BE875652A - Derives anti-tumoraux decarboxhydrazide en c-3 de la 4-desacetyl vincaleucoblastine - Google Patents

Derives anti-tumoraux decarboxhydrazide en c-3 de la 4-desacetyl vincaleucoblastine

Info

Publication number
BE875652A
BE875652A BE1/9358A BE1009358A BE875652A BE 875652 A BE875652 A BE 875652A BE 1/9358 A BE1/9358 A BE 1/9358A BE 1009358 A BE1009358 A BE 1009358A BE 875652 A BE875652 A BE 875652A
Authority
BE
Belgium
Prior art keywords
decarboxhydrazide
vincaleucoblastine
desacetyl
tumor
derivatives
Prior art date
Application number
BE1/9358A
Other languages
English (en)
Inventor
G J Cullinan
K Gerzon
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of BE875652A publication Critical patent/BE875652A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
BE1/9358A 1978-04-20 1979-04-18 Derives anti-tumoraux decarboxhydrazide en c-3 de la 4-desacetyl vincaleucoblastine BE875652A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/899,032 US4166810A (en) 1978-04-20 1978-04-20 Derivatives of 4-desacetyl VLB C-3 carboxyhydrazide

Publications (1)

Publication Number Publication Date
BE875652A true BE875652A (fr) 1979-10-18

Family

ID=25410402

Family Applications (1)

Application Number Title Priority Date Filing Date
BE1/9358A BE875652A (fr) 1978-04-20 1979-04-18 Derives anti-tumoraux decarboxhydrazide en c-3 de la 4-desacetyl vincaleucoblastine

Country Status (32)

Country Link
US (1) US4166810A (fr)
EP (1) EP0005051B1 (fr)
JP (1) JPS54141798A (fr)
AR (1) AR228940A1 (fr)
AT (1) AT369010B (fr)
AU (1) AU527109B2 (fr)
BE (1) BE875652A (fr)
BG (3) BG33294A3 (fr)
CA (1) CA1097629A (fr)
CH (1) CH643269A5 (fr)
CS (3) CS218585B2 (fr)
DD (1) DD143075A5 (fr)
DE (1) DE2964130D1 (fr)
DK (1) DK147484C (fr)
EG (1) EG14867A (fr)
ES (2) ES479754A1 (fr)
FI (1) FI791286A (fr)
FR (1) FR2423495A1 (fr)
GB (1) GB2019396B (fr)
GR (1) GR69987B (fr)
HU (1) HU181431B (fr)
IE (1) IE48213B1 (fr)
IL (1) IL57168A (fr)
LU (1) LU81166A1 (fr)
NZ (1) NZ190213A (fr)
PH (1) PH14163A (fr)
PL (3) PL125470B1 (fr)
PT (1) PT69496A (fr)
RO (3) RO81037A (fr)
SU (3) SU1225490A3 (fr)
YU (1) YU93179A (fr)
ZA (1) ZA791856B (fr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4322351A (en) * 1980-08-25 1982-03-30 Eli Lilly And Company Antineoplastic 4'-formylamino and 4'-acetylamino VLB, and derivatives thereof
DK167984A (da) * 1983-03-30 1984-10-01 Lilly Industries Ltd Alkaloidderivater
US4675400A (en) * 1985-06-17 1987-06-23 Eli Lilly And Company Bifunctional derivatives of 4-desacetyl indole-dihydroindole alkaloids
US4667030A (en) * 1985-06-17 1987-05-19 Eli Lilly And Company Hydrazide succinimide derivatives of antineoplastic indole-dihydroindole alkaloids
US4801688A (en) * 1986-05-27 1989-01-31 Eli Lilly And Company Hydrazone immunoglobulin conjugates
US5043336A (en) * 1990-04-03 1991-08-27 Eli Lilly And Company Cyclic imide derivatives of 4-desacetyl VLB c-3 carboxhydrazide
US5043340A (en) * 1990-04-03 1991-08-27 Eli Lilly And Company Derivatives of 4-desacetyl VLB C-3 carboxhydrazide
DE60231868D1 (de) 2001-04-24 2009-05-20 Purdue Research Foundation Folat-mimetika und deren folatrezeptorbindende konjugate
WO2003097647A1 (fr) * 2002-05-15 2003-11-27 Endocyte, Inc. Conjugues vitamine-mitomycine
DK1592457T3 (da) 2003-01-27 2012-10-22 Endocyte Inc Folat-vinblastin-konjugat som lægemiddel
JP5149620B2 (ja) 2004-07-23 2013-02-20 エンドサイト，インコーポレイテッド ２価リンカーおよびその結合体
US8044200B2 (en) * 2005-03-16 2011-10-25 Endocyte, Inc. Synthesis and purification of pteroic acid and conjugates thereof
AU2006279304A1 (en) 2005-08-19 2007-02-22 Endocyte, Inc. Multi-drug ligand conjugates
EP2382995A3 (fr) 2005-08-19 2013-09-25 Endocyte, Inc. Conjugués de ligands d'alcaloïdes de Vinca, analogues et dérivés
WO2008100591A2 (fr) * 2007-02-14 2008-08-21 The General Hospital Corporation Modulation de la signalisation de l'oxyde nitrique pour normaliser le système vasculaire tumoral
WO2008101231A2 (fr) * 2007-02-16 2008-08-21 Endocyte, Inc. Procédés et compositions de traitement et de diagnostic d'une maladie rénale
WO2008112873A2 (fr) * 2007-03-14 2008-09-18 Endocyte, Inc. Conjugués d'administration de médicament liés à un ligand de liaison de tubulysines
CN104383553A (zh) * 2007-06-25 2015-03-04 恩多塞特公司 含有亲水性间隔区接头的共轭物
US9877965B2 (en) 2007-06-25 2018-01-30 Endocyte, Inc. Vitamin receptor drug delivery conjugates for treating inflammation
EP2209374B1 (fr) 2007-10-25 2014-12-03 Endocyte, Inc. Tubulysines et leurs procédés de préparation
EP2476414B1 (fr) * 2009-09-07 2015-03-04 NIPRO Patch Co., Ltd. Préparation absorbable par voie transdermique
US10080805B2 (en) 2012-02-24 2018-09-25 Purdue Research Foundation Cholecystokinin B receptor targeting for imaging and therapy
US20140080175A1 (en) 2012-03-29 2014-03-20 Endocyte, Inc. Processes for preparing tubulysin derivatives and conjugates thereof
BR112015008365A2 (pt) 2012-10-16 2017-07-04 Endocyte Inc composto da fórmula b-l(d)x, ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, uso de um composto, composição de forma de dosagem unitária ou dose unitária, composição para tratar um câncer em um paciente, e método para tratar um câncer em um paciente

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3097137A (en) * 1960-05-19 1963-07-09 Canadian Patents Dev Vincaleukoblastine
US3205220A (en) * 1961-10-26 1965-09-07 Lilly Co Eli Leurosidine and leurocristine and their production
US3392173A (en) * 1964-03-09 1968-07-09 Lilly Co Eli Novel acyl derivatives of desacetyl-vincaleukoblastine and processes for their preparation
US3370057A (en) * 1964-04-27 1968-02-20 Lilly Co Eli Leurosine
US3387001A (en) * 1964-10-19 1968-06-04 Lilly Co Eli Novel aminoacyl esters of desacetyl vincaleukoblastine
US3887565A (en) * 1974-05-06 1975-06-03 Lilly Co Eli Vincadioline
US3890325A (en) * 1974-05-15 1975-06-17 Lilly Co Eli Leurocolombine
US3954773A (en) * 1974-11-21 1976-05-04 Eli Lilly And Company 4-Desacetoxyvinblastine
US3944554A (en) * 1975-01-09 1976-03-16 Eli Lilly And Company 4-Desacetoxy-3-hydroxyvinblastine
IL48685A (en) * 1975-01-09 1980-03-31 Lilly Co Eli Amides of vincadioline and vinblastine
US4029663A (en) * 1975-07-10 1977-06-14 Eli Lilly And Company Dimeric anhydro-vinca derivatives
US4115388A (en) * 1977-03-30 1978-09-19 Eli Lilly And Company 3'-Oxygenated derivatives of 4'-deoxy VLB "A" and "B" and related 1-formyl compounds

Also Published As

Publication number Publication date
AU527109B2 (en) 1983-02-17
US4166810A (en) 1979-09-04
IE48213B1 (en) 1984-10-31
PL119416B1 (en) 1981-12-31
DD143075A5 (de) 1980-07-30
EP0005051A1 (fr) 1979-10-31
ES479754A1 (es) 1980-08-16
IL57168A0 (en) 1979-07-25
PT69496A (en) 1979-05-01
DK147484B (da) 1984-08-27
BG33294A3 (en) 1983-01-14
BG33297A3 (en) 1983-01-14
JPS54141798A (en) 1979-11-05
AR228940A1 (es) 1983-05-13
YU93179A (en) 1983-01-21
SU893135A3 (ru) 1981-12-23
RO81114A (fr) 1983-02-01
LU81166A1 (fr) 1979-09-07
CS218584B2 (en) 1983-02-25
FI791286A (fi) 1979-10-21
EP0005051B1 (fr) 1982-12-01
FR2423495A1 (fr) 1979-11-16
PL215911A1 (fr) 1980-03-24
GB2019396A (en) 1979-10-31
FR2423495B1 (fr) 1983-02-11
RO81037A (fr) 1983-02-01
SU1225490A3 (ru) 1986-04-15
AU4609779A (en) 1979-10-25
BG33296A3 (en) 1983-01-14
AT369010B (de) 1982-11-25
PH14163A (en) 1981-03-19
JPS6245873B2 (fr) 1987-09-29
CH643269A5 (fr) 1984-05-30
EG14867A (en) 1986-09-30
CS218585B2 (en) 1983-02-25
DK160679A (da) 1979-10-21
ZA791856B (en) 1980-11-26
NZ190213A (en) 1982-12-21
GR69987B (fr) 1982-07-22
HU181431B (en) 1983-07-28
RO80084A (fr) 1983-02-01
RO80084B (ro) 1983-01-30
SU1061698A3 (ru) 1983-12-15
CA1097629A (fr) 1981-03-17
RO81114B (ro) 1983-01-30
RO81037B (ro) 1983-01-30
ES479753A1 (es) 1980-08-16
GB2019396B (en) 1982-09-15
DE2964130D1 (en) 1983-01-05
IE790795L (en) 1979-10-20
ATA291279A (de) 1982-04-15
DK147484C (da) 1985-03-25
CS218583B2 (en) 1983-02-25
IL57168A (en) 1983-10-31
PL125470B1 (en) 1983-05-31

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