ES2059569T3 - Sales solubles en agua del acido (+)2-(4-fluorofenil)-alfa-metil-5-benzoxazol acetico, y su procedimiento de preparacion. - Google Patents

Sales solubles en agua del acido (+)2-(4-fluorofenil)-alfa-metil-5-benzoxazol acetico, y su procedimiento de preparacion.

Info

Publication number
ES2059569T3
ES2059569T3 ES89100245T ES89100245T ES2059569T3 ES 2059569 T3 ES2059569 T3 ES 2059569T3 ES 89100245 T ES89100245 T ES 89100245T ES 89100245 T ES89100245 T ES 89100245T ES 2059569 T3 ES2059569 T3 ES 2059569T3
Authority
ES
Spain
Prior art keywords
acid
fluorophenyl
acetic
alpha
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89100245T
Other languages
English (en)
Inventor
Diego Furlan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Euroresearch SRL
Original Assignee
Euroresearch SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Euroresearch SRL filed Critical Euroresearch SRL
Application granted granted Critical
Publication of ES2059569T3 publication Critical patent/ES2059569T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D263/57—Aryl or substituted aryl radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE DESCRIBEN SALES SOLUBLES EN AGUA DEL ACIDO (+)2 - (4 FLUOROFENIL) - ALFA - METIL - 5 - BENZOXAZOL - ACETICO CON DL LISINA, D - LISINA O L - LISINA, ADECUADAS PARA LA PREPARACION DE ESPECIALIDADES FARMACEUTICAS, TALES COMO JARABES, POMADAS, SUPOSITORIOS, SOLUCIONES ACUOSAS PARA HIGIENE PERSONAL ETC, Y SU PROCESO DE PREPARACION. DICHAS SALES SE OBTIENEN POR SUSPENSION DEL CITADO ACIDO EN UN DISOLVENTE ORGANICO SOLUBLE O PARCIALMENTE SOLUBLE EN AGUA, AÑADIENDO UNA CANTIDAD EQUIVALENTE DE LA LISINA UTILIZADA Y CRISTALIZANDO LA SAL OBTENIDA.
ES89100245T 1988-01-13 1989-01-09 Sales solubles en agua del acido (+)2-(4-fluorofenil)-alfa-metil-5-benzoxazol acetico, y su procedimiento de preparacion. Expired - Lifetime ES2059569T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8819057A IT1233836B (it) 1988-01-13 1988-01-13 Sali idrosolubili dell'acido (+)2-(4 fluorofenil)-alfa-metil-5 benzoxazolo acetato.

Publications (1)

Publication Number Publication Date
ES2059569T3 true ES2059569T3 (es) 1994-11-16

Family

ID=11154181

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89100245T Expired - Lifetime ES2059569T3 (es) 1988-01-13 1989-01-09 Sales solubles en agua del acido (+)2-(4-fluorofenil)-alfa-metil-5-benzoxazol acetico, y su procedimiento de preparacion.

Country Status (8)

Country Link
US (2) US4897408A (es)
EP (1) EP0324402B1 (es)
JP (1) JPH02783A (es)
KR (1) KR890011866A (es)
AT (1) ATE95516T1 (es)
DE (1) DE68909619T2 (es)
ES (1) ES2059569T3 (es)
IT (1) IT1233836B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2687673B1 (fr) * 1992-01-13 1995-07-07 Jung Jean Sels amines d'acides arylcarboxyliques, sterilisables, solubles dans l'eau, utilises en ophtalmologie et/ou dans la sphere otorhinolaryngologique.

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3598838A (en) * 1967-08-28 1971-08-10 Ajinomoto Kk Method of purifying amino acids
FR2115060A1 (en) * 1970-11-26 1972-07-07 Metabio Freeze-dried acetylsalicylates of lysine and arginine - easily prepd derivs of aspirin
GB1435721A (en) * 1972-05-18 1976-05-12 Lilly Industries Ltd Benzoxazole derivatives
US3988466A (en) * 1973-06-01 1976-10-26 Kyowa Hakko Kogyo Co., Ltd. Prevention of gastric lesions
GB1495488A (en) * 1976-06-23 1977-12-21 Ippco Int Pharma Patents Co Es Optically active 2-(2-phenyl-5-benzoxazolyl)propionic acids
DE2945790C2 (de) * 1978-11-20 1987-03-12 Tanabe Seiyaku Co., Ltd., Osaka Neutrales L-Ornithin-L-malat-dihydrat und neutrales L-Lysin-L-malat-monohydrat und Verfahren zu deren Herstellung
ES489664A1 (es) * 1979-03-20 1980-10-01 Lipha Procedimiento de preparacion de la sal de lisina (+) del a- cido (+) amino-3-(pirrolil-1')-4 -metil-fenil-acetico
ES8101078A1 (es) * 1980-02-05 1980-12-16 Liofilizaciones Esterilizacion Procedimiento para la obtencion de una sal soluble en agua de cefadroxilo
US4434163A (en) * 1981-06-01 1984-02-28 Pfizer Inc. Water-soluble benzothiazine dioxide salts
IN160683B (es) * 1981-06-01 1987-07-25 Pfizer
LU83729A1 (fr) * 1981-11-04 1983-09-01 Galephar Sels d'acide valproique,leur preparation et leur utilisation
US4749694A (en) * 1984-04-26 1988-06-07 Merck & Co., Inc. Novel lysine esters used as absorption
IT1177017B (it) * 1984-10-22 1987-08-26 Ravizza Spa Processo per la preparazione dell'acido 2(4-flurofenil)alfa-metil-5-benzox azoloacetico
IT1207994B (it) * 1986-01-03 1989-06-01 Therapicon Srl Sali idrosulubili di composti adattivita' antiinfiammatoria ed analgesica, loro preparazione ed utilizzo in composizioni farmaceutiche.
IT1197289B (it) * 1986-09-26 1988-11-30 S I F I Societa Ind Farmaceuti Sale di lisina dell'acido 4-bifenilacetico e sue composizioni oftalmiche

Also Published As

Publication number Publication date
EP0324402A1 (en) 1989-07-19
JPH02783A (ja) 1990-01-05
ATE95516T1 (de) 1993-10-15
US4897408A (en) 1990-01-30
DE68909619T2 (de) 1994-05-11
DE68909619D1 (de) 1993-11-11
IT8819057A0 (it) 1988-01-13
IT1233836B (it) 1992-04-21
EP0324402B1 (en) 1993-10-06
KR890011866A (ko) 1989-08-23
US5120851A (en) 1992-06-09

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