RO81037B - Procedeu de preparare a unor 4-dezacelilvincaleucoblastin-c3-carboxhidrazide - Google Patents

Procedeu de preparare a unor 4-dezacelilvincaleucoblastin-c3-carboxhidrazide

Info

Publication number
RO81037B
RO81037B RO102377A RO10237779A RO81037B RO 81037 B RO81037 B RO 81037B RO 102377 A RO102377 A RO 102377A RO 10237779 A RO10237779 A RO 10237779A RO 81037 B RO81037 B RO 81037B
Authority
RO
Romania
Prior art keywords
desacetyle
vincaleucoblastin
carboxyhydrazide
preparing
vincaleucoblastine
Prior art date
Application number
RO102377A
Other languages
English (en)
Other versions
RO81037A (ro
Inventor
George Joseph Cullinan
Koert Gerzon
Original Assignee
Eli Lilly And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company
Publication of RO81037B publication Critical patent/RO81037B/ro
Publication of RO81037A publication Critical patent/RO81037A/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Se obtin 4-dezacetil-vincale-ucoblastin-C 3-carboxhidrazide cu formula generala I: (vezi formula) în care 0 reprezinta o grupa (vezi formula) în care R reprezinta alcanoil C2...C4 sau benzoil, si R1 reprezinta hidrogen printr-un procedeu caracterizatprin aceea ca se trateaza cu C3-derivat de 4-dezacetil-vincaleucoblastin cu formula generala II: (vezi formula) în care Q reprezinta NHNH2, cu o anhidrida a unui acid alcanoic C2...C4 sau a acidului benzoic, reactantii fiind luati în raport în greut ate de circa 1:5...6,4, într-un solvent organic, cum ar fi diclormetanul, la temperatura camerei.
RO79102377A 1978-04-20 1979-04-18 Procedeu de preparare a unor 4-dezacelil-vincaleucoblastin-c3-carboxuhydrazide RO81037A (ro)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/899,032 US4166810A (en) 1978-04-20 1978-04-20 Derivatives of 4-desacetyl VLB C-3 carboxyhydrazide

Publications (2)

Publication Number Publication Date
RO81037B true RO81037B (ro) 1983-01-30
RO81037A RO81037A (ro) 1983-02-01

Family

ID=25410402

Family Applications (3)

Application Number Title Priority Date Filing Date
RO79102376A RO81114A (ro) 1978-04-20 1979-04-18 Procedeu de preparare a unor 4-desacetilvincalencoblastin-c3-carboxihidracide
RO7997290A RO80084A (ro) 1978-04-20 1979-04-18 Procedeu de preparare a unor derivati ai 4-desacetil vincalencoblastinei c-o carboxi hidrazinei
RO79102377A RO81037A (ro) 1978-04-20 1979-04-18 Procedeu de preparare a unor 4-dezacelil-vincaleucoblastin-c3-carboxuhydrazide

Family Applications Before (2)

Application Number Title Priority Date Filing Date
RO79102376A RO81114A (ro) 1978-04-20 1979-04-18 Procedeu de preparare a unor 4-desacetilvincalencoblastin-c3-carboxihidracide
RO7997290A RO80084A (ro) 1978-04-20 1979-04-18 Procedeu de preparare a unor derivati ai 4-desacetil vincalencoblastinei c-o carboxi hidrazinei

Country Status (32)

