CS521486A2 - Zpusob vyroby substituovanych androsta 1,4 dien 3,17 dionu - Google Patents

Zpusob vyroby substituovanych androsta 1,4 dien 3,17 dionu

Info

Publication number
CS521486A2
CS521486A2 CS865214A CS521486A CS521486A2 CS 521486 A2 CS521486 A2 CS 521486A2 CS 865214 A CS865214 A CS 865214A CS 521486 A CS521486 A CS 521486A CS 521486 A2 CS521486 A2 CS 521486A2
Authority
CS
Czechoslovakia
Prior art keywords
substituovanych
dionu
androsta
dien
zpusob vyroby
Prior art date
Application number
CS865214A
Other languages
English (en)
Other versions
CS257794B2 (en
Inventor
Franco Buzzetti
Natale Barbugian
Paolo Lombardi
Salle Enrico Di
Original Assignee
Erba Farmitalia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10582036&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CS521486(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Erba Farmitalia filed Critical Erba Farmitalia
Publication of CS521486A2 publication Critical patent/CS521486A2/cs
Publication of CS257794B2 publication Critical patent/CS257794B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CS865214A 1985-07-09 1986-07-09 Method of substituted androsta-1,4-diene-3,17-dienes production CS257794B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB858517360A GB8517360D0 (en) 1985-07-09 1985-07-09 Substituted androsta-1,4-diene-3,17-diones

Publications (2)

Publication Number Publication Date
CS521486A2 true CS521486A2 (en) 1987-09-17
CS257794B2 CS257794B2 (en) 1988-06-15

Family

ID=10582036

Family Applications (2)

Application Number Title Priority Date Filing Date
CS873216A CS258498B2 (en) 1985-07-09 1986-07-09 Method of androsta-1,4-dien-3,17-diones production
CS865214A CS257794B2 (en) 1985-07-09 1986-07-09 Method of substituted androsta-1,4-diene-3,17-dienes production

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CS873216A CS258498B2 (en) 1985-07-09 1986-07-09 Method of androsta-1,4-dien-3,17-diones production

Country Status (38)

Country Link
US (2) US4808616A (cs)
JP (1) JPS6212797A (cs)
KR (1) KR950003614B1 (cs)
CN (1) CN86104664B (cs)
AT (1) AT395157B (cs)
AU (1) AU578840B2 (cs)
BE (1) BE905067A (cs)
BG (1) BG61370B2 (cs)
BR (1) BR1100240A (cs)
CA (1) CA1277656C (cs)
CH (1) CH668599A5 (cs)
CS (2) CS258498B2 (cs)
CZ (1) CZ413591A3 (cs)
DE (1) DE10199030I1 (cs)
DK (1) DK163520C (cs)
ES (2) ES8801304A1 (cs)
FI (1) FI83424C (cs)
FR (1) FR2584725B1 (cs)
GB (2) GB8517360D0 (cs)
GR (1) GR861780B (cs)
HK (1) HK94190A (cs)
HU (1) HU194274B (cs)
IE (1) IE58949B1 (cs)
IL (1) IL79336A (cs)
IT (1) IT1196436B (cs)
MY (1) MY102294A (cs)
NL (2) NL193616C (cs)
NO (2) NO165547C (cs)
NZ (1) NZ216763A (cs)
PH (1) PH21785A (cs)
PT (1) PT82944B (cs)
SE (1) SE468988B (cs)
SG (1) SG80490G (cs)
SK (1) SK413591A3 (cs)
SU (2) SU1442077A3 (cs)
UA (1) UA6046A1 (cs)
YU (2) YU44585B (cs)
ZA (1) ZA865079B (cs)

