ATE75750T1 - Gallensaeure-derivate, verfahren zu ihrer herstellung und pharmazeutische praeparate, die sie enthalten. - Google Patents

Gallensaeure-derivate, verfahren zu ihrer herstellung und pharmazeutische praeparate, die sie enthalten.

Info

Publication number
ATE75750T1
ATE75750T1 AT88116747T AT88116747T ATE75750T1 AT E75750 T1 ATE75750 T1 AT E75750T1 AT 88116747 T AT88116747 T AT 88116747T AT 88116747 T AT88116747 T AT 88116747T AT E75750 T1 ATE75750 T1 AT E75750T1
Authority
AT
Austria
Prior art keywords
bil
manufacture
acid derivatives
pharmaceutical preparations
preparations containing
Prior art date
Application number
AT88116747T
Other languages
English (en)
Inventor
Giuliano Frigerio
Roberto Istituto D Pellicciari
Via Del Liceo Perugia
Aldo Roda
Original Assignee
Giuliani Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Giuliani Spa filed Critical Giuliani Spa
Application granted granted Critical
Publication of ATE75750T1 publication Critical patent/ATE75750T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Nutrition Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT88116747T 1987-10-20 1988-10-10 Gallensaeure-derivate, verfahren zu ihrer herstellung und pharmazeutische praeparate, die sie enthalten. ATE75750T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT22343/87A IT1223313B (it) 1987-10-20 1987-10-20 Derivati di acidi biliari loro preparazione e composizioni farmaceutiche che li contengono
EP88116747A EP0312867B1 (de) 1987-10-20 1988-10-10 Gallensäure-Derivate, Verfahren zu ihrer Herstellung und pharmazeutische Präparate, die sie enthalten

Publications (1)

Publication Number Publication Date
ATE75750T1 true ATE75750T1 (de) 1992-05-15

Family

ID=11194953

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88116747T ATE75750T1 (de) 1987-10-20 1988-10-10 Gallensaeure-derivate, verfahren zu ihrer herstellung und pharmazeutische praeparate, die sie enthalten.

Country Status (8)

Country Link
US (1) US4921848A (de)
EP (1) EP0312867B1 (de)
JP (1) JP2813610B2 (de)
AT (1) ATE75750T1 (de)
DE (2) DE312867T1 (de)
ES (1) ES2009723T3 (de)
GR (2) GR890300125T1 (de)
IT (1) IT1223313B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1229569B (it) * 1989-04-17 1991-09-04 Giuliani Spa Derivati di acidi biliari, loro preparazione e composizioni farmaceutiche che li contengono.
US5650967A (en) * 1995-07-06 1997-07-22 Micron Technology, Inc. Method and apparatus for writing and erasing flash memory
JP2002526193A (ja) * 1998-09-18 2002-08-20 ユナイテッド ステイツ サージカル コーポレーション 脈管内ファスナーアプリケータ
CA2440680C (en) 2001-03-12 2010-06-01 Roberto Pellicciari Steroids as agonists for fxr
ITMI20021532A1 (it) * 2002-07-12 2004-01-12 Roberto Pellicciari Composti chimici
WO2004048349A1 (en) 2002-11-22 2004-06-10 Smithkline Beecham Corporation Farnesoid x receptor agonists
EP1568706A1 (de) * 2004-02-26 2005-08-31 Intercept Pharmaceuticals, Inc. Neuer Steroid-Agonist für FXR
US10987362B2 (en) 2004-03-12 2021-04-27 Intercept Pharmaceuticals, Inc. Treatment of fibrosis using FXR ligands
SI1734970T1 (sl) 2004-03-12 2015-04-30 Intercept Pharmaceuticals, Inc. Zdravljenje fibroze z uporabo FXR ligandov
ITMI20050912A1 (it) * 2005-05-19 2006-11-20 Erregierre Spa Processo di preparazione di acidi 3-a-ya(b)-diidrossi-6-a(b)-alchil-5b-colanici
EA017714B1 (ru) * 2007-01-19 2013-02-28 Интерсепт Фармасьютикалз, Инк. Модуляторы tgr5 и способы их применения
BRPI0916735B8 (pt) 2008-07-30 2021-05-25 Intercept Pharmaceuticals Inc compostos moduladores de tgr5, composições farmacêuticas compreendendo os mesmos e seus usos
DK2698375T3 (en) 2008-11-19 2018-05-28 Intercept Pharmaceuticals Inc TGR5 modulators and methods for using them
US9982008B2 (en) 2012-06-19 2018-05-29 Intercept Pharmaceuticals, Inc. Preparation and uses of obeticholic acid
KR101881245B1 (ko) 2012-06-19 2018-07-23 인터셉트 파마슈티컬즈, 인크. 오베티콜산의 제조법, 용도 및 고체 형태
EP3006557A1 (de) 2014-10-07 2016-04-13 Heinrich-Heine-Universität Düsseldorf Gallensäuren zur Induzierung hepatischer Differenzierung
MA45761A (fr) 2015-10-07 2021-04-21 Intercept Pharmaceuticals Inc Modulateurs du récepteur farnésoïde x
CN106589039B (zh) * 2015-10-15 2019-12-17 苏州朗科生物技术股份有限公司 一种奥贝胆酸的制备方法及相关化合物
CN106939030A (zh) * 2017-04-07 2017-07-11 华东师范大学 一种奥贝胆酸的中间体7‑酮基石胆酸的合成方法
CN106995478A (zh) * 2017-04-07 2017-08-01 华东师范大学 一种熊去氧胆酸的中间体7‑酮基石胆酸的合成方法
CN107021994B (zh) * 2017-04-07 2020-12-22 华东师范大学 一种奥贝胆酸的中间体3α-羟基-7-酮-5β-胆甾烷-24-酸的合成方法
CN107033208A (zh) * 2017-04-07 2017-08-11 华东师范大学 一种7‑酮基石胆酸的合成方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2615902A (en) * 1950-10-24 1952-10-28 Merck & Co Inc Chemical compounds and processes for preparing the same
US2966499A (en) * 1958-04-09 1960-12-27 Merck & Co Inc Oxidation of cholic acid with chlorine
US2938031A (en) * 1958-12-11 1960-05-24 Searle & Co 17-carboxyalkylated 3-oxygenated 6-methylandrosten-17-ol lactones and intermediates
US3591687A (en) * 1968-03-13 1971-07-06 George A Bray Bile acids and derivatives thereof as anorectic agents
US4172076A (en) * 1977-04-04 1979-10-23 Diamond Shamrock Corporation Process for preparing steroidal acids and their intermediate derivatives
US4460509A (en) 1981-08-19 1984-07-17 Beth Israel Medical Center Chemical synthesis
US4545938A (en) 1983-11-02 1985-10-08 Beth Israel Medical Center Chemical synthesis
US4648995A (en) 1983-11-02 1987-03-10 Beth Israel Medical Center Chemical synthesis

Also Published As

Publication number Publication date
IT8722343A0 (it) 1987-10-20
ES2009723A4 (es) 1989-10-16
IT1223313B (it) 1990-09-19
DE3870801D1 (de) 1992-06-11
JP2813610B2 (ja) 1998-10-22
GR890300125T1 (en) 1990-01-31
ES2009723T3 (es) 1993-02-16
DE312867T1 (de) 1989-10-05
EP0312867A1 (de) 1989-04-26
JPH01135795A (ja) 1989-05-29
US4921848A (en) 1990-05-01
EP0312867B1 (de) 1992-05-06
GR3004980T3 (de) 1993-04-28

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Legal Events

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee