EP2219629A4 - Novel compounds as cannabinoid receptor ligands - Google Patents
Novel compounds as cannabinoid receptor ligandsInfo
- Publication number
- EP2219629A4 EP2219629A4 EP20080837396 EP08837396A EP2219629A4 EP 2219629 A4 EP2219629 A4 EP 2219629A4 EP 20080837396 EP20080837396 EP 20080837396 EP 08837396 A EP08837396 A EP 08837396A EP 2219629 A4 EP2219629 A4 EP 2219629A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- novel compounds
- receptor ligands
- cannabinoid receptor
- cannabinoid
- ligands
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US97965307P | 2007-10-12 | 2007-10-12 | |
US12/246,808 US9193713B2 (en) | 2007-10-12 | 2008-10-07 | Compounds as cannabinoid receptor ligands |
PCT/US2008/079182 WO2009048936A1 (en) | 2007-10-12 | 2008-10-08 | Novel compounds as cannabinoid receptor ligands |
Publications (2)
Publication Number | Publication Date |
---|---|
EP2219629A1 EP2219629A1 (en) | 2010-08-25 |
EP2219629A4 true EP2219629A4 (en) | 2012-02-29 |
Family
ID=40549525
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP20080837396 Withdrawn EP2219629A4 (en) | 2007-10-12 | 2008-10-08 | Novel compounds as cannabinoid receptor ligands |
Country Status (7)
Country | Link |
---|---|
US (1) | US9193713B2 (en) |
EP (1) | EP2219629A4 (en) |
JP (1) | JP2011500579A (en) |
CN (1) | CN101820868A (en) |
CA (1) | CA2700049A1 (en) |
TW (1) | TW200932222A (en) |
WO (1) | WO2009048936A1 (en) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007140385A2 (en) | 2006-05-31 | 2007-12-06 | Abbott Laboratories | Thiazole compounds as cannabinoid receptor ligands and uses thereof |
US8841334B2 (en) * | 2006-05-31 | 2014-09-23 | Abbvie Inc. | Compounds as cannabinoid receptor ligands and uses thereof |
CA2647598A1 (en) * | 2006-05-31 | 2007-12-06 | Abbott Laboratories | Compounds as cannabinoid receptor ligands and uses thereof |
CN101765594A (en) | 2007-03-28 | 2010-06-30 | 雅培制药有限公司 | 1,3-thiazoles-2 (3H)-ylidene compounds as cannabinoid receptor ligand |
US7872033B2 (en) * | 2007-04-17 | 2011-01-18 | Abbott Laboratories | Compounds as cannabinoid receptor ligands |
WO2008144360A1 (en) * | 2007-05-18 | 2008-11-27 | Abbott Laboratories | Novel compounds as cannabinoid receptor ligands |
US9193713B2 (en) | 2007-10-12 | 2015-11-24 | Abbvie Inc. | Compounds as cannabinoid receptor ligands |
MX2010010023A (en) | 2008-03-11 | 2010-11-30 | Abbott Lab | Novel compounds as cannabinoid receptor ligands. |
US8846730B2 (en) * | 2008-09-08 | 2014-09-30 | Abbvie Inc. | Compounds as cannabinoid receptor ligands |
CN102216277A (en) | 2008-09-16 | 2011-10-12 | 雅培制药有限公司 | Novel compounds as cannabinoid receptor ligands |
PA8854001A1 (en) * | 2008-12-16 | 2010-07-27 | Abbott Lab | NEW COMPOUNDS AS CANABINOID RECEIVERS LIGANDS |
EP2411382A1 (en) | 2009-03-27 | 2012-02-01 | Abbott Laboratories | Compounds as cannabinoid receptor ligands |
JP6404357B2 (en) | 2013-09-19 | 2018-10-10 | ビーエーエスエフ ソシエタス・ヨーロピアBasf Se | N-Acylimino Heterocyclic Compound |
EP3046916A1 (en) * | 2013-09-19 | 2016-07-27 | Basf Se | N-acrylimino heterocyclic compounds |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2254339A1 (en) * | 1973-12-14 | 1975-07-11 | Shionogi & Co | |
JPS57171986A (en) * | 1981-04-14 | 1982-10-22 | Taiho Yakuhin Kogyo Kk | Heterocylic ring compound containing sulfur |
EP0639569A1 (en) * | 1991-03-11 | 1995-02-22 | Nippon Soda Co., Ltd. | Novel heterocyclic compound |
EP1300401A1 (en) * | 2000-06-30 | 2003-04-09 | Sumitomo Pharmaceuticals Company, Limited | Five-membered-ring compound |
EP1640369A1 (en) * | 2003-06-27 | 2006-03-29 | Dainippon Sumitomo Pharma Co., Ltd. | Thiazolimine compound and oxazolimine compound |
EP1820504A1 (en) * | 2004-11-15 | 2007-08-22 | Taisho Pharmaceutical Co., Ltd | Imine compound |
Family Cites Families (116)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1522361A1 (en) | 1966-03-08 | 1969-07-24 | Agfa Gevaert Ag | Sensitization of photosensitive polymers |
US3557142A (en) * | 1968-02-20 | 1971-01-19 | Sterling Drug Inc | 4,5,6,7-tetrahydro-indole-lower-alkanoic acids and esters |
DE1772867A1 (en) | 1968-07-15 | 1971-06-16 | Agfa Gevaert Ag | Sensitization of layers made of photo-crosslinkable polymers |
DE3333450A1 (en) * | 1983-09-16 | 1985-04-11 | Hoechst Ag, 6230 Frankfurt | CARBONYL METHYLENE HETEROCYCLES CONTAINING TRIHALOGEN METHYL GROUPS, METHOD FOR THE PRODUCTION THEREOF AND LIGHT-SENSITIVE MIXTURE THAT CONTAINS THESE COMPOUNDS |
US4978664A (en) * | 1984-08-06 | 1990-12-18 | Sterling Drug Inc. | 3-arylcarbonyl- and 3-cycloalkyl-carbonyl-1-aminoalkyl-1H-indole pharmaceutical compositions |
US4885295A (en) * | 1984-08-06 | 1989-12-05 | Sterling Drug Inc. | Method of use of 3-arylcarbonyl- and 3-cycloalkyl-carbonyl-1-aminoalkyl-1H-indoles |
DE3533331A1 (en) | 1985-09-18 | 1987-03-26 | Heumann Ludwig & Co Gmbh | Pyridothiazole derivatives, process for their preparation, and medicaments containing these compounds |
DE3807381A1 (en) * | 1988-03-07 | 1989-09-21 | Hoechst Ag | HETEROCYCLIC COMPOUNDS CONTAINING 4,6-BIS-TRICHLOROMETHYL-S-TRIAZIN-2-YL-GROUPS, PROCESS FOR THE PREPARATION THEREOF AND LIGHT-SENSITIVE MIXTURE CONTAINING THIS COMPOUND |
TW205041B (en) | 1989-08-07 | 1993-05-01 | Fujisawa Pharmaceutical Co | |
DE4021439A1 (en) * | 1989-12-14 | 1991-06-20 | Bayer Ag | 2-iminopyridine DERIVATIVES |
US6559186B1 (en) * | 1990-02-26 | 2003-05-06 | Arc 1, Inc. | Compositions and methods of treatment of sympathetically maintained pain |
US4973587A (en) * | 1990-03-08 | 1990-11-27 | Sterling Drug Inc. | 3-arylcarbonyl-1-aminoalkyl-1H-indole-containing antiglaucoma method |
US5013837A (en) * | 1990-03-08 | 1991-05-07 | Sterling Drug Inc. | 3-Arylcarbonyl-1H-indole-containing compounds |
DE69325018T2 (en) | 1992-03-03 | 1999-09-16 | Idemitsu Kosan Co | PYRAZOLE DERIVATIVES |
EP0568096B1 (en) | 1992-04-30 | 1998-07-29 | Hodogaya Chemical Co., Ltd. | Benzothiazole derivative and agricultural and horticultural fingicide composition containing the same |
US5654322A (en) * | 1992-08-11 | 1997-08-05 | Wakunaga Seiyaku Kabushiki Kaisha | Biphenylmethane derivatives and pharmaceuticals containing the same |
WO1994022821A1 (en) * | 1993-04-05 | 1994-10-13 | Fujisawa Pharmaceutical Co., Ltd. | Indole derivatives as testosterone 5 alpha-reductase inhibitors |
US5395836A (en) | 1993-04-07 | 1995-03-07 | Kyowa Hakko Kogyo Co., Ltd. | 8-tricycloalkyl xanthine derivatives |
JPH06345736A (en) | 1993-06-14 | 1994-12-20 | Tokuyama Soda Co Ltd | Production of urethane compound |
MY115155A (en) | 1993-09-09 | 2003-04-30 | Upjohn Co | Substituted oxazine and thiazine oxazolidinone antimicrobials. |
CA2189573A1 (en) | 1994-05-17 | 1995-11-23 | Ronald E. Hackler | N-(5-isothiazolyl)amide pesticides |
ES2185707T5 (en) | 1994-07-08 | 2007-05-01 | Ev3 Inc. | INTRAVASCULAR FILTRATION DEVICE. |
FR2735774B1 (en) | 1995-06-21 | 1997-09-12 | Sanofi Sa | USE OF HUMAN CB2 RECEPTOR AGONIST COMPOUNDS FOR THE PREPARATION OF IMMUNOMODULATORY DRUGS, NOVEL CB2 RECEPTOR AGONIST COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
US6277985B1 (en) | 1995-09-15 | 2001-08-21 | Pharmacia & Upjohn Company | Aminoaryl oxazolidinone N-oxides |
US20030220234A1 (en) * | 1998-11-02 | 2003-11-27 | Selvaraj Naicker | Deuterated cyclosporine analogs and their use as immunodulating agents |
US6323214B1 (en) * | 1997-10-29 | 2001-11-27 | Medco Research, Inc | Allosteric adenosine receptor modulators |
US6358992B1 (en) * | 1998-11-25 | 2002-03-19 | Cell Pathways, Inc. | Method of inhibiting neoplastic cells with indole derivatives |
IL145962A0 (en) | 1999-04-20 | 2002-07-25 | Syngenta Ltd | Pesticidal indazole or benzotriazole derivatives |
DE19928033A1 (en) | 1999-06-18 | 2000-12-21 | Basf Ag | Use of cyclic enamines as light stabilizers |
FR2796643B1 (en) | 1999-07-22 | 2005-04-29 | Sod Conseils Rech Applic | 2-ARYLIMINO-2,3-DIHYDROTHIAZOLES DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR THERAPEUTIC USE |
GB9918037D0 (en) * | 1999-07-30 | 1999-09-29 | Biochemie Gmbh | Organic compounds |
WO2001016138A1 (en) | 1999-08-27 | 2001-03-08 | Abbott Laboratories | Sulfonylphenylpyrazole compounds useful as cox-2 inhibitors |
CA2384757A1 (en) | 1999-09-14 | 2001-03-22 | Shionogi & Co., Ltd. | 2-imino-1,3-thiazine derivatives |
WO2001028557A1 (en) | 1999-10-18 | 2001-04-26 | University Of Connecticut | Cannabimimetic indole derivatives |
US7741365B2 (en) | 1999-10-18 | 2010-06-22 | University Of Connecticut | Peripheral cannabinoid receptor (CB2) selective ligands |
IL132661A (en) | 1999-10-31 | 2008-11-26 | Raphael Mechoulam | Agonists specific for the peripheral cannabinoid receptor |
GB0002032D0 (en) | 2000-01-28 | 2000-03-22 | Zeneca Ltd | Chemical compounds |
GB0002034D0 (en) | 2000-01-28 | 2000-03-22 | Zeneca Ltd | Chemical compounds |
US6653304B2 (en) | 2000-02-11 | 2003-11-25 | Bristol-Myers Squibb Co. | Cannabinoid receptor modulators, their processes of preparation, and use of cannabinoid receptor modulators for treating respiratory and non-respiratory diseases |
GB0006289D0 (en) * | 2000-03-15 | 2000-05-03 | Smithkline Beecham Plc | New use |
GB0010437D0 (en) | 2000-04-28 | 2000-06-14 | Darwin Discovery Ltd | Process |
US6369052B1 (en) * | 2000-08-07 | 2002-04-09 | Georgetown University | Combination of huperzine and nicotinic compounds as a neuroprotective agent |
FR2816938B1 (en) * | 2000-11-22 | 2003-01-03 | Sanofi Synthelabo | 3-AROYLINDOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
US7173027B2 (en) | 2001-01-29 | 2007-02-06 | University Of Connecticut | Receptor selective cannabimimetic aminoalkylindoles |
AU2002310441A1 (en) | 2001-06-14 | 2003-01-02 | The Regents Of The University Of California | A novel signaling pathway for the production of inflammatory pain and neuropathy |
US7949668B2 (en) * | 2001-08-20 | 2011-05-24 | Pardalis, Inc. | Common point authoring system for the complex sharing of hierarchically authored data objects in a distribution chain |
WO2003029199A1 (en) | 2001-09-28 | 2003-04-10 | Takeda Chemical Industries, Ltd. | Benzene derivatives, process for preparing the same and use thereof |
AU2002363174B2 (en) * | 2001-11-01 | 2008-09-25 | Janssen Pharmaceutica N.V. | Amide derivatives as glycogen synthase kinase 3-beta inhibitors |
US6727247B2 (en) | 2001-12-10 | 2004-04-27 | Hoffman-La Roche Inc. | Substituted benzothiazole amide derivatives |
WO2003097605A1 (en) * | 2002-05-16 | 2003-11-27 | Bayer Cropscience Gmbh | Pesticidal pyridinecarboxamide derivatives |
JP3902523B2 (en) * | 2002-08-05 | 2007-04-11 | 富士フイルム株式会社 | Optical information recording medium and information recording method |
US20040077617A1 (en) * | 2002-10-22 | 2004-04-22 | Bennani Youssef L. | Fused cycloalkyl amides and acids and their therapeutic applications |
FR2847899B1 (en) | 2002-11-29 | 2006-04-28 | Sanofi Synthelabo | Indole-3-carboxamide derivatives, preparation and application in therapy |
US7390670B2 (en) * | 2003-02-20 | 2008-06-24 | Lumigen, Inc. | Signalling compounds and methods for detecting hydrogen peroxide |
US20040259887A1 (en) | 2003-06-18 | 2004-12-23 | Pfizer Inc | Cannabinoid receptor ligands and uses thereof |
WO2005021547A2 (en) * | 2003-08-28 | 2005-03-10 | Pharmaxis Pty Ltd. | Heterocyclic cannabinoid cb2 receptor antagonists |
EP1670804A2 (en) | 2003-09-10 | 2006-06-21 | GPC Biotech AG | Heterobicyclic compounds as pharmaceutically active agents |
AU2004299198A1 (en) | 2003-12-08 | 2005-06-30 | F. Hoffmann-La Roche Ag | Novel thiazole derivates |
GB0402357D0 (en) | 2004-02-03 | 2004-03-10 | Glaxo Group Ltd | Novel compounds |
US7307163B2 (en) | 2004-04-19 | 2007-12-11 | Symed Labs Limited | Process for the preparation of linezolid and related compounds |
SE0401345D0 (en) | 2004-05-25 | 2004-05-25 | Astrazeneca Ab | Therapeutic compounds: Pyridine as scaffold |
