CO6210816A2 - Heterociclos biciclicos medicamentos que contienen estos compuestos su utilizacion y procedimientos para su preparacion - Google Patents

Heterociclos biciclicos medicamentos que contienen estos compuestos su utilizacion y procedimientos para su preparacion

Info

Publication number
CO6210816A2
CO6210816A2 CO09081877A CO09081877A CO6210816A2 CO 6210816 A2 CO6210816 A2 CO 6210816A2 CO 09081877 A CO09081877 A CO 09081877A CO 09081877 A CO09081877 A CO 09081877A CO 6210816 A2 CO6210816 A2 CO 6210816A2
Authority
CO
Colombia
Prior art keywords
alkyl
group
sulfonylamino
fluorine
amino
Prior art date
Application number
CO09081877A
Other languages
English (en)
Inventor
Frank Himmelsbach
Birgit Jung
Ralf Lotz
Markus Ostermeier
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP07101785A external-priority patent/EP1956010A1/de
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of CO6210816A2 publication Critical patent/CO6210816A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

1.- Heterociclos bicíclicos de la fórmula generalen los cuales Ra es un grupo fenilo, 1-feniletilo o indan-4-ilo, en los que el núcleo fenilo está sustituido en cada caso con los radicales R1 a R3, donde R1 y R2, que pueden ser iguales o diferentes, son en cada caso un átomo de hidrógeno, flúor, cloro, bromo o yodo, un grupo alquilo C1-4, hidroxi, alcoxi C1-4, alquenilo C2-3 o alquinilo C2-3, un grupo arilo, ariloxio, arilmetilo o arilmetoxi, un grupo heteroarilo, heteroariloxi, heteroarilmetilo o heteroarilmetoxi, un grupo metilo o metoxi sustituido con 1 a 3 átomos de flúor o un grupo ciano, nitro o amino, y R3 un átomo de hidrógeno, flúor, cloro o bromo o un grupo metilo o trifluorometilo, Rb un grupo azetidin-1-ilo, pirrolidin-1-ilo, piperidin-1-ilo, homiperidin-1-ilo, morfolin-4-ilo, homomorfolin-4-ilo, piperazin1-ilo, 4-(alquil C1-4-carbonil)-piperazin-1-ilo, 4-(alquil C1-4-sulfonil)-piperazin-1-ilo, homopiperazin-1-ilo, 4-(alquil C1-4-carbonil)-homopiperazin-1-ilo o 4-(alquil C1-4- sulfonil)-homopiperazin-1-ilo, que en cada caso puede estar mono-, di- o trisustituido con R4, en donde los sustituyentes pueden ser iguales o diferentes y R4 representa un átomo de flúor, cloro, bromo o yodo, un grupo alquilo C1-4, alquenilo C2-4 o alquinilo C2-4, un grupo metilo o metoxi sustituido con 1 a 3 átomos de flúor,un grupo amino, alquil C1-4-amino, di-(alquil C1-4)amino, alquil C1-4-carbonilamino, N-(alquil C1-4)-alquil C1-4-carbonilamino, alquil C1-4-sulfonilamino o N-(alquil C1-4)-alquil C1-4-sulfonilamino, un grupo amino-alquilo C1-4, alquil C1-4-amino-alquilo C1-4, di-(alquil C1-4)amino-alquilo C1-4, alquil C1-4-carbonilamino-alquilo C1-4, N-(alquil C1-4)-alquil C1-4-carbonilamino-alquilo C1-4, alquil C1-4-sulfonilamino-alquilo C1-4 o N-(alquil C1-4)-alquil C1-4-sulfonilamino-alquilo C1-4, un grupo hidroxi, alquil C1-4-oxi o alquil C1-4-carboniloxi un grupo hidroxi-alquilo C1-4, alquil C1-4-oxi-alquilo C1-4 o alquil C1-4-carboniloxi-alquilo C1-4, ...
CO09081877A 2007-02-06 2009-08-05 Heterociclos biciclicos medicamentos que contienen estos compuestos su utilizacion y procedimientos para su preparacion CO6210816A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07101785A EP1956010A1 (de) 2007-02-06 2007-02-06 Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel,deren Verwendung und Verfahren zu ihrer Herstellung
EP07118700 2007-10-17

Publications (1)

Publication Number Publication Date
CO6210816A2 true CO6210816A2 (es) 2010-10-20

Family

ID=39247377

Family Applications (1)

Application Number Title Priority Date Filing Date
CO09081877A CO6210816A2 (es) 2007-02-06 2009-08-05 Heterociclos biciclicos medicamentos que contienen estos compuestos su utilizacion y procedimientos para su preparacion

Country Status (18)

Country Link
US (1) US7998949B2 (es)
EP (1) EP2118075A1 (es)
JP (1) JP5377332B2 (es)
KR (1) KR20090116782A (es)
AR (1) AR065195A1 (es)
AU (1) AU2008212999A1 (es)
BR (1) BRPI0807234A2 (es)
CA (1) CA2677336A1 (es)
CL (1) CL2008000356A1 (es)
CO (1) CO6210816A2 (es)
EA (1) EA200901041A1 (es)
EC (1) ECSP099562A (es)
IL (1) IL199923A0 (es)
MA (1) MA31171B1 (es)
MX (1) MX2009007610A (es)
TN (1) TN2009000332A1 (es)
TW (1) TW200846330A (es)
WO (1) WO2008095847A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1921070A1 (de) * 2006-11-10 2008-05-14 Boehringer Ingelheim Pharma GmbH & Co. KG Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstelllung
CA2711582A1 (en) * 2008-02-07 2009-08-13 Boehringer Ingelheim International Gmbh Spirocyclic heterocycles, formulations containing said compounds, use thereof and processes for the preparation thereof
JP5539351B2 (ja) * 2008-08-08 2014-07-02 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング シクロヘキシルオキシ置換ヘテロ環、これらの化合物を含有する医薬、およびそれらを生成するための方法
WO2010015524A1 (de) * 2008-08-08 2010-02-11 Boehringer Ingelheim International Gmbh Verfahren zur stereoselektiven synthese bicyclischer heterocyclen
WO2010026029A1 (en) * 2008-09-03 2010-03-11 Boehringer Ingelheim International Gmbh Use of quinazoline derivatives for the treatment of viral diseases
EP2289881A1 (de) * 2009-08-06 2011-03-02 Boehringer Ingelheim International GmbH Verfahren zur stereoselektiven Synthese bicyclischer Heterocyclen
NZ600857A (en) 2010-01-29 2014-06-27 Boehringer Ingelheim Int Substituted naphthyridines and their use as syk kinase inhibitors
KR20140096571A (ko) * 2013-01-28 2014-08-06 한미약품 주식회사 1-(4-(4-(3,4-디클로로-2-플루오로페닐아미노)-7-메톡시퀴나졸린-6-일옥시)피페리딘-1-일)프로프-2-엔-1-온의 제조방법

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IL199923A0 (en) 2010-04-15
CA2677336A1 (en) 2008-08-14
AR065195A1 (es) 2009-05-20
US20100022505A1 (en) 2010-01-28
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