BG33294A3 - Metod za poluchavane na proizvodni na 4- dezacetil- vinkalevkoblastin c- 3- karboksikhidrazid - Google Patents

Metod za poluchavane na proizvodni na 4- dezacetil- vinkalevkoblastin c- 3- karboksikhidrazid

Info

Publication number
BG33294A3
BG33294A3 BG7943323A BG4332379A BG33294A3 BG 33294 A3 BG33294 A3 BG 33294A3 BG 7943323 A BG7943323 A BG 7943323A BG 4332379 A BG4332379 A BG 4332379A BG 33294 A3 BG33294 A3 BG 33294A3
Authority
BG
Bulgaria
Prior art keywords
vincaledcoblactine
dezacetyl
carboxyhydrazid
derivatives
obtaining
Prior art date
Application number
BG7943323A
Other languages
English (en)
Inventor
Cullinan
Gerzon
Original Assignee
Eli Lilly And Co,Us
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Co,Us filed Critical Eli Lilly And Co,Us
Publication of BG33294A3 publication Critical patent/BG33294A3/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
BG7943323A 1978-04-20 1979-04-20 Metod za poluchavane na proizvodni na 4- dezacetil- vinkalevkoblastin c- 3- karboksikhidrazid BG33294A3 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/899,032 US4166810A (en) 1978-04-20 1978-04-20 Derivatives of 4-desacetyl VLB C-3 carboxyhydrazide

Publications (1)

Publication Number Publication Date
BG33294A3 true BG33294A3 (bg) 1983-01-14

Family

ID=25410402

Family Applications (3)

Application Number Title Priority Date Filing Date
BG7943323A BG33294A3 (bg) 1978-04-20 1979-04-20 Metod za poluchavane na proizvodni na 4- dezacetil- vinkalevkoblastin c- 3- karboksikhidrazid
BG8256469A BG33296A3 (en) 1978-04-20 1979-04-20 Method for obtaining the derivatives of 4- dezacetyl- vincalevcoblastine c- 3- carboxyhydrazid
BG8256470A BG33297A3 (en) 1978-04-20 1979-04-20 Method for obtaining the derivatives of 4- dezacetyl- vinkalevcoblastine c- 3- carbrxyhydrazid

Family Applications After (2)

Application Number Title Priority Date Filing Date
BG8256469A BG33296A3 (en) 1978-04-20 1979-04-20 Method for obtaining the derivatives of 4- dezacetyl- vincalevcoblastine c- 3- carboxyhydrazid
BG8256470A BG33297A3 (en) 1978-04-20 1979-04-20 Method for obtaining the derivatives of 4- dezacetyl- vinkalevcoblastine c- 3- carbrxyhydrazid

Country Status (32)

Country Link
US (1) US4166810A (bg)
EP (1) EP0005051B1 (bg)
JP (1) JPS54141798A (bg)
AR (1) AR228940A1 (bg)
AT (1) AT369010B (bg)
AU (1) AU527109B2 (bg)
BE (1) BE875652A (bg)
BG (3) BG33294A3 (bg)
CA (1) CA1097629A (bg)
CH (1) CH643269A5 (bg)
CS (3) CS218583B2 (bg)
DD (1) DD143075A5 (bg)
DE (1) DE2964130D1 (bg)
DK (1) DK147484C (bg)
EG (1) EG14867A (bg)
ES (2) ES479754A1 (bg)
FI (1) FI791286A (bg)
FR (1) FR2423495A1 (bg)
GB (1) GB2019396B (bg)
GR (1) GR69987B (bg)
HU (1) HU181431B (bg)
IE (1) IE48213B1 (bg)
IL (1) IL57168A (bg)
LU (1) LU81166A1 (bg)
NZ (1) NZ190213A (bg)
PH (1) PH14163A (bg)
PL (3) PL119416B1 (bg)
PT (1) PT69496A (bg)
RO (3) RO80084A (bg)
SU (3) SU1225490A3 (bg)
YU (1) YU93179A (bg)
ZA (1) ZA791856B (bg)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4322351A (en) * 1980-08-25 1982-03-30 Eli Lilly And Company Antineoplastic 4'-formylamino and 4'-acetylamino VLB, and derivatives thereof
GR79898B (bg) * 1983-03-30 1984-10-31 Lilly Industries Ltd
US4667030A (en) * 1985-06-17 1987-05-19 Eli Lilly And Company Hydrazide succinimide derivatives of antineoplastic indole-dihydroindole alkaloids
US4675400A (en) * 1985-06-17 1987-06-23 Eli Lilly And Company Bifunctional derivatives of 4-desacetyl indole-dihydroindole alkaloids
US4801688A (en) * 1986-05-27 1989-01-31 Eli Lilly And Company Hydrazone immunoglobulin conjugates
US5043336A (en) * 1990-04-03 1991-08-27 Eli Lilly And Company Cyclic imide derivatives of 4-desacetyl VLB c-3 carboxhydrazide
US5043340A (en) * 1990-04-03 1991-08-27 Eli Lilly And Company Derivatives of 4-desacetyl VLB C-3 carboxhydrazide
US7875612B2 (en) 2001-04-24 2011-01-25 Purdue Research Foundation Folate mimetics and folate-receptor binding conjugates thereof
ATE426414T1 (de) * 2002-05-15 2009-04-15 Endocyte Inc Vitamin-mitomycin-konjugate
TWI367096B (en) 2003-01-27 2012-07-01 Endocyte Inc Vitamin-receptor binding drug delivery conjugates and pharmaceutical compositions
WO2006012527A1 (en) * 2004-07-23 2006-02-02 Endocyte, Inc. Bivalent linkers and conjugates thereof
CN101175757B (zh) * 2005-03-16 2012-11-14 恩多塞特公司 蝶酸及其缀合物的合成和纯化
US20080280937A1 (en) * 2005-08-19 2008-11-13 Christopher Paul Leamon Ligand Conjugates of Vinca Alkaloids, Analogs, and Derivatives
KR20130113543A (ko) 2005-08-19 2013-10-15 엔도사이트, 인코포레이티드 복수-약제 리간드 공액체
WO2008100591A2 (en) * 2007-02-14 2008-08-21 The General Hospital Corporation Modulation of nitric oxide signaling to normalize tumor vasculature
WO2008101231A2 (en) * 2007-02-16 2008-08-21 Endocyte, Inc. Methods and compositions for treating and diagnosing kidney disease
EP2481427A1 (en) * 2007-03-14 2012-08-01 Endocyte, Inc. Folate-Tubulysin conjugates
RU2523909C2 (ru) * 2007-06-25 2014-07-27 Эндосайт, Инк. Конъюгаты, содержащие гидрофильные спейсеры линкеров
US9877965B2 (en) 2007-06-25 2018-01-30 Endocyte, Inc. Vitamin receptor drug delivery conjugates for treating inflammation
US9187521B2 (en) * 2007-10-25 2015-11-17 Endocyte, Inc. Tubulysins and processes for preparing
US9168232B2 (en) * 2009-09-07 2015-10-27 Nipro Patch Co., Ltd. Transdermally absorbable preparation
US10080805B2 (en) 2012-02-24 2018-09-25 Purdue Research Foundation Cholecystokinin B receptor targeting for imaging and therapy
US20140080175A1 (en) 2012-03-29 2014-03-20 Endocyte, Inc. Processes for preparing tubulysin derivatives and conjugates thereof
EA201590622A1 (ru) 2012-10-16 2015-10-30 Эндосайт, Инк. Конъюгаты для доставки лекарственного средства, содержащие не встречающиеся в природе аминокислоты, и способы применения

