CS198222B2 - Method of producing derivatives of quinazolone - Google Patents

Method of producing derivatives of quinazolone Download PDF

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Publication number
CS198222B2
CS198222B2 CS768172A CS817276A CS198222B2 CS 198222 B2 CS198222 B2 CS 198222B2 CS 768172 A CS768172 A CS 768172A CS 817276 A CS817276 A CS 817276A CS 198222 B2 CS198222 B2 CS 198222B2
Authority
CS
Czechoslovakia
Prior art keywords
amino
formula
tetrazol
optionally
salts
Prior art date
Application number
CS768172A
Other languages
Czech (cs)
English (en)
Inventor
Kurt Schromm
Anton Mentrup
Ernst-Otto Renth
Armin Fuegner
Original Assignee
Boehringer Sohn Ingelheim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Sohn Ingelheim filed Critical Boehringer Sohn Ingelheim
Priority to CS778041A priority Critical patent/CS198224B2/cs
Priority to CS778040A priority patent/CS198223B2/cs
Priority to CS785382A priority patent/CS198225B2/cs
Priority to CS785381A priority patent/CS198226B2/cs
Publication of CS198222B2 publication Critical patent/CS198222B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CS768172A 1975-12-19 1976-12-14 Method of producing derivatives of quinazolone CS198222B2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CS778041A CS198224B2 (cs) 1975-12-19 1977-12-02 Způsob výroby derivátů chinazolonu
CS778040A CS198223B2 (cs) 1975-12-19 1977-12-02 Způsob výroby derivátů chinazolonu
CS785382A CS198225B2 (cs) 1975-12-19 1978-08-17 Způsob výroby derivátů chinazolonn
CS785381A CS198226B2 (cs) 1975-12-19 1978-08-17 Způsob výroby derivátů chinaxolonu

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19752557425 DE2557425A1 (de) 1975-12-19 1975-12-19 Chinazolonderivate

Publications (1)

Publication Number Publication Date
CS198222B2 true CS198222B2 (en) 1980-05-30

Family

ID=5964943

Family Applications (1)

Application Number Title Priority Date Filing Date
CS768172A CS198222B2 (en) 1975-12-19 1976-12-14 Method of producing derivatives of quinazolone

Country Status (36)

Country Link
US (2) US4083980A (sv)
JP (1) JPS5831350B2 (sv)
AT (1) AT352736B (sv)
AU (1) AU513469B2 (sv)
BE (1) BE849542A (sv)
BG (3) BG24673A3 (sv)
CA (1) CA1199914A (sv)
CH (4) CH627754A5 (sv)
CS (1) CS198222B2 (sv)
DD (1) DD128812A5 (sv)
DE (1) DE2557425A1 (sv)
DK (1) DK149107C (sv)
ES (3) ES454405A1 (sv)
FI (1) FI64159C (sv)
FR (1) FR2335229A1 (sv)
GB (1) GB1572707A (sv)
GR (1) GR62109B (sv)
HK (1) HK12984A (sv)
HU (1) HU172929B (sv)
IE (1) IE45256B1 (sv)
IL (1) IL51124A (sv)
LU (1) LU76417A1 (sv)
MX (1) MX4488E (sv)
MY (1) MY8500078A (sv)
NL (1) NL182535C (sv)
NO (1) NO147450C (sv)
NZ (1) NZ182915A (sv)
PH (1) PH16310A (sv)
PL (5) PL110780B1 (sv)
PT (1) PT65981A (sv)
RO (3) RO75248A (sv)
SE (1) SE431456B (sv)
SG (1) SG55483G (sv)
SU (4) SU645571A3 (sv)
YU (2) YU39048B (sv)
ZA (1) ZA767490B (sv)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4337255A (en) * 1977-07-29 1982-06-29 E. R. Squibb & Sons, Inc. Pyrazolo[1,5-c]quinazoline derivatives and related compounds
HU182009B (en) * 1977-08-19 1983-12-28 Chinoin Gyogyszer Es Vegyeszet Process for producing substituted pirido-square bracket-1,2-a-square bracket closed-pyrimidines, pyrrolo-square bracket-1,2-a-square bracket closed-pyrimidines
DE2739020A1 (de) 1977-08-26 1979-03-01 Schering Ag Pyrido eckige klammer auf 2,1-b eckige klammer zu -chinazolinon-derivate, ihre herstellung und verwendung
US4348396A (en) * 1978-01-23 1982-09-07 Hoffmann-La Roche Inc. Substituted 11-oxo-11H-pyrido[2,1-b]quinazolines and method of inhibiting allergic reactions with them
US4168380A (en) * 1978-04-21 1979-09-18 Hoffmann-La Roche Inc. 7-Methoxy-5-oxo-5H-thiazolo[2,3-b]quinazoline-2-carboxylic acid
US4223031A (en) * 1978-05-05 1980-09-16 Mead Johnson & Company Azolopyrimidinones
US4491587A (en) * 1978-05-05 1985-01-01 Mead Johnson & Company Tetrazole derivatives
US4209620A (en) * 1978-06-19 1980-06-24 Bristol-Myers Company Substituted 3-(1H-tetrazol-5-yl)-4H-pyrido[1,2-a]pyrimidin-4-one derivatives having antiallergy activity
DE2845766A1 (de) * 1978-10-18 1980-04-30 Schering Ag Pyrido eckige klammer auf 2,1-b eckige klammer zu -chinazolinon-derivate, ihre herstellung und verwendung
DE3065963D1 (en) * 1979-01-24 1984-02-02 Warner Lambert Co Pyrazolo (5,1-b) quinazolin-9(4h)-one derivatives, process for their preparation and pharmaceutical compositions containing them
US4282360A (en) * 1979-10-12 1981-08-04 Hoffmann-La Roche Inc. 7-Methylthio or methylsulfinyl-5-oxo-5H-thiazolo[2,3-b]quinazoline-2-carboxylic acid
US4302585A (en) 1980-12-22 1981-11-24 American Home Products Corporation 3-Hydroxy-3-substituted phenylthiazolo[2,3-b]quinazoline-2-alkanoic acids and their lactones
US4395549A (en) 1981-10-02 1983-07-26 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt. 6-Hydrazono-pyrido[2,1-b] quinazoline-11 ones
DE3142727A1 (de) * 1981-10-28 1983-05-05 Basf Ag, 6700 Ludwigshafen Thiazolo (2,3-b)-chinazolone, verfahren zu ihrer herstellung und ihre verwendung zur beeinflussung des pflanzenwachstums
DE3142728A1 (de) * 1981-10-28 1983-05-05 Basf Ag, 6700 Ludwigshafen Herbizide, enthaltend thiazolo(2,3-b)-chinazolone als wirkstoffe, und ihre verwendung zur beeinflussung des pflanzenwachstums
ES8406476A1 (es) * 1982-04-29 1984-07-01 Erba Farmitalia Procedimiento para preparar derivados cicloalifaticos condensados de pirido(1,2-a)pirimidinas sustituidas.
US4551460A (en) * 1982-05-10 1985-11-05 Hoffmann-La Roche Inc. Pyrido[2,1-b]quinazoline derivatives useful as agents for treatment of allergic conditions and vascular disorders involving thrombosis
US4455312A (en) * 1982-08-19 1984-06-19 Portnyagina Vera A 2-(o-Carboxyphenylamino)-6H-pyrimido(2,1-b)-quinazolone-6 and derivatives thereof, and application as antiphlogistics
DE3300477A1 (de) * 1983-01-08 1984-07-12 Boehringer Ingelheim KG, 6507 Ingelheim Neue heterocyclische verbindungen, ihre herstellung und verwendung
GB8300728D0 (en) * 1983-01-12 1983-02-16 Erba Farmitalia Substituted carboxy-thiazolo / 3 2 - a / pyrimidine derivatives
EP0142057A3 (en) * 1983-11-04 1988-03-30 F. Hoffmann-La Roche Ag Thiazoloquinazoline derivatives, their preparation and pharmaceutical compositions containing same
US4588812A (en) * 1984-05-30 1986-05-13 Pennwalt Corporation Substituted 2,3-dihydro-5H-thiazolo[2,3,-b]quinazoline derivatives
US4738964A (en) * 1984-05-30 1988-04-19 Pennwalt Corporation Method of suppressing the immune system comprising administering 5H-thiazolo[2,3-b]quinazoline-3(2H)-one
JPS61204475A (ja) * 1985-03-07 1986-09-10 松下電工株式会社 ２台収納立体ガレ−ジのパレツト落下防止装置
DE3634532A1 (de) * 1986-10-10 1988-04-14 Basf Ag Verfahren zur herstellung von thiazolo-(2,3-b)chinazolonen
DE3704203A1 (de) * 1987-02-11 1988-08-25 Boehringer Ingelheim Kg Verwendung von oxochinazolinderivaten bei der behandlung der hyperurikaemie
US4904667A (en) * 1989-02-24 1990-02-27 Ortho Pharmaceutical Corporation 1H-1,2,4-thiadiazolo(3,4-b)quinazolin-5-one-2,2-dioxides, and a method for increasing the cardiac output of a mammal with them
AU2001234420A1 (en) * 2000-02-03 2001-08-14 Eli Lilly And Company Potentiators of glutamate receptors
US8946223B2 (en) 2010-04-12 2015-02-03 Millennium Pharmaceuticals, Inc. Substituted hydroxamic acids and uses thereof
WO2012054332A1 (en) 2010-10-18 2012-04-26 Millennium Pharmaceuticals, Inc. Substituted hydroxamic acids and uses thereof
US10112915B2 (en) 2015-02-02 2018-10-30 Forma Therapeutics, Inc. 3-aryl bicyclic [4,5,0] hydroxamic acids as HDAC inhibitors
TW201636329A (zh) 2015-02-02 2016-10-16 佛瑪治療公司 作為ｈｄａｃ抑制劑之雙環［４，６，０］異羥肟酸
US10555935B2 (en) 2016-06-17 2020-02-11 Forma Therapeutics, Inc. 2-spiro-5- and 6-hydroxamic acid indanes as HDAC inhibitors

