AR212010A1 - Procedimiento para preparar nuevos compuestos derivados del acido 2-(p-clorofenil)-5-benzoxazolil acetico o propionico,particularmente utiles como agentes activos analgesicos,antipireticos,antiinflamatorios,asi como tamblen inhibidores de la sintesis o liberacion de prostaglandina - Google Patents

Procedimiento para preparar nuevos compuestos derivados del acido 2-(p-clorofenil)-5-benzoxazolil acetico o propionico,particularmente utiles como agentes activos analgesicos,antipireticos,antiinflamatorios,asi como tamblen inhibidores de la sintesis o liberacion de prostaglandina

Info

Publication number
AR212010A1
AR212010A1 AR257861A AR25786176A AR212010A1 AR 212010 A1 AR212010 A1 AR 212010A1 AR 257861 A AR257861 A AR 257861A AR 25786176 A AR25786176 A AR 25786176A AR 212010 A1 AR212010 A1 AR 212010A1
Authority
AR
Argentina
Prior art keywords
inflammatory
agents
inhibistable
inhibista
chlorophenil
Prior art date
Application number
AR257861A
Other languages
English (en)
Original Assignee
Lilly Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Industries Ltd filed Critical Lilly Industries Ltd
Application granted granted Critical
Publication of AR212010A1 publication Critical patent/AR212010A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D263/00Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/56Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/38Heterocyclic compounds having sulfur as a ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00Carboxylic acid nitriles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D263/00Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/56Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D263/57Aryl or substituted aryl radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D263/00Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)
AR257861A 1972-05-18 1976-03-06 Procedimiento para preparar nuevos compuestos derivados del acido 2-(p-clorofenil)-5-benzoxazolil acetico o propionico,particularmente utiles como agentes activos analgesicos,antipireticos,antiinflamatorios,asi como tamblen inhibidores de la sintesis o liberacion de prostaglandina AR212010A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2340972A GB1435721A (en) 1972-05-18 1972-05-18 Benzoxazole derivatives

Publications (1)

Publication Number Publication Date
AR212010A1 true AR212010A1 (es) 1978-04-28

Family

ID=10195157

Family Applications (4)

Application Number Title Priority Date Filing Date
AR247979A AR230991A1 (es) 1972-05-18 1973-05-11 Un procedimiento para preparar nuevos derivados benzoxazolicos
AR257862A AR207857A1 (es) 1972-05-18 1975-01-01 Procedimiento para fabricar un acido benzoxazolico
AR257863A AR205021A1 (es) 1972-05-18 1975-01-01 Intermediarios benzoxazolicos utiles en la preparacion de compuestos biologicamente activos
AR257861A AR212010A1 (es) 1972-05-18 1976-03-06 Procedimiento para preparar nuevos compuestos derivados del acido 2-(p-clorofenil)-5-benzoxazolil acetico o propionico,particularmente utiles como agentes activos analgesicos,antipireticos,antiinflamatorios,asi como tamblen inhibidores de la sintesis o liberacion de prostaglandina

Family Applications Before (3)

Application Number Title Priority Date Filing Date
AR247979A AR230991A1 (es) 1972-05-18 1973-05-11 Un procedimiento para preparar nuevos derivados benzoxazolicos
AR257862A AR207857A1 (es) 1972-05-18 1975-01-01 Procedimiento para fabricar un acido benzoxazolico
AR257863A AR205021A1 (es) 1972-05-18 1975-01-01 Intermediarios benzoxazolicos utiles en la preparacion de compuestos biologicamente activos

Country Status (31)