SE0401342D0 (en) | 2004-05-25 | 2004-05-25 | Astrazeneca Ab | Therapeutic compounds |
EP1768967B1 (en) | 2004-07-20 | 2009-04-22 | Symed Labs Limited | Novel intermediates for linezolid and related compounds |
US7511013B2 (en) * | 2004-09-29 | 2009-03-31 | Amr Technology, Inc. | Cyclosporin analogues and their pharmaceutical uses |
EP1833824B1 (en) * | 2004-12-21 | 2016-08-03 | AbbVie Inc. | 3-cycloalkylcarbonyl indoles as cannabinoid receptor ligands |
FR2880023B1 (en) | 2004-12-23 | 2007-02-23 | Sanofi Aventis Sa | N - [(4,5-DIPHENYL-3-ALKYL-2-THIENYL) METHYL] AMINE DERIVATIVES AND THEIR PREPARATION AND THERAPEUTIC USE |
US7759337B2 (en) | 2005-03-03 | 2010-07-20 | Amgen Inc. | Phthalazine compounds and methods of use |
TW200700387A (en) | 2005-03-21 | 2007-01-01 | Akzo Nobel Nv | 1-benzylindole-2-carboxamide derivatives |
US7674912B2 (en) * | 2005-04-25 | 2010-03-09 | H. Lundbeck A/S | Pro-drugs of N-thiazol-2-yl-benzamide derivatives |
US20070155738A1 (en) * | 2005-05-20 | 2007-07-05 | Alantos Pharmaceuticals, Inc. | Heterobicyclic metalloprotease inhibitors |
TW200716636A (en) * | 2005-05-31 | 2007-05-01 | Speedel Experimenta Ag | Heterocyclic spiro-compounds |
US7923465B2 (en) | 2005-06-02 | 2011-04-12 | Glenmark Pharmaceuticals S.A. | Cannabinoid receptor ligands, pharmaceutical compositions containing them, and process for their preparation |
US7514068B2 (en) * | 2005-09-14 | 2009-04-07 | Concert Pharmaceuticals Inc. | Biphenyl-pyrazolecarboxamide compounds |
WO2007046550A1 (en) * | 2005-10-21 | 2007-04-26 | Mitsubishi Tanabe Pharma Corporation | Pyrazole compounds having cannabinoid receptor (cb1) antagonizing activity |
TW200804338A (en) | 2005-11-24 | 2008-01-16 | Astrazeneca Ab | New compounds |
CA2647598A1 (en) | 2006-05-31 | 2007-12-06 | Abbott Laboratories | Compounds as cannabinoid receptor ligands and uses thereof |
US8841334B2 (en) * | 2006-05-31 | 2014-09-23 | Abbvie Inc. | Compounds as cannabinoid receptor ligands and uses thereof |
WO2007140385A2 (en) * | 2006-05-31 | 2007-12-06 | Abbott Laboratories | Thiazole compounds as cannabinoid receptor ligands and uses thereof |
TW200813000A (en) * | 2006-06-27 | 2008-03-16 | Abbott Lab | Thiazoline and oxazoline derivatives and their methods of use |
EP2054393A1 (en) * | 2006-07-28 | 2009-05-06 | Synthon B.V. | Crystalline erlotinib |
US7985768B2 (en) * | 2006-08-31 | 2011-07-26 | Abbott Laboratories | Compounds as cannabinoid receptor ligands |
WO2008028093A1 (en) * | 2006-08-31 | 2008-03-06 | Abbott Laboratories | Compounds as cb2 cannabinoid receptor ligands |
WO2008063781A2 (en) | 2006-10-12 | 2008-05-29 | Abbott Laboratories | Chemical compounds as cannabinoid receptor ligands |
US8796267B2 (en) * | 2006-10-23 | 2014-08-05 | Concert Pharmaceuticals, Inc. | Oxazolidinone derivatives and methods of use |
US9763894B2 (en) * | 2006-12-05 | 2017-09-19 | Virginia Commonwealth University | Inflammation therapy |
TW200831092A (en) * | 2006-12-21 | 2008-08-01 | Astrazeneca Ab | Therapeutic agents |
WO2008079687A1 (en) | 2006-12-22 | 2008-07-03 | Abbott Laboratories | Novel compounds as cannabinoid receptor ligands and uses thereof |
KR101222412B1 (en) * | 2007-02-15 | 2013-01-15 | 에프. 호프만-라 로슈 아게 | 2-aminooxazolines as taar1 ligands |
CN101765594A (en) * | 2007-03-28 | 2010-06-30 | 雅培制药有限公司 | 1,3-thiazoles-2 (3H)-ylidene compounds as cannabinoid receptor ligand |
US8501794B2 (en) * | 2007-04-17 | 2013-08-06 | Abbvie Inc. | Compounds as cannabinoid receptor ligands |
US7872033B2 (en) | 2007-04-17 | 2011-01-18 | Abbott Laboratories | Compounds as cannabinoid receptor ligands |
KR20100012031A (en) * | 2007-04-19 | 2010-02-04 | 콘서트 파마슈티컬즈, 인크. | Deuterated morpholinyl compounds |
WO2008144360A1 (en) | 2007-05-18 | 2008-11-27 | Abbott Laboratories | Novel compounds as cannabinoid receptor ligands |
US7531685B2 (en) * | 2007-06-01 | 2009-05-12 | Protia, Llc | Deuterium-enriched oxybutynin |
US8338623B2 (en) | 2007-07-09 | 2012-12-25 | Abbvie Inc. | Compounds as cannabinoid receptor ligands |
US20090131485A1 (en) * | 2007-09-10 | 2009-05-21 | Concert Pharmaceuticals, Inc. | Deuterated pirfenidone |
US20090118238A1 (en) * | 2007-09-17 | 2009-05-07 | Protia, Llc | Deuterium-enriched alendronate |
US20090088416A1 (en) * | 2007-09-26 | 2009-04-02 | Protia, Llc | Deuterium-enriched lapaquistat |
US20090082471A1 (en) * | 2007-09-26 | 2009-03-26 | Protia, Llc | Deuterium-enriched fingolimod |
WO2009045476A1 (en) * | 2007-10-02 | 2009-04-09 | Concert Pharmaceuticals, Inc. | Pyrimidinedione derivatives |
US9193713B2 (en) | 2007-10-12 | 2015-11-24 | Abbvie Inc. | Compounds as cannabinoid receptor ligands |
US20090105338A1 (en) * | 2007-10-18 | 2009-04-23 | Protia, Llc | Deuterium-enriched gabexate mesylate |
EP2212298B1 (en) * | 2007-10-18 | 2013-03-27 | Concert Pharmaceuticals Inc. | Deuterated etravirine |
US8044071B2 (en) * | 2007-10-18 | 2011-10-25 | Abbott Laboratories | Method for reducing side effects of CB2 receptor agonist therapy using a combination of a selective CB2 receptor agonist and a selective CB1 receptor antagonist |
CA2703591C (en) * | 2007-10-26 | 2013-05-07 | Concert Pharmaceuticals, Inc. | Deuterated darunavir |
CA2706586A1 (en) | 2007-11-21 | 2009-05-28 | Alan S. Florjancic | Novel compounds as cannabinoid receptor ligands and uses thereof |
MX2010010023A (en) * | 2008-03-11 | 2010-11-30 | Abbott Lab | Novel compounds as cannabinoid receptor ligands. |
MX2011001755A (en) * | 2008-08-15 | 2011-03-24 | Abbott Lab | Imine derivatives as cannabinoid receptor ligands. |
US8846730B2 (en) * | 2008-09-08 | 2014-09-30 | Abbvie Inc. | Compounds as cannabinoid receptor ligands |
CN102216277A (en) * | 2008-09-16 | 2011-10-12 | 雅培制药有限公司 | Novel compounds as cannabinoid receptor ligands |
CA2741047A1 (en) | 2008-11-04 | 2010-05-14 | Abbott Laboratories | Novel compounds as cannabinoid receptor ligands |
PA8854001A1 (en) | 2008-12-16 | 2010-07-27 | Abbott Lab | NEW COMPOUNDS AS CANABINOID RECEIVERS LIGANDS |
ES2542234T3 (en) | 2009-03-27 | 2015-08-03 | Abbvie Inc. | Compounds as cannabinoid receptor ligands |
WO2010111573A1 (en) | 2009-03-27 | 2010-09-30 | Abbott Laboratories | Compounds as cannabinoid receptor ligands |
EP2411382A1 (en) * | 2009-03-27 | 2012-02-01 | Abbott Laboratories | Compounds as cannabinoid receptor ligands |
WO2011159785A1 (en) * | 2010-06-15 | 2011-12-22 | Abbott Laboratories | Novel compounds as cannabinoid receptor ligands |
-
2008
- 2008-10-07 US US12/246,808 patent/US9193713B2/en not_active Expired - Fee Related
- 2008-10-08 CA CA 2700049 patent/CA2700049A1/en not_active Abandoned
- 2008-10-08 TW TW97138782A patent/TW200932222A/en unknown
- 2008-10-08 WO PCT/US2008/079182 patent/WO2009048936A1/en active Application Filing
- 2008-10-08 CN CN200880110998A patent/CN101820868A/en active Pending
- 2008-10-08 EP EP20080837396 patent/EP2219629A4/en not_active Withdrawn
- 2008-10-08 JP JP2010528997A patent/JP2011500579A/en active Pending
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2254339A1 (en) * | 1973-12-14 | 1975-07-11 | Shionogi & Co | |
JPS57171986A (en) * | 1981-04-14 | 1982-10-22 | Taiho Yakuhin Kogyo Kk | Heterocylic ring compound containing sulfur |
EP0639569A1 (en) * | 1991-03-11 | 1995-02-22 | Nippon Soda Co., Ltd. | Novel heterocyclic compound |
EP1300401A1 (en) * | 2000-06-30 | 2003-04-09 | Sumitomo Pharmaceuticals Company, Limited | Five-membered-ring compound |
EP1640369A1 (en) * | 2003-06-27 | 2006-03-29 | Dainippon Sumitomo Pharma Co., Ltd. | Thiazolimine compound and oxazolimine compound |
EP1820504A1 (en) * | 2004-11-15 | 2007-08-22 | Taisho Pharmaceutical Co., Ltd | Imine compound |
Non-Patent Citations (4)
Title |
---|
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; SCHUART, J. ET AL: "2-Aminooxazole and 2-iminooxazoline. 3. Chosen examples of the homologous series of 3-substituted-2-imino-4-methyl-5- phenyloxazoline", XP002667122, retrieved from STN Database accession no. 1974:403802 * |
OHTA ET AL: "N-Alkylidenearylcarboxamides as new potent and selective CB2 cannabinoid receptor agonists with good oral bioavailability", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, ELSEVIER SCIENCE, GB, vol. 17, no. 22, 7 September 2007 (2007-09-07), pages 6299 - 6304, XP022297147, ISSN: 0960-894X, DOI: 10.1016/J.BMCL.2007.09.004 * |
See also references of WO2009048936A1 * |
VASIL'EVA V F ET AL: "Synthesis and properties of 2-imino-3-benzyl-5-phenyl-1,3,4-oxadiazoline", CAPLUS, 1970, XP002996394 * |
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US20090105306A1 (en) | 2009-04-23 |
JP2011500579A (en) | 2011-01-06 |
EP2219629A1 (en) | 2010-08-25 |
US9193713B2 (en) | 2015-11-24 |
TW200932222A (en) | 2009-08-01 |
WO2009048936A1 (en) | 2009-04-16 |
CA2700049A1 (en) | 2009-04-16 |
CN101820868A (en) | 2010-09-01 |
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