CO6251368A2 - Derivados de (1)-2- dihidro-4h, 9h-imidazo[1, 2, 3-ij]-1, 8- naftiridina-4,9-diona o 1, 2-dihidro-3h, 8h-2a,5, 8a- triazaacenaphtileno-3, 8- diona utiles como antibacterianos - Google Patents

Derivados de (1)-2- dihidro-4h, 9h-imidazo[1, 2, 3-ij]-1, 8- naftiridina-4,9-diona o 1, 2-dihidro-3h, 8h-2a,5, 8a- triazaacenaphtileno-3, 8- diona utiles como antibacterianos

Info

Publication number
CO6251368A2
CO6251368A2 CO09116570A CO09116570A CO6251368A2 CO 6251368 A2 CO6251368 A2 CO 6251368A2 CO 09116570 A CO09116570 A CO 09116570A CO 09116570 A CO09116570 A CO 09116570A CO 6251368 A2 CO6251368 A2 CO 6251368A2
Authority
CO
Colombia
Prior art keywords
alkyl
dihidro
diona
hydrogen
substituted
Prior art date
Application number
CO09116570A
Other languages
English (en)
Spanish (es)
Inventor
David Evan Davies
David Thomas Davies
Llaria Giordano
Alan Joseph Hennessy
Neil David Pearson
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39580226&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO6251368(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB0707705A external-priority patent/GB0707705D0/en
Priority claimed from GB0720569A external-priority patent/GB0720569D0/en
Priority claimed from GB0805311A external-priority patent/GB0805311D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of CO6251368A2 publication Critical patent/CO6251368A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/16—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/16—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CO09116570A 2007-04-20 2009-10-19 Derivados de (1)-2- dihidro-4h, 9h-imidazo[1, 2, 3-ij]-1, 8- naftiridina-4,9-diona o 1, 2-dihidro-3h, 8h-2a,5, 8a- triazaacenaphtileno-3, 8- diona utiles como antibacterianos CO6251368A2 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0707705A GB0707705D0 (en) 2007-04-20 2007-04-20 Compounds
GB0720569A GB0720569D0 (en) 2007-10-19 2007-10-19 Compounds
GB0805311A GB0805311D0 (en) 2008-03-20 2008-03-20 Compounds

Publications (1)

Publication Number Publication Date
CO6251368A2 true CO6251368A2 (es) 2011-02-21

Family

ID=39580226

Family Applications (1)

Application Number Title Priority Date Filing Date
CO09116570A CO6251368A2 (es) 2007-04-20 2009-10-19 Derivados de (1)-2- dihidro-4h, 9h-imidazo[1, 2, 3-ij]-1, 8- naftiridina-4,9-diona o 1, 2-dihidro-3h, 8h-2a,5, 8a- triazaacenaphtileno-3, 8- diona utiles como antibacterianos

Country Status (31)

Country Link
US (1) US8389524B2 (enExample)
EP (1) EP2137196B1 (enExample)
JP (1) JP5389013B2 (enExample)
KR (1) KR101567096B1 (enExample)
CN (1) CN101687887B (enExample)
AR (1) AR066111A1 (enExample)
AT (1) ATE483717T1 (enExample)
AU (1) AU2008240764C1 (enExample)
BR (1) BRPI0810064B8 (enExample)
CA (1) CA2684659C (enExample)
CL (1) CL2008001122A1 (enExample)
CO (1) CO6251368A2 (enExample)
CR (2) CR11123A (enExample)
CY (1) CY1111248T1 (enExample)
DE (1) DE602008002912D1 (enExample)
DK (1) DK2137196T3 (enExample)
DO (1) DOP2009000240A (enExample)
EA (1) EA015821B1 (enExample)
HR (1) HRP20100574T1 (enExample)
IL (1) IL201204A0 (enExample)
MA (1) MA31324B1 (enExample)
MX (1) MX2009011317A (enExample)
MY (1) MY149347A (enExample)
NZ (1) NZ579877A (enExample)
PE (1) PE20090274A1 (enExample)
PL (1) PL2137196T3 (enExample)
PT (1) PT2137196E (enExample)
SI (1) SI2137196T1 (enExample)
TW (1) TWI431006B (enExample)
UY (1) UY31038A1 (enExample)
WO (1) WO2008128942A1 (enExample)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20100194T8 (hr) * 2005-10-21 2010-06-30 Glaxo Group Limited Perikondenzirani triciklički spojevi, korisni kao antibakterijska sredstva
EP1847543A1 (de) 2006-04-19 2007-10-24 Boehringer Ingelheim Pharma GmbH & Co. KG Dihydrothienopyrimidine zur Behandlung von entzündlichen Erkrankungen
GB0608263D0 (en) 2006-04-26 2006-06-07 Glaxo Group Ltd Compounds
EP2215093B1 (de) 2007-10-19 2011-12-14 Boehringer Ingelheim International GmbH Neue piperazino-dihydrothienopyrimidin-derivate
RU2500681C2 (ru) 2007-10-19 2013-12-10 Берингер Ингельхайм Интернациональ Гмбх Замещенные гетероциклом пиперазинодигидротиенопиримидины
SI2610258T1 (sl) 2007-10-19 2014-12-31 Boehringer Ingelheim International Gmbh Substituirani piperidino-dihidrotienopirimidini
BRPI0907892A2 (pt) 2008-02-20 2015-07-28 Actelion Pharmaceuticals Ltd Composto antibiótico azatricíclico, medicamento, composição farmacêutica que o contém e uso do mesmo
WO2009141399A1 (en) * 2008-05-23 2009-11-26 Glaxo Group Limited Tricyclic nitrogen containing compounds and their use as antibacterials
CN102105473B (zh) * 2008-05-23 2013-05-08 葛兰素集团有限公司 三环含氮化合物及其作为抗菌剂的用途
JP4833385B1 (ja) 2008-10-07 2011-12-07 アクテリオン ファーマシューティカルズ リミテッド 三環式オキサゾリジノン抗生物質化合物
JP2012505866A (ja) * 2008-10-17 2012-03-08 グラクソ グループ リミテッド 抗菌剤として使用される三環式窒素化合物
CA2749163A1 (en) 2009-01-14 2010-07-22 The Salk Institute For Biological Studies Methods for screening and compounds that protect against amyloid diseases
AR076222A1 (es) 2009-04-09 2011-05-26 Actelion Pharmaceuticals Ltd Derivados 2-hidroxietil-1h-quinolin-ona y sus analogos azaisotericos con actividad antibacteriana y composiciones farmaceuticas que los contienen
TW201130854A (en) 2009-12-22 2011-09-16 Bayer Schering Pharma Ag Pyridinone derivatives and pharmaceutical compositions thereof
JP5857040B2 (ja) 2010-05-04 2016-02-10 アルカーメス ファーマ アイルランド リミテッド 酸化ラクタム化合物の合成方法
US20130059866A1 (en) 2011-08-24 2013-03-07 Boehringer Ingelheim International Gmbh Novel piperidino-dihydrothienopyrimidine sulfoxides and their use for treating copd and asthma
US9802954B2 (en) 2011-08-24 2017-10-31 Boehringer Ingelheim International Gmbh Piperidino-dihydrothienopyrimidine sulfoxides and their use for treating COPD and asthma
CN103113291B (zh) * 2013-02-04 2015-03-04 浙江大学 一种3位烯基吡啶衍生物的合成方法
JP6453216B2 (ja) * 2013-07-23 2019-01-16 エーザイ・アール・アンド・ディー・マネジメント株式会社 ヘテロ縮合環化合物
AR101674A1 (es) 2014-08-22 2017-01-04 Glaxosmithkline Ip Dev Ltd Uso de un compuesto tricíclico que contiene nitrógeno
KR102474326B1 (ko) * 2016-06-22 2022-12-05 반더빌트유니버시티 무스카린성 아세틸콜린 수용체 m4의 양성 알로스테릭 조절제
CA3060545A1 (en) 2017-04-17 2018-10-25 Ohio State Innovation Foundation Type ii topoisomerase inhibitors and methods of making and using thereof
BR112021018815A2 (pt) 2019-04-03 2022-03-03 Glaxosmithkline Ip Dev Ltd Gepotidacina para uso no tratamento de infecções bacterianas do trato urinário
CN114173789A (zh) * 2019-07-05 2022-03-11 葛兰素史克知识产权发展有限公司 用于治疗由生殖支原体引起的感染的组合
JP2023528560A (ja) * 2020-04-02 2023-07-05 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッド ゲポチダシンを用いて淋菌感染症を治療するためのレジメン
CN115667261A (zh) * 2020-04-29 2023-01-31 葛兰素史克知识产权发展有限公司 吉泊达星的结晶形式
CN111494241B (zh) * 2020-06-01 2023-03-24 湖北洁世达环保科技有限公司 一种纸巾柔润保湿液
WO2022167515A1 (en) 2021-02-05 2022-08-11 Glaxosmithkline Intellectual Property Development Limited Oral solid dose formulations
CA3240991A1 (en) 2022-01-21 2023-07-27 Nicole SCANGARELLA-OMAN Gepotidacin and vancomycin for use in the treatment of an infection caused by staphylococcus saprophyticus
EP4316463A1 (en) 2022-08-02 2024-02-07 GlaxoSmithKline Intellectual Property Development Limited Novel formulation
CN119546302A (zh) 2022-09-26 2025-02-28 葛兰素史密斯克莱知识产权发展有限公司 用于治疗细菌性前列腺炎的吉泊达星
CN121537412B (zh) * 2026-01-16 2026-04-03 南京道尔医药研究院有限公司 一种吉泊达星甲磺酸盐的制备方法

Family Cites Families (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6403610B1 (en) 1999-09-17 2002-06-11 Aventis Pharma S.A. Quinolylpropylpiperidine derivatives, their preparation and the compositions which comprise them
US6525049B2 (en) 2000-07-05 2003-02-25 Pharmacia & Upjohn Company Pyrroloquinolones as antiviral agents
US6624159B2 (en) 2000-07-12 2003-09-23 Pharmacia & Upjohn Company Heterocycle carboxamides as antiviral agents
CN1452619A (zh) 2000-07-26 2003-10-29 史密斯克莱·比奇曼公司 具有抗细菌活性的氨基哌啶喹啉和它们的氮杂等排的类似物
US6603005B2 (en) 2000-11-15 2003-08-05 Aventis Pharma S.A. Heterocyclylalkylpiperidine derivatives, their preparation and compositions containing them
GB0031088D0 (en) 2000-12-20 2001-01-31 Smithkline Beecham Plc Medicaments
AU2002219175A1 (en) 2000-12-21 2002-07-01 Ciba Speciality Chemicals Holding Inc. Crystalline forms of cerivastatin sodium
GB0101577D0 (en) 2001-01-22 2001-03-07 Smithkline Beecham Plc Compounds
US6602884B2 (en) 2001-03-13 2003-08-05 Aventis Pharma S.A. Quinolylpropylpiperidine derivatives, their preparation, and compositions containing them
GB0112836D0 (en) 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
GB0112834D0 (en) 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
GB0118238D0 (en) 2001-07-26 2001-09-19 Smithkline Beecham Plc Medicaments
WO2003048081A2 (en) 2001-12-04 2003-06-12 Bristol-Myers Squibb Company Glycinamides as factor xa inhibitors
JP4445753B2 (ja) 2002-01-29 2010-04-07 グラクソ グループ リミテッド アミノピペリジン誘導体
US7109213B2 (en) 2002-01-29 2006-09-19 Glaxo Group Limited Aminopiperidine compounds, process for their preparation, and pharmaceutical compositions containing them
AR040336A1 (es) * 2002-06-26 2005-03-30 Glaxo Group Ltd Compuesto de piperidina, uso del mismo para la fabricacion de un medicamento, composicion farmaceutica que lo comprende y procedimiento para preparar dicho compuesto
AR040335A1 (es) 2002-06-26 2005-03-30 Glaxo Group Ltd Compuesto de ciclohexano o ciclohexeno, uso del mismo para preparar un medicamento, composicion farmaceutica que lo comprende, procedimiento y compuestos intermediarios de utilidad para preparar dicho compuesto
GB0217294D0 (en) 2002-07-25 2002-09-04 Glaxo Group Ltd Medicaments
FR2844268B1 (fr) 2002-09-11 2004-10-22 Aventis Pharma Sa Derives de la quinolyl propyl piperidine, leurs procedes et intermediaires de preparation et les compositions qui les contiennent
FR2844270B1 (fr) 2002-09-11 2006-05-19 Aventis Pharma Sa Derives de la quinolyl propyl piperidine, leur procede et intermediaires de preparation et les compositions qui les contiennent
JP4602903B2 (ja) 2002-10-10 2010-12-22 モルフォケム アクチェンゲゼルシャフト フュア コンビナトリシェ ヘミー 抗菌活性を有する新規化合物
ES2350977T3 (es) 2002-11-05 2011-01-28 Glaxo Group Limited Agentes antibacterianos.
AU2003303956A1 (en) 2002-11-05 2004-11-23 Smithkline Beecham Corporation Antibacterial agents
AR042486A1 (es) 2002-12-18 2005-06-22 Glaxo Group Ltd Compuesto de quinolina y naftiridina halosustituido en la posicion 3, procedimiento para preparar el compuesto, composicion farmaceutica que lo comprende y su uso para preparar dicha composicion .
TW200507841A (en) 2003-03-27 2005-03-01 Glaxo Group Ltd Antibacterial agents
US7232833B2 (en) 2003-03-28 2007-06-19 Novexel 4-substituted quinoline derivatives, method and intermediates for their preparation and pharmaceutical compositions containing them
DE10316081A1 (de) 2003-04-08 2004-10-21 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Neue Verbindungen mit antibakterieller Aktivität
US7348434B2 (en) 2003-08-08 2008-03-25 Antony Bigot 4-substituted quinoline derivatives, method and intermediates for their preparation and pharmaceutical compositions containing them
