CR10138A - 1h indoles sustituidos por sulfonilo como ligandos para los receptores 5-hidroxitriptamina - Google Patents
1h indoles sustituidos por sulfonilo como ligandos para los receptores 5-hidroxitriptaminaInfo
- Publication number
- CR10138A CR10138A CR10138A CR10138A CR10138A CR 10138 A CR10138 A CR 10138A CR 10138 A CR10138 A CR 10138A CR 10138 A CR10138 A CR 10138A CR 10138 A CR10138 A CR 10138A
- Authority
- CR
- Costa Rica
- Prior art keywords
- receptors
- hydroxitriptamine
- sulfonyl
- ligands
- hydroxytryptamine
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
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- A61P1/10—Laxatives
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
La presente invención se dirige a compuestos de Fórmula I: que son moduladores de los receptores 5-hidroxitriptamina-6 y 5-hidroxitriptamina-2A y que son inhibidores de retoma de norepinefrina. Los compuestos de la invención, y la composición farmacéutica de estos, son útiles en el tratamiento de trastornos relacionados con o asociados con los receptores 5-hidroxitriptamina-6 y 5-hidroxitriptamina-2A o con la inhibición de retoma de norepinefrina.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US75883306P | 2006-01-13 | 2006-01-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
CR10138A true CR10138A (es) | 2008-10-03 |
Family
ID=38179679
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CR10138A CR10138A (es) | 2006-01-13 | 2008-07-11 | 1h indoles sustituidos por sulfonilo como ligandos para los receptores 5-hidroxitriptamina |
Country Status (16)
Country | Link |
---|---|
US (1) | US7645752B2 (es) |
EP (1) | EP1973876A2 (es) |
JP (1) | JP2009523734A (es) |
KR (1) | KR20080114688A (es) |
CN (1) | CN101370775A (es) |
AU (1) | AU2007206016A1 (es) |
BR (1) | BRPI0706523A2 (es) |
CA (1) | CA2636007A1 (es) |
CR (1) | CR10138A (es) |
EC (1) | ECSP088620A (es) |
IL (1) | IL192695A0 (es) |
MX (1) | MX2008009022A (es) |
NO (1) | NO20083057L (es) |
RU (1) | RU2008127501A (es) |
WO (1) | WO2007084841A2 (es) |
ZA (1) | ZA200806071B (es) |
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MX2010013020A (es) | 2008-05-27 | 2011-03-21 | Intra Cellular Therapies Inc | Metodos y composiciones para trastornos del sueño y otros trastornos. |
CN103201262B (zh) * | 2010-08-20 | 2016-06-01 | 艾米拉医药股份有限公司 | 自分泌运动因子抑制剂及其用途 |
US9260416B2 (en) | 2011-05-27 | 2016-02-16 | Amira Pharmaceuticals, Inc. | Heterocyclic autotaxin inhibitors and uses thereof |
US9708322B2 (en) | 2013-03-15 | 2017-07-18 | Intra-Cellular Therapies, Inc. | Substituted pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalines for inhibiting serotonin reuptake transporter activity |
MX2016007219A (es) | 2013-12-03 | 2016-09-16 | Intra-Cellular Therapies Inc | Metodos novedosos. |
US10077267B2 (en) | 2014-04-04 | 2018-09-18 | Intra-Cellular Therapies, Inc. | Organic compounds |
CA2953004C (en) | 2014-07-08 | 2023-02-21 | Sunshine Lake Pharma Co., Ltd. | Aromatic heterocyclic derivatives and pharmaceutical applications thereof |
CN113786407A (zh) | 2016-01-26 | 2021-12-14 | 细胞内治疗公司 | 有机化合物 |
KR20230003461A (ko) | 2016-03-25 | 2023-01-05 | 인트라-셀룰라 써래피스, 인코퍼레이티드. | 유기 화합물 |
WO2017172795A1 (en) | 2016-03-28 | 2017-10-05 | Intra-Cellular Therapies, Inc. | Novel compositions and methods |
