CY1110038T1 - 4-(διαρυλομεθυλ)-1- πιπεραζινυλ παραγωγα - Google Patents
4-(διαρυλομεθυλ)-1- πιπεραζινυλ παραγωγαInfo
- Publication number
- CY1110038T1 CY1110038T1 CY20101100428T CY101100428T CY1110038T1 CY 1110038 T1 CY1110038 T1 CY 1110038T1 CY 20101100428 T CY20101100428 T CY 20101100428T CY 101100428 T CY101100428 T CY 101100428T CY 1110038 T1 CY1110038 T1 CY 1110038T1
- Authority
- CY
- Cyprus
- Prior art keywords
- substituted
- aryl
- groups
- heteroaryl
- heteroatoms
- Prior art date
Links
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 125000001072 heteroaryl group Chemical group 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 125000004122 cyclic group Chemical group 0.000 abstract 3
- 125000005842 heteroatom Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 3
- 229910052757 nitrogen Inorganic materials 0.000 abstract 3
- 229910052760 oxygen Inorganic materials 0.000 abstract 3
- 229910052717 sulfur Inorganic materials 0.000 abstract 3
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
- C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
- C07D295/03—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Μια ένωση του τύπου I, όπου τα Χ, Υ, X' & Υ' εκλέγονται από υδρογόνο, αλογόνο, υποκατεστημένη ή μη υποκατεστημένη αλκύλ (γραμμική, διακλαδισμένη ή κύκλο), αρύλ, αλκυλόξυ και αλογονοαλκύλ ομάδα· τα R1, R2, R3 & R4 εκλέγονται από υδρογόνο, υποκατεστημένες ή μη υποκατεστημένες αλκύλ ομάδες (γραμμικές, διακλαδισμένες ή κύκλο), αρύλ, ετεροαρύλ ομάδες ή αραλκυλ ομάδες, ετερόκυκλους, που περιλαμβάνουν ένα ή περισσότερα ετεροάτομα, (δηλαδή N,S,O), υποκατεστημένες ή μη υποκατεστημένες αλκενύλ ή αλκυνύλ ομάδες 2 έως 6 ατόμων άνθρακα, όπου οι υποκατάστατες R1 & R2 του πιπεραζινυλ υπολοίπου ευρίσκονται σε θέση συν ή αντί ο ένας ως προς τον άλλο και ενδεχομένως τα R1 & R2 μαζί με τα άτομα άνθρακα, προς τα οποία είναι προσαρτημένα, σχηματίζουν έναν μονοκυκλικό κεκορεσμένο ή αρύλ ή υποκατεστημένο αρύλ ή ετεροαρύλ ή υποκατεστημένο ετεροαρύλ δακτύλιο, ο οποίος περιλαμβάνει ένα ή περισσότερα ετεροάτομα, που εκλέγονται από Ν, S και Ο με ένα μέγεθος δακτυλίου, που κυμαίνεται από 3 έως 6· υπό τον όρο ότι όταν τα R3 & R4 μαζί δεν σχηματίζουν μέρος ενός δακτυλίου μπορούν να υφίστανται είτε υπό την στερεοδιάταξη Ε είτε υπό την στερεοδιάταξη Ζ· το R5 είναι (CH2)n-O-CH2-CO-Z, όπου n είναι 1 έως 6· το Ζ εκλέγεται από OH, OR, NRR', N(OR)R', N(R)- N(R)R' όπου τα R & R' εκλέγονται από υδρογόνο, υποκατεστημένες ή μη υποκατεστημένες αλκύλ ομάδες (γραμμικές, διακλαδισμένες ή κύκλο) αρύλ, ετεροαρύλ ομάδες ή αραλκυλ ομάδες ετερόκυκλους, που περιλαμβάνουν ένα ή περισσότερα ετεροάτομα (δηλαδή Ν, S ,O), υποκατεστημένες ή μη υποκατεστημένες αλκενύλ ή αλκυνύλ ομάδες 2 έως 6 ατόμων άνθρακα· και το Β εκλέγεται από -CH2)n- (το n είναι 1 έως 6), (CH2)X -D- (CH2)y, όπου το D είναι Ο, NR, S, SO2, τα x, y είναι ανεξάρτητα 1 έως 6· και το m εκλέγεται από 1 έως 6· και τα φαρμακευτικώς αποδεκτά άλατα αυτής.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN302MU2002 | 2002-03-27 | ||
