CS200455B2 - Method of producing derivatives of benzoxazole - Google Patents

Method of producing derivatives of benzoxazole Download PDF

Info

Publication number
CS200455B2
CS200455B2 CS733508A CS350873A CS200455B2 CS 200455 B2 CS200455 B2 CS 200455B2 CS 733508 A CS733508 A CS 733508A CS 350873 A CS350873 A CS 350873A CS 200455 B2 CS200455 B2 CS 200455B2
Authority
CS
Czechoslovakia
Prior art keywords
acid
group
propionic acid
benzoxazolyl
hydroxyphenyl
Prior art date
Application number
CS733508A
Other languages
Czech (cs)
English (en)
Inventor
Delme Evans
David W Dunwell
Terence A Hicks
Original Assignee
Lilly Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Industries Ltd filed Critical Lilly Industries Ltd
Priority to CS763951A priority Critical patent/CS200456B2/cs
Publication of CS200455B2 publication Critical patent/CS200455B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D263/57—Aryl or substituted aryl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
CS733508A 1972-05-18 1973-05-16 Method of producing derivatives of benzoxazole CS200455B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CS763951A CS200456B2 (cs) 1972-05-18 1976-06-15 Způsob výroby derivátů benzoxazolu

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2340972A GB1435721A (en) 1972-05-18 1972-05-18 Benzoxazole derivatives

Publications (1)

Publication Number Publication Date
CS200455B2 true CS200455B2 (en) 1980-09-15

Family

ID=10195157

Family Applications (1)

Application Number Title Priority Date Filing Date
CS733508A CS200455B2 (en) 1972-05-18 1973-05-16 Method of producing derivatives of benzoxazole

Country Status (31)

