IL57168A - N-substituted derivatives of 4-desacetyl vlb c-3 carbohydrazide,their preparation and pharmaceutical compositions containing them - Google Patents

N-substituted derivatives of 4-desacetyl vlb c-3 carbohydrazide,their preparation and pharmaceutical compositions containing them

Info

Publication number
IL57168A
IL57168A IL57168A IL5716879A IL57168A IL 57168 A IL57168 A IL 57168A IL 57168 A IL57168 A IL 57168A IL 5716879 A IL5716879 A IL 5716879A IL 57168 A IL57168 A IL 57168A
Authority
IL
Israel
Prior art keywords
carbohydrazide
preparation
pharmaceutical compositions
compositions containing
substituted derivatives
Prior art date
Application number
IL57168A
Other languages
English (en)
Other versions
IL57168A0 (en
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of IL57168A0 publication Critical patent/IL57168A0/xx
Publication of IL57168A publication Critical patent/IL57168A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
IL57168A 1978-04-20 1979-04-29 N-substituted derivatives of 4-desacetyl vlb c-3 carbohydrazide,their preparation and pharmaceutical compositions containing them IL57168A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/899,032 US4166810A (en) 1978-04-20 1978-04-20 Derivatives of 4-desacetyl VLB C-3 carboxyhydrazide

Publications (2)

Publication Number Publication Date
IL57168A0 IL57168A0 (en) 1979-07-25
IL57168A true IL57168A (en) 1983-10-31

Family

ID=25410402

Family Applications (1)

Application Number Title Priority Date Filing Date
IL57168A IL57168A (en) 1978-04-20 1979-04-29 N-substituted derivatives of 4-desacetyl vlb c-3 carbohydrazide,their preparation and pharmaceutical compositions containing them

Country Status (32)

Country Link
US (1) US4166810A (fr)
EP (1) EP0005051B1 (fr)
JP (1) JPS54141798A (fr)
AR (1) AR228940A1 (fr)
AT (1) AT369010B (fr)
AU (1) AU527109B2 (fr)
BE (1) BE875652A (fr)
BG (3) BG33296A3 (fr)
CA (1) CA1097629A (fr)
CH (1) CH643269A5 (fr)
CS (3) CS218583B2 (fr)
DD (1) DD143075A5 (fr)
DE (1) DE2964130D1 (fr)
DK (1) DK147484C (fr)
EG (1) EG14867A (fr)
ES (2) ES479753A1 (fr)
FI (1) FI791286A (fr)
FR (1) FR2423495A1 (fr)
GB (1) GB2019396B (fr)
GR (1) GR69987B (fr)
HU (1) HU181431B (fr)
IE (1) IE48213B1 (fr)
IL (1) IL57168A (fr)
LU (1) LU81166A1 (fr)
NZ (1) NZ190213A (fr)
PH (1) PH14163A (fr)
PL (3) PL215911A1 (fr)
PT (1) PT69496A (fr)
RO (3) RO81114A (fr)
SU (3) SU1225490A3 (fr)
YU (1) YU93179A (fr)
ZA (1) ZA791856B (fr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4322351A (en) * 1980-08-25 1982-03-30 Eli Lilly And Company Antineoplastic 4'-formylamino and 4'-acetylamino VLB, and derivatives thereof
EP0123441B1 (fr) * 1983-03-30 1990-10-03 Lilly Industries Limited Dérivés de vincaleukoblastine
US4675400A (en) * 1985-06-17 1987-06-23 Eli Lilly And Company Bifunctional derivatives of 4-desacetyl indole-dihydroindole alkaloids
US4667030A (en) * 1985-06-17 1987-05-19 Eli Lilly And Company Hydrazide succinimide derivatives of antineoplastic indole-dihydroindole alkaloids
US4801688A (en) * 1986-05-27 1989-01-31 Eli Lilly And Company Hydrazone immunoglobulin conjugates
US5043336A (en) * 1990-04-03 1991-08-27 Eli Lilly And Company Cyclic imide derivatives of 4-desacetyl VLB c-3 carboxhydrazide
US5043340A (en) * 1990-04-03 1991-08-27 Eli Lilly And Company Derivatives of 4-desacetyl VLB C-3 carboxhydrazide
WO2002085908A1 (fr) * 2001-04-24 2002-10-31 Purdue Research Foundation Mimetiques de folate et ses conjugues de liaison aux recepteurs de folate
WO2003097647A1 (fr) * 2002-05-15 2003-11-27 Endocyte, Inc. Conjugues vitamine-mitomycine
CA2512867C (fr) 2003-01-27 2014-08-26 Endocyte, Inc. Conjugues de delivrance de medicaments de liaison au recepteur de vitamines
US8288557B2 (en) * 2004-07-23 2012-10-16 Endocyte, Inc. Bivalent linkers and conjugates thereof
JP5289935B2 (ja) * 2005-03-16 2013-09-11 エンドサイト，インコーポレイテッド プテロイン酸およびその結合体の合成と精製
KR101364912B1 (ko) * 2005-08-19 2014-02-21 엔도사이트, 인코포레이티드 복수-약제 리간드 공액체
EP2382995A3 (fr) 2005-08-19 2013-09-25 Endocyte, Inc. Conjugués de ligands d'alcaloïdes de Vinca, analogues et dérivés
US20100087370A1 (en) * 2007-02-14 2010-04-08 The General Hospital Corporation Modulation of nitric oxide signaling to normalize tumor vasculature
US20100104626A1 (en) * 2007-02-16 2010-04-29 Endocyte, Inc. Methods and compositions for treating and diagnosing kidney disease
CN104127878A (zh) * 2007-03-14 2014-11-05 恩多塞特公司 结合配体连接的微管溶素递药缀合物
JP5690589B2 (ja) * 2007-06-25 2015-03-25 エンドサイト・インコーポレイテッドＥｎｄｏｃｙｔｅ， Ｉｎｃ． 親水性スペーサーリンカーを含有する結合体
US9877965B2 (en) 2007-06-25 2018-01-30 Endocyte, Inc. Vitamin receptor drug delivery conjugates for treating inflammation
JP2011500835A (ja) 2007-10-25 2011-01-06 エンドサイト，インコーポレイテッド チューブリシン類および調製プロセス
ES2574032T3 (es) * 2009-09-07 2016-06-14 Nipro Patch Co., Ltd. Preparación absorbible por vía transdérmica
WO2013126797A1 (fr) 2012-02-24 2013-08-29 Purdue Research Foundation Ciblage du récepteur de la cholécystokinine de type b pour imagerie et thérapie
US20140080175A1 (en) 2012-03-29 2014-03-20 Endocyte, Inc. Processes for preparing tubulysin derivatives and conjugates thereof
CN104869998A (zh) 2012-10-16 2015-08-26 恩多塞特公司 含有非天然氨基酸的药物递送缀合物以及其使用方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3097137A (en) * 1960-05-19 1963-07-09 Canadian Patents Dev Vincaleukoblastine
US3205220A (en) * 1961-10-26 1965-09-07 Lilly Co Eli Leurosidine and leurocristine and their production
US3392173A (en) * 1964-03-09 1968-07-09 Lilly Co Eli Novel acyl derivatives of desacetyl-vincaleukoblastine and processes for their preparation
US3370057A (en) * 1964-04-27 1968-02-20 Lilly Co Eli Leurosine
US3387001A (en) * 1964-10-19 1968-06-04 Lilly Co Eli Novel aminoacyl esters of desacetyl vincaleukoblastine
US3887565A (en) * 1974-05-06 1975-06-03 Lilly Co Eli Vincadioline
US3890325A (en) * 1974-05-15 1975-06-17 Lilly Co Eli Leurocolombine
US3954773A (en) * 1974-11-21 1976-05-04 Eli Lilly And Company 4-Desacetoxyvinblastine
IL48685A (en) 1975-01-09 1980-03-31 Lilly Co Eli Amides of vincadioline and vinblastine
US3944554A (en) * 1975-01-09 1976-03-16 Eli Lilly And Company 4-Desacetoxy-3-hydroxyvinblastine
US4029663A (en) * 1975-07-10 1977-06-14 Eli Lilly And Company Dimeric anhydro-vinca derivatives
US4115388A (en) * 1977-03-30 1978-09-19 Eli Lilly And Company 3'-Oxygenated derivatives of 4'-deoxy VLB "A" and "B" and related 1-formyl compounds

