FR2407919A1 - Nouveaux derives de 2-imino-imidazolidine, leur preparation et leur application en tant que medicament - Google Patents

Nouveaux derives de 2-imino-imidazolidine, leur preparation et leur application en tant que medicament

Info

Publication number
FR2407919A1
FR2407919A1 FR7831026A FR7831026A FR2407919A1 FR 2407919 A1 FR2407919 A1 FR 2407919A1 FR 7831026 A FR7831026 A FR 7831026A FR 7831026 A FR7831026 A FR 7831026A FR 2407919 A1 FR2407919 A1 FR 2407919A1
Authority
FR
France
Prior art keywords
methyl
hydrogen
application
medicinal product
alcoxycarbonylclenet
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR7831026A
Other languages
English (en)
Inventor
Henri Ramuz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of FR2407919A1 publication Critical patent/FR2407919A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/40—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of thiourea or isothiourea groups further bound to other hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/44—Nitrogen atoms not forming part of a nitro radical
    • C07D233/50—Nitrogen atoms not forming part of a nitro radical with carbocyclic radicals directly attached to said nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Abstract

NOUVEAUX DERIVES DE 2-IMINO-IMIDAZOLIDINE, LEUR PREPARATION ET LEUR APPLICATION EN TANT QUE MEDICAMENT. LES COMPOSES DE L'INVENTION REPONDENT A LA FORMULE GENERALE: (CF DESSIN DANS BOPI) OU R, R ET R REPRESENTENT CHACUN, INDEPENDAMMENT L'UN DE L'AUTRE, UN HYDROGENE, UN ALCOYLE, UN ALCOXY, UN ALCOYLTHIO, UN HALOGENE, UN TRIFLUOROMETHYLE, UN CYANO OU UN HYDROXY ET OU R REPRESENTE UN HYDROGENE, UN ALCOYLE, UN CYCLOALCOYLE, UN CYCLOALCENYLE, UN ALCENYLE, UN ALCYNYLE, UN DIALCOYLAMINOALCOYLE, UN CARBOXYALCOYLE, UN CARBOXYALCENYLE, UN HYDROXY ALCOYLE, UN CYANOALCOYLE, UN ARYLALCOYLE, UN ALCOYLTHIOALCOYLE, UN ALCOXYCARBONYLALCOYLE, UN ALCOXYALCOXYALCOYLE, UN AMINOCARBONYLALCOYLE, UN MONOALCOYLAMINOCARBONYLALCOYLE, UN DIALCOYLAMINOCARBONYLALCOYLE, UN ALCOXYCARBONYLALCENYLE, UN ALCOXYALCOYLE, UN AMINOALCOYLE, UN AMINOALCOYLE SUBSTITUE, UN ARYLE, UN (2,2,8-TRIMETHYL-4H-M-DIOXINO4,5-C-PYRIDIN-5-YL)METHYLE, UN 5-HYDROXY-4-(HYDROXYMETHYL)-6-METHYL-3-PYRIDYLMETHYLE, UN A-CARBOXYBENZYLE, UN A-ALCOXYCARBONYL-A-ALCOYLPHENYLE OU UN RADICAL HETEROCYCLIQUE AROMATIQUE, LIE PAR L'INTERMEDIAIRE D'UN GROUPE -CH(R)-, COMPORTANT 5CHAINONS, EVENTUELLEMENT SUBSTITUE PAR UN ALCOYLE OU LE GROUPE -COOR OU, COMPORTANT 6CHAINONS, EVENTUELLEMENT SUBSTITUE PAR UN ALCOYLE, UN ALCOXY OU LE GROUPE -COOR, ET AYANT UN OU DEUX HETEROATOMES, CES HETEROATOMES POUVANT ETRE DE L'OXYGENE, DE L'AZOTE OU DU SOUFRE, R REPRESENTE UN HYDROGENE, UN METHYLE, UN ETHYLE OU UN N-PROPYLE ET R REPRESENTE UN HYDROGENE OU UN ALCOYLE, AINSI QUE LEURS SELS D'ADDITION ACIDES UTILISABLES EN PHARMACIE. APPLICATION EN TANT QUE MEDICAMENTS.
FR7831026A 1977-11-07 1978-11-02 Nouveaux derives de 2-imino-imidazolidine, leur preparation et leur application en tant que medicament Withdrawn FR2407919A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
LU78467 1977-11-07
CH966878 1978-09-15

Publications (1)

