SE434399B - Forfarande for framstellning av benoxazolderivat - Google Patents
Forfarande for framstellning av benoxazolderivatInfo
- Publication number
- SE434399B SE434399B SE7509387A SE7509387A SE434399B SE 434399 B SE434399 B SE 434399B SE 7509387 A SE7509387 A SE 7509387A SE 7509387 A SE7509387 A SE 7509387A SE 434399 B SE434399 B SE 434399B
- Authority
- SE
- Sweden
- Prior art keywords
- derivatives
- preparing
- benoxazold
- procedure
- cyclising
- Prior art date
Links
- CDAWCLOXVUBKRW-UHFFFAOYSA-N 2-aminophenol Chemical class NC1=CC=CC=C1O CDAWCLOXVUBKRW-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- BCMCBBGGLRIHSE-UHFFFAOYSA-N 1,3-benzoxazole Chemical compound C1=CC=C2OC=NC2=C1 BCMCBBGGLRIHSE-UHFFFAOYSA-N 0.000 abstract 1
- -1 6-benzoxazolyl Chemical group 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 230000001760 anti-analgesic effect Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 230000001754 anti-pyretic effect Effects 0.000 abstract 1
- 239000002221 antipyretic Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D263/57—Aryl or substituted aryl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Furan Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB2340972A GB1435721A (en) | 1972-05-18 | 1972-05-18 | Benzoxazole derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
SE7509387L SE7509387L (sv) | 1975-08-22 |
SE434399B true SE434399B (sv) | 1984-07-23 |
Family
ID=10195157
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE7307005A SE386174B (sv) | 1972-05-18 | 1973-05-17 | Forfarande for framstellning av bensoxazolderivat. |
SE7509387A SE434399B (sv) | 1972-05-18 | 1975-08-22 | Forfarande for framstellning av benoxazolderivat |
SE7710602A SE435838B (sv) | 1972-05-18 | 1977-09-21 | Bensoxazolderivat sasom mellanprodukt |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE7307005A SE386174B (sv) | 1972-05-18 | 1973-05-17 | Forfarande for framstellning av bensoxazolderivat. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE7710602A SE435838B (sv) | 1972-05-18 | 1977-09-21 | Bensoxazolderivat sasom mellanprodukt |
Country Status (31)
Country | Link |
---|---|
US (1) | US3912748A (xx) |
JP (6) | JPS5912672B2 (xx) |
KR (1) | KR780000234B1 (xx) |
AR (4) | AR230991A1 (xx) |
AT (1) | AT333752B (xx) |
BE (1) | BE799790A (xx) |
BG (1) | BG21408A3 (xx) |
CA (1) | CA1029019A (xx) |
CH (5) | CH594643A5 (xx) |
CS (1) | CS200455B2 (xx) |
CY (1) | CY1016A (xx) |
DD (1) | DD105229A5 (xx) |
DE (1) | DE2324443A1 (xx) |
DK (1) | DK140340B (xx) |
ES (1) | ES414863A1 (xx) |
FR (2) | FR2184966B1 (xx) |
GB (1) | GB1435721A (xx) |
HK (1) | HK72579A (xx) |
HU (1) | HU167933B (xx) |
IE (2) | IE37564B1 (xx) |
IL (2) | IL42102A (xx) |
KE (1) | KE2975A (xx) |
MY (1) | MY8000063A (xx) |
NL (1) | NL170145C (xx) |
PH (3) | PH9685A (xx) |
PL (3) | PL94208B1 (xx) |
RO (2) | RO66278A (xx) |
SE (3) | SE386174B (xx) |