Also Published As

Publication number Publication date
LU81166A1 (fr) 1979-09-07
FI791286A (fi) 1979-10-21
AU4609779A (en) 1979-10-25
IL57168A0 (en) 1979-07-25
PH14163A (en) 1981-03-19
ATA291279A (de) 1982-04-15
RO81114B (ro) 1983-01-30
ZA791856B (en) 1980-11-26
RO81037A (fr) 1983-02-01
RO80084B (ro) 1983-01-30
FR2423495A1 (fr) 1979-11-16
BG33294A3 (en) 1983-01-14
JPS54141798A (en) 1979-11-05
DD143075A5 (de) 1980-07-30
GB2019396A (en) 1979-10-31
RO80084A (fr) 1983-02-01
YU93179A (en) 1983-01-21
US4166810A (en) 1979-09-04
NZ190213A (en) 1982-12-21
BE875652A (fr) 1979-10-18
DK160679A (da) 1979-10-21
ES479754A1 (es) 1980-08-16
CS218584B2 (en) 1983-02-25
DE2964130D1 (en) 1983-01-05
GB2019396B (en) 1982-09-15
DK147484C (da) 1985-03-25
BG33296A3 (en) 1983-01-14
CS218585B2 (en) 1983-02-25
AU527109B2 (en) 1983-02-17
BG33297A3 (en) 1983-01-14
HU181431B (en) 1983-07-28
AR228940A1 (es) 1983-05-13
RO81114A (fr) 1983-02-01
SU1061698A3 (ru) 1983-12-15
EG14867A (en) 1986-09-30
SU893135A3 (ru) 1981-12-23
DK147484B (da) 1984-08-27
CA1097629A (fr) 1981-03-17
FR2423495B1 (fr) 1983-02-11
IE790795L (en) 1979-10-20
CH643269A5 (fr) 1984-05-30
SU1225490A3 (ru) 1986-04-15
PL125470B1 (en) 1983-05-31
EP0005051B1 (fr) 1982-12-01
AT369010B (de) 1982-11-25
IE48213B1 (en) 1984-10-31
PL215911A1 (fr) 1980-03-24
JPS6245873B2 (fr) 1987-09-29
RO81037B (ro) 1983-01-30
GR69987B (fr) 1982-07-22
PT69496A (en) 1979-05-01
ES479753A1 (es) 1980-08-16
PL119416B1 (en) 1981-12-31
CS218583B2 (en) 1983-02-25
EP0005051A1 (fr) 1979-10-31

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