CO6440523A2 - Análogos de esfingosina-1-fosfato de arilo bicíclico - Google Patents

Análogos de esfingosina-1-fosfato de arilo bicíclico

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Publication number
CO6440523A2
CO6440523A2 CO12029572A CO12029572A CO6440523A2 CO 6440523 A2 CO6440523 A2 CO 6440523A2 CO 12029572 A CO12029572 A CO 12029572A CO 12029572 A CO12029572 A CO 12029572A CO 6440523 A2 CO6440523 A2 CO 6440523A2
Authority
CO
Colombia
Prior art keywords
sphingosine
bicyclic aryl
aryl phosphate
phosphate analogs
analogs
Prior art date
Application number
CO12029572A
Other languages
English (en)
Inventor
Jermaine Thomas
Xiaogao Xiaogao Liu
Arthur G Taversas
Gnanasambandam Kumaravel
Kevin M Guckian
richard d Caldwell
Bin Ma
Guo Zhu Zheng
Edwar Yin-Shiang Lin
Original Assignee
Biogen Idec Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogen Idec Inc filed Critical Biogen Idec Inc
Publication of CO6440523A2 publication Critical patent/CO6440523A2/es

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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Abstract

Se proporcionan compuestos que tienen actividad agonista en uno o más de los receptores de S1P. Los compuestos son análogos de la esfingosina que, tras la fosforilación, pueden comportarse como agonistas en los receptores de S1P.
CO12029572A 2009-08-05 2012-02-20 Análogos de esfingosina-1-fosfato de arilo bicíclico CO6440523A2 (es)

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