FR2867472B1 (fr) 2004-03-12 2008-07-18 Aventis Pharma Sa Derives de quinoleines-4-substituees, leurs procede et intermediaires de preparation et les compositions pharmaceutiques qui les contiennent
EP1796466A4 (en) 2004-06-15 2009-09-02 Glaxo Group Ltd ANTIBACTERIAL AGENTS
FR2872164B1 (fr) 2004-06-29 2006-11-17 Aventis Pharma Sa Derives de quinoleines-4-substituees, leur procede et intermediaires de preparation et les compositions pharmaceutiques qui les contiennent
US20070254872A1 (en) 2004-07-08 2007-11-01 Glaxo Group Limited Antibacterial Agents
US20080194547A1 (en) 2004-07-09 2008-08-14 Glaxo Group Limited Antibacterial Agents
JP2008506695A (ja) 2004-07-13 2008-03-06 グラクソ　グループ　リミテッド 抗細菌剤
WO2006012396A1 (en) 2004-07-22 2006-02-02 Glaxo Group Limited Antibacterial agents
ATE484509T1 (de) 2004-08-02 2010-10-15 Glaxo Group Ltd Antibakterielle mittel
EP1784410A4 (en) 2004-08-09 2009-07-15 Glaxo Group Ltd ANTIBACTERIAL AGENTS
DE102004041163A1 (de) 2004-08-25 2006-03-02 Morphochem Aktiengesellschaft für kombinatorische Chemie Neue Verbindungen mit antibakterieller Aktivität
JP4887297B2 (ja) 2004-09-24 2012-02-29 アクテリオン ファーマシューティカルズ リミテッド 新規二環式抗生物質
CA2581057A1 (en) 2004-10-05 2006-04-13 Actelion Pharmaceuticals Ltd New piperidine antibiotics
JP5314244B2 (ja) 2004-10-27 2013-10-16 富山化学工業株式会社 新規な含窒素複素環化合物およびその塩
JP2008528598A (ja) 2005-01-25 2008-07-31 グラクソ グループ リミテッド 抗菌剤
JP2008528586A (ja) 2005-01-25 2008-07-31 グラクソ グループ リミテッド 抗菌剤
JP2008528604A (ja) 2005-01-25 2008-07-31 グラクソ グループ リミテッド 抗菌剤
WO2006081182A2 (en) 2005-01-25 2006-08-03 Glaxo Group Limited Antibacterial agents
EP1845995A4 (en) 2005-01-25 2010-03-03 Glaxo Group Ltd ANTIBACTERIAL AGENTS
WO2006099884A1 (en) 2005-03-24 2006-09-28 Actelion Percurex Ag Beta-aminoalcohol antibiotics
AU2006230364B2 (en) 2005-03-31 2012-09-13 Janssen Pharmaceutica N.V. Bicyclic pyrazole compounds as antibacterial agents
KR20080016577A (ko) 2005-05-24 2008-02-21 아스트라제네카 아베 항균 활성을 갖는 아미노피페리딘 퀴놀린 및 이들의아자이소스테릭 유사체
CA2608687A1 (en) 2005-05-25 2006-11-30 Actelion Pharmaceuticals Ltd. New antibiotic derivatives
MY150958A (en) 2005-06-16 2014-03-31 Astrazeneca Ab Compounds for the treatment of multi-drug resistant bacterial infections
EP2468743A1 (en) * 2005-06-24 2012-06-27 Toyama Chemical Co., Ltd. Nitrogen-containing bicyclic compounds useful as antibacterial agents
HRP20100194T8 (hr) * 2005-10-21 2010-06-30 Glaxo Group Limited Perikondenzirani triciklički spojevi, korisni kao antibakterijska sredstva
WO2007071936A1 (en) 2005-12-22 2007-06-28 Glaxo Group Limited Heterocyclic compounds, their preparation and their use as antibacterials
US7709496B2 (en) 2006-04-06 2010-05-04 Glaxo Group Limited Antibacterial agents
ATE481406T1 (de) 2006-04-06 2010-10-15 Glaxo Group Ltd Pyrrolochinoxalinonderivate als antibakterielle mittel
GB0608263D0 (en) 2006-04-26 2006-06-07 Glaxo Group Ltd Compounds
EP2029612A1 (en) 2006-06-09 2009-03-04 Glaxo Group Limited Substituted 1-methyl-1h-quinolin-2-ones and 1-methyl-1h-1,5-naphthyridin-2-ones as antibacterials
GB0613208D0 (en) 2006-07-03 2006-08-09 Glaxo Group Ltd Compounds
EP1992628A1 (en) 2007-05-18 2008-11-19 Glaxo Group Limited Derivatives and analogs of N-ethylquinolones and N-ethylazaquinolones
GB0705672D0 (en) * 2007-03-23 2007-05-02 Glaxo Group Ltd Compounds
EP1980251A1 (en) 2007-04-13 2008-10-15 Glaxo Group Limited Pyrrolo[3,2,1-ij]quinoline-4-one derivatives for treating tuberculosis
GB0707706D0 (en) 2007-04-20 2007-05-30 Glaxo Group Ltd Compounds
GB0707708D0 (en) 2007-04-20 2007-05-30 Glaxo Group Ltd Compounds
EP2005995A1 (en) 2007-06-22 2008-12-24 Glaxo Group Limited Heterocyclic compounds for the treatment of tuberculosis
GB0800367D0 (en) 2008-01-09 2008-02-20 Glaxo Group Ltd Compounds

Also Published As

Publication number Publication date
JP5389013B2 (ja) 2014-01-15
EP2137196A1 (en) 2009-12-30
CA2684659C (en) 2015-11-24
IL201204A0 (en) 2010-05-17
CL2008001122A1 (es) 2008-10-24
MA31324B1 (fr) 2010-04-01
TW200848420A (en) 2008-12-16
CR20150586A (es) 2016-04-04
AU2008240764B2 (en) 2011-04-07
BRPI0810064B1 (pt) 2021-03-30
BRPI0810064A2 (pt) 2019-08-27
HK1138000A1 (en) 2010-08-13
KR20100017133A (ko) 2010-02-16
DE602008002912D1 (de) 2010-11-18
CA2684659A1 (en) 2008-10-30
TWI431006B (zh) 2014-03-21
WO2008128942A1 (en) 2008-10-30
ATE483717T1 (de) 2010-10-15
PE20090274A1 (es) 2009-04-03
PT2137196E (pt) 2010-12-16
PL2137196T3 (pl) 2011-03-31
MX2009011317A (es) 2009-11-05
HRP20100574T1 (hr) 2010-12-31
US20100137282A1 (en) 2010-06-03
JP2010524884A (ja) 2010-07-22
CR11123A (es) 2010-03-08
UY31038A1 (es) 2008-11-28
US8389524B2 (en) 2013-03-05
AU2008240764C1 (en) 2011-10-20
CY1111248T1 (el) 2015-06-11
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DOP2009000240A (es) 2009-12-31
CN101687887A (zh) 2010-03-31
EA015821B1 (ru) 2011-12-30
SI2137196T1 (sl) 2011-01-31
MY149347A (en) 2013-08-30
BRPI0810064B8 (pt) 2021-05-25
AU2008240764A1 (en) 2008-10-30
EA200970987A1 (ru) 2010-04-30
EP2137196B1 (en) 2010-10-06
NZ579877A (en) 2011-09-30
CN101687887B (zh) 2012-08-29
AR066111A1 (es) 2009-07-22
KR101567096B1 (ko) 2015-11-06

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