Country Link
US (1) US3912748A (fr)
JP (6) JPS5912672B2 (fr)
KR (1) KR780000234B1 (fr)
AR (4) AR230991A1 (fr)
AT (1) AT333752B (fr)
BE (1) BE799790A (fr)
BG (1) BG21408A3 (fr)
CA (1) CA1029019A (fr)
CH (5) CH592071A5 (fr)
CS (1) CS200455B2 (fr)
CY (1) CY1016A (fr)
DD (1) DD105229A5 (fr)
DE (1) DE2324443A1 (fr)
DK (1) DK140340B (fr)
ES (1) ES414863A1 (fr)
FR (2) FR2184966B1 (fr)
GB (1) GB1435721A (fr)
HK (1) HK72579A (fr)
HU (1) HU167933B (fr)
IE (2) IE37564B1 (fr)
IL (2) IL42102A (fr)
KE (1) KE2975A (fr)
MY (1) MY8000063A (fr)
NL (1) NL170145C (fr)
PH (3) PH9685A (fr)
PL (3) PL92565B1 (fr)
RO (2) RO66278A (fr)
SE (3) SE386174B (fr)
SU (3) SU574157A3 (fr)
YU (3) YU130473A (fr)
ZA (1) ZA732791B (fr)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3888864A (en) 1973-06-29 1975-06-10 Hoffmann La Roche Amino lower alkyl ether derivatives of opium alkaloids
GB1495488A (en) * 1976-06-23 1977-12-21 Ippco Int Pharma Patents Co Es Optically active 2-(2-phenyl-5-benzoxazolyl)propionic acids
US4087437A (en) * 1976-09-07 1978-05-02 Eli Lilly And Company 2-Phenyl-5-benzoxazolylalkanoic acid purification process
GB1590587A (en) * 1977-06-28 1981-06-03 Lilly Industries Ltd Benoxaprofen
IT1099589B (it) * 1978-08-04 1985-09-18 Ravizza Spa Processo per la preparazione di derivati dell'acido benzoxazolil propionico
CA1125768A (fr) * 1978-10-31 1982-06-15 Hoffmann-La Roche Limited Derives de benzoxazole
GB2058381B (en) 1979-07-18 1983-01-19 Fuji Photo Film Co Ltd Colour photographic light-sensitive material containing dye-releasing redox compound
GR75153B (fr) * 1981-03-27 1984-07-13 Lilly Co Eli
IT1157295B (it) * 1982-07-19 1987-02-11 Ravizza Spa Processo perfezionato per la preparazione di derivati dell'acido benzoxazolil propionico
DE3413875A1 (de) * 1984-04-12 1985-10-17 Ludwig Heumann & Co GmbH, 8500 Nürnberg Benzothiazolderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltendes arzneimittel
IT1177017B (it) * 1984-10-22 1987-08-26 Ravizza Spa Processo per la preparazione dell'acido 2(4-flurofenil)alfa-metil-5-benzox azoloacetico
US4873259A (en) * 1987-06-10 1989-10-10 Abbott Laboratories Indole, benzofuran, benzothiophene containing lipoxygenase inhibiting compounds
US4822809A (en) * 1987-11-13 1989-04-18 Abbott Laboratories Benzazole lipoxygenase inhibiting compounds
IT1233836B (it) * 1988-01-13 1992-04-21 Euroresearch Srl Sali idrosolubili dell'acido (+)2-(4 fluorofenil)-alfa-metil-5 benzoxazolo acetato.
UA83620C2 (ru) * 2001-12-05 2008-08-11 Уайт Замещенные бензоксазолы и их аналоги как эстрогенные агенты
WO2004046122A2 (fr) * 2002-11-16 2004-06-03 Oxford Glycosciences (Uk) Ltd Derives d'acides de benzoxazole, de benzothiazole, et de benzimidazole pharmaceutiquement actifs
JP4790594B2 (ja) * 2003-02-25 2011-10-12 トポターゲット ユーケー リミテッド Ｈｄａｃインヒビターとしての、二環式ヘテロアリール基を含むヒドロキサム酸化合物
MX2007007133A (es) * 2004-12-15 2007-08-08 Dompe Pha R Ma Spa Res & Mfg Derivados de acido 2-arilpropionico y composiciones farmaceuticas que los contienen.
EP1888548B1 (fr) 2005-05-26 2012-08-22 Neuron Systems, Inc Dérivé de quinoline pour le traitement de maladies rétiniennes
JP5369854B2 (ja) * 2008-04-21 2013-12-18 住友化学株式会社 有害節足動物防除組成物および縮合複素環化合物
RU2676694C9 (ru) 2013-01-23 2019-06-25 Альдейра Терапьютикс, Инк. Заболевания, связанные с токсичным альдегидом, и их лечение
EP2948436A4 (fr) 2013-01-25 2016-07-13 Aldeyra Therapeutics Inc Nouveaux pièges dans le traitement de la dégénérescence maculaire
CN107001267A (zh) * 2014-08-08 2017-08-01 马合伙人株式会社 稠合杂环化合物
JP6947406B2 (ja) 2015-08-21 2021-10-13 アルデイラ セラピューティクス， インコーポレイテッド 重水素化化合物およびその使用
AU2017264697A1 (en) 2016-05-09 2018-11-22 Aldeyra Therapeutics, Inc. Combination treatment of ocular inflammatory disorders and diseases
EP3596040B1 (fr) 2017-03-16 2023-10-11 Aldeyra Therapeutics, Inc. Composés polymorphes de sels de 6-chloro-3-amino-2(2-hydroxypropyl)quinoline et leurs utilisations
MX2020003425A (es) 2017-10-10 2020-07-29 Aldeyra Therapeutics Inc Tratamiento de trastornos inflamatorios.
JP2021533154A (ja) 2018-08-06 2021-12-02 アルデイラ セラピューティクス， インコーポレイテッド 多形化合物およびその使用
WO2020068986A1 (fr) 2018-09-25 2020-04-02 Aldeyra Therapeutics, Inc. Formulations pour le traitement de la maladie de l'œil sec
WO2020198064A1 (fr) 2019-03-26 2020-10-01 Aldeyra Therapeutics, Inc. Formulations ophtalmiques et leurs utilisations