Publication Number Publication Date
FR2407919A1 true FR2407919A1 (fr) 1979-06-01

Family

ID=25705131

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7831026A Withdrawn FR2407919A1 (fr) 1977-11-07 1978-11-02 Nouveaux derives de 2-imino-imidazolidine, leur preparation et leur application en tant que medicament

Country Status (30)

Country Link
US (3) US4244957A (fr)
EP (1) EP0002010B1 (fr)
JP (1) JPS5473779A (fr)
AR (1) AR223656A1 (fr)
AT (1) AT371112B (fr)
AU (1) AU4132478A (fr)
BR (1) BR7807317A (fr)
CA (1) CA1106847A (fr)
CS (1) CS212309B2 (fr)
DD (1) DD139847A5 (fr)
DE (2) DE2861952D1 (fr)
DK (1) DK494978A (fr)
EG (1) EG13665A (fr)
ES (3) ES480111A1 (fr)
FI (1) FI783393A (fr)
FR (1) FR2407919A1 (fr)
GB (2) GB2008579B (fr)
IL (1) IL55832A0 (fr)
IT (1) IT1160046B (fr)
MC (1) MC1223A1 (fr)
MT (1) MTP837B (fr)
NL (1) NL7811070A (fr)
NO (1) NO783719L (fr)
NZ (1) NZ188798A (fr)
OA (1) OA06084A (fr)
PL (1) PL210759A1 (fr)
PT (1) PT68752A (fr)
RO (1) RO76151A (fr)
SE (1) SE7811455L (fr)
SU (2) SU831073A3 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4287201A (en) * 1980-03-03 1981-09-01 Merck & Co., Inc. Anovulatory method and chicken feed compositions
CA1175434A (fr) * 1980-09-10 1984-10-02 Hoffmann-La Roche Limited Derives de ¬(2-phenylamino-1-imidazolidinyloxy) methyl|pyridine 1-oxyde
DE3642453A1 (de) * 1986-12-12 1988-06-23 Bayer Ag Neue, fluor enthaltende 5-trihalogenmethyl-isoxazole und ein verfahren zu deren herstellung
DE19514579A1 (de) * 1995-04-20 1996-10-24 Boehringer Ingelheim Kg Verwendung von alpha¶1¶¶L¶-Agonisten zur Behandlung der Harninkontinenz
US6417204B1 (en) * 2000-07-07 2002-07-09 Medicure International Inc. Pyridoxine AMD pyridoxal analogues: cardiovascular therapeutics
GB2374251A (en) * 2001-04-04 2002-10-09 Secr Defence Base station transmitter
WO2003042193A1 (fr) * 2001-11-09 2003-05-22 Geneva Pharmaceuticals, Inc. Procede de preparation de (4'-trifluoromethyl)-anilide5-methylisoxazole-4-carboxylique
EP1333028A1 (fr) * 2002-01-31 2003-08-06 Boehringer Ingelheim Pharma GmbH & Co.KG Dérivés de 2'-halo-3',5'-dialkoxyphen-1'-yl-imino-2-imidazolidine et lur utilisation pour le traitement de l'incontinence urinaire
US6703409B2 (en) 2002-01-31 2004-03-09 Boehringer Ingelheim Pharma Gmbh & Co Kg 2′-Halo-3′,5′-dialkoxyphen-1′-yl-imino-2-imidazolidine and the use thereof as a drug
JP5731385B2 (ja) * 2008-08-22 2015-06-10 バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ ポリマーベンジルカルボネート誘導体

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1592709A (fr) * 1968-01-10 1970-05-19
FR2073369A1 (fr) * 1969-11-17 1971-10-01 Boehringer Sohn Ingelheim
FR2092011A1 (fr) * 1970-04-06 1972-01-21 Boehringer Sohn Ingelheim
DE2626128A1 (de) * 1976-06-11 1977-12-22 Beiersdorf Ag N-substituierte benzimidazolin-2-one und verfahren zu deren herstellung
DE2709720A1 (de) * 1977-03-05 1978-09-07 Beiersdorf Ag N-substituierte 2-arylamino-imidazoline-(2), verfahren zu deren herstellung und neue hydroxylamine als zwischenprodukte

