ES464136A1 - Procedimiento para la preparacion de derivados de quinazolo-na. - Google Patents

Procedimiento para la preparacion de derivados de quinazolo-na.

Info

Publication number
ES464136A1
ES464136A1 ES464136A ES464136A ES464136A1 ES 464136 A1 ES464136 A1 ES 464136A1 ES 464136 A ES464136 A ES 464136A ES 464136 A ES464136 A ES 464136A ES 464136 A1 ES464136 A1 ES 464136A1
Authority
ES
Spain
Prior art keywords
amino
tetrazol
lower alkoxy
cyano
hydroxyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES464136A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CH Boehringer Sohn AG and Co KG
Original Assignee
CH Boehringer Sohn AG and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CH Boehringer Sohn AG and Co KG filed Critical CH Boehringer Sohn AG and Co KG
Publication of ES464136A1 publication Critical patent/ES464136A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Abstract

Procedimiento para la preparación de derivados de quinazolana de la fórmula **(Fórmula)** en la que A significa uno de los grupos -CH=CH, -CH=N- o -S-; R1 significa a) hidrógeno, un radical alcohilo o alcoxi inferior, el grupo amino o acetilamino o un anillo bencénico adyacentemente condensado o b) un radical ciano, tetrazol-5-ilo o -COR3; R2 significa un radical ciano, tetrazol-5-ilo o -COR4, o, caso de que R1 tenga uno de los significados indicados en b), también hidrógeno, un radical alcohilo o alcoxi inferior, el grupo amino o acetilamino o un anillo bencénico adyacentemente condensado; R3 significa un radical alcoxi inferior, el grupo amino, hidroxilamino o tetrazol-5-ilamino o, si R2 no representa hidrogeno, también el grupo hidroxi; y R4 significa un radical alcoxi inferior, el grupo hidroxi, amino, hidroxilamino o tetrazol-5-ilamino; en forma de compuestos libres o como sales con ácidos o eventualmente con bases.
ES464136A 1975-12-19 1977-11-15 Procedimiento para la preparacion de derivados de quinazolo-na. Expired ES464136A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19752557425 DE2557425A1 (de) 1975-12-19 1975-12-19 Chinazolonderivate

Publications (1)

Publication Number Publication Date
ES464136A1 true ES464136A1 (es) 1978-09-01

Family

ID=5964943

Family Applications (3)

Application Number Title Priority Date Filing Date
ES454405A Expired ES454405A1 (es) 1975-12-19 1976-12-18 Procedimiento para la preparacion de derivados de quinazoli-na.
ES464162A Expired ES464162A1 (es) 1975-12-19 1977-11-15 Procedimiento para la preparacion de derivados de quinazolo-na.
ES464136A Expired ES464136A1 (es) 1975-12-19 1977-11-15 Procedimiento para la preparacion de derivados de quinazolo-na.

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES454405A Expired ES454405A1 (es) 1975-12-19 1976-12-18 Procedimiento para la preparacion de derivados de quinazoli-na.
ES464162A Expired ES464162A1 (es) 1975-12-19 1977-11-15 Procedimiento para la preparacion de derivados de quinazolo-na.

Country Status (36)

Country Link
US (2) US4083980A (es)
JP (1) JPS5831350B2 (es)
AT (1) AT352736B (es)
AU (1) AU513469B2 (es)
BE (1) BE849542A (es)
BG (3) BG25093A3 (es)
CA (1) CA1199914A (es)
CH (4) CH625522A5 (es)
CS (1) CS198222B2 (es)
DD (1) DD128812A5 (es)
DE (1) DE2557425A1 (es)
DK (1) DK149107C (es)
ES (3) ES454405A1 (es)
FI (1) FI64159C (es)
FR (1) FR2335229A1 (es)
GB (1) GB1572707A (es)
GR (1) GR62109B (es)
HK (1) HK12984A (es)
HU (1) HU172929B (es)
IE (1) IE45256B1 (es)
IL (1) IL51124A (es)
LU (1) LU76417A1 (es)
MX (1) MX4488E (es)
MY (1) MY8500078A (es)
NL (1) NL182535C (es)
NO (1) NO147450C (es)
NZ (1) NZ182915A (es)
PH (1) PH16310A (es)
PL (5) PL110780B1 (es)
PT (1) PT65981A (es)
RO (3) RO69411A (es)
SE (1) SE431456B (es)
SG (1) SG55483G (es)
SU (4) SU645571A3 (es)
YU (2) YU39048B (es)
ZA (1) ZA767490B (es)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4337255A (en) * 1977-07-29 1982-06-29 E. R. Squibb & Sons, Inc. Pyrazolo[1,5-c]quinazoline derivatives and related compounds
HU182009B (en) * 1977-08-19 1983-12-28 Chinoin Gyogyszer Es Vegyeszet Process for producing substituted pirido-square bracket-1,2-a-square bracket closed-pyrimidines, pyrrolo-square bracket-1,2-a-square bracket closed-pyrimidines
DE2739020A1 (de) 1977-08-26 1979-03-01 Schering Ag Pyrido eckige klammer auf 2,1-b eckige klammer zu -chinazolinon-derivate, ihre herstellung und verwendung
US4348396A (en) * 1978-01-23 1982-09-07 Hoffmann-La Roche Inc. Substituted 11-oxo-11H-pyrido[2,1-b]quinazolines and method of inhibiting allergic reactions with them
US4168380A (en) * 1978-04-21 1979-09-18 Hoffmann-La Roche Inc. 7-Methoxy-5-oxo-5H-thiazolo[2,3-b]quinazoline-2-carboxylic acid
US4223031A (en) * 1978-05-05 1980-09-16 Mead Johnson & Company Azolopyrimidinones
US4491587A (en) * 1978-05-05 1985-01-01 Mead Johnson & Company Tetrazole derivatives
US4209620A (en) * 1978-06-19 1980-06-24 Bristol-Myers Company Substituted 3-(1H-tetrazol-5-yl)-4H-pyrido[1,2-a]pyrimidin-4-one derivatives having antiallergy activity
DE2845766A1 (de) * 1978-10-18 1980-04-30 Schering Ag Pyrido eckige klammer auf 2,1-b eckige klammer zu -chinazolinon-derivate, ihre herstellung und verwendung
EP0015065B1 (en) * 1979-01-24 1983-12-28 Warner-Lambert Company Pyrazolo (5,1-b) quinazolin-9(4h)-one derivatives, process for their preparation and pharmaceutical compositions containing them
US4282360A (en) * 1979-10-12 1981-08-04 Hoffmann-La Roche Inc. 7-Methylthio or methylsulfinyl-5-oxo-5H-thiazolo[2,3-b]quinazoline-2-carboxylic acid
US4302585A (en) 1980-12-22 1981-11-24 American Home Products Corporation 3-Hydroxy-3-substituted phenylthiazolo[2,3-b]quinazoline-2-alkanoic acids and their lactones
US4395549A (en) 1981-10-02 1983-07-26 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt. 6-Hydrazono-pyrido[2,1-b] quinazoline-11 ones
DE3142727A1 (de) * 1981-10-28 1983-05-05 Basf Ag, 6700 Ludwigshafen Thiazolo (2,3-b)-chinazolone, verfahren zu ihrer herstellung und ihre verwendung zur beeinflussung des pflanzenwachstums
DE3142728A1 (de) * 1981-10-28 1983-05-05 Basf Ag, 6700 Ludwigshafen Herbizide, enthaltend thiazolo(2,3-b)-chinazolone als wirkstoffe, und ihre verwendung zur beeinflussung des pflanzenwachstums
ES521739A0 (es) * 1982-04-29 1984-07-01 Erba Farmitalia Procedimiento para preparar derivados cicloalifaticos condensados de pirido(1,2-a)pirimidinas sustituidas.
US4551460A (en) * 1982-05-10 1985-11-05 Hoffmann-La Roche Inc. Pyrido[2,1-b]quinazoline derivatives useful as agents for treatment of allergic conditions and vascular disorders involving thrombosis
US4455312A (en) * 1982-08-19 1984-06-19 Portnyagina Vera A 2-(o-Carboxyphenylamino)-6H-pyrimido(2,1-b)-quinazolone-6 and derivatives thereof, and application as antiphlogistics
DE3300477A1 (de) * 1983-01-08 1984-07-12 Boehringer Ingelheim KG, 6507 Ingelheim Neue heterocyclische verbindungen, ihre herstellung und verwendung
GB8300728D0 (en) * 1983-01-12 1983-02-16 Erba Farmitalia Substituted carboxy-thiazolo / 3 2 - a / pyrimidine derivatives
EP0142057A3 (en) * 1983-11-04 1988-03-30 F. Hoffmann-La Roche Ag Thiazoloquinazoline derivatives, their preparation and pharmaceutical compositions containing same
US4588812A (en) * 1984-05-30 1986-05-13 Pennwalt Corporation Substituted 2,3-dihydro-5H-thiazolo[2,3,-b]quinazoline derivatives
US4738964A (en) * 1984-05-30 1988-04-19 Pennwalt Corporation Method of suppressing the immune system comprising administering 5H-thiazolo[2,3-b]quinazoline-3(2H)-one
JPS61204475A (ja) * 1985-03-07 1986-09-10 松下電工株式会社 ２台収納立体ガレ−ジのパレツト落下防止装置
DE3634532A1 (de) * 1986-10-10 1988-04-14 Basf Ag Verfahren zur herstellung von thiazolo-(2,3-b)chinazolonen
DE3704203A1 (de) * 1987-02-11 1988-08-25 Boehringer Ingelheim Kg Verwendung von oxochinazolinderivaten bei der behandlung der hyperurikaemie
US4904667A (en) * 1989-02-24 1990-02-27 Ortho Pharmaceutical Corporation 1H-1,2,4-thiadiazolo(3,4-b)quinazolin-5-one-2,2-dioxides, and a method for increasing the cardiac output of a mammal with them
US6800651B2 (en) 2000-02-03 2004-10-05 Eli Lilly And Company Potentiators of glutamate receptors
WO2011130163A1 (en) 2010-04-12 2011-10-20 Millennium Pharmaceuticals, Inc. Substituted hydroxamic acids and uses thereof
US8765773B2 (en) 2010-10-18 2014-07-01 Millennium Pharmaceuticals, Inc. Substituted hydroxamic acids and uses thereof
MX2020003488A (es) 2015-02-02 2022-05-24 Forma Therapeutics Inc Acidos 3-alquil-4-amido-biciclico [4,5,0] hidroxamicos como inhibidores de histona desacetilasas (hdac).
AR103598A1 (es) 2015-02-02 2017-05-24 Forma Therapeutics Inc Ácidos bicíclicos[4,6,0]hidroxámicos como inhibidores de hdac
EP3472131B1 (en) 2016-06-17 2020-02-19 Forma Therapeutics, Inc. 2-spiro-5- and 6-hydroxamic acid indanes as hdac inhibitors

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1242863A (en) * 1968-05-10 1971-08-18 Pharmacia As 2,3-DIHYDRO-5H-THIAZOLO[2,3-b]QUINAZOLINES AND PROCESSES FOR THE PREPARATION THEREOF
US3598823A (en) * 1969-05-28 1971-08-10 Sandoz Ag Tricyclic quinazolinones
CA984842A (en) 1972-02-28 1976-03-02 Charles M. Hall 1,4,6,9-tetrahydro-4,6-dioxopyrido-(3,2-g)-quinoline-2,8-dicarboxylic acid compounds
US3833588A (en) * 1972-04-25 1974-09-03 Sandoz Ag Unsaturated-substituted tricyclic quinazolinones
JPS5752352B2 (es) * 1974-02-28 1982-11-06
US4012387A (en) * 1975-09-18 1977-03-15 Warner-Lambert Company Benzo-[g]pyrido[2,1-b]quinazolinones
US4033961A (en) * 1975-10-07 1977-07-05 Warner-Lambert Company Pyrido[2-1-b]quinazolin-ones and their methods of preparation
US4142049A (en) * 1976-10-18 1979-02-27 Warner-Lambert Company Benzo[g]pyrido[2,1-b]quinazolinones
US4066767A (en) * 1976-11-01 1978-01-03 Warner-Lambert Company 8-(1H-Tetrazol-5-yl)-11H-pyrido[2,1-b]quinazolin-11-ones and method of treating bronchial asthma using them
NZ186759A (en) * 1977-03-24 1981-03-16 Hoffmann La Roche 11h-pyrido(2,1-b)quinazolin-11-ones
DE2739020A1 (de) * 1977-08-26 1979-03-01 Schering Ag Pyrido eckige klammer auf 2,1-b eckige klammer zu -chinazolinon-derivate, ihre herstellung und verwendung
US4168380A (en) * 1978-04-21 1979-09-18 Hoffmann-La Roche Inc. 7-Methoxy-5-oxo-5H-thiazolo[2,3-b]quinazoline-2-carboxylic acid

Also Published As

Publication number Publication date
CA1199914A (en) 1986-01-28
FR2335229A1 (fr) 1977-07-15
ES454405A1 (es) 1978-01-16
YU39048B (en) 1984-02-29
LU76417A1 (es) 1978-01-18
MX4488E (es) 1982-05-21
RO69411A (ro) 1982-02-01
PL110780B1 (en) 1980-07-31
CH631983A5 (de) 1982-09-15
NL182535C (nl) 1988-04-05
DE2557425C2 (es) 1987-03-19
ES464162A1 (es) 1978-09-01
SE7614258L (sv) 1977-06-20
NO764303L (es) 1977-06-21
RO75248A (ro) 1980-11-30
CH625522A5 (es) 1981-09-30
SE431456B (sv) 1984-02-06
YU40078B (en) 1985-06-30
SU652894A3 (ru) 1979-03-15
JPS5831350B2 (ja) 1983-07-05
NL7614013A (nl) 1977-06-21
PT65981A (pt) 1977-01-01
PH16310A (en) 1983-09-05
SU645571A3 (ru) 1979-01-30
NL182535B (nl) 1987-11-02
FI763469A (es) 1977-06-20
BE849542A (fr) 1977-06-17
NZ182915A (en) 1979-07-11
PL101141B1 (pl) 1978-12-30
DK567376A (da) 1977-06-20
BG25092A3 (en) 1978-07-12
AU2069576A (en) 1978-06-22
AU513469B2 (en) 1980-12-04
NO147450C (no) 1983-04-13
US4083980A (en) 1978-04-11
DD128812A5 (de) 1977-12-14
BG25093A3 (en) 1978-07-12
DK149107C (da) 1986-06-09
YU115282A (en) 1983-12-31
DK149107B (da) 1986-01-27
RO75734A (ro) 1982-07-06
CH627754A5 (de) 1982-01-29
PL111422B1 (en) 1980-08-30
US4332802A (en) 1982-06-01
GB1572707A (en) 1980-07-30
HK12984A (en) 1984-02-24
CH625243A5 (es) 1981-09-15
PL102308B1 (pl) 1979-03-31
MY8500078A (en) 1985-12-31
PL103556B1 (pl) 1979-06-30
GR62109B (en) 1979-02-26
DE2557425A1 (de) 1977-06-30
CS198222B2 (en) 1980-05-30
FR2335229B1 (es) 1980-04-11
ZA767490B (en) 1978-08-30
IE45256L (en) 1977-06-19
IL51124A (en) 1980-06-30
FI64159C (fi) 1983-10-10
JPS5277096A (en) 1977-06-29
SU733516A3 (ru) 1980-05-05
YU308276A (en) 1982-08-31
SG55483G (en) 1984-07-27
IE45256B1 (en) 1982-07-28
IL51124A0 (en) 1977-02-28
BG24673A3 (en) 1978-04-12
AT352736B (de) 1979-10-10
ATA883976A (de) 1979-03-15
NO147450B (no) 1983-01-03
SU784776A3 (ru) 1980-11-30
FI64159B (fi) 1983-06-30
HU172929B (hu) 1979-01-28

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19991118