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD70860A (fr) *
NL285932A (fr) * 1961-11-27
CH516339A (de) * 1969-03-03 1971-12-15 Ciba Geigy Ag Verwendung von Azolverbindungen als Antioxydantien
DE2118315C3 (de) * 1970-04-20 1975-04-03 Sumitomo Chemical Co., Ltd., Osaka (Japan) 2-(1H)-Chinazolinonderivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
IL37633A (en) * 1970-09-10 1975-08-31 Merck & Co Inc 2-(4-(2-benzoxazolyl)phenyl)alkanoic acid derivatives
DE2115926C3 (de) * 1971-04-01 1978-05-03 C.H. Boehringer Sohn, 6507 Ingelheim 1 -(4-Hydroxy-3-dimethylaminosuIfamidophenyI)-2-aminoäthanderivate, Verfahren zu ihrer Herstellung und diese enthaltende Mittel
GB1491863A (en) * 1973-10-23 1977-11-16 Lilly Industries Ltd 2,5-or 2,6-disubstituted benzoxazoles
GB1590587A (en) * 1977-06-28 1981-06-03 Lilly Industries Ltd Benoxaprofen

Also Published As

Publication number Publication date
IE37564B1 (en) 1977-08-17
FR2284592A1 (fr) 1976-04-09
SE435838B (sv) 1984-10-22
FR2184966A1 (fr) 1973-12-28
JPS5912672B2 (ja) 1984-03-24
CH595361A5 (fr) 1978-02-15
PL89247B1 (fr) 1976-11-30
YU130473A (en) 1981-08-31
KR780000234B1 (en) 1978-07-01
YU117179A (en) 1981-08-31
JPS56167673A (en) 1981-12-23
IL42102A (en) 1977-07-31
YU117079A (en) 1981-08-31
ATA432573A (de) 1976-04-15
PH11718A (en) 1978-05-30
CH595362A5 (fr) 1978-02-15
CY1016A (en) 1979-11-23
PL94208B1 (fr) 1977-07-30
JPS56167675A (en) 1981-12-23
BG21408A3 (fr) 1976-05-20
JPS6021976B2 (ja) 1985-05-30
JPS56167645A (en) 1981-12-23
PH10704A (en) 1977-08-24
DE2324443A1 (de) 1973-11-29
NL170145C (nl) 1982-10-01
AR230991A1 (es) 1984-08-31
JPS56167674A (en) 1981-12-23
FR2184966B1 (fr) 1979-01-12
SU580837A3 (ru) 1977-11-15
SE434399B (sv) 1984-07-23
AR205021A1 (es) 1976-03-31
ES414863A1 (es) 1976-02-01
MY8000063A (en) 1980-12-31
PL92565B1 (fr) 1977-04-30
BE799790A (fr) 1973-11-19
JPS5929185B2 (ja) 1984-07-18
DD105229A5 (fr) 1974-04-12
AR212010A1 (es) 1978-04-28
CH592071A5 (fr) 1977-10-14
NL170145B (nl) 1982-05-03
DK140340B (da) 1979-08-06
GB1435721A (en) 1976-05-12
RO66800A (fr) 1982-03-24
FR2284592B1 (fr) 1979-01-05
HK72579A (en) 1979-10-19
AT333752B (de) 1976-12-10
HU167933B (fr) 1976-01-28
PH9685A (en) 1976-02-10
CA1029019A (fr) 1978-04-04
JPS59161346A (ja) 1984-09-12
SE386174B (sv) 1976-08-02
IE37563L (en) 1973-11-18
SE7509387L (sv) 1975-08-22
IE37564L (en) 1973-11-18
SU574157A3 (ru) 1977-09-25
CH594643A5 (fr) 1978-01-13
CH587834A5 (fr) 1977-05-13
AR207857A1 (es) 1976-11-08
NL7307018A (fr) 1973-11-20
US3912748A (en) 1975-10-14
IE37563B1 (en) 1977-08-17
SU582762A3 (ru) 1977-11-30
ZA732791B (en) 1974-12-24
JPS4954363A (fr) 1974-05-27
KE2975A (en) 1979-07-20
RO66278A (fr) 1981-06-26
SE7710602L (sv) 1977-09-21
AU5590773A (en) 1974-11-21
DK140340C (fr) 1979-12-31
YU36298B (en) 1982-06-18
IL42102A0 (en) 1973-06-29
IL48711A0 (en) 1976-02-29

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