| EP03744972A EP1487810B9 (en) | 2002-03-27 | 2003-03-27 | 4-(diarylmethyl)-1-piperazinyl derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1110038T1 true CY1110038T1 (el) | 2015-01-14 |
Family
ID=28053441
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20101100428T CY1110038T1 (el) | 2002-03-27 | 2010-05-14 | 4-(διαρυλομεθυλ)-1- πιπεραζινυλ παραγωγα |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US7297697B2 (el) |
| EP (1) | EP1487810B9 (el) |
| JP (1) | JP4454314B2 (el) |
| KR (1) | KR100995557B1 (el) |
| CN (1) | CN100340551C (el) |
| AT (1) | ATE457983T1 (el) |
| AU (1) | AU2003231921B8 (el) |
| BR (1) | BR0308913A (el) |
| CA (1) | CA2480367C (el) |
| CY (1) | CY1110038T1 (el) |
| DE (1) | DE60331295D1 (el) |
| DK (1) | DK1487810T3 (el) |
| EA (1) | EA007794B1 (el) |
| EG (1) | EG24927A (el) |
| ES (1) | ES2341236T3 (el) |
| IL (1) | IL164196A0 (el) |
| MX (1) | MXPA04009387A (el) |
| NZ (1) | NZ535476A (el) |
| PL (1) | PL375439A1 (el) |
| PT (1) | PT1487810E (el) |
| SI (1) | SI1487810T1 (el) |
| UA (1) | UA76609C2 (el) |
| WO (1) | WO2003079970A2 (el) |
| ZA (1) | ZA200407731B (el) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4782441B2 (ja) * | 2005-02-28 | 2011-09-28 | 勤 竹内 | ジフェニルメチルピペラジン誘導体及びそれを含有する医薬組成物 |
| EP2041088B1 (en) | 2006-06-28 | 2014-01-08 | Amgen Inc. | Glycine transporter-1 inhibitors |
| CN106309443B (zh) * | 2016-07-26 | 2021-01-22 | 上海璃道医药科技有限公司 | 二苯甲烷类药物的用途 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2082168A5 (en) * | 1970-03-05 | 1971-12-10 | Aries Robert | (-1-benzhydryl-4-piperazinyl)-alkoxy-alkyl esters of benzoic - or phenyl-alkanoic acids - analgesic, antipyretic, sympathomimetic, |
| FI75816C (fi) | 1981-02-06 | 1988-08-08 | Ucb Sa | Foerfarande foer framstaellning av terapeutiskt aktiv 2-/4-(difenylmetyl)-1-piperazinyl/-aettiksyror eller dess amid. |
| EP0598123A4 (en) | 1991-07-19 | 1995-02-15 | Zeria Pharm Co Ltd | PIPERAZINE DERIVATIVE AND MEDICINAL PRODUCT CONTAINING THE SAME. |
| JP3352184B2 (ja) * | 1993-11-12 | 2002-12-03 | 株式会社アズウェル | ピペラジン不飽和脂肪酸誘導体 |
| PE20001566A1 (es) | 1999-03-26 | 2001-02-05 | Ucb Sa | Piperazinas 1,4-sustituidas, piperidinas 1,4-sustituidas y 4-alquilidenilpiperidinas 1-sustituidas |
| US6239277B1 (en) * | 1999-10-20 | 2001-05-29 | Salsbury Chemicals, Inc. | Process for preparing piperazine-substituted aliphatic carboxylates |
| GB0009479D0 (en) | 2000-04-17 | 2000-06-07 | Cipla Limited | Antihistaminic compounds |
-
2003
- 2003-03-27 SI SI200331786T patent/SI1487810T1/sl unknown
- 2003-03-27 PL PL03375439A patent/PL375439A1/xx not_active Application Discontinuation
- 2003-03-27 UA UA20041008775A patent/UA76609C2/uk unknown
- 2003-03-27 CA CA2480367A patent/CA2480367C/en not_active Expired - Fee Related
- 2003-03-27 EA EA200401259A patent/EA007794B1/ru not_active IP Right Cessation
- 2003-03-27 US US10/509,052 patent/US7297697B2/en not_active Expired - Fee Related
- 2003-03-27 EP EP03744972A patent/EP1487810B9/en not_active Expired - Lifetime
- 2003-03-27 AT AT03744972T patent/ATE457983T1/de active