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670274U (de) 1953-07-30 1954-01-14 Leo Schirk Stahlblechschalttafel.
DE1815788U (de) 1959-12-12 1960-07-28 Walther Loeffler Ventil fuer spuelbecken, waschbecken, bidets, wannen.
US3236857A (en) 1961-10-09 1966-02-22 Boehringer Sohn Ingelheim 2-(phenyl-amino)-1, 3-diazacyclopentene-(2) substitution products
NL123037C (fr) 1963-10-04
DE1545628A1 (de) 1965-10-01 1970-06-25 Boehringer Sohn Ingelheim Verfahren zur Herstellung von blutdrucksenkend und sedativ wirksamen Derivaten des 2-(2-Halogenanilino)-1,3-diazacyclopentens-(2)
DE1670274A1 (de) * 1966-10-31 1970-07-16 Boehringer Sohn Ingelheim Neues Verfahren zur Herstellung von 2-Arylamino-1,3-diazacycloalkenen-(2)
DE1670230A1 (de) 1967-05-26 1971-01-21 Boehringer Sohn Ingelheim Neues Verfahren zur Herstellung von in 2-Stellung substituierten 1,3-Diazacycloalkenen(2)
ES352379A1 (es) 1967-05-26 1969-08-01 Boehringer Sohn Ingelheim Procedimiento para la preparacion de 1,3-diazaciclopenteno-(2) sustituido en posicion 2.
US3454301A (en) * 1967-09-29 1969-07-08 John W Lehmann Glare-inhibiting device
DE1770872A1 (de) 1968-08-26 1972-01-13 Dresden Arzneimittel Verfahren zur Herstellung von Imidazolin-2-Derivaten
BE721781A (fr) 1968-10-03 1969-04-03
US3740412A (en) * 1970-04-08 1973-06-19 Synvar Ass Imidazoline-3-oxide-1-oxyl derivatives
DE2038107A1 (de) * 1970-07-31 1972-02-10 Henkel & Cie Gmbh Fluessige,gegebenenfalls als Wasch- oder Reinigungsmittel brauchbare stabilisierte Enzympraeparate
US3799942A (en) * 1971-04-12 1974-03-26 Syva Corp 4,5-substituted n-oxy and hydroxy hydroimidazoles
BE787477A (fr) * 1971-08-12 1973-02-12 Bayer Ag 1-phenyl-2-imino-imidazolidines, leur procede de preparation etleur application comme repulsifs a l'egard des oiseaux
DE2457979A1 (de) 1974-12-07 1976-06-16 Beiersdorf Ag 2-n-aryl-hydroxyamino-imidazoline-(2) und verfahren zu deren herstellung
DE2523103C3 (de) * 1975-05-24 1979-11-29 C.H. Boehringer Sohn, 6507 Ingelheim Substituierte 2-[N-Progargyl-N-(2-chlorphenyl)amino] -imidazoline-^), deren Säureadditionssalze, Verfahren zu ihrer Herstellung und deren Verwendung
AT339897B (de) * 1975-09-25 1977-11-10 Chemie Linz Ag Verfahren zur herstellung des neuen 1-benzoyl-2- (2',6'-dichlorphenylamino) -2-imidazolins und von dessen salzen
US4131679A (en) * 1977-07-26 1978-12-26 Sandoz, Inc. Substituted 4-hydroxy pyridones
DE2811847A1 (de) * 1978-03-17 1979-09-20 Lentia Gmbh Neue arylaminoimidazolinderivate, deren herstellung und verwendung als arzneimittel

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1592709A (fr) * 1968-01-10 1970-05-19
FR2073369A1 (fr) * 1969-11-17 1971-10-01 Boehringer Sohn Ingelheim
FR2092011A1 (fr) * 1970-04-06 1972-01-21 Boehringer Sohn Ingelheim
DE2626128A1 (de) * 1976-06-11 1977-12-22 Beiersdorf Ag N-substituierte benzimidazolin-2-one und verfahren zu deren herstellung
DE2709720A1 (de) * 1977-03-05 1978-09-07 Beiersdorf Ag N-substituierte 2-arylamino-imidazoline-(2), verfahren zu deren herstellung und neue hydroxylamine als zwischenprodukte

