IT1233836B - Sali idrosolubili dell'acido (+)2-(4 fluorofenil)-alfa-metil-5 benzoxazolo acetato. - Google Patents

Sali idrosolubili dell'acido (+)2-(4 fluorofenil)-alfa-metil-5 benzoxazolo acetato.

Info

Publication number
IT1233836B
IT1233836B IT8819057A IT1905788A IT1233836B IT 1233836 B IT1233836 B IT 1233836B IT 8819057 A IT8819057 A IT 8819057A IT 1905788 A IT1905788 A IT 1905788A IT 1233836 B IT1233836 B IT 1233836B
Authority
IT
Italy
Prior art keywords
acid
lysine
fluorofenil
methy
alfa
Prior art date
Application number
IT8819057A
Other languages
English (en)
Other versions
IT8819057A0 (it
Inventor
Diego Furlan
Original Assignee
Euroresearch Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Euroresearch Srl filed Critical Euroresearch Srl
Publication of IT8819057A0 publication Critical patent/IT8819057A0/it
Priority to IT8819057A priority Critical patent/IT1233836B/it
Priority to US07/293,668 priority patent/US4897408A/en
Priority to DE89100245T priority patent/DE68909619T2/de
Priority to EP89100245A priority patent/EP0324402B1/en
Priority to ES89100245T priority patent/ES2059569T3/es
Priority to AT89100245T priority patent/ATE95516T1/de
Priority to KR1019890000247A priority patent/KR890011866A/ko
Priority to JP1005056A priority patent/JPH02783A/ja
Priority to US07/437,664 priority patent/US5120851A/en
Application granted granted Critical
Publication of IT1233836B publication Critical patent/IT1233836B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D263/57—Aryl or substituted aryl radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IT8819057A 1988-01-13 1988-01-13 Sali idrosolubili dell'acido (+)2-(4 fluorofenil)-alfa-metil-5 benzoxazolo acetato. IT1233836B (it)

Priority Applications (9)

Application Number Priority Date Filing Date Title
IT8819057A IT1233836B (it) 1988-01-13 1988-01-13 Sali idrosolubili dell'acido (+)2-(4 fluorofenil)-alfa-metil-5 benzoxazolo acetato.
US07/293,668 US4897408A (en) 1988-01-13 1989-01-05 Water-soluble lysine salts of (T)2-(4-Fluorophenyl)-alpha-methyl-5-benzoxazole acetic acid and their preparation process
ES89100245T ES2059569T3 (es) 1988-01-13 1989-01-09 Sales solubles en agua del acido (+)2-(4-fluorofenil)-alfa-metil-5-benzoxazol acetico, y su procedimiento de preparacion.
EP89100245A EP0324402B1 (en) 1988-01-13 1989-01-09 Water-soluble salts of (+)2-(4-fluorophenyl)-alpha-methyl-5-benzoxazole acetic acid and their preparation process
DE89100245T DE68909619T2 (de) 1988-01-13 1989-01-09 Wasserlösliche Salze der (+)2-(4-fluorphenyl)-alpha-methyl-5-benzoxazolessigsäure und deren Herstellung.
AT89100245T ATE95516T1 (de) 1988-01-13 1989-01-09 Wasserloesliche salze der (+)2-(4-fluorphenyl)alpha-methyl-5-benzoxazolessigsaeure und deren herstellung.
KR1019890000247A KR890011866A (ko) 1988-01-13 1989-01-12 (+)2-(4- 플루오로페닐)-알파- 메틸-5- 벤즈옥사졸 아세트산의 수용성 염 및 이의 제조방법
JP1005056A JPH02783A (ja) 1988-01-13 1989-01-13 （＋）２―（４―フルオロフェニル）―α―メチル―５―ベンズオキサゾール酢酸の水溶性塩及びそれらの製造方法
US07/437,664 US5120851A (en) 1988-01-13 1989-11-17 Preparation process for making water-soluble lysine salts of (+)2-(4-fluorophenyl)-alpha-methyl-5-benzoxazole acetic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8819057A IT1233836B (it) 1988-01-13 1988-01-13 Sali idrosolubili dell'acido (+)2-(4 fluorofenil)-alfa-metil-5 benzoxazolo acetato.

