AU2003283597A1 - Benzoxazole, benzthiazole and benzimidazole acid derivatives and their use as heparanase inhibitors - Google Patents

Benzoxazole, benzthiazole and benzimidazole acid derivatives and their use as heparanase inhibitors

Info

Publication number
AU2003283597A1
AU2003283597A1 AU2003283597A AU2003283597A AU2003283597A1 AU 2003283597 A1 AU2003283597 A1 AU 2003283597A1 AU 2003283597 A AU2003283597 A AU 2003283597A AU 2003283597 A AU2003283597 A AU 2003283597A AU 2003283597 A1 AU2003283597 A1 AU 2003283597A1
Authority
AU
Australia
Prior art keywords
benzthiazole
benzoxazole
acid derivatives
heparanase inhibitors
benzimidazole acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003283597A
Other versions
AU2003283597A8 (en
Inventor
Stephen Martin Courtney
Philip Andrew Hay
David Ian Carter Scopes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oxford Glycosciences UK Ltd
Original Assignee
Oxford Glycosciences UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0226820A external-priority patent/GB0226820D0/en
Priority claimed from GB0319542A external-priority patent/GB0319542D0/en
Application filed by Oxford Glycosciences UK Ltd filed Critical Oxford Glycosciences UK Ltd
Publication of AU2003283597A1 publication Critical patent/AU2003283597A1/en
Publication of AU2003283597A8 publication Critical patent/AU2003283597A8/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D263/57—Aryl or substituted aryl radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2003283597A 2002-11-16 2003-11-17 Benzoxazole, benzthiazole and benzimidazole acid derivatives and their use as heparanase inhibitors Abandoned AU2003283597A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0226820A GB0226820D0 (en) 2002-11-16 2002-11-16 Novel compounds
GB0226820.9 2002-11-16
GB0319542A GB0319542D0 (en) 2003-08-20 2003-08-20 Novel compounds
GB0319542.7 2003-08-20
PCT/GB2003/004991 WO2004046122A2 (en) 2002-11-16 2003-11-17 Benzoxazole, benzthiazole and benzimidazole acid derivatives and their use as heparanase inhibitors

Publications (2)

Publication Number Publication Date
AU2003283597A1 true AU2003283597A1 (en) 2004-06-15
AU2003283597A8 AU2003283597A8 (en) 2004-06-15

Family

ID=32328067

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003283597A Abandoned AU2003283597A1 (en) 2002-11-16 2003-11-17 Benzoxazole, benzthiazole and benzimidazole acid derivatives and their use as heparanase inhibitors

Country Status (2)

Country Link
AU (1) AU2003283597A1 (en)
WO (1) WO2004046122A2 (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006044682A1 (en) * 2004-10-13 2006-04-27 Ptc Therapeutics, Inc. Compounds for nonsense suppression, and methods for their use
EP1688413A1 (en) * 2005-02-03 2006-08-09 Hikma Pharmaceuticals Co. Ltd. Benzoxazole derivatives for the prophylaxis and treatment of inflammatory bowel diseases
WO2006094236A1 (en) * 2005-03-03 2006-09-08 Sirtris Pharmaceuticals, Inc. N-phenyl benzamide derivatives as sirtuin modulators
WO2007042816A1 (en) * 2005-10-12 2007-04-19 Biolipox Ab Benzoxazoles useful in the treatment of inflammation
ATE533485T1 (en) 2005-10-31 2011-12-15 Merck Sharp & Dohme CETP INHIBITORS
EP2038272B8 (en) * 2006-06-30 2013-10-23 Sunesis Pharmaceuticals, Inc. Pyridinonyl pdk1 inhibitors
WO2008071944A1 (en) * 2006-12-14 2008-06-19 Boehringer Ingelheim International Gmbh Benzoxazoles useful in the treatment of inflammation
WO2008086014A2 (en) * 2007-01-09 2008-07-17 Amgen Inc. Bis-aryl amide derivatives useful for the treatment of cancer
MX2011011326A (en) * 2009-04-27 2012-02-13 Elan Pharm Inc Pyridinone antagonists of alpha-4 integrins.
JP6037396B2 (en) 2012-01-27 2016-12-07 国立大学法人富山大学 Serine racemase inhibitor
KR102202242B1 (en) 2014-04-29 2021-01-13 에프엠씨 코포레이션 Pyridazinone herbicides
CN104529729B (en) * 2014-12-31 2016-03-30 浙江永太科技股份有限公司 The preparation method of the fluoro-3-chlorobenzaldehyde of a kind of 2-
CA3003419C (en) 2015-10-28 2023-01-24 Thomas Martin Stevenson Novel pyridazinone herbicides
US11787783B2 (en) 2016-12-13 2023-10-17 Beta Therapeutics Pty Ltd Heparanase inhibitors and use thereof
CN110291073A (en) 2016-12-13 2019-09-27 贝塔医疗私人有限公司 Heparanase inhibitors and application thereof
EP3381908A1 (en) 2017-03-27 2018-10-03 Leadiant Biosciences SA 2-(4-(4-(bromo-methoxybenzamido)benzylamino)phenyl)benzazole derivatives and their use as anti-heparanase
EP3381907A1 (en) 2017-03-27 2018-10-03 Leadiant Biosciences SA Symmetrical 2-aminophenyl-benzazolyl-5-acetate compounds and their use as anti-heparanase
TWI785022B (en) 2017-03-28 2022-12-01 美商富曼西公司 Novel pyridazinone herbicides
US11548867B2 (en) 2017-07-19 2023-01-10 Idea Ya Biosciences, Inc. Amido compounds as AhR modulators
KR102064611B1 (en) 2017-10-13 2020-01-09 이화여자대학교 산학협력단 Benzoxazole derivatives, method for preparing the same and pharmaceutical composition comprising the same
JP7556584B2 (en) * 2019-11-18 2024-09-26 ワイジェイ セラピューティクス インコーポレイテッド Composition for treating spinal cord injury comprising stem cells treated with a novel compound
WO2021116820A1 (en) * 2019-12-10 2021-06-17 Aurobindo Pharma Limited An improved process for the preparation of benoxaprofen
CN117924386B (en) * 2023-12-22 2024-07-12 合肥综合性国家科学中心大健康研究院 HPA1 degradation agent and preparation method and application thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3267081A (en) * 1962-09-19 1966-08-16 Koppers Co Inc Benzothiazole dicarboxylic acids and polymers derived therefrom
GB1435721A (en) * 1972-05-18 1976-05-12 Lilly Industries Ltd Benzoxazole derivatives
JPS4943974A (en) * 1972-09-06 1974-04-25
DE3443594A1 (en) * 1984-11-29 1986-05-28 Bayer Ag, 5090 Leverkusen AMINOPHENYLBENZTHIAZOLE
US4659360A (en) * 1984-11-30 1987-04-21 Fmc Corporation Plant growth and development modification using benzoxazole derivatives
WO2002060374A2 (en) * 2001-01-29 2002-08-08 Insight Strategy And Marketing Ltd Benz-1,3-azole derivatives and their uses as heparanase inhibitors

Also Published As

Publication number Publication date
WO2004046122A3 (en) 2004-07-15
WO2004046122A2 (en) 2004-06-03
AU2003283597A8 (en) 2004-06-15

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase