DE3870801D1 - Gallensaeure-derivate, verfahren zu ihrer herstellung und pharmazeutische praeparate, die sie enthalten. - Google Patents

Gallensaeure-derivate, verfahren zu ihrer herstellung und pharmazeutische praeparate, die sie enthalten.

Info

Publication number
DE3870801D1
DE3870801D1 DE8888116747T DE3870801T DE3870801D1 DE 3870801 D1 DE3870801 D1 DE 3870801D1 DE 8888116747 T DE8888116747 T DE 8888116747T DE 3870801 T DE3870801 T DE 3870801T DE 3870801 D1 DE3870801 D1 DE 3870801D1
Authority
DE
Germany
Prior art keywords
gallen
contain
production
acid derivatives
pharmaceutical preparations
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8888116747T
Other languages
English (en)
Inventor
Giuliano Frigerio
Roberto Istituto D Pellicciari
Aldo Roda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gipharmex SpA
Original Assignee
Gipharmex SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gipharmex SpA filed Critical Gipharmex SpA
Application granted granted Critical
Publication of DE3870801D1 publication Critical patent/DE3870801D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Nutrition Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE8888116747T 1987-10-20 1988-10-10 Gallensaeure-derivate, verfahren zu ihrer herstellung und pharmazeutische praeparate, die sie enthalten. Expired - Fee Related DE3870801D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT22343/87A IT1223313B (it) 1987-10-20 1987-10-20 Derivati di acidi biliari loro preparazione e composizioni farmaceutiche che li contengono

Publications (1)

Publication Number Publication Date
DE3870801D1 true DE3870801D1 (de) 1992-06-11

Family

ID=11194953

Family Applications (2)

Application Number Title Priority Date Filing Date
DE8888116747T Expired - Fee Related DE3870801D1 (de) 1987-10-20 1988-10-10 Gallensaeure-derivate, verfahren zu ihrer herstellung und pharmazeutische praeparate, die sie enthalten.
DE198888116747T Pending DE312867T1 (de) 1987-10-20 1988-10-10 Gallensaeure-derivate, verfahren zu ihrer herstellung und pharmazeutische praeparate, die sie enthalten.

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE198888116747T Pending DE312867T1 (de) 1987-10-20 1988-10-10 Gallensaeure-derivate, verfahren zu ihrer herstellung und pharmazeutische praeparate, die sie enthalten.

Country Status (8)

Country Link
US (1) US4921848A (de)
EP (1) EP0312867B1 (de)
JP (1) JP2813610B2 (de)
AT (1) ATE75750T1 (de)
DE (2) DE3870801D1 (de)
ES (1) ES2009723T3 (de)
GR (2) GR890300125T1 (de)
IT (1) IT1223313B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1229569B (it) * 1989-04-17 1991-09-04 Giuliani Spa Derivati di acidi biliari, loro preparazione e composizioni farmaceutiche che li contengono.
US5650967A (en) * 1995-07-06 1997-07-22 Micron Technology, Inc. Method and apparatus for writing and erasing flash memory
US6592593B1 (en) * 1998-09-18 2003-07-15 United States Surgical Corporation Endovascular fastener applicator
DK1392714T3 (da) 2001-03-12 2006-01-09 Intercept Pharmaceuticals Inc Steroider som agonister for FXR
ITMI20021532A1 (it) * 2002-07-12 2004-01-12 Roberto Pellicciari Composti chimici
EP1562915A1 (de) 2002-11-22 2005-08-17 SmithKline Beecham Corporation Farnesoid x rezeptor agonisten
EP1568706A1 (de) * 2004-02-26 2005-08-31 Intercept Pharmaceuticals, Inc. Neuer Steroid-Agonist für FXR
US10987362B2 (en) 2004-03-12 2021-04-27 Intercept Pharmaceuticals, Inc. Treatment of fibrosis using FXR ligands
PL1734970T3 (pl) 2004-03-12 2015-05-29 Intercept Pharmaceuticals Inc Leczenie zwłóknienia z zastosowaniem ligandów FXR
ITMI20050912A1 (it) * 2005-05-19 2006-11-20 Erregierre Spa Processo di preparazione di acidi 3-a-ya(b)-diidrossi-6-a(b)-alchil-5b-colanici
JP5292310B2 (ja) 2007-01-19 2013-09-18 インターセプト ファーマシューティカルズ， インコーポレイテッド Ｔｇｒ５調節剤としての２３−置換胆汁酸およびその使用方法
EA020310B1 (ru) 2008-07-30 2014-10-30 Интерсепт Фармасьютикалз, Инк. Модуляторы рецептора tgr5 и их применение
ES2458168T3 (es) 2008-11-19 2014-04-30 Intercept Pharmaceuticals, Inc. Moduladores de TGR5 y método de uso de los mismos
US9982008B2 (en) 2012-06-19 2018-05-29 Intercept Pharmaceuticals, Inc. Preparation and uses of obeticholic acid
CN104781272A (zh) 2012-06-19 2015-07-15 英特塞普特医药品公司 奥贝胆酸的制备、用途和固体形式
EP3006557A1 (de) 2014-10-07 2016-04-13 Heinrich-Heine-Universität Düsseldorf Gallensäuren zur Induzierung hepatischer Differenzierung
CA3000881C (en) 2015-10-07 2024-03-19 Intercept Pharmaceuticals, Inc. Farnesoid x receptor modulators
CN106589039B (zh) * 2015-10-15 2019-12-17 苏州朗科生物技术股份有限公司 一种奥贝胆酸的制备方法及相关化合物
CN106995478A (zh) * 2017-04-07 2017-08-01 华东师范大学 一种熊去氧胆酸的中间体7‑酮基石胆酸的合成方法
CN106939030A (zh) * 2017-04-07 2017-07-11 华东师范大学 一种奥贝胆酸的中间体7‑酮基石胆酸的合成方法
CN107033208A (zh) * 2017-04-07 2017-08-11 华东师范大学 一种7‑酮基石胆酸的合成方法
CN107021994B (zh) * 2017-04-07 2020-12-22 华东师范大学 一种奥贝胆酸的中间体3α-羟基-7-酮-5β-胆甾烷-24-酸的合成方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2615902A (en) * 1950-10-24 1952-10-28 Merck & Co Inc Chemical compounds and processes for preparing the same
US2966499A (en) * 1958-04-09 1960-12-27 Merck & Co Inc Oxidation of cholic acid with chlorine
US2938031A (en) * 1958-12-11 1960-05-24 Searle & Co 17-carboxyalkylated 3-oxygenated 6-methylandrosten-17-ol lactones and intermediates
US3591687A (en) * 1968-03-13 1971-07-06 George A Bray Bile acids and derivatives thereof as anorectic agents
US4172076A (en) * 1977-04-04 1979-10-23 Diamond Shamrock Corporation Process for preparing steroidal acids and their intermediate derivatives
US4460509A (en) 1981-08-19 1984-07-17 Beth Israel Medical Center Chemical synthesis
US4545938A (en) 1983-11-02 1985-10-08 Beth Israel Medical Center Chemical synthesis
US4648995A (en) 1983-11-02 1987-03-10 Beth Israel Medical Center Chemical synthesis