SU (3) | SU574157A3 (xx) |
YU (3) | YU130473A (xx) |
ZA (1) | ZA732791B (xx) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3888864A (en) | 1973-06-29 | 1975-06-10 | Hoffmann La Roche | Amino lower alkyl ether derivatives of opium alkaloids |
GB1495488A (en) * | 1976-06-23 | 1977-12-21 | Ippco Int Pharma Patents Co Es | Optically active 2-(2-phenyl-5-benzoxazolyl)propionic acids |
US4087437A (en) * | 1976-09-07 | 1978-05-02 | Eli Lilly And Company | 2-Phenyl-5-benzoxazolylalkanoic acid purification process |
GB1590587A (en) * | 1977-06-28 | 1981-06-03 | Lilly Industries Ltd | Benoxaprofen |
IT1099589B (it) * | 1978-08-04 | 1985-09-18 | Ravizza Spa | Processo per la preparazione di derivati dell'acido benzoxazolil propionico |
CA1125768A (en) * | 1978-10-31 | 1982-06-15 | Hoffmann-La Roche Limited | Benzoxazole derivatives |
GB2058381B (en) | 1979-07-18 | 1983-01-19 | Fuji Photo Film Co Ltd | Colour photographic light-sensitive material containing dye-releasing redox compound |
GR75153B (xx) * | 1981-03-27 | 1984-07-13 | Lilly Co Eli | |
IT1157295B (it) * | 1982-07-19 | 1987-02-11 | Ravizza Spa | Processo perfezionato per la preparazione di derivati dell'acido benzoxazolil propionico |
DE3413875A1 (de) * | 1984-04-12 | 1985-10-17 | Ludwig Heumann & Co GmbH, 8500 Nürnberg | Benzothiazolderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltendes arzneimittel |
IT1177017B (it) * | 1984-10-22 | 1987-08-26 | Ravizza Spa | Processo per la preparazione dell'acido 2(4-flurofenil)alfa-metil-5-benzox azoloacetico |
US4873259A (en) * | 1987-06-10 | 1989-10-10 | Abbott Laboratories | Indole, benzofuran, benzothiophene containing lipoxygenase inhibiting compounds |
US4822809A (en) * | 1987-11-13 | 1989-04-18 | Abbott Laboratories | Benzazole lipoxygenase inhibiting compounds |
IT1233836B (it) * | 1988-01-13 | 1992-04-21 | Euroresearch Srl | Sali idrosolubili dell'acido (+)2-(4 fluorofenil)-alfa-metil-5 benzoxazolo acetato. |
UA83620C2 (ru) * | 2001-12-05 | 2008-08-11 | Уайт | Замещенные бензоксазолы и их аналоги как эстрогенные агенты |
WO2004046122A2 (en) * | 2002-11-16 | 2004-06-03 | Oxford Glycosciences (Uk) Ltd | Benzoxazole, benzthiazole and benzimidazole acid derivatives and their use as heparanase inhibitors |
AU2004215624B2 (en) * | 2003-02-25 | 2011-06-02 | Topotarget Uk Limited | Hydroxamic acid compounds comprising a bicyclic heteroaryl group as HDAC inhibitors |
ME01868B (me) * | 2004-12-15 | 2010-10-31 | Dompe Pha R Ma Spa Res & Mfg | Derivati 2-arilpropionske kiseline i farmaceutske smeše, koje ih sadrže |
ES2441873T3 (es) | 2005-05-26 | 2014-02-06 | Aldexa Therapeutics, Inc. | Derivados de quinolina para el tratamiento de enfermedades retinianas |
JP5369854B2 (ja) | 2008-04-21 | 2013-12-18 | 住友化学株式会社 | 有害節足動物防除組成物および縮合複素環化合物 |
EP2948149A4 (en) | 2013-01-23 | 2016-12-14 | Aldeyra Therapeutics Inc | BY TOXIC ALDEHYDIC DISEASES AND TREATMENT |
