CS212309B2 - Method of making the new 2-iminoimidazolidine derivatives - Google Patents

Method of making the new 2-iminoimidazolidine derivatives Download PDF

Info

Publication number
CS212309B2
CS212309B2 CS787188A CS718878A CS212309B2 CS 212309 B2 CS212309 B2 CS 212309B2 CS 787188 A CS787188 A CS 787188A CS 718878 A CS718878 A CS 718878A CS 212309 B2 CS212309 B2 CS 212309B2
Authority
CS
Czechoslovakia
Prior art keywords
compound
group
formula
alkyl
acid addition
Prior art date
Application number
CS787188A
Other languages
Czech (cs)
English (en)
Inventor
Henri Ramiz
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Priority to CS802610A priority Critical patent/CS212311B2/cs
Priority to CS802609A priority patent/CS212310B2/cs
Publication of CS212309B2 publication Critical patent/CS212309B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/40—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of thiourea or isothiourea groups further bound to other hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/44—Nitrogen atoms not forming part of a nitro radical
    • C07D233/50—Nitrogen atoms not forming part of a nitro radical with carbocyclic radicals directly attached to said nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Indole Compounds (AREA)
  • Medicinal Preparation (AREA)
CS787188A 1977-11-07 1978-11-03 Method of making the new 2-iminoimidazolidine derivatives CS212309B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CS802610A CS212311B2 (cs) 1977-11-07 1980-04-15 Způsob výroby nových 2-iminoimidazolidinových derivátů
CS802609A CS212310B2 (cs) 1977-11-07 1980-04-15 Způsob výroby nových 2-iminoimidazolidinových derivátů

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
LU78467 1977-11-07
CH966878 1978-09-15

Publications (1)

Publication Number Publication Date
CS212309B2 true CS212309B2 (en) 1982-03-26

Family

ID=25705131

Family Applications (1)

Application Number Title Priority Date Filing Date
CS787188A CS212309B2 (en) 1977-11-07 1978-11-03 Method of making the new 2-iminoimidazolidine derivatives

Country Status (30)

Country Link
US (3) US4244957A (xx)
EP (1) EP0002010B1 (xx)
JP (1) JPS5473779A (xx)
AR (1) AR223656A1 (xx)
AT (1) AT371112B (xx)
AU (1) AU4132478A (xx)
BR (1) BR7807317A (xx)
CA (1) CA1106847A (xx)
CS (1) CS212309B2 (xx)
DD (1) DD139847A5 (xx)
DE (2) DE2861952D1 (xx)
DK (1) DK494978A (xx)
EG (1) EG13665A (xx)
ES (3) ES480113A1 (xx)
FI (1) FI783393A (xx)
FR (1) FR2407919A1 (xx)
GB (2) GB2086379B (xx)
IL (1) IL55832A0 (xx)
IT (1) IT1160046B (xx)
MC (1) MC1223A1 (xx)
MT (1) MTP837B (xx)
NL (1) NL7811070A (xx)
NO (1) NO783719L (xx)
NZ (1) NZ188798A (xx)
OA (1) OA06084A (xx)
PL (1) PL210759A1 (xx)
PT (1) PT68752A (xx)
RO (1) RO76151A (xx)
SE (1) SE7811455L (xx)
SU (2) SU831073A3 (xx)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4287201A (en) * 1980-03-03 1981-09-01 Merck & Co., Inc. Anovulatory method and chicken feed compositions
CA1175434A (en) * 1980-09-10 1984-10-02 Hoffmann-La Roche Limited ¬(2-phenylamino-1-imidazolidinyloxy)methyl| pyridine 1-oxide derivatives
DE3642453A1 (de) * 1986-12-12 1988-06-23 Bayer Ag Neue, fluor enthaltende 5-trihalogenmethyl-isoxazole und ein verfahren zu deren herstellung
DE19514579A1 (de) * 1995-04-20 1996-10-24 Boehringer Ingelheim Kg Verwendung von alpha¶1¶¶L¶-Agonisten zur Behandlung der Harninkontinenz
ATE364595T1 (de) * 2000-07-07 2007-07-15 Medicure Int Inc Pyridoxin- und pyridoxalanaloga als cardiovasculäre therapeutika
GB2374251A (en) * 2001-04-04 2002-10-09 Secr Defence Base station transmitter
US20030139606A1 (en) * 2001-11-09 2003-07-24 Ray Anup Kumar Process for preparing 5-methylisoxazole-4-carboxylic- (4'-trifluoromethyl)-anilide
US6703409B2 (en) 2002-01-31 2004-03-09 Boehringer Ingelheim Pharma Gmbh & Co Kg 2′-Halo-3′,5′-dialkoxyphen-1′-yl-imino-2-imidazolidine and the use thereof as a drug
EP1333028A1 (en) * 2002-01-31 2003-08-06 Boehringer Ingelheim Pharma GmbH & Co.KG 2'-Halo-3',5'-dialkoxyphen-1'-yl-imino-2-imidazolidine derivatives and the use thereof for the treatment of urinary incontinence
DK2328619T3 (en) * 2008-08-22 2017-03-13 Baxalta GmbH POLYMER BENZYL CARBONATE DERIVATES