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1242863A (en) * 1968-05-10 1971-08-18 Pharmacia As 2,3-DIHYDRO-5H-THIAZOLO[2,3-b]QUINAZOLINES AND PROCESSES FOR THE PREPARATION THEREOF
US3598823A (en) * 1969-05-28 1971-08-10 Sandoz Ag Tricyclic quinazolinones
CA984842A (en) 1972-02-28 1976-03-02 Charles M. Hall 1,4,6,9-tetrahydro-4,6-dioxopyrido-(3,2-g)-quinoline-2,8-dicarboxylic acid compounds
US3833588A (en) * 1972-04-25 1974-09-03 Sandoz Ag Unsaturated-substituted tricyclic quinazolinones
JPS5752352B2 (sv) * 1974-02-28 1982-11-06
US4012387A (en) * 1975-09-18 1977-03-15 Warner-Lambert Company Benzo-[g]pyrido[2,1-b]quinazolinones
US4033961A (en) * 1975-10-07 1977-07-05 Warner-Lambert Company Pyrido[2-1-b]quinazolin-ones and their methods of preparation
US4142049A (en) * 1976-10-18 1979-02-27 Warner-Lambert Company Benzo[g]pyrido[2,1-b]quinazolinones
US4066767A (en) * 1976-11-01 1978-01-03 Warner-Lambert Company 8-(1H-Tetrazol-5-yl)-11H-pyrido[2,1-b]quinazolin-11-ones and method of treating bronchial asthma using them
IL54326A (en) * 1977-03-24 1982-04-30 Sparamedica Ag Polysubstituted pyrido(2,1-b)quinazolin-11-one derivatives,their preparation and pharmaceutical compositions containing them
DE2739020A1 (de) * 1977-08-26 1979-03-01 Schering Ag Pyrido eckige klammer auf 2,1-b eckige klammer zu -chinazolinon-derivate, ihre herstellung und verwendung
US4168380A (en) * 1978-04-21 1979-09-18 Hoffmann-La Roche Inc. 7-Methoxy-5-oxo-5H-thiazolo[2,3-b]quinazoline-2-carboxylic acid

