ES2109236T3 - Reactivos tioacilantes y compuestos intermedios, tiopeptidos, y metodos para prepararlos y utilizarlos. - Google Patents

Reactivos tioacilantes y compuestos intermedios, tiopeptidos, y metodos para prepararlos y utilizarlos.

Info

Publication number
ES2109236T3
ES2109236T3 ES90911857T ES90911857T ES2109236T3 ES 2109236 T3 ES2109236 T3 ES 2109236T3 ES 90911857 T ES90911857 T ES 90911857T ES 90911857 T ES90911857 T ES 90911857T ES 2109236 T3 ES2109236 T3 ES 2109236T3
Authority
ES
Spain
Prior art keywords
compounds
reagents
thiopeptides
relates
thioacilant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90911857T
Other languages
English (en)
Inventor
Denis Brillon
Gilles Sauve
Boulos Zacharie
Bernard Belleau
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shire Canada Inc
Original Assignee
IAF BioChem International Inc
Biochem Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by IAF BioChem International Inc, Biochem Pharma Inc filed Critical IAF BioChem International Inc
Application granted granted Critical
Publication of ES2109236T3 publication Critical patent/ES2109236T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/66—Thymopoietins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0815—Tripeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0819—Tripeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

SE DESCRIBEN REACTIVOS TIOACILATADORES PARA LA PRODUCCION DE UNIONES TIOAMIDAS EN PEPTIDOS QUE ESTAN SIENDO CULTIVADOS REPRESENTADOS POR LA ESTRUCTURA (I), DONDE SE DESCRIBEN LOS SUSTITUYENTES. SE DESCRIBEN TAMBIEN PRECURSORES INTERMEDIOS PARA PREPARAR ESTOS REACTIVOS TIOACILATADORES. ADEMAS, SE DESCRIBE UN PROCESO PARA PREPARAR LOS REACTIVOS TIOACILATADORES Y LOS PRECURSORES INTERMEDIOS. SE DEFINEN TIOPEPTIDOS, Y SUS SALES, QUE EXHIBEN UTILIDAD FARMACOLOGICA Y ESTAN REPRESENTADOS POR LA FORMULA (II) DONDE R ELEVADO 1, R ELEVADO 3, R ELEVAD 4, X Y N SON TAL COMO SE DEFINEN AQUI. SE DESCRIBEN TAMBIEN METODOS PARA PREPARAR ESTOS TIOPEPTIDOS DESDE SINTESIS DE SOLUCION Y DE FASE SOLIDA, UTILIZANDO LOS REACTIVOS TIOACILETADORES AQUI DESCRITOS.
ES90911857T 1989-08-04 1990-08-03 Reactivos tioacilantes y compuestos intermedios, tiopeptidos, y metodos para prepararlos y utilizarlos. Expired - Lifetime ES2109236T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/389,852 US5138061A (en) 1989-08-04 1989-08-04 Thioacylating reagents

Publications (1)

Publication Number Publication Date
ES2109236T3 true ES2109236T3 (es) 1998-01-16

Family

ID=23540015

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90911857T Expired - Lifetime ES2109236T3 (es) 1989-08-04 1990-08-03 Reactivos tioacilantes y compuestos intermedios, tiopeptidos, y metodos para prepararlos y utilizarlos.

Country Status (11)

Country Link
US (2) US5138061A (es)
EP (1) EP0485458B1 (es)
JP (1) JP3165698B2 (es)
AT (1) ATE159521T1 (es)
CA (1) CA2059647C (es)
DE (1) DE69031623T2 (es)
DK (1) DK0485458T3 (es)
ES (1) ES2109236T3 (es)
HU (1) HU220756B1 (es)
OA (1) OA09561A (es)
WO (1) WO1991001976A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5138061A (en) * 1989-08-04 1992-08-11 Biochem Pharma Inc. Thioacylating reagents
PT655055E (pt) * 1992-08-13 2001-03-30 Warner Lambert Co Antagonistas de taquiquinina
US5449761A (en) * 1993-09-28 1995-09-12 Cytogen Corporation Metal-binding targeted polypeptide constructs
EP0997147B1 (en) 1997-07-08 2006-03-15 Ono Pharmaceutical Co., Ltd. Amino acid derivatives
KR100281826B1 (ko) * 1998-04-21 2001-02-15 박호군 N,n-디아실이미다졸론 유도체를 이용한 아민의 아실화 방법
TWI245035B (en) 1998-06-26 2005-12-11 Ono Pharmaceutical Co Amino acid derivatives and a pharmaceutical composition comprising the derivatives
WO2000004005A1 (fr) 1998-07-14 2000-01-27 Ono Pharmaceutical Co., Ltd. Derives acides amines et medicaments dont ces derives sont les principes actifs
GB0401008D0 (en) * 2004-01-17 2004-02-18 Univ Manchester Drug delivery system

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2927116A (en) * 1960-03-01 Chlorobenzimidazolone compounds
DE1542886A1 (de) * 1966-10-04 1970-05-14 Bayer Ag Fungizide Mittel
US3901909A (en) * 1972-12-04 1975-08-26 Squibb & Sons Inc Mercaptobenzimidazolyl ureas and thioureas
DE3540495A1 (de) * 1985-11-15 1987-05-21 Merck Patent Gmbh Aminosaeurederivate
JPS62255485A (ja) * 1986-04-25 1987-11-07 Kissei Pharmaceut Co Ltd ベンズイミダゾリン誘導体
US4835166A (en) * 1986-06-09 1989-05-30 Pfizer Inc. Antiallergy and antiinflammatory agents
US5138061A (en) * 1989-08-04 1992-08-11 Biochem Pharma Inc. Thioacylating reagents

Also Published As

Publication number Publication date
EP0485458A1 (en) 1992-05-20
ATE159521T1 (de) 1997-11-15
DK0485458T3 (da) 1998-04-20
US5371185A (en) 1994-12-06
OA09561A (en) 1993-01-31
US5138061A (en) 1992-08-11
HU220756B1 (hu) 2002-05-28
WO1991001976A1 (en) 1991-02-21
AU651557B2 (en) 1994-07-28
HUT63395A (en) 1993-08-30
EP0485458B1 (en) 1997-10-22
JP3165698B2 (ja) 2001-05-14
CA2059647C (en) 2001-06-05
HU9200338D0 (en) 1992-04-28
DE69031623T2 (de) 1998-02-19
JPH05501865A (ja) 1993-04-08
DE69031623D1 (de) 1997-11-27
CA2059647A1 (en) 1991-02-05
AU6064290A (en) 1991-03-11

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