WO2014116593A1 (en) | 2013-01-25 | 2014-07-31 | Aldexa Therapeutics, Inc. | Novel traps in the treatment of macular degeneration |
CN107001267A (zh) * | 2014-08-08 | 2017-08-01 | 马合伙人株式会社 | 稠合杂环化合物 |
KR102664994B1 (ko) | 2015-08-21 | 2024-05-13 | 알데이라 테라퓨틱스, 아이엔씨. | 중수소화 화합물 및 이의 용도 |
AU2017264697A1 (en) | 2016-05-09 | 2018-11-22 | Aldeyra Therapeutics, Inc. | Combination treatment of ocular inflammatory disorders and diseases |
CN110431130A (zh) | 2017-03-16 | 2019-11-08 | 奥尔德拉医疗公司 | 多晶型化合物和其用途 |
US11040039B2 (en) | 2017-10-10 | 2021-06-22 | Aldeyra Therapeutics, Inc. | Treatment of inflammatory disorders |
WO2020033344A1 (en) | 2018-08-06 | 2020-02-13 | Aldeyra Therapeutics, Inc. | Polymorphic compounds and uses thereof |
JP7505786B2 (ja) | 2018-09-25 | 2024-06-25 | アルデイラ セラピューティクス, インコーポレイテッド | ドライアイ疾患を処置するための製剤 |
US11786518B2 (en) | 2019-03-26 | 2023-10-17 | Aldeyra Therapeutics, Inc. | Ophthalmic formulations and uses thereof |
CN113784954A (zh) | 2019-05-02 | 2021-12-10 | 奥尔德拉医疗公司 | 多晶型化合物和其用途 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DD70860A (xx) * | ||||
NL285932A (xx) * | 1961-11-27 | |||
CH516339A (de) * | 1969-03-03 | 1971-12-15 | Ciba Geigy Ag | Verwendung von Azolverbindungen als Antioxydantien |
DE2118315C3 (de) * | 1970-04-20 | 1975-04-03 | Sumitomo Chemical Co., Ltd., Osaka (Japan) | 2-(1H)-Chinazolinonderivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
IL37633A (en) * | 1970-09-10 | 1975-08-31 | Merck & Co Inc | 2-(4-(2-benzoxazolyl)phenyl)alkanoic acid derivatives |
DE2115926C3 (de) * | 1971-04-01 | 1978-05-03 | C.H. Boehringer Sohn, 6507 Ingelheim | 1 -(4-Hydroxy-3-dimethylaminosuIfamidophenyI)-2-aminoäthanderivate, Verfahren zu ihrer Herstellung und diese enthaltende Mittel |
GB1491863A (en) * | 1973-10-23 | 1977-11-16 | Lilly Industries Ltd | 2,5-or 2,6-disubstituted benzoxazoles |
GB1590587A (en) * | 1977-06-28 | 1981-06-03 | Lilly Industries Ltd | Benoxaprofen |
-
1972
- 1972-05-18 GB GB2340972A patent/GB1435721A/en not_active Expired
-
1973
- 1973-04-25 ZA ZA732791A patent/ZA732791B/xx unknown
- 1973-04-25 IL IL42102A patent/IL42102A/en unknown
- 1973-04-25 IE IE1898/76A patent/IE37564B1/xx unknown
- 1973-04-28 IE IE648/73A patent/IE37563B1/xx unknown
- 1973-05-01 CA CA170,186A patent/CA1029019A/en not_active Expired
- 1973-05-01 US US356251A patent/US3912748A/en not_active Expired - Lifetime
- 1973-05-07 PH PH14592*UA patent/PH9685A/en unknown
- 1973-05-11 AR AR247979A patent/AR230991A1/es active
- 1973-05-15 CY CY1016A patent/CY1016A/xx unknown
- 1973-05-15 DE DE2324443A patent/DE2324443A1/de not_active Ceased
- 1973-05-16 KR KR7300790A patent/KR780000234B1/ko active
- 1973-05-16 DD DD170872A patent/DD105229A5/xx unknown
- 1973-05-16 HU HULI244A patent/HU167933B/hu not_active IP Right Cessation
- 1973-05-16 CS CS733508A patent/CS200455B2/cs unknown