Also Published As

Publication number Publication date
FI783393A (fi) 1979-05-08
IT1160046B (it) 1987-03-04
GB2086379B (en) 1982-11-10
IL55832A0 (en) 1978-12-17
SU910119A3 (ru) 1982-02-28
ATA791378A (de) 1982-10-15
CS212309B2 (en) 1982-03-26
EG13665A (en) 1982-03-31
PT68752A (en) 1978-12-01
PL210759A1 (fr) 1980-03-10
JPS5473779A (en) 1979-06-13
DE2861952D1 (en) 1982-09-02
EP0002010A1 (fr) 1979-05-30
DK494978A (da) 1979-05-08
CA1106847A (fr) 1981-08-11
SU831073A3 (ru) 1981-05-15
AT371112B (de) 1983-06-10
NZ188798A (en) 1981-04-24
GB2008579A (en) 1979-06-06
NO783719L (no) 1979-05-08
EP0002010B1 (fr) 1982-07-14
OA06084A (fr) 1981-06-30
RO76151A (fr) 1981-08-30
ES480112A1 (es) 1980-04-01
SE7811455L (sv) 1979-07-02
ES480111A1 (es) 1980-04-01
MTP837B (en) 1979-10-22
GB2008579B (en) 1982-11-03
IT7829486A0 (it) 1978-11-06
DE2847766A1 (de) 1979-05-10
AU4132478A (en) 1979-05-17
US4511720A (en) 1985-04-16
MC1223A1 (fr) 1979-07-20
US4244957A (en) 1981-01-13
ES480113A1 (es) 1980-04-01
BR7807317A (pt) 1979-07-24
AR223656A1 (es) 1981-09-15
GB2086379A (en) 1982-05-12
DD139847A5 (de) 1980-01-23
US4355033A (en) 1982-10-19
NL7811070A (nl) 1979-05-09

Similar Documents

Publication Publication Date Title
FR2407919A1 (fr) Nouveaux derives de 2-imino-imidazolidine, leur preparation et leur application en tant que medicament
FR2387941A1 (fr) Homologue de la somatostatine, ses intermediaires de preparation, et son utilisation comme medicament
FI872910A0 (fi) Antiviralt aemne med brett verkningsspektrum.
KR970703749A (ko) 포유동물의 피부에서 과잉색소침착된 부위를 미백시키기 위한 조성물
ES499870A0 (es) Un procedimiento para la preparacion de derivados de indano
PT1106178E (pt) Utilizacao de ibudilast para a preparacao de um medicamento para o tratamento da esclerose multipla
ATE14884T1 (de) S-adenosinylmethionine-derivate, verfahren zu ihrer herstellung und die pharmazeutischen zusammensetzungen welche als aktive substanz diese derivate enthalten.
AU2007341218A1 (en) Isosorbide mononitrate derivatives for the treatment of intestinal disorders
SE8700714D0 (sv) Anvendning av substituerade 4-fenyl-4-oxo-2-butensyraderivat for framstellning av lekemedel for behandling av sjukdomar i matsmeltningskanalen och som antiulcerost lekemedel
RU2222532C2 (ru) Соединения ряда бензофуроксана, способ их получения (варианты), фармацевтическая композиция, способ получения парентерального состава и способ лечения коронарных сердечных заболеваний
FR2395272A1 (fr) Nouveaux medicaments derives de l'acide amidinopenicillanique
IT1241079B (it) Composizioni farmaceutiche contenenti ipriflavone,procedimento per la loro preparazione e relativo impiego terapeutico
FR2355012A1 (fr) Nouveaux derives de dihydro- et tetrahydro-iminothiazine, et leur application en tant que medicaments
KR900014397A (ko) 티에노-트리아졸로-디아제핀 술포닐 유도체, 그의 제조 방법 및 그를 함유하는 치료 조성물
FR2379538A1 (fr) Nouveaux derives d'oxadiazolopyrimidine, leur preparation et leur application en tant que medicaments
Westhorpe et al. The intravenous barbiturates
FR2401160A1 (fr) Nouveaux derives d'esters de vincaminol, leur preparation et leur application en tant que medicaments
IE51737B1 (en) Topical formulations of 3-deazaadenosine
CY1106819T1 (el) Φαρμακα για το ξηρο δερμα
IT1097994B (it) Derivati della dibenzo aperta par.quadrata d,g chiusa par.quadrata aperta par.quadrata 1,3,6 chiusa par.quadrata diossazocina,procedimento per la loro preparazione e preparati medicamentosi contenenti tali composti
US3564095A (en) Anti-inflammatory hydroxy cyclic sulfones
FR2384767A1 (fr) Nouveaux derives d'acides benzo-heteroxyclylglyoxyliques, leur preparation et leur application en tant que medicament
ATE123497T1 (de) Substituierte pyridin-verbindungen, ihre herstellung und sie enthaltende pharmazeutische zusammensetzungen.
FR2404008A1 (fr) Derives de lasalocide, leur preparation et leur application en tant que medicaments
KR880001652A (ko) 이소퀴놀린 유도체 및 이의 제조 방법

Legal Events

Date Code Title Description
ST Notification of lapse