Also Published As

Publication number Publication date
EP0312867B1 (de) 1992-05-06
ATE75750T1 (de) 1992-05-15
GR890300125T1 (en) 1990-01-31
IT1223313B (it) 1990-09-19
ES2009723A4 (es) 1989-10-16
EP0312867A1 (de) 1989-04-26
ES2009723T3 (es) 1993-02-16
JPH01135795A (ja) 1989-05-29
US4921848A (en) 1990-05-01
GR3004980T3 (de) 1993-04-28
DE312867T1 (de) 1989-10-05
IT8722343A0 (it) 1987-10-20
JP2813610B2 (ja) 1998-10-22

Similar Documents

Publication Publication Date Title
DE3870801D1 (de) Gallensaeure-derivate, verfahren zu ihrer herstellung und pharmazeutische praeparate, die sie enthalten.
ATE131173T1 (de) Fluorierte gallensäure-derivate, verfahren zu deren herstellung und pharmazeutische zusammensetzungen daraus.
IS1564B (is) Aðferð við framleiðslu á N1-súbstitúeruðum bensimidasólafleiðum til að nota við lækningar
SE8804036D0 (sv) New use of 11,28-dioxa-4-azatricyclo(22.3.1.0?724,9 )octacos-18-ene derivatives and pharmaceutical compositions containing them
ZA928170B (en) Antiviral 4-substituted-2-deoxy-2,3-didehydro-derivatives of alpha-D-neuraminic acid
FI946073A (fi) Vitamiini D-sarjan, 20-asemassa modifioituja johdannaisia, menetelmä tällaisten johdannaisten valmistamiseksi, menetelmässä käytettäviä välituotteita, mainittuja johdannaisia sisältäviä farmaseuttisia valmisteita ja johdannaisten käyttö lääkeaineiden valmistamiseen
ATE51231T1 (de) Pyrimidopyrimidinderivate, verfahren zu ihrer herstellung, diese enthaltende pharmazeutische zubereitungen und ihre verwendung als antiallergische mittel.
DE3783356D1 (de) Benzimidazolderivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische praeparate.
ATE46164T1 (de) 1,4:3,6-dianhydro-hexit-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
NO933200L (no) Substituerte cykloheksanderivater, fremgangsmåte til fremstilling derav og anvendelsen av forbindelsene til behandling av sykdommer
ATE124953T1 (de) Gallensäure-derivate, verfahren zu deren herstellung und pharmazeutische zusammensetzungen daraus.
ES8404361A1 (es) Un procedimiento para la preparacion de un derivado de cefalosporina.
ES2039267T3 (es) Dihidropiridinamidas, procedimiento para su preparacion y su empleo en medicamentos.
ATE25679T1 (de) Isochinolinderivate, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen und ihre verwendung.
ES8704468A1 (es) Procedimiento para preparar nuevos 1,2,4-triazolo-carbamatos
ES8201169A1 (es) Un procedimiento para la preparacion de derivados de quina- zolina
HUT46214A (en) Process for producing medical preparation suitable for treatment of peptic ulcer
ES8106290A1 (es) Un procedimiento para la preparacion de derivados de pirro- lidina
ATE59035T1 (de) Basisch substituierte benzofurancarbonsaeureamide, verfahren zu ihrer herstellung und sie enthaltende therapeutische mittel.
DE3767533D1 (de) D-nor-7-ergolinderivate, verfahren zu ihrer herstellung, pharmazeutische zubereitung und verwendung.
DE3674250D1 (de) Phenylpyrazinderivate, verfahren zu deren herstellung, pharmazeutische zusammensetzung und verwendung.
ATE95174T1 (de) 1,4-dihydropyridin-derivate, verfahren zu ihrer herstellung, pharmazeutische zusammensetzung und ihre verwendung.
DE3862404D1 (de) Benzylaminoaryl-dihydropyridinelactone, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln.
DE3578065D1 (de) 3-mercapto-2-oxo-1-pyrrolidinessigsaeurederivate, verfahren zur herstellung und pharmazeutische zusammensetzungen die sie enthalten.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee