ZA200806071B - Sulfonyl substituted 1H-indoles as ligands for the 5-hydroxytryptamine receptors - Google Patents
Sulfonyl substituted 1H-indoles as ligands for the 5-hydroxytryptamine receptorsInfo
- Publication number
- ZA200806071B ZA200806071B ZA200806071A ZA200806071A ZA200806071B ZA 200806071 B ZA200806071 B ZA 200806071B ZA 200806071 A ZA200806071 A ZA 200806071A ZA 200806071 A ZA200806071 A ZA 200806071A ZA 200806071 B ZA200806071 B ZA 200806071B
- Authority
- ZA
- South Africa
- Prior art keywords
- indoles
- ligands
- sulfonyl substituted
- hydroxytryptamine receptors
- hydroxytryptamine
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
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- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Cardiology (AREA)
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- Diabetes (AREA)
- Hematology (AREA)
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- Vascular Medicine (AREA)
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- Psychology (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Nutrition Science (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Child & Adolescent Psychology (AREA)
- Toxicology (AREA)
- Gynecology & Obstetrics (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US75883306P | 2006-01-13 | 2006-01-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200806071B true ZA200806071B (en) | 2009-04-29 |
Family
ID=38179679
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200806071A ZA200806071B (en) | 2006-01-13 | 2008-07-11 | Sulfonyl substituted 1H-indoles as ligands for the 5-hydroxytryptamine receptors |
Country Status (16)
Country | Link |
---|---|
US (1) | US7645752B2 (xx) |
EP (1) | EP1973876A2 (xx) |
JP (1) | JP2009523734A (xx) |
KR (1) | KR20080114688A (xx) |
CN (1) | CN101370775A (xx) |
AU (1) | AU2007206016A1 (xx) |
BR (1) | BRPI0706523A2 (xx) |
CA (1) | CA2636007A1 (xx) |
CR (1) | CR10138A (xx) |
EC (1) | ECSP088620A (xx) |
IL (1) | IL192695A0 (xx) |
MX (1) | MX2008009022A (xx) |
NO (1) | NO20083057L (xx) |
RU (1) | RU2008127501A (xx) |
WO (1) | WO2007084841A2 (xx) |
ZA (1) | ZA200806071B (xx) |
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US8759579B2 (en) * | 2008-04-23 | 2014-06-24 | Merck Sharp & Dohme Corp. | Cyclobutyl sulfones as notch sparing gamma secretase inhibitors |
CA2725342C (en) * | 2008-05-27 | 2024-02-20 | Intra-Cellular Therapies, Inc. | Substituted heterocycle fused gamma-carbolines for sleep disorders and other disorders |
CN103201262B (zh) | 2010-08-20 | 2016-06-01 | 艾米拉医药股份有限公司 | 自分泌运动因子抑制剂及其用途 |
EP2714680B1 (en) | 2011-05-27 | 2015-11-25 | Amira Pharmaceuticals, Inc. | Heterocyclic autotaxin inhibitors and uses thereof |
EP2968320B1 (en) | 2013-03-15 | 2020-11-11 | Intra-Cellular Therapies, Inc. | Organic compounds |
IL305990A (en) | 2013-12-03 | 2023-11-01 | Intra Cellular Therapies Inc | Compressed gamma-carboline heterocyclic compounds are modified for use in the treatment of type I and/or type II bipolar disorders |
ES2961843T3 (es) | 2014-04-04 | 2024-03-14 | Intra Cellular Therapies Inc | Gamma-carbolinas condensadas con heterociclo deuteradas como antagonistas de los receptores de 5-HT2A |
AU2015286049B2 (en) | 2014-07-08 | 2018-03-01 | Sunshine Lake Pharma Co., Ltd. | Aromatic heterocyclic derivatives and pharmaceutical applications thereof |
CN108883111B (zh) | 2016-01-26 | 2021-10-08 | 细胞内治疗公司 | 有机化合物 |
AU2017238842B2 (en) | 2016-03-25 | 2019-06-20 | Intra-Cellular Therapies, Inc. | Organic compounds |
US10682354B2 (en) | 2016-03-28 | 2020-06-16 | Intra-Cellular Therapies, Inc. | Compositions and methods |
