BE875652A - Derives anti-tumoraux decarboxhydrazide en c-3 de la 4-desacetyl vincaleucoblastine - Google Patents

Derives anti-tumoraux decarboxhydrazide en c-3 de la 4-desacetyl vincaleucoblastine

Info

Publication number
BE875652A
BE875652A BE1/9358A BE1009358A BE875652A BE 875652 A BE875652 A BE 875652A BE 1/9358 A BE1/9358 A BE 1/9358A BE 1009358 A BE1009358 A BE 1009358A BE 875652 A BE875652 A BE 875652A
Authority
BE
Belgium
Prior art keywords
decarboxhydrazide
vincaleucoblastine
desacetyl
tumor
derivatives
Prior art date
Application number
BE1/9358A
Other languages
English (en)
French (fr)
Inventor
G J Cullinan
K Gerzon
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of BE875652A publication Critical patent/BE875652A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
BE1/9358A 1978-04-20 1979-04-18 Derives anti-tumoraux decarboxhydrazide en c-3 de la 4-desacetyl vincaleucoblastine BE875652A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/899,032 US4166810A (en) 1978-04-20 1978-04-20 Derivatives of 4-desacetyl VLB C-3 carboxyhydrazide

Publications (1)

Publication Number Publication Date
BE875652A true BE875652A (fr) 1979-10-18

Family

ID=25410402

Family Applications (1)

Application Number Title Priority Date Filing Date
BE1/9358A BE875652A (fr) 1978-04-20 1979-04-18 Derives anti-tumoraux decarboxhydrazide en c-3 de la 4-desacetyl vincaleucoblastine

Country Status (32)

Country Link
US (1) US4166810A (de)
EP (1) EP0005051B1 (de)
JP (1) JPS54141798A (de)
AR (1) AR228940A1 (de)
AT (1) AT369010B (de)
AU (1) AU527109B2 (de)
BE (1) BE875652A (de)
BG (3) BG33297A3 (de)
CA (1) CA1097629A (de)
CH (1) CH643269A5 (de)
CS (3) CS218585B2 (de)
DD (1) DD143075A5 (de)
DE (1) DE2964130D1 (de)
DK (1) DK147484C (de)
EG (1) EG14867A (de)
ES (2) ES479753A1 (de)
FI (1) FI791286A (de)
FR (1) FR2423495A1 (de)
GB (1) GB2019396B (de)
GR (1) GR69987B (de)
HU (1) HU181431B (de)
IE (1) IE48213B1 (de)
IL (1) IL57168A (de)
LU (1) LU81166A1 (de)
NZ (1) NZ190213A (de)
PH (1) PH14163A (de)
PL (3) PL125470B1 (de)
PT (1) PT69496A (de)
RO (3) RO81037A (de)
SU (3) SU1225490A3 (de)
YU (1) YU93179A (de)
ZA (1) ZA791856B (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4322351A (en) * 1980-08-25 1982-03-30 Eli Lilly And Company Antineoplastic 4'-formylamino and 4'-acetylamino VLB, and derivatives thereof
DE3483336D1 (de) * 1983-03-30 1990-11-08 Lilly Industries Ltd Vincaleukoblastin-derivate.
US4675400A (en) * 1985-06-17 1987-06-23 Eli Lilly And Company Bifunctional derivatives of 4-desacetyl indole-dihydroindole alkaloids
US4667030A (en) * 1985-06-17 1987-05-19 Eli Lilly And Company Hydrazide succinimide derivatives of antineoplastic indole-dihydroindole alkaloids
US4801688A (en) * 1986-05-27 1989-01-31 Eli Lilly And Company Hydrazone immunoglobulin conjugates
US5043340A (en) * 1990-04-03 1991-08-27 Eli Lilly And Company Derivatives of 4-desacetyl VLB C-3 carboxhydrazide
US5043336A (en) * 1990-04-03 1991-08-27 Eli Lilly And Company Cyclic imide derivatives of 4-desacetyl VLB c-3 carboxhydrazide
US7875612B2 (en) 2001-04-24 2011-01-25 Purdue Research Foundation Folate mimetics and folate-receptor binding conjugates thereof
JP4814520B2 (ja) * 2002-05-15 2011-11-16 エンドサイト，インコーポレイテッド ビタミン−マイトマイシン結合体
PT1592457E (pt) 2003-01-27 2012-11-02 Endocyte Inc Conjugados de entrega farmacológica de ligação a recetores de vitaminas
EP1789391B1 (de) 2004-07-23 2017-06-28 Endocyte, Inc. Zweiwertige linker und konjugate davon
JP5289935B2 (ja) * 2005-03-16 2013-09-11 エンドサイト，インコーポレイテッド プテロイン酸およびその結合体の合成と精製
EP2382995A3 (de) 2005-08-19 2013-09-25 Endocyte, Inc. Ligandenkonjugate von Vincaalkaloiden, Analoga und Derivaten
JP5475992B2 (ja) 2005-08-19 2014-04-16 エンドサイト，インコーポレイテッド 多剤リガンド結合体
US20100087370A1 (en) * 2007-02-14 2010-04-08 The General Hospital Corporation Modulation of nitric oxide signaling to normalize tumor vasculature
US20100104626A1 (en) 2007-02-16 2010-04-29 Endocyte, Inc. Methods and compositions for treating and diagnosing kidney disease
NZ580132A (en) * 2007-03-14 2012-11-30 Endocyte Inc Binding ligand linked drug delivery conjugates of tubulysins to vitamins
AU2008268432B2 (en) * 2007-06-25 2015-01-15 Endocyte, Inc. Conjugates containing hydrophilic spacer linkers
US9877965B2 (en) 2007-06-25 2018-01-30 Endocyte, Inc. Vitamin receptor drug delivery conjugates for treating inflammation
CN101909441B (zh) 2007-10-25 2015-05-13 恩多塞特公司 微管蛋白抑制剂及其制备方法
WO2011027786A1 (ja) * 2009-09-07 2011-03-10 ニプロパッチ株式会社 経皮吸収型製剤
US10080805B2 (en) 2012-02-24 2018-09-25 Purdue Research Foundation Cholecystokinin B receptor targeting for imaging and therapy
US20140080175A1 (en) 2012-03-29 2014-03-20 Endocyte, Inc. Processes for preparing tubulysin derivatives and conjugates thereof
KR20150070318A (ko) 2012-10-16 2015-06-24 엔도사이트, 인코포레이티드 비천연 아미노산을 함유하는 약물 전달 컨쥬게이트 및 사용 방법

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3097137A (en) * 1960-05-19 1963-07-09 Canadian Patents Dev Vincaleukoblastine
US3205220A (en) * 1961-10-26 1965-09-07 Lilly Co Eli Leurosidine and leurocristine and their production
US3392173A (en) * 1964-03-09 1968-07-09 Lilly Co Eli Novel acyl derivatives of desacetyl-vincaleukoblastine and processes for their preparation
US3370057A (en) * 1964-04-27 1968-02-20 Lilly Co Eli Leurosine
US3387001A (en) * 1964-10-19 1968-06-04 Lilly Co Eli Novel aminoacyl esters of desacetyl vincaleukoblastine
US3887565A (en) * 1974-05-06 1975-06-03 Lilly Co Eli Vincadioline
US3890325A (en) * 1974-05-15 1975-06-17 Lilly Co Eli Leurocolombine
US3954773A (en) * 1974-11-21 1976-05-04 Eli Lilly And Company 4-Desacetoxyvinblastine
IL48685A (en) 1975-01-09 1980-03-31 Lilly Co Eli Amides of vincadioline and vinblastine
US3944554A (en) * 1975-01-09 1976-03-16 Eli Lilly And Company 4-Desacetoxy-3-hydroxyvinblastine
US4029663A (en) * 1975-07-10 1977-06-14 Eli Lilly And Company Dimeric anhydro-vinca derivatives
US4115388A (en) * 1977-03-30 1978-09-19 Eli Lilly And Company 3'-Oxygenated derivatives of 4'-deoxy VLB "A" and "B" and related 1-formyl compounds

Also Published As

Publication number Publication date
IL57168A0 (en) 1979-07-25
PL125470B1 (en) 1983-05-31
EG14867A (en) 1986-09-30
SU893135A3 (ru) 1981-12-23
PH14163A (en) 1981-03-19
DK147484B (da) 1984-08-27
CA1097629A (en) 1981-03-17
GB2019396B (en) 1982-09-15
AU527109B2 (en) 1983-02-17
AR228940A1 (es) 1983-05-13
FR2423495A1 (fr) 1979-11-16
NZ190213A (en) 1982-12-21
EP0005051A1 (de) 1979-10-31
GB2019396A (en) 1979-10-31
CS218585B2 (en) 1983-02-25
ES479753A1 (es) 1980-08-16
RO81037A (ro) 1983-02-01
PT69496A (en) 1979-05-01
PL119416B1 (en) 1981-12-31
ZA791856B (en) 1980-11-26
RO80084B (ro) 1983-01-30
GR69987B (de) 1982-07-22
IE790795L (en) 1979-10-20
BG33294A3 (en) 1983-01-14
RO81114B (ro) 1983-01-30
US4166810A (en) 1979-09-04
DD143075A5 (de) 1980-07-30
SU1225490A3 (ru) 1986-04-15
FI791286A (fi) 1979-10-21
DK160679A (da) 1979-10-21
ES479754A1 (es) 1980-08-16
SU1061698A3 (ru) 1983-12-15
RO81114A (ro) 1983-02-01
AT369010B (de) 1982-11-25
IE48213B1 (en) 1984-10-31
EP0005051B1 (de) 1982-12-01
IL57168A (en) 1983-10-31
HU181431B (en) 1983-07-28
BG33297A3 (en) 1983-01-14
CH643269A5 (fr) 1984-05-30
AU4609779A (en) 1979-10-25
YU93179A (en) 1983-01-21
PL215911A1 (de) 1980-03-24
JPS6245873B2 (de) 1987-09-29
FR2423495B1 (de) 1983-02-11
JPS54141798A (en) 1979-11-05
DE2964130D1 (en) 1983-01-05
ATA291279A (de) 1982-04-15
BG33296A3 (en) 1983-01-14
LU81166A1 (fr) 1979-09-07
DK147484C (da) 1985-03-25
CS218583B2 (en) 1983-02-25
RO80084A (ro) 1983-02-01
CS218584B2 (en) 1983-02-25
RO81037B (ro) 1983-01-30

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