FR2423495A1 - Derives anti-tumoraux de carboxhydrazide en c-3 de la 4-desacetyl vincaleublastine - Google Patents

Derives anti-tumoraux de carboxhydrazide en c-3 de la 4-desacetyl vincaleublastine

Info

Publication number
FR2423495A1
FR2423495A1 FR7909874A FR7909874A FR2423495A1 FR 2423495 A1 FR2423495 A1 FR 2423495A1 FR 7909874 A FR7909874 A FR 7909874A FR 7909874 A FR7909874 A FR 7909874A FR 2423495 A1 FR2423495 A1 FR 2423495A1
Authority
FR
France
Prior art keywords
carboxhydrazide
vincaleublastine
desacetyl
tumor derivatives
tumor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7909874A
Other languages
English (en)
Other versions
FR2423495B1 (fr
Inventor
George Joseph Cullinan
Koert Gerzon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of FR2423495A1 publication Critical patent/FR2423495A1/fr
Application granted granted Critical
Publication of FR2423495B1 publication Critical patent/FR2423495B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Carboxhydrazide en C-3 de 4-désacétyl vincaleucoblastine de formule générale :
FR7909874A 1978-04-20 1979-04-19 Derives anti-tumoraux de carboxhydrazide en c-3 de la 4-desacetyl vincaleublastine Granted FR2423495A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/899,032 US4166810A (en) 1978-04-20 1978-04-20 Derivatives of 4-desacetyl VLB C-3 carboxyhydrazide

Publications (2)

Publication Number Publication Date
FR2423495A1 true FR2423495A1 (fr) 1979-11-16
FR2423495B1 FR2423495B1 (fr) 1983-02-11

Family

ID=25410402

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7909874A Granted FR2423495A1 (fr) 1978-04-20 1979-04-19 Derives anti-tumoraux de carboxhydrazide en c-3 de la 4-desacetyl vincaleublastine

Country Status (32)

Country Link
US (1) US4166810A (fr)
EP (1) EP0005051B1 (fr)
JP (1) JPS54141798A (fr)
AR (1) AR228940A1 (fr)
AT (1) AT369010B (fr)
AU (1) AU527109B2 (fr)
BE (1) BE875652A (fr)
BG (3) BG33297A3 (fr)
CA (1) CA1097629A (fr)
CH (1) CH643269A5 (fr)
CS (3) CS218583B2 (fr)
DD (1) DD143075A5 (fr)
DE (1) DE2964130D1 (fr)
DK (1) DK147484C (fr)
EG (1) EG14867A (fr)
ES (2) ES479754A1 (fr)
FI (1) FI791286A (fr)
FR (1) FR2423495A1 (fr)
GB (1) GB2019396B (fr)
GR (1) GR69987B (fr)
HU (1) HU181431B (fr)
IE (1) IE48213B1 (fr)
IL (1) IL57168A (fr)
LU (1) LU81166A1 (fr)
NZ (1) NZ190213A (fr)
PH (1) PH14163A (fr)
PL (3) PL119416B1 (fr)
PT (1) PT69496A (fr)
RO (3) RO81114A (fr)
SU (3) SU1225490A3 (fr)
YU (1) YU93179A (fr)
ZA (1) ZA791856B (fr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4322351A (en) * 1980-08-25 1982-03-30 Eli Lilly And Company Antineoplastic 4'-formylamino and 4'-acetylamino VLB, and derivatives thereof
GR79898B (fr) * 1983-03-30 1984-10-31 Lilly Industries Ltd
US4675400A (en) * 1985-06-17 1987-06-23 Eli Lilly And Company Bifunctional derivatives of 4-desacetyl indole-dihydroindole alkaloids
US4667030A (en) * 1985-06-17 1987-05-19 Eli Lilly And Company Hydrazide succinimide derivatives of antineoplastic indole-dihydroindole alkaloids
US4801688A (en) * 1986-05-27 1989-01-31 Eli Lilly And Company Hydrazone immunoglobulin conjugates
US5043336A (en) * 1990-04-03 1991-08-27 Eli Lilly And Company Cyclic imide derivatives of 4-desacetyl VLB c-3 carboxhydrazide
US5043340A (en) * 1990-04-03 1991-08-27 Eli Lilly And Company Derivatives of 4-desacetyl VLB C-3 carboxhydrazide
ATE427948T1 (de) * 2001-04-24 2009-04-15 Purdue Research Foundation Folat-mimetika und deren folatrezeptorbindende konjugate
ES2324708T3 (es) * 2002-05-15 2009-08-13 Endocyte, Inc. Conjugados de vitamina-mitomicina.
US7601332B2 (en) 2003-01-27 2009-10-13 Endocyte, Inc. Vitamin receptor binding drug delivery conjugates
EP1789391B1 (fr) 2004-07-23 2017-06-28 Endocyte, Inc. Groupes de liaison bivalents et conjugués de ceux-ci
EP1863816B1 (fr) * 2005-03-16 2014-06-25 Endocyte, Inc. Synthese et purification d'acide pteroique et des conjugues de celui-ci
WO2007022493A2 (fr) 2005-08-19 2007-02-22 Endocyte, Inc. Conjugues de ligand d'alcaloides vinca, analogues et derives
EP1948241B1 (fr) * 2005-08-19 2014-03-05 Endocyte, Inc. Conjugues de ligand multi medicament
WO2008100591A2 (fr) * 2007-02-14 2008-08-21 The General Hospital Corporation Modulation de la signalisation de l'oxyde nitrique pour normaliser le système vasculaire tumoral
US20100104626A1 (en) * 2007-02-16 2010-04-29 Endocyte, Inc. Methods and compositions for treating and diagnosing kidney disease
AU2008224988A1 (en) * 2007-03-14 2008-09-18 Endocyte, Inc. Binding ligand linked drug delivery conjugates of tubulysins
US9877965B2 (en) 2007-06-25 2018-01-30 Endocyte, Inc. Vitamin receptor drug delivery conjugates for treating inflammation
US9138484B2 (en) 2007-06-25 2015-09-22 Endocyte, Inc. Conjugates containing hydrophilic spacer linkers
CA2703491C (fr) * 2007-10-25 2017-06-13 Endocyte, Inc. Tubulysines et leurs procedes de preparation
US9168232B2 (en) * 2009-09-07 2015-10-27 Nipro Patch Co., Ltd. Transdermally absorbable preparation
WO2013126797A1 (fr) 2012-02-24 2013-08-29 Purdue Research Foundation Ciblage du récepteur de la cholécystokinine de type b pour imagerie et thérapie
US20140080175A1 (en) 2012-03-29 2014-03-20 Endocyte, Inc. Processes for preparing tubulysin derivatives and conjugates thereof
SG11201502896XA (en) 2012-10-16 2015-05-28 Endocyte Inc Drug delivery conjugates containing unnatural amino acids and methods for using