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GB8617107D0 (en) * 1986-07-14 1986-08-20 Erba Farmitalia 6-/7-methylenandrosta-1 4-diene-3 17-dione derivatives
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GB8721383D0 (en) * 1987-09-11 1987-10-21 Erba Farmitalia Preparation of methylene derivatives
GB8721384D0 (en) * 1987-09-11 1987-10-21 Erba Farmitalia 17-substituted andro-sta-1 4-dien-3-one derivatives
GB8801697D0 (en) * 1988-01-26 1988-02-24 Erba Farmitalia Improvements in synthesis of 6-methylene derivatives of androsta-1 4-diene-3 17-dione
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GB9201224D0 (en) * 1992-01-21 1992-03-11 Erba Carlo Spa Difluoromethylenandrostenone derivatives and process for their preparation
CA2145643A1 (en) * 1992-09-30 1994-04-14 Naoyuki Koizumi Novel 7-substituted oxa-or azasteroid compound
US6407082B1 (en) * 1996-09-13 2002-06-18 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of a vitamin D compound
GB9313420D0 (en) * 1993-06-29 1993-08-11 Erba Carlo Spa Fluorinated 6-methylenandrosta-1,4-dien-3-one-derivatives and process for their preparations
US6028064A (en) 1996-09-13 2000-02-22 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of progestin products
US6034074A (en) 1996-09-13 2000-03-07 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of a Vitamin D compound
US6511970B1 (en) 1996-09-13 2003-01-28 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of products that induce transforming growth factor-beta and/or apoptosis in the ovarian epithelium
US6765002B2 (en) 2000-03-21 2004-07-20 Gustavo Rodriguez Prevention of ovarian cancer by administration of products that induce transforming growth factor-β and/or apoptosis in the ovarian epithelium
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GB9930839D0 (en) * 1999-12-30 2000-02-16 Pharmacia & Upjohn Spa Process for treating gynecomastia
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US20010044431A1 (en) * 2000-03-21 2001-11-22 Rodriguez Gustavo C. Prevention of ovarian cancer by administration of products that induce biologic effects in the ovarian epithelium
GB0017635D0 (en) * 2000-07-18 2000-09-06 Pharmacia & Upjohn Spa Antitumor combined therapy
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MXPA03001983A (es) * 2000-09-08 2003-06-24 Pharmacia Italia Spa Exemestano como agente quimiopreventivo.
US20040082557A1 (en) * 2001-01-26 2004-04-29 Wajszczuk Charles Paul Methods for treating estrogen-dependent disorders
ES2269682T3 (es) * 2001-01-26 2007-04-01 Pfizer Italia S.R.L. Exemestano para tratar transtornos que dependen de hormonas.
EP2762140B1 (en) 2001-02-19 2017-03-22 Novartis AG Treatment of solid brain tumours with a rapamycin derivative
JP4477303B2 (ja) 2001-05-16 2010-06-09 ノバルティス アーゲー Ｎ−｛５−［４−（４−メチル−ピペラジノ−メチル）−ベンゾイルアミド］−２−メチルフェニル｝−４−（３−ピリジル）−２−ピリミジン−アミンおよび化学療法剤を含んでなる併用剤
GB0120147D0 (en) * 2001-08-17 2001-10-10 Metris Therapeutics Ltd Treatment method
US20040043938A1 (en) * 2001-11-06 2004-03-04 Dinesh Purandare Combination therapy for estrogen-dependent disorders
GB0128510D0 (en) * 2001-11-28 2002-01-23 Novartis Ag Organic compounds
JP5227492B2 (ja) 2002-05-16 2013-07-03 ノバルティス アーゲー 癌におけるｅｄｇレセプター結合剤の使用
CN1304413C (zh) * 2002-10-24 2007-03-14 上海华拓医药科技发展有限公司 一种抗癌药物依西美坦制备方法
CN1317293C (zh) * 2002-10-24 2007-05-23 南京长澳医药科技有限公司 一种依西美坦的合成工艺
US20040186160A1 (en) * 2002-12-13 2004-09-23 Sugen, Inc. Hexahydro-cyclohepta-pyrrole oxindole as potent kinase inhibitors
WO2005027916A1 (en) * 2003-09-19 2005-03-31 Pfizer Products Inc. Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and aromatase inhibitors
US20050101579A1 (en) * 2003-11-06 2005-05-12 Shippen Eugene R. Endometriosis treatment protocol
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US7435757B2 (en) * 2004-07-02 2008-10-14 Schering Ag 2-substituted D-homo-estra-1,3,5(10)-trienes as inhibitors of 17β-hydroxy steroid dehydrogenase type 1
US10174070B2 (en) * 2005-09-30 2019-01-08 Endece Llc 6-substituted estradiol derivatives and methods of use
US8168621B2 (en) 2005-09-30 2012-05-01 Endece, Llc 6-substituted estradiol derivatives and methods of use
KR101484134B1 (ko) 2005-09-30 2015-01-21 엔디씨, 엘엘씨 (ｓ)-６-메틸옥사알킬 엑스메스탄 화합물 및 관련 사용방법
US20080119447A1 (en) * 2005-09-30 2008-05-22 James Yarger 6-alkoxyalkyl estradiol derivatives and methods of use
DE102006008074B4 (de) * 2006-02-22 2013-08-14 RUHR-UNIVERSITäT BOCHUM Behandlung von Krebs mit Geruchsrezeptor-Liganden
CA2649792A1 (en) 2006-05-09 2007-11-15 Novartis Ag Combination comprising an iron chelator and an anti-neoplastic agent and use thereof
WO2008033466A2 (en) * 2006-09-14 2008-03-20 Combinatorx (Singapore) Pre. Ltd. Compositions and methods for treatment of viral diseases
US20080275259A1 (en) * 2007-05-04 2008-11-06 Scinopharm Taiwan, Ltd Process for preparing aromatase inhibitors
EP2211848A1 (en) 2007-10-16 2010-08-04 Repros Therapeutics Inc. Trans-clomiphene for metabolic syndrome
EP2070943A1 (en) * 2007-12-14 2009-06-17 Crystal Pharma, S.A. Process for obtaining 6-Alkylidenandrost-1,4-diene-3one
CN101468023B (zh) * 2007-12-26 2011-02-02 上海复星医药（集团）股份有限公司 依西美坦片及其制备工艺
US8288571B2 (en) * 2008-01-21 2012-10-16 Cadila Healthcare Limited Process for preparing aromatiase inhibitor exemestane
GB0813628D0 (en) * 2008-07-25 2008-09-03 Arrow Int Ltd Stable coated anti-cancer agent
WO2010076811A2 (en) * 2008-12-30 2010-07-08 Ind-Swift Laboratories Limited Process for the preparation of exemestane
EP2429299B1 (en) 2009-05-01 2016-06-01 Celloxess Llc Treating male infertility secondary to sperm oxidative stress
RU2425052C1 (ru) * 2010-03-04 2011-07-27 Татьяна Степановна Савинова Способ получения 6-метиленандрост-4-ен-3,17-диона из андрост-4-ен-3,17-диона, способ получения 6-метиленандроста-1,4-диен-3,17-диона (эксеместана) с использованием полученного 6-метиленандрост-4-ен-3,17-диона
DE102010003494A1 (de) * 2010-03-31 2011-10-06 Bayer Schering Pharma Aktiengesellschaft Parenterales Abgabesystem, das Aromatasehemmer und Gestagene freisetzt, für die Behandlung von Endometriose
CN102884072A (zh) 2010-04-08 2013-01-16 爱默蕾大学 被取代的雄甾-4-烯二酮
EP2558098A2 (en) 2010-04-16 2013-02-20 Novartis AG Treatment of endocrine resistant breast cancer
ES2605960T3 (es) 2010-09-14 2017-03-17 Endece, Llc Derivados de desmetil-estradiol 6-sustituido como agonistas del RE-beta
AU2013225869B2 (en) 2012-02-29 2017-06-08 Repros Therapeutics Inc. Combination therapy for treating androgen deficiency
AU2015216590A1 (en) * 2014-02-11 2016-06-30 Novartis Ag Pharmaceutical combinations comprising a PI3K inhibitor for the treatment of cancer
EP3373967B9 (en) 2015-11-10 2023-10-04 Paracrine Therapeutics AB Treatment of er-negative breast cancer with an pdgf-cc inhibitor and an anti estrogen
CN112409432B (zh) * 2020-11-16 2023-07-07 陕西理工大学 一种依西美坦的合成方法