Country Link
US (1) US3912748A (es)
JP (6) JPS5912672B2 (es)
KR (1) KR780000234B1 (es)
AR (4) AR230991A1 (es)
AT (1) AT333752B (es)
BE (1) BE799790A (es)
BG (1) BG21408A3 (es)
CA (1) CA1029019A (es)
CH (5) CH587834A5 (es)
CS (1) CS200455B2 (es)
CY (1) CY1016A (es)
DD (1) DD105229A5 (es)
DE (1) DE2324443A1 (es)
DK (1) DK140340B (es)
ES (1) ES414863A1 (es)
FR (2) FR2184966B1 (es)
GB (1) GB1435721A (es)
HK (1) HK72579A (es)
HU (1) HU167933B (es)
IE (2) IE37564B1 (es)
IL (2) IL42102A (es)
KE (1) KE2975A (es)
MY (1) MY8000063A (es)
NL (1) NL170145C (es)
PH (3) PH9685A (es)
PL (3) PL94208B1 (es)
RO (2) RO66278A (es)
SE (3) SE386174B (es)
SU (3) SU574157A3 (es)
YU (3) YU130473A (es)
ZA (1) ZA732791B (es)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3888864A (en) 1973-06-29 1975-06-10 Hoffmann La Roche Amino lower alkyl ether derivatives of opium alkaloids
GB1495488A (en) * 1976-06-23 1977-12-21 Ippco Int Pharma Patents Co Es Optically active 2-(2-phenyl-5-benzoxazolyl)propionic acids
US4087437A (en) * 1976-09-07 1978-05-02 Eli Lilly And Company 2-Phenyl-5-benzoxazolylalkanoic acid purification process
GB1590587A (en) * 1977-06-28 1981-06-03 Lilly Industries Ltd Benoxaprofen
IT1099589B (it) * 1978-08-04 1985-09-18 Ravizza Spa Processo per la preparazione di derivati dell'acido benzoxazolil propionico
CA1125768A (en) * 1978-10-31 1982-06-15 Hoffmann-La Roche Limited Benzoxazole derivatives
GB2058381B (en) 1979-07-18 1983-01-19 Fuji Photo Film Co Ltd Colour photographic light-sensitive material containing dye-releasing redox compound
GR75153B (es) * 1981-03-27 1984-07-13 Lilly Co Eli
IT1157295B (it) * 1982-07-19 1987-02-11 Ravizza Spa Processo perfezionato per la preparazione di derivati dell'acido benzoxazolil propionico
DE3413875A1 (de) * 1984-04-12 1985-10-17 Ludwig Heumann & Co GmbH, 8500 Nürnberg Benzothiazolderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltendes arzneimittel
IT1177017B (it) * 1984-10-22 1987-08-26 Ravizza Spa Processo per la preparazione dell'acido 2(4-flurofenil)alfa-metil-5-benzox azoloacetico
US4873259A (en) * 1987-06-10 1989-10-10 Abbott Laboratories Indole, benzofuran, benzothiophene containing lipoxygenase inhibiting compounds
US4822809A (en) * 1987-11-13 1989-04-18 Abbott Laboratories Benzazole lipoxygenase inhibiting compounds
IT1233836B (it) * 1988-01-13 1992-04-21 Euroresearch Srl Sali idrosolubili dell'acido (+)2-(4 fluorofenil)-alfa-metil-5 benzoxazolo acetato.
UA83620C2 (ru) * 2001-12-05 2008-08-11 Уайт Замещенные бензоксазолы и их аналоги как эстрогенные агенты
AU2003283597A1 (en) * 2002-11-16 2004-06-15 Oxford Glycosciences (Uk) Ltd Benzoxazole, benzthiazole and benzimidazole acid derivatives and their use as heparanase inhibitors
WO2004076386A2 (en) 2003-02-25 2004-09-10 Topotarget Uk Limited Carbamic acid compounds comprising a bicyclic heteroaryl group as hdac inhibitors
AU2005315591B2 (en) * 2004-12-15 2011-03-17 Dompe' Farmaceutici S.P.A. 2-arylpropionic acid derivatives and pharmaceutical compositions containing them
PL1888548T3 (pl) 2005-05-26 2013-01-31 Neuron Systems Inc Pochodna chinoliny do leczenia schorzeń siatkówki
JP5369854B2 (ja) 2008-04-21 2013-12-18 住友化学株式会社 有害節足動物防除組成物および縮合複素環化合物
CA2782015C (en) 2009-12-11 2020-08-25 Neuron Systems, Inc. Topical ophthalmic compositions and methods for the treatment of macular degeneration
KR102435676B1 (ko) 2013-01-23 2022-08-24 알데이라 테라퓨틱스, 아이엔씨. 독성 알데히드 관련된 질병 및 치료
EP2948436A4 (en) 2013-01-25 2016-07-13 Aldeyra Therapeutics Inc NOVEL CASES IN THE TREATMENT OF MACULAR GENERATION
WO2016021706A1 (ja) * 2014-08-08 2016-02-11 カズマパートナーズ株式会社 縮合複素環化合物
BR112018003250A2 (pt) 2015-08-21 2018-09-25 Aldeyra Therapeutics Inc compostos deuterados e usos dos mesmos
AU2017264697A1 (en) 2016-05-09 2018-11-22 Aldeyra Therapeutics, Inc. Combination treatment of ocular inflammatory disorders and diseases
WO2018170476A1 (en) 2017-03-16 2018-09-20 Aldeyra Therapeutics, Inc. Polymorphic compounds and uses thereof
CA3077362A1 (en) 2017-10-10 2019-04-18 Aldeyra Therapeutics, Inc. Treatment of inflammatory disorders
US12006298B2 (en) 2018-08-06 2024-06-11 Aldeyra Therapeutics, Inc. Polymorphic compounds and uses thereof
JP7505786B2 (ja) 2018-09-25 2024-06-25 アルデイラ セラピューティクス, インコーポレイテッド ドライアイ疾患を処置するための製剤
WO2020198064A1 (en) 2019-03-26 2020-10-01 Aldeyra Therapeutics, Inc. Ophthalmic formulations and uses thereof
US12098132B2 (en) 2019-05-02 2024-09-24 Aldeyra Therapeutics, Inc. Process for preparation of aldehyde scavenger and intermediates
CA3137301A1 (en) 2019-05-02 2020-11-05 Aldeyra Therapeutics, Inc. Polymorphic compounds and uses thereof
EP4149470A4 (en) 2020-05-13 2024-04-24 Aldeyra Therapeutics, Inc. PHARMACEUTICAL FORMULATIONS AND USES THEREOF