- 1973-05-17 CH CH1298676A patent/CH594643A5/xx not_active IP Right Cessation
- 1973-05-17 DK DK274673AA patent/DK140340B/da not_active IP Right Cessation
- 1973-05-17 FR FR7317894A patent/FR2184966B1/fr not_active Expired
- 1973-05-17 CH CH703673A patent/CH592071A5/xx not_active IP Right Cessation
- 1973-05-17 YU YU01304/73A patent/YU130473A/xx unknown
- 1973-05-17 JP JP48055110A patent/JPS5912672B2/ja not_active Expired
- 1973-05-17 SE SE7307005A patent/SE386174B/xx unknown
- 1973-05-17 AT AT432573A patent/AT333752B/de not_active IP Right Cessation
- 1973-05-17 CH CH1621275A patent/CH595361A5/xx not_active IP Right Cessation
- 1973-05-17 CH CH1621375A patent/CH587834A5/xx not_active IP Right Cessation
- 1973-05-17 CH CH1298576A patent/CH595362A5/xx not_active IP Right Cessation
- 1973-05-17 ES ES414863A patent/ES414863A1/es not_active Expired
- 1973-05-17 SU SU7301916802A patent/SU574157A3/ru active
- 1973-05-18 PL PL1973183011A patent/PL94208B1/pl unknown
- 1973-05-18 PL PL1973162653A patent/PL89247B1/pl unknown
- 1973-05-18 PL PL1973182614A patent/PL92565B1/pl unknown
- 1973-05-18 BG BG23657A patent/BG21408A3/xx unknown
- 1973-05-18 BE BE6044169A patent/BE799790A/xx not_active IP Right Cessation
- 1973-05-18 NL NLAANVRAGE7307018,A patent/NL170145C/xx not_active IP Right Cessation
- 1973-05-18 RO RO7374829A patent/RO66278A/ro unknown
- 1973-05-18 RO RO7384621A patent/RO66800A/ro unknown
-
1974
- 1974-11-21 PH PH16542A patent/PH10704A/en unknown
- 1974-11-21 PH PH16541A patent/PH11718A/en unknown
- 1974-11-29 SU SU7402079274A patent/SU580837A3/ru active
- 1974-11-29 SU SU7402079273A patent/SU582762A3/ru active
-
1975
- 1975-01-01 AR AR257863A patent/AR205021A1/es active
- 1975-01-01 AR AR257862A patent/AR207857A1/es active
- 1975-06-12 FR FR7518361A patent/FR2284592A1/fr active Granted
- 1975-08-22 SE SE7509387A patent/SE434399B/xx not_active IP Right Cessation
- 1975-12-23 IL IL48711A patent/IL48711A0/xx unknown
-
1976
- 1976-03-06 AR AR257861A patent/AR212010A1/es active
-
1977
- 1977-09-21 SE SE7710602A patent/SE435838B/xx not_active IP Right Cessation
-
1979
- 1979-05-17 YU YU1171/79A patent/YU36298B/xx unknown
- 1979-05-17 YU YU01170/79A patent/YU117079A/xx unknown
- 1979-07-03 KE KE2975A patent/KE2975A/xx unknown
- 1979-10-11 HK HK725/79A patent/HK72579A/xx unknown
-
1980
- 1980-12-31 MY MY198063A patent/MY8000063A/xx unknown
-
1981
- 1981-05-13 JP JP56072123A patent/JPS5929185B2/ja not_active Expired
- 1981-05-13 JP JP7212181A patent/JPS56167673A/ja active Pending
- 1981-05-13 JP JP7212481A patent/JPS56167675A/ja active Pending
- 1981-05-13 JP JP7212281A patent/JPS56167674A/ja active Pending
-
1984
- 1984-02-02 JP JP59017637A patent/JPS6021976B2/ja not_active Expired
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
NUG | Patent has lapsed |
Ref document number: 7509387-2 Effective date: 19921204 Format of ref document f/p: F |