CO5251445A1 - Forma de estado solido de celecoxib que tiene mejorada biodisponibilidad - Google Patents
Forma de estado solido de celecoxib que tiene mejorada biodisponibilidadInfo
- Publication number
- CO5251445A1 CO5251445A1 CO00094077A CO00094077A CO5251445A1 CO 5251445 A1 CO5251445 A1 CO 5251445A1 CO 00094077 A CO00094077 A CO 00094077A CO 00094077 A CO00094077 A CO 00094077A CO 5251445 A1 CO5251445 A1 CO 5251445A1
- Authority
- CO
- Colombia
- Prior art keywords
- celecoxib
- drug substance
- amorphous
- solid state
- state form
- Prior art date
Links
Classifications
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- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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Abstract
Celecoxib amorfo. Una sustancia de droga celecoxib donde el celecoxib está presente, en por lo menos una cantidad detectable, como celecoxib amorfo. Un compuesto inhibidor de cristalización de celecoxib que comprende partículas de celecoxib amorfo o una sustancia de droga celecoxib de alguna de las Reivindicaciones 2 a 4 en intima asociación con uno o más inhibidor (es) de cristalización en una cantidad efectiva para reducir la transformación de celecoxib amorfo a celecoxib cristalino. 1Un proceso para preparar a sustancia de droga celecoxib, el proceso que comprende: (a) fundir celecoxib; (b) enfriar rápidamente el resultante celecoxib fundido para formar una sustancia de droga celecoxib donde el celecoxib está presente, en por lo menos una cantidad detectable, en forma amorfa; y opcionalmente (c) triunfar la sustancia de droga celecoxib para formar un polvo de sustancia de droga celecoxib.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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US16985699P | 1999-12-08 | 1999-12-08 |
Publications (1)
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CO5251445A1 true CO5251445A1 (es) | 2003-02-28 |
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CO00094077A CO5251445A1 (es) | 1999-12-08 | 2000-12-11 | Forma de estado solido de celecoxib que tiene mejorada biodisponibilidad |
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CN (1) | CN1216869C (es) |
AR (2) | AR027897A1 (es) |
AU (1) | AU2041201A (es) |
BG (1) | BG65239B1 (es) |
CO (1) | CO5251445A1 (es) |
CZ (1) | CZ20012875A3 (es) |
EA (1) | EA200401397A1 (es) |
EC (1) | ECSP003807A (es) |
ES (1) | ES2236011T3 (es) |
HU (1) | HUP0200580A3 (es) |
MY (2) | MY128366A (es) |
NZ (1) | NZ529933A (es) |
OA (1) | OA11831A (es) |
PE (1) | PE20010911A1 (es) |
PT (2) | PT1150960E (es) |
SV (1) | SV2002000235A (es) |
TW (1) | TWI276435B (es) |
WO (1) | WO2001041536A2 (es) |
YU (1) | YU57801A (es) |
ZA (2) | ZA200107146B (es) |
Families Citing this family (21)
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ATE366569T1 (de) * | 2000-07-20 | 2007-08-15 | Lauras As | Verwendung von cox-2 inhibitoren als immunostimulantien zur behandlung von hiv oder aids |
EP1404300B1 (en) | 2001-06-22 | 2009-09-30 | Pfizer Products Inc. | Pharmaceutical compositions of dispersions of drugs and neutral polymers |
WO2004061433A1 (en) * | 2002-12-30 | 2004-07-22 | Transform Pharmaceuticals, Inc. | Pharmaceutical compositions with improved dissolution |
US7446107B2 (en) | 2002-02-15 | 2008-11-04 | Transform Pharmaceuticals, Inc. | Crystalline forms of conazoles and methods of making and using the same |
US7790905B2 (en) | 2002-02-15 | 2010-09-07 | Mcneil-Ppc, Inc. | Pharmaceutical propylene glycol solvate compositions |
US7927613B2 (en) | 2002-02-15 | 2011-04-19 | University Of South Florida | Pharmaceutical co-crystal compositions |
EP1494998A2 (en) | 2002-03-01 | 2005-01-12 | University Of South Florida | Multiple-component solid phases containing at least one active pharmaceutical ingredient |
BR0309913A (pt) * | 2002-05-13 | 2005-06-07 | Pharmacia Corp | Compósito estável de celecoxib amorfo e processo para fabricar o mesmo |
AU2003243354A1 (en) | 2002-05-31 | 2003-12-19 | Transform Pharmaceuticals, Inc. | Novel conazole crystalline forms and related processes, pharmaceutical compositions and methods |
CA2489984A1 (en) * | 2002-06-21 | 2003-12-31 | Transform Pharmaceuticals, Inc. | Pharmaceutical compositions with improved dissolution |
AU2003267231A1 (en) * | 2002-09-20 | 2004-04-08 | Transform Pharmaceuticals, Inc. | Pharmaceutical compositions with improved dissolution |