JP2019513143A (ja) | 2016-03-28 | 2019-05-23 | イントラ−セルラー・セラピーズ・インコーポレイテッドIntra−Cellular Therapies, Inc. | 新規塩類および結晶 |
EP3436016B1 (en) | 2016-03-28 | 2022-04-27 | Intra-Cellular Therapies, Inc. | Novel co-crystals |
WO2018071233A1 (en) | 2016-10-12 | 2018-04-19 | Intra-Cellular Therapies, Inc. | Amorphous solid dispersions |
WO2018126143A1 (en) | 2016-12-29 | 2018-07-05 | Intra-Cellular Therapies, Inc. | Organic compounds |
US10961245B2 (en) | 2016-12-29 | 2021-03-30 | Intra-Cellular Therapies, Inc. | Substituted heterocycle fused gamma-carbolines for treatment of central nervous system disorders |
IL268970B2 (en) | 2017-03-24 | 2023-12-01 | Intra Cellular Therapies Inc | Oral preparations of heterocyclic gamma carboline derivatives fused for absorption through mucous membranes |
WO2019014651A1 (en) * | 2017-07-13 | 2019-01-17 | Tonix Pharmaceuticals Holding Corp. | ANALOGUES OF CYCLOBENZAPRINE AND AMITRYPTILENE |
WO2019023063A1 (en) | 2017-07-26 | 2019-01-31 | Intra-Cellular Therapies, Inc. | ORGANIC COMPOUNDS |
JP7223742B2 (ja) | 2017-07-26 | 2023-02-16 | イントラ-セルラー・セラピーズ・インコーポレイテッド | 有機化合物 |
WO2019178484A1 (en) | 2018-03-16 | 2019-09-19 | Intra-Cellular Therapies, Inc. | Novel methods |
WO2019237037A1 (en) | 2018-06-08 | 2019-12-12 | Intra-Cellular Therapies, Inc. | Novel methods |
KR20210052472A (ko) | 2018-08-31 | 2021-05-10 | 인트라-셀룰라 써래피스, 인코퍼레이티드. | 신규한 방법 |
CN112584837A (zh) | 2018-08-31 | 2021-03-30 | 细胞内治疗公司 | 新方法 |
JP2022508648A (ja) | 2018-10-05 | 2022-01-19 | アンナプルナ バイオ インコーポレイテッド | Apj受容体活性に関連する状態を処置するための化合物および組成物 |
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-
2007
- 2007-01-12 MX MX2008009022A patent/MX2008009022A/es not_active Application Discontinuation
- 2007-01-12 WO PCT/US2007/060454 patent/WO2007084841A2/en active Application Filing
- 2007-01-12 AU AU2007206016A patent/AU2007206016A1/en not_active Abandoned
- 2007-01-12 CA CA002636007A patent/CA2636007A1/en not_active Abandoned
- 2007-01-12 JP JP2008550530A patent/JP2009523734A/ja not_active Withdrawn
- 2007-01-12 CN CNA2007800023497A patent/CN101370775A/zh not_active Withdrawn
- 2007-01-12 EP EP07710091A patent/EP1973876A2/en not_active Withdrawn
- 2007-01-12 KR KR1020087019566A patent/KR20080114688A/ko not_active Application Discontinuation
- 2007-01-12 BR BRPI0706523-0A patent/BRPI0706523A2/pt not_active Application Discontinuation
- 2007-01-12 US US11/622,649 patent/US7645752B2/en not_active Expired - Fee Related
- 2007-01-12 RU RU2008127501/04A patent/RU2008127501A/ru not_active Application Discontinuation
-
2008
- 2008-07-08 IL IL192695A patent/IL192695A0/en unknown
- 2008-07-09 NO NO20083057A patent/NO20083057L/no not_active Application Discontinuation
- 2008-07-11 CR CR10138A patent/CR10138A/es not_active Application Discontinuation
- 2008-07-11 ZA ZA200806071A patent/ZA200806071B/xx unknown
- 2008-07-11 EC EC2008008620A patent/ECSP088620A/es unknown
Also Published As
Publication number | Publication date |
---|---|
ECSP088620A (es) | 2008-08-29 |
CA2636007A1 (en) | 2007-07-26 |
WO2007084841A3 (en) | 2007-09-13 |
CR10138A (es) | 2008-10-03 |
RU2008127501A (ru) | 2010-02-20 |
WO2007084841A2 (en) | 2007-07-26 |
US20070203120A1 (en) | 2007-08-30 |
MX2008009022A (es) | 2008-09-24 |
NO20083057L (no) | 2008-10-03 |
US7645752B2 (en) | 2010-01-12 |
CN101370775A (zh) | 2009-02-18 |
BRPI0706523A2 (pt) | 2011-01-04 |
EP1973876A2 (en) | 2008-10-01 |
JP2009523734A (ja) | 2009-06-25 |
KR20080114688A (ko) | 2008-12-31 |
AU2007206016A1 (en) | 2007-07-26 |
IL192695A0 (en) | 2009-02-11 |
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