Also Published As

Publication number Publication date
NO147450C (no) 1983-04-13
NL182535B (nl) 1987-11-02
DD128812A5 (de) 1977-12-14
MX4488E (es) 1982-05-21
FR2335229A1 (fr) 1977-07-15
ES454405A1 (es) 1978-01-16
SU784776A3 (ru) 1980-11-30
SU645571A3 (ru) 1979-01-30
NO764303L (sv) 1977-06-21
LU76417A1 (sv) 1978-01-18
ES464136A1 (es) 1978-09-01
RO75734A (ro) 1982-07-06
YU39048B (en) 1984-02-29
FI64159C (fi) 1983-10-10
NO147450B (no) 1983-01-03
FR2335229B1 (sv) 1980-04-11
IL51124A (en) 1980-06-30
GB1572707A (en) 1980-07-30
PL110780B1 (en) 1980-07-31
NZ182915A (en) 1979-07-11
PT65981A (pt) 1977-01-01
PL102308B1 (pl) 1979-03-31
US4083980A (en) 1978-04-11
BE849542A (fr) 1977-06-17
AU2069576A (en) 1978-06-22
AU513469B2 (en) 1980-12-04
RO69411A (ro) 1982-02-01
ES464162A1 (es) 1978-09-01
US4332802A (en) 1982-06-01
BG24673A3 (en) 1978-04-12
YU40078B (en) 1985-06-30
PL111422B1 (en) 1980-08-30
BG25092A3 (en) 1978-07-12
HU172929B (hu) 1979-01-28
JPS5831350B2 (ja) 1983-07-05
DE2557425A1 (de) 1977-06-30
CH627754A5 (de) 1982-01-29
ATA883976A (de) 1979-03-15
MY8500078A (en) 1985-12-31
DK149107C (da) 1986-06-09
JPS5277096A (en) 1977-06-29
SU652894A3 (ru) 1979-03-15
NL7614013A (nl) 1977-06-21
CH625522A5 (sv) 1981-09-30
CH631983A5 (de) 1982-09-15
YU115282A (en) 1983-12-31
YU308276A (en) 1982-08-31
SG55483G (en) 1984-07-27
DE2557425C2 (sv) 1987-03-19
FI64159B (fi) 1983-06-30
PL101141B1 (pl) 1978-12-30
HK12984A (en) 1984-02-24
IE45256B1 (en) 1982-07-28
GR62109B (en) 1979-02-26
IE45256L (en) 1977-06-19
NL182535C (nl) 1988-04-05
ZA767490B (en) 1978-08-30
DK149107B (da) 1986-01-27
SU733516A3 (ru) 1980-05-05
IL51124A0 (en) 1977-02-28
SE7614258L (sv) 1977-06-20
CA1199914A (en) 1986-01-28
AT352736B (de) 1979-10-10
CH625243A5 (sv) 1981-09-15
SE431456B (sv) 1984-02-06
FI763469A (sv) 1977-06-20
DK567376A (da) 1977-06-20
RO75248A (ro) 1980-11-30
PL103556B1 (pl) 1979-06-30
PH16310A (en) 1983-09-05
BG25093A3 (en) 1978-07-12

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