CS218583B2 - Method of making the c3-carboxhydrazides 4-deacetylvinkaleukoblastine - Google Patents
Method of making the c3-carboxhydrazides 4-deacetylvinkaleukoblastine Download PDFInfo
- Publication number
- CS218583B2 CS218583B2 CS792678A CS267879A CS218583B2 CS 218583 B2 CS218583 B2 CS 218583B2 CS 792678 A CS792678 A CS 792678A CS 267879 A CS267879 A CS 267879A CS 218583 B2 CS218583 B2 CS 218583B2
- Authority
- CS
- Czechoslovakia
- Prior art keywords
- vlb
- carboxhydrazide
- deacetyl
- compounds
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US05/899,032 US4166810A (en) | 1978-04-20 | 1978-04-20 | Derivatives of 4-desacetyl VLB C-3 carboxyhydrazide |
Publications (1)
Publication Number | Publication Date |
---|---|
CS218583B2 true CS218583B2 (en) | 1983-02-25 |
Family
ID=25410402
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CS807545A CS218584B2 (en) | 1978-04-20 | 1979-04-19 | Process for production of c3- carboxyhydrazides c4-diacetylvinkaleukoblastime |
CS792678A CS218583B2 (en) | 1978-04-20 | 1979-04-19 | Method of making the c3-carboxhydrazides 4-deacetylvinkaleukoblastine |
CS807546A CS218585B2 (en) | 1978-04-20 | 1979-04-19 | Method of making the c3-carboxhydrazides 4-deacetylvinkaleukoblastine |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CS807545A CS218584B2 (en) | 1978-04-20 | 1979-04-19 | Process for production of c3- carboxyhydrazides c4-diacetylvinkaleukoblastime |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CS807546A CS218585B2 (en) | 1978-04-20 | 1979-04-19 | Method of making the c3-carboxhydrazides 4-deacetylvinkaleukoblastine |
Country Status (32)
Country | Link |
---|---|
US (1) | US4166810A (bg) |
EP (1) | EP0005051B1 (bg) |
JP (1) | JPS54141798A (bg) |
AR (1) | AR228940A1 (bg) |
AT (1) | AT369010B (bg) |
AU (1) | AU527109B2 (bg) |
BE (1) | BE875652A (bg) |
BG (3) | BG33297A3 (bg) |
CA (1) | CA1097629A (bg) |
CH (1) | CH643269A5 (bg) |
CS (3) | CS218584B2 (bg) |
DD (1) | DD143075A5 (bg) |
DE (1) | DE2964130D1 (bg) |
DK (1) | DK147484C (bg) |
EG (1) | EG14867A (bg) |
ES (2) | ES479753A1 (bg) |
FI (1) | FI791286A (bg) |
FR (1) | FR2423495A1 (bg) |
GB (1) | GB2019396B (bg) |
GR (1) | GR69987B (bg) |
HU (1) | HU181431B (bg) |
IE (1) | IE48213B1 (bg) |
IL (1) | IL57168A (bg) |
LU (1) | LU81166A1 (bg) |
NZ (1) | NZ190213A (bg) |
PH (1) | PH14163A (bg) |
PL (3) | PL119416B1 (bg) |
PT (1) | PT69496A (bg) |
RO (3) | RO81114A (bg) |
SU (3) | SU893135A3 (bg) |
YU (1) | YU93179A (bg) |
ZA (1) | ZA791856B (bg) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4322351A (en) * | 1980-08-25 | 1982-03-30 | Eli Lilly And Company | Antineoplastic 4'-formylamino and 4'-acetylamino VLB, and derivatives thereof |
EP0123441B1 (en) * | 1983-03-30 | 1990-10-03 | Lilly Industries Limited | Vincaleukoblastine derivatives |
US4675400A (en) * | 1985-06-17 | 1987-06-23 | Eli Lilly And Company | Bifunctional derivatives of 4-desacetyl indole-dihydroindole alkaloids |
US4667030A (en) * | 1985-06-17 | 1987-05-19 | Eli Lilly And Company | Hydrazide succinimide derivatives of antineoplastic indole-dihydroindole alkaloids |
US4801688A (en) * | 1986-05-27 | 1989-01-31 | Eli Lilly And Company | Hydrazone immunoglobulin conjugates |