Family Cites Families (8)

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Publication number Priority date Publication date Assignee Title
DD70860A (es) *
BE625278A (es) * 1961-11-27
CH516339A (de) * 1969-03-03 1971-12-15 Ciba Geigy Ag Verwendung von Azolverbindungen als Antioxydantien
DE2118315C3 (de) * 1970-04-20 1975-04-03 Sumitomo Chemical Co., Ltd., Osaka (Japan) 2-(1H)-Chinazolinonderivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
IL37633A (en) * 1970-09-10 1975-08-31 Merck & Co Inc 2-(4-(2-benzoxazolyl)phenyl)alkanoic acid derivatives
DE2115926C3 (de) * 1971-04-01 1978-05-03 C.H. Boehringer Sohn, 6507 Ingelheim 1 -(4-Hydroxy-3-dimethylaminosuIfamidophenyI)-2-aminoäthanderivate, Verfahren zu ihrer Herstellung und diese enthaltende Mittel
GB1491863A (en) * 1973-10-23 1977-11-16 Lilly Industries Ltd 2,5-or 2,6-disubstituted benzoxazoles
GB1590587A (en) * 1977-06-28 1981-06-03 Lilly Industries Ltd Benoxaprofen

Also Published As

Publication number Publication date
IE37564B1 (en) 1977-08-17
FR2184966B1 (es) 1979-01-12
SE7710602L (sv) 1977-09-21
FR2284592A1 (fr) 1976-04-09
DD105229A5 (es) 1974-04-12
ES414863A1 (es) 1976-02-01
JPS5912672B2 (ja) 1984-03-24
DK140340C (es) 1979-12-31
KE2975A (en) 1979-07-20
AT333752B (de) 1976-12-10
YU36298B (en) 1982-06-18
HU167933B (es) 1976-01-28
HK72579A (en) 1979-10-19
YU117179A (en) 1981-08-31
US3912748A (en) 1975-10-14
FR2184966A1 (es) 1973-12-28
JPS5929185B2 (ja) 1984-07-18
SU580837A3 (ru) 1977-11-15
SE434399B (sv) 1984-07-23
IL42102A0 (en) 1973-06-29
JPS6021976B2 (ja) 1985-05-30
SU582762A3 (ru) 1977-11-30
IL42102A (en) 1977-07-31
CS200455B2 (en) 1980-09-15
ZA732791B (en) 1974-12-24
CH595362A5 (es) 1978-02-15
YU117079A (en) 1981-08-31
ATA432573A (de) 1976-04-15
SE386174B (sv) 1976-08-02
BE799790A (fr) 1973-11-19
SE7509387L (sv) 1975-08-22
PH9685A (en) 1976-02-10
CA1029019A (en) 1978-04-04
DK140340B (da) 1979-08-06
JPS56167674A (en) 1981-12-23
CH594643A5 (es) 1978-01-13
PH11718A (en) 1978-05-30
CH587834A5 (es) 1977-05-13
SU574157A3 (ru) 1977-09-25
RO66800A (ro) 1982-03-24
BG21408A3 (bg) 1976-05-20
PH10704A (en) 1977-08-24
NL170145C (nl) 1982-10-01
JPS59161346A (ja) 1984-09-12
DE2324443A1 (de) 1973-11-29
JPS56167645A (en) 1981-12-23
AR230991A1 (es) 1984-08-31
YU130473A (en) 1981-08-31
FR2284592B1 (es) 1979-01-05
CH592071A5 (es) 1977-10-14
MY8000063A (en) 1980-12-31
SE435838B (sv) 1984-10-22
AR205021A1 (es) 1976-03-31
NL7307018A (es) 1973-11-20
IE37564L (en) 1973-11-18
JPS56167673A (en) 1981-12-23
JPS4954363A (es) 1974-05-27
KR780000234B1 (en) 1978-07-01
CH595361A5 (es) 1978-02-15
AR207857A1 (es) 1976-11-08
RO66278A (ro) 1981-06-26
PL94208B1 (es) 1977-07-30
PL89247B1 (es) 1976-11-30
NL170145B (nl) 1982-05-03
PL92565B1 (es) 1977-04-30
GB1435721A (en) 1976-05-12
IL48711A0 (en) 1976-02-29
JPS56167675A (en) 1981-12-23
CY1016A (en) 1979-11-23
AU5590773A (en) 1974-11-21
IE37563L (en) 1973-11-18
IE37563B1 (en) 1977-08-17

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