Country Link
US (1) US4166810A (ro)
EP (1) EP0005051B1 (ro)
JP (1) JPS54141798A (ro)
AR (1) AR228940A1 (ro)
AT (1) AT369010B (ro)
AU (1) AU527109B2 (ro)
BE (1) BE875652A (ro)
BG (3) BG33294A3 (ro)
CA (1) CA1097629A (ro)
CH (1) CH643269A5 (ro)
CS (3) CS218583B2 (ro)
DD (1) DD143075A5 (ro)
DE (1) DE2964130D1 (ro)
DK (1) DK147484C (ro)
EG (1) EG14867A (ro)
ES (2) ES479753A1 (ro)
FI (1) FI791286A7 (ro)
FR (1) FR2423495A1 (ro)
GB (1) GB2019396B (ro)
GR (1) GR69987B (ro)
HU (1) HU181431B (ro)
IE (1) IE48213B1 (ro)
IL (1) IL57168A (ro)
LU (1) LU81166A1 (ro)
NZ (1) NZ190213A (ro)
PH (1) PH14163A (ro)
PL (3) PL119416B1 (ro)
PT (1) PT69496A (ro)
RO (3) RO81114A (ro)
SU (3) SU893135A3 (ro)
YU (1) YU93179A (ro)
ZA (1) ZA791856B (ro)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4322351A (en) * 1980-08-25 1982-03-30 Eli Lilly And Company Antineoplastic 4'-formylamino and 4'-acetylamino VLB, and derivatives thereof
GR79898B (ro) * 1983-03-30 1984-10-31 Lilly Industries Ltd
US4675400A (en) * 1985-06-17 1987-06-23 Eli Lilly And Company Bifunctional derivatives of 4-desacetyl indole-dihydroindole alkaloids
US4667030A (en) * 1985-06-17 1987-05-19 Eli Lilly And Company Hydrazide succinimide derivatives of antineoplastic indole-dihydroindole alkaloids
US4801688A (en) * 1986-05-27 1989-01-31 Eli Lilly And Company Hydrazone immunoglobulin conjugates
US5043336A (en) * 1990-04-03 1991-08-27 Eli Lilly And Company Cyclic imide derivatives of 4-desacetyl VLB c-3 carboxhydrazide
US5043340A (en) * 1990-04-03 1991-08-27 Eli Lilly And Company Derivatives of 4-desacetyl VLB C-3 carboxhydrazide
DE60231868D1 (de) * 2001-04-24 2009-05-20 Purdue Research Foundation Folat-mimetika und deren folatrezeptorbindende konjugate
DE60326833D1 (de) * 2002-05-15 2009-05-07 Endocyte Inc Vitamin-mitomycin-konjugate
TWI367096B (en) 2003-01-27 2012-07-01 Endocyte Inc Vitamin-receptor binding drug delivery conjugates and pharmaceutical compositions
WO2006012527A1 (en) 2004-07-23 2006-02-02 Endocyte, Inc. Bivalent linkers and conjugates thereof
CN101175757B (zh) * 2005-03-16 2012-11-14 恩多塞特公司 蝶酸及其缀合物的合成和纯化
US8465724B2 (en) 2005-08-19 2013-06-18 Endocyte, Inc. Multi-drug ligand conjugates
WO2007022493A2 (en) 2005-08-19 2007-02-22 Endocyte, Inc. Ligand conjugates of vinca alkaloids, analogs, and derivatives
WO2008100591A2 (en) * 2007-02-14 2008-08-21 The General Hospital Corporation Modulation of nitric oxide signaling to normalize tumor vasculature
WO2008101231A2 (en) 2007-02-16 2008-08-21 Endocyte, Inc. Methods and compositions for treating and diagnosing kidney disease
EP2489372A3 (en) * 2007-03-14 2013-01-02 Endocyte, Inc. Binding ligand linked drug delivery conjugates of tubulysins
RU2523909C2 (ru) * 2007-06-25 2014-07-27 Эндосайт, Инк. Конъюгаты, содержащие гидрофильные спейсеры линкеров
US9877965B2 (en) 2007-06-25 2018-01-30 Endocyte, Inc. Vitamin receptor drug delivery conjugates for treating inflammation
CN101909441B (zh) * 2007-10-25 2015-05-13 恩多塞特公司 微管蛋白抑制剂及其制备方法
PH12012500472A1 (en) * 2009-09-07 2012-10-22 Nipro Patch Co Ltd Transdermally absorbable preparation
WO2013126797A1 (en) 2012-02-24 2013-08-29 Purdue Research Foundation Cholecystokinin b receptor targeting for imaging and therapy
US20140080175A1 (en) 2012-03-29 2014-03-20 Endocyte, Inc. Processes for preparing tubulysin derivatives and conjugates thereof
IN2015DN04147A (ro) 2012-10-16 2015-10-16 Endocyte Inc

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3097137A (en) * 1960-05-19 1963-07-09 Canadian Patents Dev Vincaleukoblastine
US3205220A (en) * 1961-10-26 1965-09-07 Lilly Co Eli Leurosidine and leurocristine and their production
US3392173A (en) * 1964-03-09 1968-07-09 Lilly Co Eli Novel acyl derivatives of desacetyl-vincaleukoblastine and processes for their preparation
US3370057A (en) * 1964-04-27 1968-02-20 Lilly Co Eli Leurosine
US3387001A (en) * 1964-10-19 1968-06-04 Lilly Co Eli Novel aminoacyl esters of desacetyl vincaleukoblastine
US3887565A (en) * 1974-05-06 1975-06-03 Lilly Co Eli Vincadioline
US3890325A (en) * 1974-05-15 1975-06-17 Lilly Co Eli Leurocolombine
US3954773A (en) * 1974-11-21 1976-05-04 Eli Lilly And Company 4-Desacetoxyvinblastine
US3944554A (en) * 1975-01-09 1976-03-16 Eli Lilly And Company 4-Desacetoxy-3-hydroxyvinblastine
IL48685A (en) * 1975-01-09 1980-03-31 Lilly Co Eli Amides of vincadioline and vinblastine
US4029663A (en) * 1975-07-10 1977-06-14 Eli Lilly And Company Dimeric anhydro-vinca derivatives
US4115388A (en) * 1977-03-30 1978-09-19 Eli Lilly And Company 3'-Oxygenated derivatives of 4'-deoxy VLB "A" and "B" and related 1-formyl compounds

Also Published As

Publication number Publication date
ZA791856B (en) 1980-11-26
BG33296A3 (bg) 1983-01-14
CS218585B2 (en) 1983-02-25
FR2423495B1 (ro) 1983-02-11
GB2019396B (en) 1982-09-15
IE790795L (en) 1979-10-20
ATA291279A (de) 1982-04-15
PL125470B1 (en) 1983-05-31
ES479753A1 (es) 1980-08-16
GB2019396A (en) 1979-10-31
IL57168A0 (en) 1979-07-25
BE875652A (fr) 1979-10-18
AU527109B2 (en) 1983-02-17
DD143075A5 (de) 1980-07-30
AR228940A1 (es) 1983-05-13
PL119416B1 (en) 1981-12-31
FI791286A7 (fi) 1981-01-01
PL215911A1 (ro) 1980-03-24
BG33294A3 (bg) 1983-01-14
SU893135A3 (ru) 1981-12-23
BG33297A3 (bg) 1983-01-14
DE2964130D1 (en) 1983-01-05
RO81037A (ro) 1983-02-01
HU181431B (en) 1983-07-28
YU93179A (en) 1983-01-21
LU81166A1 (fr) 1979-09-07
AU4609779A (en) 1979-10-25
RO81114A (ro) 1983-02-01
IL57168A (en) 1983-10-31
ES479754A1 (es) 1980-08-16
DK160679A (da) 1979-10-21
SU1225490A3 (ru) 1986-04-15
DK147484B (da) 1984-08-27
NZ190213A (en) 1982-12-21
PH14163A (en) 1981-03-19
US4166810A (en) 1979-09-04
IE48213B1 (en) 1984-10-31
CH643269A5 (fr) 1984-05-30
AT369010B (de) 1982-11-25
JPS6245873B2 (ro) 1987-09-29
EP0005051B1 (en) 1982-12-01
RO80084A (ro) 1983-02-01
SU1061698A3 (ru) 1983-12-15
JPS54141798A (en) 1979-11-05
GR69987B (ro) 1982-07-22
FR2423495A1 (fr) 1979-11-16
RO80084B (ro) 1983-01-30
EG14867A (en) 1986-09-30
CS218583B2 (en) 1983-02-25
CA1097629A (en) 1981-03-17
DK147484C (da) 1985-03-25
PT69496A (en) 1979-05-01
CS218584B2 (en) 1983-02-25
EP0005051A1 (en) 1979-10-31
RO81114B (ro) 1983-01-30

