 | Pfizer | Method of preparing substituted derivatives of 1,4-dihydropyridine |
| DK161312C (da) * | 1982-03-11 | 1991-12-09 | Pfizer | Analogifremgangsmaade til fremstilling af 2-aminoalkoxymethyl-4-phenyl-6-methyl-1,4-dihydropyridin-3,5-dicarboxylsyreestere eller syreadditionssalte deraf samt phthalimidoderivater til anvendelse som udgangsmateriale ved fremgangsmaaden |
| US4568677A (en) * | 1983-07-23 | 1986-02-04 | Pfizer Inc. | 2-(4-Pyrimidone alkoxyalkyl) dihydropyridine anti-ischaemic and antihypertensive agents |
-
1983
- 1983-03-10 GB GB838306666A patent/GB8306666D0/en active Pending
-
1984
- 1984-02-29 DK DK135884A patent/DK168378B1/da not_active IP Right Cessation
- 1984-03-05 US US06/586,514 patent/US4590195A/en not_active Expired - Lifetime
- 1984-03-06 EP EP84301452A patent/EP0119050B1/en not_active Expired
- 1984-03-06 PH PH30346A patent/PH20692A/en unknown
- 1984-03-06 DE DE8484301452T patent/DE3477379D1/de not_active Expired
- 1984-03-08 GR GR74031A patent/GR81872B/el unknown
- 1984-03-08 PT PT78219A patent/PT78219B/pt not_active IP Right Cessation
- 1984-03-08 PL PL24657484A patent/PL246574A1/xx unknown
- 1984-03-08 FI FI840955A patent/FI840955A7/fi not_active Application Discontinuation
- 1984-03-08 ES ES530379A patent/ES530379A0/es active Granted
- 1984-03-08 PL PL25277384A patent/PL252773A1/xx unknown
- 1984-03-08 IL IL71187A patent/IL71187A0/xx unknown
- 1984-03-09 HU HU84964A patent/HU191220B/hu unknown
- 1984-03-09 KR KR1019840001209A patent/KR840008147A/ko not_active Ceased
- 1984-03-09 IE IE585/84A patent/IE57116B1/en not_active IP Right Cessation
- 1984-03-09 AU AU25464/84A patent/AU546634B2/en not_active Ceased
- 1984-03-10 JP JP59046375A patent/JPS59175466A/ja active Pending
- 1984-10-31 ES ES537268A patent/ES537268A0/es active Granted
- 1984-10-31 ES ES537269A patent/ES8507112A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| EP0119050B1 (en) | 1989-03-22 |
| ES8506275A1 (es) | 1985-07-01 |
| EP0119050A3 (en) | 1987-07-01 |
| IE840585L (en) | 1984-09-10 |
| JPS59175466A (ja) | 1984-10-04 |
| ES537269A0 (es) | 1985-08-16 |
| DK135884D0 (da) | 1984-02-29 |
| PL252773A1 (en) | 1985-11-19 |
| EP0119050A2 (en) | 1984-09-19 |
| PT78219A (en) | 1984-04-01 |
| KR840008147A (ko) | 1984-12-13 |
| US4590195A (en) | 1986-05-20 |
| ES8507112A1 (es) | 1985-08-16 |
| GR81872B (da) | 1984-12-12 |
| PH20692A (en) | 1987-03-24 |
| DK168378B1 (da) | 1994-03-21 |
| HU191220B (en) | 1987-01-28 |
| AU546634B2 (en) | 1985-09-12 |
| GB8306666D0 (en) | 1983-04-13 |
| FI840955A0 (fi) | 1984-03-08 |
| PL246574A1 (en) | 1985-08-13 |
| FI840955A7 (fi) | 1984-09-11 |
| PT78219B (en) | 1986-08-12 |
| IL71187A0 (en) | 1984-06-29 |
| DE3477379D1 (en) | 1989-04-27 |
| ES8507111A1 (es) | 1985-08-16 |
| ES530379A0 (es) | 1985-07-01 |
| IE57116B1 (en) | 1992-05-06 |
| ES537268A0 (es) | 1985-08-16 |
| AU2546484A (en) | 1984-09-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PUP | Patent expired |