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670274U (de) 1953-07-30 1954-01-14 Leo Schirk Stahlblechschalttafel.
DE1815788U (de) 1959-12-12 1960-07-28 Walther Loeffler Ventil fuer spuelbecken, waschbecken, bidets, wannen.
US3236857A (en) * 1961-10-09 1966-02-22 Boehringer Sohn Ingelheim 2-(phenyl-amino)-1, 3-diazacyclopentene-(2) substitution products
NL123037C (xx) 1963-10-04
DE1545628A1 (de) * 1965-10-01 1970-06-25 Boehringer Sohn Ingelheim Verfahren zur Herstellung von blutdrucksenkend und sedativ wirksamen Derivaten des 2-(2-Halogenanilino)-1,3-diazacyclopentens-(2)
DE1670274A1 (de) * 1966-10-31 1970-07-16 Boehringer Sohn Ingelheim Neues Verfahren zur Herstellung von 2-Arylamino-1,3-diazacycloalkenen-(2)
ES352379A1 (es) 1967-05-26 1969-08-01 Boehringer Sohn Ingelheim Procedimiento para la preparacion de 1,3-diazaciclopenteno-(2) sustituido en posicion 2.
DE1670230A1 (de) 1967-05-26 1971-01-21 Boehringer Sohn Ingelheim Neues Verfahren zur Herstellung von in 2-Stellung substituierten 1,3-Diazacycloalkenen(2)
US3454301A (en) * 1967-09-29 1969-07-08 John W Lehmann Glare-inhibiting device
GB1246312A (en) * 1968-01-10 1971-09-15 Syntex Energy Res Inc 4,5-substituted n-oxy and hydroxy hydroimidazoles
DE1770872A1 (de) 1968-08-26 1972-01-13 Dresden Arzneimittel Verfahren zur Herstellung von Imidazolin-2-Derivaten
BE721781A (xx) 1968-10-03 1969-04-03
BE759048A (fr) * 1969-11-17 1971-05-17 Boehringer Sohn Ingelheim Nouvelles n-aminoalcoyl-arylamino-imidazolines-(2) substituees et procedes pour les fabriquer
DE2016290A1 (de) * 1970-04-06 1971-11-04 C H Boehrmger Sohn, 6507 Ingel heim Substituierte N Hydroxylakyl 2 arylamine) imidazoline (2) und Verfahren zu deren Herstellung
US3740412A (en) * 1970-04-08 1973-06-19 Synvar Ass Imidazoline-3-oxide-1-oxyl derivatives
DE2038107A1 (de) * 1970-07-31 1972-02-10 Henkel & Cie Gmbh Fluessige,gegebenenfalls als Wasch- oder Reinigungsmittel brauchbare stabilisierte Enzympraeparate
US3799942A (en) * 1971-04-12 1974-03-26 Syva Corp 4,5-substituted n-oxy and hydroxy hydroimidazoles
BE787477A (fr) * 1971-08-12 1973-02-12 Bayer Ag 1-phenyl-2-imino-imidazolidines, leur procede de preparation etleur application comme repulsifs a l'egard des oiseaux
DE2457979A1 (de) 1974-12-07 1976-06-16 Beiersdorf Ag 2-n-aryl-hydroxyamino-imidazoline-(2) und verfahren zu deren herstellung
DE2523103C3 (de) * 1975-05-24 1979-11-29 C.H. Boehringer Sohn, 6507 Ingelheim Substituierte 2-[N-Progargyl-N-(2-chlorphenyl)amino] -imidazoline-^), deren Säureadditionssalze, Verfahren zu ihrer Herstellung und deren Verwendung
AT339897B (de) * 1975-09-25 1977-11-10 Chemie Linz Ag Verfahren zur herstellung des neuen 1-benzoyl-2- (2',6'-dichlorphenylamino) -2-imidazolins und von dessen salzen
DE2626128A1 (de) * 1976-06-11 1977-12-22 Beiersdorf Ag N-substituierte benzimidazolin-2-one und verfahren zu deren herstellung
DE2709720A1 (de) * 1977-03-05 1978-09-07 Beiersdorf Ag N-substituierte 2-arylamino-imidazoline-(2), verfahren zu deren herstellung und neue hydroxylamine als zwischenprodukte
US4131679A (en) * 1977-07-26 1978-12-26 Sandoz, Inc. Substituted 4-hydroxy pyridones
DE2811847A1 (de) * 1978-03-17 1979-09-20 Lentia Gmbh Neue arylaminoimidazolinderivate, deren herstellung und verwendung als arzneimittel