Publications (2)

Publication Number Publication Date
IT8819057A0 IT8819057A0 (it) 1988-01-13
IT1233836B true IT1233836B (it) 1992-04-21

Family

ID=11154181

Family Applications (1)

Application Number Title Priority Date Filing Date
IT8819057A IT1233836B (it) 1988-01-13 1988-01-13 Sali idrosolubili dell'acido (+)2-(4 fluorofenil)-alfa-metil-5 benzoxazolo acetato.

Country Status (8)

Country Link
US (2) US4897408A (it)
EP (1) EP0324402B1 (it)
JP (1) JPH02783A (it)
KR (1) KR890011866A (it)
AT (1) ATE95516T1 (it)
DE (1) DE68909619T2 (it)
ES (1) ES2059569T3 (it)
IT (1) IT1233836B (it)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2687673B1 (fr) * 1992-01-13 1995-07-07 Jung Jean Sels amines d'acides arylcarboxyliques, sterilisables, solubles dans l'eau, utilises en ophtalmologie et/ou dans la sphere otorhinolaryngologique.

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3598838A (en) * 1967-08-28 1971-08-10 Ajinomoto Kk Method of purifying amino acids
FR2115060A1 (en) * 1970-11-26 1972-07-07 Metabio Freeze-dried acetylsalicylates of lysine and arginine - easily prepd derivs of aspirin
GB1435721A (en) * 1972-05-18 1976-05-12 Lilly Industries Ltd Benzoxazole derivatives
US3988466A (en) * 1973-06-01 1976-10-26 Kyowa Hakko Kogyo Co., Ltd. Prevention of gastric lesions
GB1495488A (en) * 1976-06-23 1977-12-21 Ippco Int Pharma Patents Co Es Optically active 2-(2-phenyl-5-benzoxazolyl)propionic acids
DE2945790A1 (de) * 1978-11-20 1980-05-29 Tanabe Seiyaku Co Neutrales kristallines salz einer basischen l-aminosaeure mit l-apfelsaeure und verfahren zu dessen herstellung
EP0016703A1 (fr) * 1979-03-20 1980-10-01 Lipha, Lyonnaise Industrielle Pharmaceutique Sel de lysine de l'acide (+/-) amino-3 (pyrrolyl-1)-4-alpha-méthyl phényl acétique, procédé de préparation et médicament le contenant
ES488286A0 (es) * 1980-02-05 1980-12-16 Liofilizaciones Esterilizacion Procedimiento para la obtencion de una sal soluble en agua de cefadroxilo
US4434163A (en) * 1981-06-01 1984-02-28 Pfizer Inc. Water-soluble benzothiazine dioxide salts
IN160683B (it) * 1981-06-01 1987-07-25 Pfizer
LU83729A1 (fr) * 1981-11-04 1983-09-01 Galephar Sels d'acide valproique,leur preparation et leur utilisation
US4749694A (en) * 1984-04-26 1988-06-07 Merck & Co., Inc. Novel lysine esters used as absorption
IT1177017B (it) * 1984-10-22 1987-08-26 Ravizza Spa Processo per la preparazione dell'acido 2(4-flurofenil)alfa-metil-5-benzox azoloacetico
IT1207994B (it) * 1986-01-03 1989-06-01 Therapicon Srl Sali idrosulubili di composti adattivita' antiinfiammatoria ed analgesica, loro preparazione ed utilizzo in composizioni farmaceutiche.
IT1197289B (it) * 1986-09-26 1988-11-30 S I F I Societa Ind Farmaceuti Sale di lisina dell'acido 4-bifenilacetico e sue composizioni oftalmiche

Also Published As

Publication number Publication date
EP0324402B1 (en) 1993-10-06
ATE95516T1 (de) 1993-10-15
EP0324402A1 (en) 1989-07-19
KR890011866A (ko) 1989-08-23
DE68909619D1 (de) 1993-11-11
IT8819057A0 (it) 1988-01-13
JPH02783A (ja) 1990-01-05
US5120851A (en) 1992-06-09
ES2059569T3 (es) 1994-11-16
US4897408A (en) 1990-01-30
DE68909619T2 (de) 1994-05-11

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TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19940203