JP5021934B2 (ja) * | 2002-12-30 | 2012-09-12 | トランスフォーム・ファーマシューティカルズ・インコーポレイテッド | 改善された溶解性を有する医薬組成物 |
US8183290B2 (en) | 2002-12-30 | 2012-05-22 | Mcneil-Ppc, Inc. | Pharmaceutically acceptable propylene glycol solvate of naproxen |
PL1916994T3 (pl) * | 2004-06-29 | 2014-05-30 | Takeda Pharma As | Wytwarzanie kompozycji farmaceutycznej o szybkim uwalnianiu leków nierozpuszczalnych w wodzie i kompozycje farmaceutyczne otrzymywane sposobem według wynalazku |
GB0423103D0 (en) * | 2004-10-19 | 2004-11-17 | Boots Healthcare Int Ltd | Therapeutic agents |
US20080171746A1 (en) * | 2005-03-14 | 2008-07-17 | Thomas Klein | Method for Preventing Cardiovascular Diseases |
CN103462920A (zh) * | 2012-06-06 | 2013-12-25 | 南京亿华药业有限公司 | 一种口服环加氧酶-2抑制剂塞来昔布的组合物 |
CN103524416B (zh) * | 2013-10-29 | 2016-08-17 | 湖北华世通生物医药科技有限公司 | 一种塞来昔布新晶型a及其制备方法 |
CN103539739B (zh) * | 2013-10-30 | 2016-02-10 | 中美华世通生物医药科技(武汉)有限公司 | 一种塞来昔布新晶型b及其制备方法 |
CN103508958A (zh) * | 2013-10-30 | 2014-01-15 | 中美华世通生物医药科技(武汉)有限公司 | 一种塞来昔布新晶型c及其制备方法 |
KR101476096B1 (ko) * | 2014-03-28 | 2014-12-24 | 대원제약주식회사 | 용해도가 향상된 쎄레콕시브의 약제학적 조성물 |
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US5474995A (en) * | 1993-06-24 | 1995-12-12 | Merck Frosst Canada, Inc. | Phenyl heterocycles as cox-2 inhibitors |
PL180717B1 (pl) * | 1993-11-30 | 2001-03-30 | Searle & Co | N o w e 1 -[4-(aminosulfonylo)fenylo]pirazolilobenzenosulfonamidy do leczenia stanów zapalnych PL PL PL PL PL PL PL |
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CA2328992A1 (en) * | 1998-04-27 | 1999-11-04 | Northwest Hospital | Nr-cam gene, nucleic acids and nucleic acid products for therapeutic and diagnostic uses for tumors |
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2000
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- 2000-12-01 OA OA1200100210A patent/OA11831A/en unknown
- 2000-12-01 CN CN008060835A patent/CN1216869C/zh not_active Expired - Fee Related
- 2000-12-01 NZ NZ529933A patent/NZ529933A/en unknown
- 2000-12-01 CZ CZ20012875A patent/CZ20012875A3/cs unknown
- 2000-12-01 ES ES00983865T patent/ES2236011T3/es not_active Expired - Lifetime
- 2000-12-01 YU YU57801A patent/YU57801A/sh unknown
- 2000-12-04 EC EC2000003807A patent/ECSP003807A/es unknown
- 2000-12-04 AU AU20412/01A patent/AU2041201A/en not_active Withdrawn
- 2000-12-04 WO PCT/US2000/030180 patent/WO2001041536A2/en not_active Application Discontinuation
- 2000-12-05 AR ARP000106473A patent/AR027897A1/es unknown
- 2000-12-06 AR ARP000106475A patent/AR030039A1/es unknown
- 2000-12-06 PE PE2000001299A patent/PE20010911A1/es not_active Application Discontinuation
- 2000-12-06 KR KR1020017010017A patent/KR100717570B1/ko not_active IP Right Cessation
- 2000-12-06 EA EA200401397A patent/EA200401397A1/ru unknown
- 2000-12-06 MY MYPI20005733A patent/MY128366A/en unknown
- 2000-12-06 MY MYPI20005730A patent/MY128971A/en unknown
- 2000-12-06 PT PT00982255T patent/PT1150959E/pt unknown
- 2000-12-08 SV SV2000000235A patent/SV2002000235A/es not_active Application Discontinuation
- 2000-12-11 CO CO00094077A patent/CO5251445A1/es not_active Application Discontinuation
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- 2001-05-18 TW TW089125991A patent/TWI276435B/zh not_active IP Right Cessation
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Also Published As
Publication number | Publication date |
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BG105808A (en) | 2002-09-30 |
MY128366A (en) | 2007-01-31 |
OA11831A (en) | 2005-08-23 |
AR027897A1 (es) | 2003-04-16 |
ECSP003807A (es) | 2005-07-06 |
HUP0200580A2 (hu) | 2002-11-28 |
CN1411447A (zh) | 2003-04-16 |
CN1216869C (zh) | 2005-08-31 |
PT1150959E (pt) | 2008-04-21 |
CZ20012875A3 (cs) | 2002-02-13 |
PT1150960E (pt) | 2005-06-30 |
BG65239B1 (bg) | 2007-09-28 |
AR030039A1 (es) | 2003-08-13 |
YU57801A (sh) | 2005-07-19 |
ZA200107149B (en) | 2003-02-28 |
PE20010911A1 (es) | 2001-09-10 |
MY128971A (en) | 2007-03-30 |
TWI276435B (en) | 2007-03-21 |
EA200401397A1 (ru) | 2005-08-25 |
ES2236011T3 (es) | 2005-07-16 |
HUP0200580A3 (en) | 2002-12-28 |
KR100717570B1 (ko) | 2007-05-15 |
WO2001041536A2 (en) | 2001-06-14 |
SV2002000235A (es) | 2002-06-13 |
ZA200107146B (en) | 2002-08-29 |
KR20020002386A (ko) | 2002-01-09 |
AU2041201A (en) | 2001-06-18 |
NZ529933A (en) | 2005-06-24 |
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