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3097137A (en) * 1960-05-19 1963-07-09 Canadian Patents Dev Vincaleukoblastine
US3205220A (en) * 1961-10-26 1965-09-07 Lilly Co Eli Leurosidine and leurocristine and their production
US3392173A (en) * 1964-03-09 1968-07-09 Lilly Co Eli Novel acyl derivatives of desacetyl-vincaleukoblastine and processes for their preparation
US3370057A (en) * 1964-04-27 1968-02-20 Lilly Co Eli Leurosine
US3387001A (en) * 1964-10-19 1968-06-04 Lilly Co Eli Novel aminoacyl esters of desacetyl vincaleukoblastine
US3887565A (en) * 1974-05-06 1975-06-03 Lilly Co Eli Vincadioline
US3890325A (en) * 1974-05-15 1975-06-17 Lilly Co Eli Leurocolombine
US3954773A (en) * 1974-11-21 1976-05-04 Eli Lilly And Company 4-Desacetoxyvinblastine
US3944554A (en) * 1975-01-09 1976-03-16 Eli Lilly And Company 4-Desacetoxy-3-hydroxyvinblastine
IL48685A (en) * 1975-01-09 1980-03-31 Lilly Co Eli Amides of vincadioline and vinblastine
US4029663A (en) * 1975-07-10 1977-06-14 Eli Lilly And Company Dimeric anhydro-vinca derivatives
US4115388A (en) * 1977-03-30 1978-09-19 Eli Lilly And Company 3'-Oxygenated derivatives of 4'-deoxy VLB "A" and "B" and related 1-formyl compounds

Also Published As

Publication number Publication date
ES479754A1 (es) 1980-08-16
EP0005051B1 (en) 1982-12-01
AU4609779A (en) 1979-10-25
EG14867A (en) 1986-09-30
RO81037B (ro) 1983-01-30
FR2423495B1 (bg) 1983-02-11
RO81114B (ro) 1983-01-30
YU93179A (en) 1983-01-21
CS218584B2 (en) 1983-02-25
ES479753A1 (es) 1980-08-16
ATA291279A (de) 1982-04-15
PH14163A (en) 1981-03-19
CS218583B2 (en) 1983-02-25
AU527109B2 (en) 1983-02-17
IE790795L (en) 1979-10-20
LU81166A1 (fr) 1979-09-07
CA1097629A (en) 1981-03-17
EP0005051A1 (en) 1979-10-31
RO81114A (ro) 1983-02-01
RO80084A (ro) 1983-02-01
DK147484C (da) 1985-03-25
BG33296A3 (en) 1983-01-14
DD143075A5 (de) 1980-07-30
IL57168A (en) 1983-10-31
PL119416B1 (en) 1981-12-31
BG33297A3 (en) 1983-01-14
HU181431B (en) 1983-07-28
IL57168A0 (en) 1979-07-25
JPS54141798A (en) 1979-11-05
CH643269A5 (fr) 1984-05-30
GB2019396A (en) 1979-10-31
NZ190213A (en) 1982-12-21
AR228940A1 (es) 1983-05-13
GB2019396B (en) 1982-09-15
PL125470B1 (en) 1983-05-31
DE2964130D1 (en) 1983-01-05
GR69987B (bg) 1982-07-22
IE48213B1 (en) 1984-10-31
FR2423495A1 (fr) 1979-11-16
SU1061698A3 (ru) 1983-12-15
SU893135A3 (ru) 1981-12-23
SU1225490A3 (ru) 1986-04-15
DK147484B (da) 1984-08-27
CS218585B2 (en) 1983-02-25
RO80084B (ro) 1983-01-30
DK160679A (da) 1979-10-21
RO81037A (ro) 1983-02-01
PT69496A (en) 1979-05-01
FI791286A (fi) 1979-10-21
US4166810A (en) 1979-09-04
ZA791856B (en) 1980-11-26
PL215911A1 (bg) 1980-03-24
JPS6245873B2 (bg) 1987-09-29
BE875652A (fr) 1979-10-18
AT369010B (de) 1982-11-25

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