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3097137A (en) * 1960-05-19 1963-07-09 Canadian Patents Dev Vincaleukoblastine
US3205220A (en) * 1961-10-26 1965-09-07 Lilly Co Eli Leurosidine and leurocristine and their production
US3392173A (en) * 1964-03-09 1968-07-09 Lilly Co Eli Novel acyl derivatives of desacetyl-vincaleukoblastine and processes for their preparation
US3370057A (en) * 1964-04-27 1968-02-20 Lilly Co Eli Leurosine
US3387001A (en) * 1964-10-19 1968-06-04 Lilly Co Eli Novel aminoacyl esters of desacetyl vincaleukoblastine
US3887565A (en) * 1974-05-06 1975-06-03 Lilly Co Eli Vincadioline
US3890325A (en) * 1974-05-15 1975-06-17 Lilly Co Eli Leurocolombine
US3954773A (en) * 1974-11-21 1976-05-04 Eli Lilly And Company 4-Desacetoxyvinblastine
IL48685A (en) 1975-01-09 1980-03-31 Lilly Co Eli Amides of vincadioline and vinblastine
US3944554A (en) * 1975-01-09 1976-03-16 Eli Lilly And Company 4-Desacetoxy-3-hydroxyvinblastine
US4029663A (en) * 1975-07-10 1977-06-14 Eli Lilly And Company Dimeric anhydro-vinca derivatives
US4115388A (en) * 1977-03-30 1978-09-19 Eli Lilly And Company 3'-Oxygenated derivatives of 4'-deoxy VLB "A" and "B" and related 1-formyl compounds

Also Published As

Publication number Publication date
BG33297A3 (en) 1983-01-14
PL119416B1 (en) 1981-12-31
LU81166A1 (fr) 1979-09-07
EP0005051A1 (fr) 1979-10-31
US4166810A (en) 1979-09-04
AU527109B2 (en) 1983-02-17
RO81037B (ro) 1983-01-30
SU1061698A3 (ru) 1983-12-15
RO81114A (fr) 1983-02-01
CA1097629A (fr) 1981-03-17
ATA291279A (de) 1982-04-15
DD143075A5 (de) 1980-07-30
BG33294A3 (en) 1983-01-14
CS218584B2 (en) 1983-02-25
JPS6245873B2 (fr) 1987-09-29
ZA791856B (en) 1980-11-26
BG33296A3 (en) 1983-01-14
GB2019396B (en) 1982-09-15
GR69987B (fr) 1982-07-22
JPS54141798A (en) 1979-11-05
RO81037A (fr) 1983-02-01
AR228940A1 (es) 1983-05-13
CS218583B2 (en) 1983-02-25
AT369010B (de) 1982-11-25
DE2964130D1 (en) 1983-01-05
NZ190213A (en) 1982-12-21
IE48213B1 (en) 1984-10-31
GB2019396A (en) 1979-10-31
FI791286A (fi) 1979-10-21
HU181431B (en) 1983-07-28
IL57168A (en) 1983-10-31
PT69496A (en) 1979-05-01
PH14163A (en) 1981-03-19
PL125470B1 (en) 1983-05-31
EG14867A (en) 1986-09-30
DK147484C (da) 1985-03-25
YU93179A (en) 1983-01-21
ES479753A1 (es) 1980-08-16
BE875652A (fr) 1979-10-18
SU1225490A3 (ru) 1986-04-15
DK147484B (da) 1984-08-27
CH643269A5 (fr) 1984-05-30
IE790795L (en) 1979-10-20
IL57168A0 (en) 1979-07-25
CS218585B2 (en) 1983-02-25
FR2423495B1 (fr) 1983-02-11
RO80084A (fr) 1983-02-01
RO80084B (ro) 1983-01-30
RO81114B (ro) 1983-01-30
PL215911A1 (fr) 1980-03-24
EP0005051B1 (fr) 1982-12-01
AU4609779A (en) 1979-10-25
SU893135A3 (ru) 1981-12-23
DK160679A (da) 1979-10-21
ES479754A1 (es) 1980-08-16

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