CS218585B2 - Method of making the c3-carboxhydrazides 4-deacetylvinkaleukoblastine - Google Patents

Method of making the c3-carboxhydrazides 4-deacetylvinkaleukoblastine Download PDF

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Publication number
CS218585B2
CS218585B2 CS807546A CS754680A CS218585B2 CS 218585 B2 CS218585 B2 CS 218585B2 CS 807546 A CS807546 A CS 807546A CS 754680 A CS754680 A CS 754680A CS 218585 B2 CS218585 B2 CS 218585B2
Authority
CS
Czechoslovakia
Prior art keywords
vlb
deacetyl
carboxhydrazide
formula
compounds
Prior art date
Application number
CS807546A
Other languages
Czech (cs)
English (en)
Inventor
George J Cullinan
Koert Gerzon
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of CS218585B2 publication Critical patent/CS218585B2/cs

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CS807546A 1978-04-20 1979-04-19 Method of making the c3-carboxhydrazides 4-deacetylvinkaleukoblastine CS218585B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/899,032 US4166810A (en) 1978-04-20 1978-04-20 Derivatives of 4-desacetyl VLB C-3 carboxyhydrazide

Publications (1)

Publication Number Publication Date
CS218585B2 true CS218585B2 (en) 1983-02-25

Family

ID=25410402

Family Applications (3)

Application Number Title Priority Date Filing Date
CS807545A CS218584B2 (en) 1978-04-20 1979-04-19 Process for production of c3- carboxyhydrazides c4-diacetylvinkaleukoblastime
CS807546A CS218585B2 (en) 1978-04-20 1979-04-19 Method of making the c3-carboxhydrazides 4-deacetylvinkaleukoblastine
CS792678A CS218583B2 (en) 1978-04-20 1979-04-19 Method of making the c3-carboxhydrazides 4-deacetylvinkaleukoblastine

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CS807545A CS218584B2 (en) 1978-04-20 1979-04-19 Process for production of c3- carboxyhydrazides c4-diacetylvinkaleukoblastime

Family Applications After (1)

Application Number Title Priority Date Filing Date
CS792678A CS218583B2 (en) 1978-04-20 1979-04-19 Method of making the c3-carboxhydrazides 4-deacetylvinkaleukoblastine

Country Status (32)

Country Link
US (1) US4166810A (de)
EP (1) EP0005051B1 (de)
JP (1) JPS54141798A (de)
AR (1) AR228940A1 (de)
AT (1) AT369010B (de)
AU (1) AU527109B2 (de)
BE (1) BE875652A (de)
BG (3) BG33296A3 (de)
CA (1) CA1097629A (de)
CH (1) CH643269A5 (de)
CS (3) CS218584B2 (de)
DD (1) DD143075A5 (de)
DE (1) DE2964130D1 (de)
DK (1) DK147484C (de)
EG (1) EG14867A (de)
ES (2) ES479753A1 (de)
FI (1) FI791286A (de)
FR (1) FR2423495A1 (de)
GB (1) GB2019396B (de)
GR (1) GR69987B (de)
HU (1) HU181431B (de)
IE (1) IE48213B1 (de)
IL (1) IL57168A (de)
LU (1) LU81166A1 (de)
NZ (1) NZ190213A (de)
PH (1) PH14163A (de)
PL (3) PL215911A1 (de)
PT (1) PT69496A (de)
RO (3) RO81037A (de)
SU (3) SU893135A3 (de)
YU (1) YU93179A (de)
ZA (1) ZA791856B (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4322351A (en) * 1980-08-25 1982-03-30 Eli Lilly And Company Antineoplastic 4'-formylamino and 4'-acetylamino VLB, and derivatives thereof
DK167984A (da) * 1983-03-30 1984-10-01 Lilly Industries Ltd Alkaloidderivater
US4675400A (en) * 1985-06-17 1987-06-23 Eli Lilly And Company Bifunctional derivatives of 4-desacetyl indole-dihydroindole alkaloids
US4667030A (en) * 1985-06-17 1987-05-19 Eli Lilly And Company Hydrazide succinimide derivatives of antineoplastic indole-dihydroindole alkaloids
US4801688A (en) * 1986-05-27 1989-01-31 Eli Lilly And Company Hydrazone immunoglobulin conjugates
US5043340A (en) * 1990-04-03 1991-08-27 Eli Lilly And Company Derivatives of 4-desacetyl VLB C-3 carboxhydrazide
US5043336A (en) * 1990-04-03 1991-08-27 Eli Lilly And Company Cyclic imide derivatives of 4-desacetyl VLB c-3 carboxhydrazide
ATE427948T1 (de) 2001-04-24 2009-04-15 Purdue Research Foundation Folat-mimetika und deren folatrezeptorbindende konjugate
KR20040106547A (ko) * 2002-05-15 2004-12-17 엔도사이트, 인코포레이티드 비타민-마이토마이신 공액체
EP2517730A3 (de) 2003-01-27 2013-01-02 Endocyte, Inc. Vitaminrezeptorbindende Wirkstofffreisetzungskonjugate
US8288557B2 (en) * 2004-07-23 2012-10-16 Endocyte, Inc. Bivalent linkers and conjugates thereof
US8044200B2 (en) * 2005-03-16 2011-10-25 Endocyte, Inc. Synthesis and purification of pteroic acid and conjugates thereof
ES2468240T3 (es) 2005-08-19 2014-06-16 Endocyte, Inc. Conjugados de ligando de múltiples fármacos
JP2009504783A (ja) * 2005-08-19 2009-02-05 エンドサイト，インコーポレイテッド ビンカアルカロイド、類似体および誘導体のリガンド結合体
WO2008100591A2 (en) * 2007-02-14 2008-08-21 The General Hospital Corporation Modulation of nitric oxide signaling to normalize tumor vasculature
WO2008101231A2 (en) 2007-02-16 2008-08-21 Endocyte, Inc. Methods and compositions for treating and diagnosing kidney disease
EP2481427A1 (de) * 2007-03-14 2012-08-01 Endocyte, Inc. Folat-Tubulysin Konjugate
CN101784565B (zh) 2007-06-25 2014-12-10 恩多塞特公司 含有亲水性间隔区接头的共轭物
US9877965B2 (en) 2007-06-25 2018-01-30 Endocyte, Inc. Vitamin receptor drug delivery conjugates for treating inflammation
CA2703491C (en) 2007-10-25 2017-06-13 Endocyte, Inc. Tubulysins and processes for preparing
US9168232B2 (en) * 2009-09-07 2015-10-27 Nipro Patch Co., Ltd. Transdermally absorbable preparation
US10080805B2 (en) 2012-02-24 2018-09-25 Purdue Research Foundation Cholecystokinin B receptor targeting for imaging and therapy
US20140080175A1 (en) 2012-03-29 2014-03-20 Endocyte, Inc. Processes for preparing tubulysin derivatives and conjugates thereof
AU2013331440A1 (en) 2012-10-16 2015-04-30 Endocyte, Inc. Drug delivery conjugates containing unnatural amino acids and methods for using

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3097137A (en) * 1960-05-19 1963-07-09 Canadian Patents Dev Vincaleukoblastine
US3205220A (en) * 1961-10-26 1965-09-07 Lilly Co Eli Leurosidine and leurocristine and their production
US3392173A (en) * 1964-03-09 1968-07-09 Lilly Co Eli Novel acyl derivatives of desacetyl-vincaleukoblastine and processes for their preparation
US3370057A (en) * 1964-04-27 1968-02-20 Lilly Co Eli Leurosine
US3387001A (en) * 1964-10-19 1968-06-04 Lilly Co Eli Novel aminoacyl esters of desacetyl vincaleukoblastine
US3887565A (en) * 1974-05-06 1975-06-03 Lilly Co Eli Vincadioline
US3890325A (en) * 1974-05-15 1975-06-17 Lilly Co Eli Leurocolombine
US3954773A (en) * 1974-11-21 1976-05-04 Eli Lilly And Company 4-Desacetoxyvinblastine
IL48685A (en) * 1975-01-09 1980-03-31 Lilly Co Eli Amides of vincadioline and vinblastine
US3944554A (en) * 1975-01-09 1976-03-16 Eli Lilly And Company 4-Desacetoxy-3-hydroxyvinblastine
US4029663A (en) * 1975-07-10 1977-06-14 Eli Lilly And Company Dimeric anhydro-vinca derivatives
US4115388A (en) * 1977-03-30 1978-09-19 Eli Lilly And Company 3'-Oxygenated derivatives of 4'-deoxy VLB "A" and "B" and related 1-formyl compounds

Also Published As

Publication number Publication date
DK147484B (da) 1984-08-27
YU93179A (en) 1983-01-21
IE790795L (en) 1979-10-20
CS218584B2 (en) 1983-02-25
SU1061698A3 (ru) 1983-12-15
GB2019396B (en) 1982-09-15
IL57168A0 (en) 1979-07-25
CS218583B2 (en) 1983-02-25
SU1225490A3 (ru) 1986-04-15
LU81166A1 (fr) 1979-09-07
GB2019396A (en) 1979-10-31
DK160679A (da) 1979-10-21
PL119416B1 (en) 1981-12-31
FI791286A (fi) 1979-10-21
NZ190213A (en) 1982-12-21
CA1097629A (en) 1981-03-17
JPS54141798A (en) 1979-11-05
FR2423495A1 (fr) 1979-11-16
ATA291279A (de) 1982-04-15
PL215911A1 (de) 1980-03-24
ZA791856B (en) 1980-11-26
CH643269A5 (fr) 1984-05-30
US4166810A (en) 1979-09-04
AU4609779A (en) 1979-10-25
RO80084A (ro) 1983-02-01
BG33297A3 (en) 1983-01-14
DE2964130D1 (en) 1983-01-05
PL125470B1 (en) 1983-05-31
DK147484C (da) 1985-03-25
IE48213B1 (en) 1984-10-31
RO81037A (ro) 1983-02-01
ES479753A1 (es) 1980-08-16
AT369010B (de) 1982-11-25
GR69987B (de) 1982-07-22
IL57168A (en) 1983-10-31
AU527109B2 (en) 1983-02-17
HU181431B (en) 1983-07-28
RO80084B (ro) 1983-01-30
RO81114B (ro) 1983-01-30
PT69496A (en) 1979-05-01
BG33294A3 (en) 1983-01-14
JPS6245873B2 (de) 1987-09-29
DD143075A5 (de) 1980-07-30
PH14163A (en) 1981-03-19
FR2423495B1 (de) 1983-02-11
RO81037B (ro) 1983-01-30
AR228940A1 (es) 1983-05-13
EP0005051B1 (de) 1982-12-01
SU893135A3 (ru) 1981-12-23
BE875652A (fr) 1979-10-18
ES479754A1 (es) 1980-08-16
EP0005051A1 (de) 1979-10-31
BG33296A3 (en) 1983-01-14
RO81114A (ro) 1983-02-01
EG14867A (en) 1986-09-30

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