Also Published As

Publication number Publication date
NL7811070A (nl) 1979-05-09
MC1223A1 (fr) 1979-07-20
US4244957A (en) 1981-01-13
BR7807317A (pt) 1979-07-24
AR223656A1 (es) 1981-09-15
MTP837B (en) 1979-10-22
OA06084A (fr) 1981-06-30
IT7829486A0 (it) 1978-11-06
NO783719L (no) 1979-05-08
US4511720A (en) 1985-04-16
ES480112A1 (es) 1980-04-01
FR2407919A1 (fr) 1979-06-01
IL55832A0 (en) 1978-12-17
RO76151A (ro) 1981-08-30
ES480111A1 (es) 1980-04-01
NZ188798A (en) 1981-04-24
DK494978A (da) 1979-05-08
PL210759A1 (xx) 1980-03-10
GB2086379A (en) 1982-05-12
GB2086379B (en) 1982-11-10
PT68752A (en) 1978-12-01
CA1106847A (en) 1981-08-11
SU831073A3 (ru) 1981-05-15
ATA791378A (de) 1982-10-15
IT1160046B (it) 1987-03-04
FI783393A (fi) 1979-05-08
SU910119A3 (ru) 1982-02-28
EG13665A (en) 1982-03-31
AU4132478A (en) 1979-05-17
SE7811455L (sv) 1979-07-02
ES480113A1 (es) 1980-04-01
US4355033A (en) 1982-10-19
AT371112B (de) 1983-06-10
JPS5473779A (en) 1979-06-13
GB2008579B (en) 1982-11-03
DE2861952D1 (en) 1982-09-02
EP0002010A1 (de) 1979-05-30
GB2008579A (en) 1979-06-06
DD139847A5 (de) 1980-01-23
EP0002010B1 (de) 1982-07-14
DE2847766A1 (de) 1979-05-10

Similar Documents

Publication Publication Date Title
US3736331A (en) Isothioureas
Petersen et al. Synthesis and hypotensive activity of N-alkyl-N''-cyano-N'-pyridylguanidines
HUT61747A (en) Process for producing 5-member-heterocyclic compounds and pharmaceutical compositions comprising same
AU777859B2 (en) N-substituted carbamoyloxyalkyl-azolium derivatives
LT4982B (lt) N-heterocikliniai dariniai kaip nos inhibitoriai
CZ18194A3 (en) Five-membered heterocycles, processes of their preparations and medicaments in which they are comprised
WO2009026701A1 (en) Sirtuin inhibitors
FI79104C (fi) Foerfarande foer framstaellning av ett nytt terapeutiskt anvaendbart dihydropyridinderivat.
NL193583C (nl) Ethyleendiaminemonoamidederivaten, werkwijzen ter bereiding daarvan, alsmede farmaceutische preparaten en de toepassing daarvan.
US6492407B2 (en) Pharmaceutical compositions containing triazolones and methods of treating neurodegenerative disease using triazolones
CS212309B2 (en) Method of making the new 2-iminoimidazolidine derivatives
HU184259B (en) Process for producing 2-imidazoline derivatives
HU187478B (en) Process for preparing new imidazolyl-phenyl-amidines and pharmaceutical compositions containing thereof
EP0510036B1 (en) 2-substituted 4,5-diphenyl-imidazoles
WO2006089664A2 (de) Heterocyclylamid-substituierte imidazole
EP1000036A1 (en) Hydantoin derivatives having an inhibitory activity for farnesyl transferase
EP0401707B1 (en) Heterocyclic triazin or triazolo compounds having serotonin 2-receptor antagonistic activity
EP0354788B1 (en) Novel imidazole derivatives
JPH01279872A (ja) イミダゾール誘導体、その製法及び該化合物を含有する精神病薬
US5332737A (en) Amino-1,3,5-triazines and their anhydrobase derivatives as agents for cardiovascular system
FI75154B (fi) Foerfarande foer framstaellning av terapeutiskt verkande, med en hexahydro-2-(1h)-azokinylidenrest substituerade guanidinderivat.
DE19907813A1 (de) Substituierte bicyclische Heterocyclen, deren Herstellung und deren Verwendung als Arzneimittel
EP0229922B1 (en) Novel 2,2'-bi-1h-imidazoles
US4990507A (en) N-containing heterocyclic compounds, and composition comprising the same
EP0064705B1 (en) 5-aminomethyl-2,3-dihydro-2-oxo-1h-imidazole-4-carboxylic acid derivatives