CS257289B2 - Preparation method of complex compound of at least one flavanolignane with at least one phospholipide - Google Patents

Preparation method of complex compound of at least one flavanolignane with at least one phospholipide Download PDF

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Publication number
CS257289B2
CS257289B2 CS865455A CS545586A CS257289B2 CS 257289 B2 CS257289 B2 CS 257289B2 CS 865455 A CS865455 A CS 865455A CS 545586 A CS545586 A CS 545586A CS 257289 B2 CS257289 B2 CS 257289B2
Authority
CS
Czechoslovakia
Prior art keywords
silybin
complex compound
complex
phosphatidylcholine
silymarin
Prior art date
Application number
CS865455A
Other languages
Czech (cs)
English (en)
Inventor
Bruno Gabetta
Ezio Bombardelli
Giorgio Pifferi
Original Assignee
Inverni Della Beffa Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=11184188&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CS257289(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Inverni Della Beffa Spa filed Critical Inverni Della Beffa Spa
Publication of CS257289B2 publication Critical patent/CS257289B2/cs

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin
    • C07F9/106—Adducts, complexes, salts of phosphatides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
CS865455A 1985-07-17 1986-06-17 Preparation method of complex compound of at least one flavanolignane with at least one phospholipide CS257289B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8521602A IT1215291B (it) 1985-07-17 1985-07-17 Complessi di flavanolignani con fosfolipidi, loro preparazione e relative composizioni farmaceutiche.

Publications (1)

Publication Number Publication Date
CS257289B2 true CS257289B2 (en) 1988-04-15

Family

ID=11184188

Family Applications (1)

Application Number Title Priority Date Filing Date
CS865455A CS257289B2 (en) 1985-07-17 1986-06-17 Preparation method of complex compound of at least one flavanolignane with at least one phospholipide

Country Status (18)

Country Link
US (1) US4764508A (de)
EP (1) EP0209038B2 (de)
JP (1) JPH0692399B2 (de)
KR (1) KR890002430B1 (de)
AR (1) AR241117A1 (de)
AT (1) ATE46513T1 (de)
CA (1) CA1259324A (de)
CS (1) CS257289B2 (de)
DE (1) DE3665717D1 (de)
DK (1) DK170804B1 (de)
ES (1) ES2002101A6 (de)
FI (1) FI82940C (de)
GR (1) GR861825B (de)
HU (1) HU197332B (de)
IT (1) IT1215291B (de)
MX (1) MX3173A (de)
PT (1) PT82988B (de)
YU (1) YU45790B (de)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1201149B (it) * 1987-01-14 1989-01-27 Indena Spa Complessi di bioflavonoidi con fosfolipidi,loro preparazione,uso e composizioni farmaceutici e cosmetiche
IT1201151B (it) * 1987-01-14 1989-01-27 Indena Spa Complessi fosfolipidici con estratti da vitis vinifera,procedimento per la loro preparazione e composizioni che li cntengono
IT1222012B (it) * 1987-07-10 1990-08-31 Indena Spa Composizioni farmaceutiche e cosmetiche contenenti complessi di flavonolignani con fosfolipidi
GB8716918D0 (en) * 1987-07-17 1987-08-26 Inverni Della Beffa Spa Soluble derivatives of silybin
IT1241673B (it) * 1989-10-09 1994-01-27 Istituto Biochimico Italiano Complessi di inclusione di silibinina con ciclodestrina, loro preparazione e composizioni farmaceutiche che li contengono.
IT1238684B (it) * 1990-02-09 1993-09-01 Indena Spa Derivati del bilobalide,loro usi e formulazioni che li contegono
DE69019517T2 (de) * 1990-07-05 1995-12-14 Indena Spa Neolignanderivatkomplexen mit Phospolipiden, deren Verwendung und sie enthaltende pharmazeutische und kosmetische Zusammensetzungen.
JP2672439B2 (ja) * 1991-09-25 1997-11-05 倉敷紡績 株式会社 強化押出成形体
GB9211659D0 (en) * 1992-06-02 1992-07-15 Indena Spa New alkaloid derivatives,their use and pharmaceutical formulations containing them
DE19501266A1 (de) * 1995-01-18 1996-07-25 Madaus Ag Verfahren zur Herstellung von Flavano-Lignan-Zubereitungen mit verbesserter Freisetzung und Resorbierbarkeit danach erhältliche Zubereitungen und deren Verwendung zur Herstellung von Arzneimitteln
IT1274549B (it) * 1995-05-23 1997-07-17 Indena Spa Uso di flavanolignani per la preparazione di medicamenti ad attivita' antiproliferativa nei tumori dell'utero,dell'ovaio e del seno
US6218437B1 (en) 1996-09-30 2001-04-17 The Regents Of The University Of California Treatment and prevention of hepatic disorders
US5922757A (en) * 1996-09-30 1999-07-13 The Regents Of The University Of California Treatment and prevention of hepatic disorders
ITMI20010429A1 (it) * 2001-03-02 2002-09-02 Indena Spa Composizioni farmaceutiche e cosmetiche per la protezione della pelledai danni indotti dalle radiazioni solari
KR100385366B1 (ko) * 2001-03-05 2003-05-27 부광약품 주식회사 생체이용율을 개선한 실리마린 제제 조성물
ES2288193T3 (es) 2001-07-27 2008-01-01 NEPTUNE TECHNOLOGIES & BIORESSOURCES INC. Fosfolipidos naturales de origen marino que contienen flavonoides y fosfolipidos poliinsaturados y sus usos.
EP1414484A1 (de) * 2001-08-01 2004-05-06 ALTANA Pharma AG Kombination eines selektiv cox-2 hemmer und eines lungenflügeltensids für atmungssyndrom
CZ292832B6 (cs) * 2001-08-30 2003-12-17 Ivax Pharmaceuticals S.R.O. Způsob přípravy silymarinu se zvýšenou rozpustností
ITMI20031388A1 (it) * 2003-07-08 2005-01-09 Indena Spa Formulazioni per il trattamento e la prevenzione di patologie della prostata.
ITMI20051942A1 (it) * 2005-10-14 2007-04-15 S I I T S R L Servizio Interna Composizioni galattogeniche a base di silimarina
RU2319498C2 (ru) * 2005-12-26 2008-03-20 Автономная некоммерческая организация Научно-технический центр "Фармбиопресс" Биокомпозиция, обладающая антитоксическим и антиапоптозным действием, профилактическая биологическая добавка на ее основе
EP1837030A1 (de) 2006-03-09 2007-09-26 INDENA S.p.A. Curcumin-phospholipid-Komplexe mit verbesserter Bioverfügbarkeit
EP1844785A1 (de) * 2006-04-13 2007-10-17 Indena S.P.A. Phospholipidkomplexe der Extrakte aus Oliven und Olivenblättern mit verbesserter Bioverfügbarkeit
US20110182858A1 (en) * 2007-11-15 2011-07-28 Madaus Gmbh Silibinin component for the treatment of hepatitis
CZ300846B6 (cs) * 2008-06-26 2009-08-26 Agra Group, A. S. Vodorozpustný prípravek na bázi flavanonol lignanu a zpusob jeho prípravy
US8337835B2 (en) 2009-04-10 2012-12-25 Washington University Use of an endogenous ligand for peroxisome proliferator activated receptor alpha to treat liver disorders
IT1395351B1 (it) 2009-07-09 2012-09-14 Axioma Srl Formulazioni orali ad elevata biodisponibilita' orale costituite da miscele di frazioni lipofile e idrofile ottenute a partire dalla propoli
JP5827625B2 (ja) 2009-10-29 2015-12-02 アカスティ ファーマ インコーポレイテッド 濃縮治療用リン脂質組成物
ITMI20121317A1 (it) * 2012-07-27 2014-01-28 Indena Spa Composizioni per il trattamento della fatica oncologica
ITMI20121784A1 (it) 2012-10-22 2014-04-23 Velleja Res Srl Composizioni galattogeniche a base di fosfatidilserina
ITMI20130425A1 (it) * 2013-03-20 2014-09-21 Istituto Biochimico Italiano Composizione per il trattamento della sindrome metabolica e delle alterazioni metabolico-ossidative nei pazienti con steatoepatite non alcolica (nash)
CN103751785A (zh) * 2014-01-27 2014-04-30 江苏健佳药业有限公司 一种水飞蓟素磷脂复合物及其制备方法
CN104306332B (zh) * 2014-09-24 2017-02-15 东南大学 一种喜树碱类磷脂化合物、其药物组合物及应用
CN105983013A (zh) * 2015-03-23 2016-10-05 天士力制药集团股份有限公司 一种含有水飞蓟宾、葛根提取物的药物组合物
CN105983016B (zh) * 2015-03-23 2023-08-11 天士力医药集团股份有限公司 一种含有水飞蓟宾的药物组合
ITUB20155532A1 (it) * 2015-11-12 2017-05-12 St Biochimico Italiano Giovanni Lorenzini Spa Formulazione farmaceutica orale comprendente silibina
IT201600105201A1 (it) 2016-10-19 2018-04-19 Nutrilinea Srl Uso della fosfatidilserina per la prevenzione e il trattamento dei disturbi della prostata e relative composizioni farmaceutiche e nutraceutiche
WO2019070109A1 (es) * 2017-10-03 2019-04-11 Infinite Clinical Research International, S.A. De C.V. Triconjugado para el tratamiento de diabetes mellitus
AU2022277553A1 (en) 2021-05-18 2023-11-09 Prostasis, Llc Compositions comprising mixtures of compounds and uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR5060M (de) * 1965-12-22 1967-05-08
DE1767666C3 (de) * 1968-06-01 1986-07-31 Dr. Madaus & Co, 5000 Koeln Pharmazeutische Zubereitung gegen Lebererkrankungen
DE1963318A1 (de) * 1969-12-17 1971-06-24 Schwabe Willmar Gmbh & Co Silybinhalbester der Bernsteinsaeure und der Phthalsaeure,ihre Salze mit pharmakologisch vertraglichen Basen,Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung von Arzneipraeparaten
DE2952115C2 (de) * 1979-12-22 1982-05-06 A. Nattermann & Cie GmbH, 5000 Köln Rosmarinsäure-Phospholipid-Komplex
JPS5958354U (ja) * 1982-10-13 1984-04-16 三菱重工業株式会社 伝熱板
SE442562B (sv) * 1983-01-26 1986-01-13 Asea Ab Sett att innesluta radioaktivt eller annat farligt avfall och en behallare for sadant avfall

Also Published As

Publication number Publication date
EP0209038B1 (de) 1989-09-20
IT1215291B (it) 1990-01-31
AR241117A1 (es) 1991-11-15
DK339086D0 (da) 1986-07-16
KR890002430B1 (ko) 1989-07-03
DK339086A (da) 1987-01-18
AR241117A2 (es) 1991-11-15
YU45790B (sh) 1992-07-20
EP0209038B2 (de) 1996-03-27
FI862850A0 (fi) 1986-07-04
CA1259324A (en) 1989-09-12
JPS6222781A (ja) 1987-01-30
EP0209038A1 (de) 1987-01-21
PT82988B (pt) 1988-07-01
PT82988A (en) 1986-08-01
HUT44567A (en) 1988-03-28
DE3665717D1 (en) 1989-10-26
ES2002101A6 (es) 1988-07-16
KR870001188A (ko) 1987-03-12
MX3173A (es) 1993-09-01
IT8521602A0 (it) 1985-07-17
FI82940B (fi) 1991-01-31
ATE46513T1 (de) 1989-10-15
JPH0692399B2 (ja) 1994-11-16
FI862850L (fi) 1987-01-18
FI82940C (fi) 1991-05-10
HU197332B (en) 1989-03-28
GR861825B (en) 1986-11-18
YU128086A (en) 1988-02-29
DK170804B1 (da) 1996-01-22
US4764508A (en) 1988-08-16

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Legal Events

Date Code Title Description
IF00 In force as of 2000-06-30 in czech republic
MK4A Patent expired

Effective date: 20010717