US5043336A (en) * | 1990-04-03 | 1991-08-27 | Eli Lilly And Company | Cyclic imide derivatives of 4-desacetyl VLB c-3 carboxhydrazide |
US5043340A (en) * | 1990-04-03 | 1991-08-27 | Eli Lilly And Company | Derivatives of 4-desacetyl VLB C-3 carboxhydrazide |
EP1389209B1 (en) * | 2001-04-24 | 2009-04-08 | Purdue Research Foundation | Folate mimetics and folate-receptor binding conjugates thereof |
KR20040106547A (ko) * | 2002-05-15 | 2004-12-17 | 엔도사이트, 인코포레이티드 | 비타민-마이토마이신 공액체 |
NZ541846A (en) | 2003-01-27 | 2008-12-24 | Endocyte Inc | Vitamin receptor binding drug delivery conjugates |
JP5149620B2 (ja) | 2004-07-23 | 2013-02-20 | エンドサイト,インコーポレイテッド | 2価リンカーおよびその結合体 |
CN101175757B (zh) * | 2005-03-16 | 2012-11-14 | 恩多塞特公司 | 蝶酸及其缀合物的合成和纯化 |
BRPI0615354A2 (pt) | 2005-08-19 | 2011-05-17 | Endocyte Inc | conjugado de liberação de fármaco de ligação de receptor, composição farmacêutica que o compreende, bem como seu uso |
EP2382995A3 (en) | 2005-08-19 | 2013-09-25 | Endocyte, Inc. | Ligand conjugates of Vinca alkaloids, analogs and derivatives |
WO2008100591A2 (en) * | 2007-02-14 | 2008-08-21 | The General Hospital Corporation | Modulation of nitric oxide signaling to normalize tumor vasculature |
US20100104626A1 (en) | 2007-02-16 | 2010-04-29 | Endocyte, Inc. | Methods and compositions for treating and diagnosing kidney disease |
NZ599239A (en) * | 2007-03-14 | 2013-10-25 | Endocyte Inc | Binding ligand linked drug delivery conjugates of tubulysins |
WO2009002993A1 (en) | 2007-06-25 | 2008-12-31 | Endocyte, Inc. | Conjugates containing hydrophilic spacer linkers |
US9877965B2 (en) | 2007-06-25 | 2018-01-30 | Endocyte, Inc. | Vitamin receptor drug delivery conjugates for treating inflammation |
US9187521B2 (en) * | 2007-10-25 | 2015-11-17 | Endocyte, Inc. | Tubulysins and processes for preparing |
EP2476414B1 (en) * | 2009-09-07 | 2015-03-04 | NIPRO Patch Co., Ltd. | Transdermally absorbable preparation |
US10080805B2 (en) | 2012-02-24 | 2018-09-25 | Purdue Research Foundation | Cholecystokinin B receptor targeting for imaging and therapy |
US20140080175A1 (en) | 2012-03-29 | 2014-03-20 | Endocyte, Inc. | Processes for preparing tubulysin derivatives and conjugates thereof |
IN2015DN04147A (bg) | 2012-10-16 | 2015-10-16 | Endocyte Inc |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3097137A (en) * | 1960-05-19 | 1963-07-09 | Canadian Patents Dev | Vincaleukoblastine |
US3205220A (en) * | 1961-10-26 | 1965-09-07 | Lilly Co Eli | Leurosidine and leurocristine and their production |
US3392173A (en) * | 1964-03-09 | 1968-07-09 | Lilly Co Eli | Novel acyl derivatives of desacetyl-vincaleukoblastine and processes for their preparation |
US3370057A (en) * | 1964-04-27 | 1968-02-20 | Lilly Co Eli | Leurosine |
US3387001A (en) * | 1964-10-19 | 1968-06-04 | Lilly Co Eli | Novel aminoacyl esters of desacetyl vincaleukoblastine |
US3887565A (en) * | 1974-05-06 | 1975-06-03 | Lilly Co Eli | Vincadioline |
US3890325A (en) * | 1974-05-15 | 1975-06-17 | Lilly Co Eli | Leurocolombine |
US3954773A (en) * | 1974-11-21 | 1976-05-04 | Eli Lilly And Company | 4-Desacetoxyvinblastine |