- 2003-03-27 AU AU2003231921A patent/AU2003231921B8/en not_active Ceased
- 2003-03-27 ES ES03744972T patent/ES2341236T3/es not_active Expired - Lifetime
- 2003-03-27 PT PT03744972T patent/PT1487810E/pt unknown
- 2003-03-27 DK DK03744972.5T patent/DK1487810T3/da active
- 2003-03-27 MX MXPA04009387A patent/MXPA04009387A/es active IP Right Grant
- 2003-03-27 KR KR1020047015302A patent/KR100995557B1/ko not_active IP Right Cessation
- 2003-03-27 BR BR0308913-4A patent/BR0308913A/pt not_active IP Right Cessation
- 2003-03-27 NZ NZ535476A patent/NZ535476A/xx not_active IP Right Cessation
- 2003-03-27 JP JP2003577803A patent/JP4454314B2/ja not_active Expired - Fee Related
- 2003-03-27 WO PCT/IN2003/000089 patent/WO2003079970A2/en active Application Filing
- 2003-03-27 IL IL16419603A patent/IL164196A0/xx not_active IP Right Cessation
- 2003-03-27 CN CNB038095645A patent/CN100340551C/zh not_active Expired - Fee Related
- 2003-03-27 DE DE60331295T patent/DE60331295D1/de not_active Expired - Lifetime
-
2004
- 2004-09-23 ZA ZA200407731A patent/ZA200407731B/xx unknown
- 2004-09-27 EG EGNA2004000094 patent/EG24927A/xx active
-
2010
- 2010-05-14 CY CY20101100428T patent/CY1110038T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CY1117132T1 (el) | Παραγωγο θειαζολιου | |
| TW200606137A (en) | Urea derivatives | |
| CY1108019T1 (el) | Ενωσεις πυριμιδινης | |
| CY1106947T1 (el) | Ανταγωνιστες υποδοχεα θρομβινης | |
| CY1108313T1 (el) | Παραγωγα της κινολινης και η χρηση τους ως προσδεματων 5-ht6 | |
| CY1107978T1 (el) | Νeα παρaγωγα πυριδαζiν -3 (2h) - oνης | |
| UY26899A1 (es) | Derivados de pirazol fusionados | |
| DK0593641T3 (da) | Fremgangsmåde til fremstilling af derivater af baccatin III og 10-desacetyl-baccatin III | |
| FI934366A (fi) | Atp-analoger | |
| CY1107206T1 (el) | Παραγωγα οξαζολιου/θειαζολιου ενεργοποιητες του υποδοχεα hppar-a | |
| SE7606440L (sv) | Nya n-substituerade bensensulfonamider och sett att framstella desamma | |
| CY1110038T1 (el) | 4-(διαρυλομεθυλ)-1- πιπεραζινυλ παραγωγα | |
| DK393486D0 (da) | Dihydropyridin-derivater og fremgangsmaade til fremstilling deraf | |
| DK0520883T3 (da) | Derivater af 2-aminopyrimidin-4-carboxamid, deres fremstilling og deres terapeutiske anvendelse | |
| ATE95816T1 (de) | 2-((4-piperidinyl)methyl>-1,2,3,4tetrahydroisochinolin-derivate, ihre herstellung und ihre therapeutische verwendung. | |
| FI800224A (fi) | 2-hydroxi-naftalinderivat och anvaendningen av dessa som kopplingskomponenter i diazotypiefieringsmaterial | |
| NO20053302D0 (no) | Imidazolderivater med affinitet for alfa 2-reseptoraktivitet. | |
| CO5180536A1 (es) | Inhibidores de proteasas catepsina | |
| DE69626624D1 (de) | Medikamente gegen trhombocytopenie | |
| SE8107680L (sv) | Piperazinderivat och forfarande for framstellning derav | |
| DE60103732D1 (de) | Pyrimidinderivate mit antitumor-wirkung | |
| DK104488A (da) | Acetamider afledt af 2,3-dihydro-3-phenyl-2-benzofuranon, fremgangsmaader til deres fremstilling og farmaceutiske midler indeholdende dem |