US11014925B2 (en) | 2016-03-28 | 2021-05-25 | Intra-Cellular Therapies, Inc. | Co-crystals of 1-(4-fluoro-phenyl)-4-((6bR,1OaS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H,7H- pyrido[3′,4′:4,51_pyrrolo [1,2,3-delqcuinoxalin-8-yl)-butan-1-one with nicotinamide or isonicotinamide |
WO2017172784A1 (en) | 2016-03-28 | 2017-10-05 | Intra-Cellular Therapies, Inc. | Novel salts and crystals |
JP7013454B2 (ja) | 2016-10-12 | 2022-02-15 | イントラ-セルラー・セラピーズ・インコーポレイテッド | アモルファス固体分散体 |
JP6987868B2 (ja) | 2016-12-29 | 2022-01-05 | イントラ−セルラー・セラピーズ・インコーポレイテッドIntra−Cellular Therapies, Inc. | 有機化合物 |
US10961245B2 (en) | 2016-12-29 | 2021-03-30 | Intra-Cellular Therapies, Inc. | Substituted heterocycle fused gamma-carbolines for treatment of central nervous system disorders |
MX2021013640A (es) | 2017-03-24 | 2022-08-31 | Intra Cellular Therapies Inc | Composiciones novedosas y metodos. |
JP2020526592A (ja) * | 2017-07-13 | 2020-08-31 | トニックス ファーマシューティカルズ ホールディング コーポレーション | シクロベンザプリン類似体及びアミトリプチレン類似体 |
IL272249B2 (en) | 2017-07-26 | 2023-11-01 | Intra Cellular Therapies Inc | organic compounds |
BR112020001654A2 (pt) | 2017-07-26 | 2020-07-21 | Intra-Cellular Therapies, Inc. | compostos orgânicos |
CA3108558A1 (en) | 2018-08-31 | 2020-03-05 | Intra-Cellular Therapies, Inc. | Novel methods |
CN112584837A (zh) | 2018-08-31 | 2021-03-30 | 细胞内治疗公司 | 新方法 |
DK3860998T3 (da) | 2018-10-05 | 2024-03-25 | Annapurna Bio Inc | Forbindelser og sammensætninger til behandlinger af tilstande, der er forbundet med APJ-receptoraktivitet |
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-
2007
- 2007-01-12 RU RU2008127501/04A patent/RU2008127501A/ru not_active Application Discontinuation
- 2007-01-12 EP EP07710091A patent/EP1973876A2/en not_active Withdrawn
- 2007-01-12 BR BRPI0706523-0A patent/BRPI0706523A2/pt not_active Application Discontinuation
- 2007-01-12 AU AU2007206016A patent/AU2007206016A1/en not_active Abandoned
- 2007-01-12 CA CA002636007A patent/CA2636007A1/en not_active Abandoned
- 2007-01-12 CN CNA2007800023497A patent/CN101370775A/zh not_active Withdrawn
- 2007-01-12 US US11/622,649 patent/US7645752B2/en not_active Expired - Fee Related
- 2007-01-12 WO PCT/US2007/060454 patent/WO2007084841A2/en active Application Filing
- 2007-01-12 JP JP2008550530A patent/JP2009523734A/ja not_active Withdrawn
- 2007-01-12 MX MX2008009022A patent/MX2008009022A/es not_active Application Discontinuation
- 2007-01-12 KR KR1020087019566A patent/KR20080114688A/ko not_active Application Discontinuation
-
2008
- 2008-07-08 IL IL192695A patent/IL192695A0/en unknown
- 2008-07-09 NO NO20083057A patent/NO20083057L/no not_active Application Discontinuation
- 2008-07-11 CR CR10138A patent/CR10138A/es not_active Application Discontinuation
- 2008-07-11 ZA ZA200806071A patent/ZA200806071B/xx unknown
- 2008-07-11 EC EC2008008620A patent/ECSP088620A/es unknown
Also Published As
Publication number | Publication date |
---|---|
ECSP088620A (es) | 2008-08-29 |
IL192695A0 (en) | 2009-02-11 |
JP2009523734A (ja) | 2009-06-25 |
EP1973876A2 (en) | 2008-10-01 |
AU2007206016A1 (en) | 2007-07-26 |
KR20080114688A (ko) | 2008-12-31 |
US20070203120A1 (en) | 2007-08-30 |
CA2636007A1 (en) | 2007-07-26 |
ZA200806071B (en) | 2009-04-29 |
BRPI0706523A2 (pt) | 2011-01-04 |
WO2007084841A3 (en) | 2007-09-13 |
NO20083057L (no) | 2008-10-03 |
US7645752B2 (en) | 2010-01-12 |
CN101370775A (zh) | 2009-02-18 |
RU2008127501A (ru) | 2010-02-20 |
MX2008009022A (es) | 2008-09-24 |
WO2007084841A2 (en) | 2007-07-26 |
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