IL48685A (en) | 1975-01-09 | 1980-03-31 | Lilly Co Eli | Amides of vincadioline and vinblastine |
US3944554A (en) * | 1975-01-09 | 1976-03-16 | Eli Lilly And Company | 4-Desacetoxy-3-hydroxyvinblastine |
US4029663A (en) * | 1975-07-10 | 1977-06-14 | Eli Lilly And Company | Dimeric anhydro-vinca derivatives |
US4115388A (en) * | 1977-03-30 | 1978-09-19 | Eli Lilly And Company | 3'-Oxygenated derivatives of 4'-deoxy VLB "A" and "B" and related 1-formyl compounds |
-
1978
- 1978-04-20 US US05/899,032 patent/US4166810A/en not_active Expired - Lifetime
-
1979
- 1979-04-17 PT PT69496A patent/PT69496A/pt unknown
- 1979-04-17 PH PH23391A patent/PH14163A/en unknown
- 1979-04-17 JP JP4715279A patent/JPS54141798A/ja active Granted
- 1979-04-18 EP EP79300638A patent/EP0005051B1/en not_active Expired
- 1979-04-18 RO RO79102376A patent/RO81114A/ro unknown
- 1979-04-18 DE DE7979300638T patent/DE2964130D1/de not_active Expired
- 1979-04-18 EG EG238/79A patent/EG14867A/xx active
- 1979-04-18 GB GB7913460A patent/GB2019396B/en not_active Expired
- 1979-04-18 LU LU81166A patent/LU81166A1/xx unknown
- 1979-04-18 NZ NZ190213A patent/NZ190213A/xx unknown
- 1979-04-18 YU YU00931/79A patent/YU93179A/xx unknown
- 1979-04-18 AU AU46097/79A patent/AU527109B2/en not_active Ceased
- 1979-04-18 RO RO7997290A patent/RO80084A/ro unknown
- 1979-04-18 AT AT0291279A patent/AT369010B/de not_active IP Right Cessation
- 1979-04-18 GR GR58950A patent/GR69987B/el unknown
- 1979-04-18 RO RO79102377A patent/RO81037A/ro unknown
- 1979-04-18 BE BE1/9358A patent/BE875652A/xx unknown
- 1979-04-19 CA CA325,844A patent/CA1097629A/en not_active Expired
- 1979-04-19 HU HU79EI850A patent/HU181431B/hu not_active IP Right Cessation
- 1979-04-19 CS CS807545A patent/CS218584B2/cs unknown
- 1979-04-19 DK DK160679A patent/DK147484C/da not_active IP Right Cessation
- 1979-04-19 ES ES479753A patent/ES479753A1/es not_active Expired
- 1979-04-19 PL PL1979215011A patent/PL119416B1/pl unknown
- 1979-04-19 FI FI791286A patent/FI791286A/fi not_active Application Discontinuation
- 1979-04-19 ES ES479754A patent/ES479754A1/es not_active Expired
- 1979-04-19 PL PL1979230538A patent/PL125470B1/pl unknown
- 1979-04-19 ZA ZA791856A patent/ZA791856B/xx unknown
- 1979-04-19 CH CH370779A patent/CH643269A5/fr not_active IP Right Cessation
- 1979-04-19 CS CS792678A patent/CS218583B2/cs unknown
- 1979-04-19 FR FR7909874A patent/FR2423495A1/fr active Granted
- 1979-04-19 CS CS807546A patent/CS218585B2/cs unknown
- 1979-04-19 PL PL21591179A patent/PL215911A1/xx unknown
- 1979-04-20 AR AR276248A patent/AR228940A1/es active
- 1979-04-20 BG BG8256470A patent/BG33297A3/xx unknown
- 1979-04-20 SU SU792759650A patent/SU893135A3/ru active
- 1979-04-20 DD DD79212369A patent/DD143075A5/de unknown
- 1979-04-20 BG BG8256469A patent/BG33296A3/xx unknown
- 1979-04-20 BG BG7943323A patent/BG33294A3/bg unknown
- 1979-04-20 SU SU792925606A patent/SU1225490A3/ru active
- 1979-04-29 IL IL57168A patent/IL57168A/xx unknown
- 1979-08-08 IE IE795/79A patent/IE48213B1/en unknown
-
1980
- 1980-05-26 SU SU802925605A patent/SU1061698A3/ru active
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