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GB929985A (cs) *
US2744120A (en) * 1953-01-14 1956-05-01 Olin Mathieson 1-dehydrotestololactone
US3112305A (en) * 1960-11-07 1963-11-26 British Drug Houses Ltd 6-methylene-3-oxo-delta4-steroids and process for their preparation
GB1042291A (en) * 1961-11-08 1966-09-14 Organon Labor Ltd í¸-6ª‡-amino steroids and the preparation thereof
DK120154B (da) * 1968-02-29 1971-04-19 Schering Ag Fremgangsmåde til fremstilling af N-substituerede 4-amino-3-oxosteroid-4,6-diener af androstan- eller pregnanrækken eller deres ammoniumsalte.
BE759143A (fr) * 1969-11-19 1971-05-19 Upjohn Co Procede de preparation d'un nouveau compose steroide
US4235893A (en) * 1978-05-08 1980-11-25 Brodie Angela M Ester derivatives of 4-hydroxy-4-androstene-3,17-dione and a method for inhibiting estrogen biosynthesis
DE3004508C2 (de) * 1980-02-05 1981-12-10 Schering Ag Berlin Und Bergkamen, 1000 Berlin Verfahren zur Herstellung von 6-Methylensteroiden
DE3322285A1 (de) * 1983-06-18 1984-12-20 Schering AG, 1000 Berlin und 4709 Bergkamen 1-alkyl-androsta-1,4-dien-3,17-dione, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate
US4512986A (en) * 1983-07-26 1985-04-23 Research Triangle Institute Progrestationally active steroids
GB8517360D0 (en) * 1985-07-09 1985-08-14 Erba Farmitalia Substituted androsta-1,4-diene-3,17-diones

Also Published As

Publication number Publication date
CN86104664B (zh) 1988-06-29
KR870001140A (ko) 1987-03-11
US4904650A (en) 1990-02-27
SG80490G (en) 1990-11-23
DK324386A (da) 1987-01-10
CS257794B2 (en) 1988-06-15
SE8603046L (sv) 1987-01-10
GR861780B (en) 1986-11-11
PT82944A (en) 1986-08-01
CH668599A5 (de) 1989-01-13
NL300017I2 (nl) 2001-01-02
UA6046A1 (uk) 1994-12-29
IL79336A0 (en) 1986-10-31
CN86104664A (zh) 1987-02-18
IL79336A (en) 1991-06-10
GB8616585D0 (en) 1986-08-13
HU194274B (en) 1988-01-28
JPH0443919B2 (cs) 1992-07-20
ES8802429A1 (es) 1988-06-01
DK163520B (da) 1992-03-09
GB2177700B (en) 1988-12-07
HUT42780A (en) 1987-08-28
YU44628B (en) 1990-10-31
NO2000009I1 (no) 2000-10-05
ES557466A0 (es) 1988-06-01
FR2584725B1 (fr) 1988-05-13
DK163520C (da) 1992-07-27
PH21785A (en) 1988-02-24
NO165547B (no) 1990-11-19
NO165547C (no) 1991-02-27
SE468988B (sv) 1993-04-26
FI862871A0 (fi) 1986-07-07
SU1501923A3 (ru) 1989-08-15
NL300017I1 (nl) 2000-11-01
CZ413591A3 (en) 1994-03-16
AT395157B (de) 1992-10-12
AU5979986A (en) 1987-01-15
ZA865079B (en) 1987-03-25
FR2584725A1 (fr) 1987-01-16
US4808616A (en) 1989-02-28
NZ216763A (en) 1988-05-30
ES556550A0 (es) 1987-12-16
NL193616B (nl) 1999-12-01
FI862871A7 (fi) 1987-01-10
BR1100240A (pt) 1999-12-28
ES8801304A1 (es) 1987-12-16
FI83424B (fi) 1991-03-28
SU1442077A3 (ru) 1988-11-30
YU120186A (en) 1988-02-29
DK324386D0 (da) 1986-07-08
DE10199030I1 (de) 2001-10-04
IT1196436B (it) 1988-11-16
SE8603046D0 (sv) 1986-07-08
SK413591A3 (en) 1995-07-11
PT82944B (pt) 1989-01-30
CA1277656C (en) 1990-12-11
GB2177700A (en) 1987-01-28
GB8517360D0 (en) 1985-08-14
IE58949B1 (en) 1993-12-01
NL193616C (nl) 2000-04-04
AU578840B2 (en) 1988-11-03
BG61370B2 (bg) 1997-06-30
CS258498B2 (en) 1988-08-16
ATA181986A (de) 1992-02-15
HK94190A (en) 1990-11-23
KR950003614B1 (ko) 1995-04-17
MY102294A (en) 1992-05-15
IT8621004A0 (it) 1986-07-02
NO862753L (no) 1987-01-12
FI83424C (fi) 1991-07-10
NO862753D0 (no) 1986-07-08
JPS6212797A (ja) 1987-01-21
IE861821L (en) 1987-01-09
NL8601785A (nl) 1987-02-02
BE905067A (fr) 1987-01-08
YU103687A (en) 1988-08-31
YU44585B (en) 1990-10-31

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Legal Events

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IF00 In force as of 2000-06-30 in czech republic
MK4A Patent expired

Effective date: 20010709