Similar Documents

Publication Publication Date Title
RO81037B (ro) Procedeu de preparare a unor 4-dezacelilvincaleucoblastin-c3-carboxhidrazide
BG30474A3 (bg) Метод за получаване на 6-п-пропил-8-метоксиметил-или- метилмеркаптометилерголини и сродни съединения
FR2405946A1 (fr) Nouveaux derives de l'acide 3-methyl-crotonique et procede pour leur preparation
BG35189A3 (en) Method for preparing derivatives of 6- beta- hydroxyalkylpenicillanic acid
BG34615A3 (bg) Метод за получаване на 1- окиси на пеницилановата киселина
ES8801311A1 (es) Un procedimiento para preparar derivados de alamil-prolina.
BG31945A3 (bg) Метод за получаване на 4-ациламино-фенил-етаноламини
FR2360643A1 (fr) Procede de preparation d'hemi-esters sulfuriques des groupements hydroxy-ethylsulfonyles de colorants organiques
ATE55116T1 (de) Neue sulfobetaine von ammoniocarbonsaeureamiden und verfahren zu ihrer herstellung.
JPS5413483A (en) Method of manufacturing maleic acid anhydride from 4 carbon hydrocarbon by using catalyst produced by hydrothermic method
BG32855A3 (bg) Метод за получаване на 1-оксадетиацефалоспорини
FR2360539A2 (fr) Procede de preparation d'hemi-esters sulfuriques
ES8106897A1 (es) Un procedimiento para preparar nuevos 2-cloro-tiazoles di- sustituidos en las posiciones 4 y 5
DK246479A (da) Steroidsyntese under anvendelse af blandet anhydrid
ES8104192A1 (es) Procedimiento para preparar nuevas 1-(aminoalquilamino)-5,8-dihidroxi-4-sustituido-antraquinonas.
FR2446841A1 (fr) Procede de preparation de 1a,3b-dihydroxy-d5-steroides
KR830006180A (ko) 뱃트물감제조용 신규중간물 α-벤즈아미도-5'(또는 8')-할로게노-1, 1'-디안트 리미드류 등의 α-벤즈아미도 -α'-할로게노-1, 1'-디안트리미드류의 제조방법
BG33280A3 (bg) Метод за получаване на (2, 2- диметил- 1, 2- хидрохинолин- 4- ил)- метилсулфонова киселина и нейни соли
FR2415127A1 (fr) Procede pour la preparation de colorants pour cuve
BE857293A (fr) Procede de preparation de l'anthraquinone par oxydation catalytique du naphtalene
BG34451A3 (bg) Метод за получаване на заместени 4н- s- триазоло /3, 4с/ тиено /2, 3е/ 1, 4- диазепини
ES440270A1 (es) Procedimiento para preparar imidas de esteres de acidos n- (aminometiliden)-tiolfosforicos y tionofosforicos.
ATE63740T1 (de) Verfahren zur herstellung von dien-1-olen, 9hydroxydodec-10-enyl-1-tert.-butylether und seine verwendung als zwischenprodukt zur synthese von 8,10-dodecadienol.
SU591457A1 (ru) Способ очистки 3,3-диокси-4,4диаминодифенилметана
LU80336A1 (fr) Procede de preparation d'ureidonitriles utiles comme antihypertenseurs