IN2012DN01241A - - Google Patents

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Publication number
IN2012DN01241A
IN2012DN01241A IN1241DEN2012A IN2012DN01241A IN 2012DN01241 A IN2012DN01241 A IN 2012DN01241A IN 1241DEN2012 A IN1241DEN2012 A IN 1241DEN2012A IN 2012DN01241 A IN2012DN01241 A IN 2012DN01241A
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IN
India
Prior art keywords
compounds
sip receptors
behave
phosphorylation
agonists
Prior art date
Application number
Inventor
Thomas Jermaine
Liu Xiaogao
Yin-Shiang Lin Edward
Zhu Zheng Guo
Ma Bin
D Caldwell Richard
M Guckian Kevin
Kumaravel Gnanasambandam
G Taveras Arthur
Original Assignee
Biogen Idec Inc
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Application filed by Biogen Idec Inc filed Critical Biogen Idec Inc
Publication of IN2012DN01241A publication Critical patent/IN2012DN01241A/en

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    • A61K31/695—Silicon compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
    • C07C311/51—Y being a hydrogen or a carbon atom
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Abstract

Compounds that have agonist activity at one or more of the SIP receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at SIP receptors.
IN1241DEN2012 2009-08-05 2010-08-05 IN2012DN01241A (en)

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PCT/US2010/044607 WO2011017561A1 (en) 2009-08-05 2010-08-05 Bicyclic aryl sphingosine 1-phosphate analogs

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