AR034124A1 - Forma cristalina alfa de la sal de terbutilamina de perindopril, procedimiento para su preparacion y composiciones farmaceuticas que la contienen - Google Patents
Forma cristalina alfa de la sal de terbutilamina de perindopril, procedimiento para su preparacion y composiciones farmaceuticas que la contienenInfo
- Publication number
- AR034124A1 AR034124A1 ARP010103226A ARP010103226A AR034124A1 AR 034124 A1 AR034124 A1 AR 034124A1 AR P010103226 A ARP010103226 A AR P010103226A AR P010103226 A ARP010103226 A AR P010103226A AR 034124 A1 AR034124 A1 AR 034124A1
- Authority
- AR
- Argentina
- Prior art keywords
- perindopril
- salt
- procedure
- pharmaceutical compositions
- compositions containing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Forma cristalina alfa del compuesto de fórmula (1),cuyo diagrama de difracción de rayos X sobre polvo siguiente, medido en difractómetro (anticátodo de cobre) y expresado en términos de distancia interplanar d, de ángulo de Bragg 2 theta, de intensidad y de intensidad relativa (expresada en porcentaje con respecto al rayo más intenso) es el siguiente: Procedimiento de preparación de la forma cristalina alfa del compuesto de fórmula (1) en la cual se calienta a reflujo una solución de la sal de terbutilamina de perindopril en acetato de etilo, luego se enfría progresivamente hasta que se completa la cristalización. Composiciones farmacéuticas que contienen la forma cristalina alfa del compuesto de fórmula (1). Son útiles como inhibidores de la enzima de conversión de la angiotensina I y por lo tanto en el tratamiento de las enfermedades cardiovasculares.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0008793A FR2811320B1 (fr) | 2000-07-06 | 2000-07-06 | Nouvelle forme cristalline alpha du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent |
Publications (1)
Publication Number | Publication Date |
---|---|
AR034124A1 true AR034124A1 (es) | 2004-02-04 |
Family
ID=8852172
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP010103226A AR034124A1 (es) | 2000-07-06 | 2001-07-06 | Forma cristalina alfa de la sal de terbutilamina de perindopril, procedimiento para su preparacion y composiciones farmaceuticas que la contienen |
Country Status (35)
Country | Link |
---|---|
US (2) | US20030186896A1 (es) |
EP (1) | EP1296947B1 (es) |
JP (2) | JP3602826B2 (es) |
KR (1) | KR100513570B1 (es) |
CN (1) | CN1328259C (es) |
AP (1) | AP1537A (es) |
AR (1) | AR034124A1 (es) |
AT (1) | ATE258918T1 (es) |
AU (2) | AU2001276418B2 (es) |
BG (1) | BG64868B1 (es) |
BR (1) | BR0112367A (es) |
CA (1) | CA2415438C (es) |
CZ (1) | CZ297672B6 (es) |
DE (1) | DE60101968T2 (es) |
DK (1) | DK1296947T3 (es) |
EA (1) | EA005008B1 (es) |
EE (1) | EE05268B1 (es) |
ES (1) | ES2214434T3 (es) |
FR (1) | FR2811320B1 (es) |
GE (1) | GEP20043361B (es) |
HK (1) | HK1055425A1 (es) |
HR (1) | HRP20030077B1 (es) |
ME (1) | ME00443B (es) |
MX (1) | MXPA02012949A (es) |
NO (1) | NO323447B1 (es) |
NZ (1) | NZ523173A (es) |
OA (1) | OA12304A (es) |
PL (1) | PL206359B1 (es) |
PT (1) | PT1296947E (es) |
RS (1) | RS50915B (es) |
SK (1) | SK285714B6 (es) |
TR (1) | TR200400238T4 (es) |
UA (1) | UA57188C2 (es) |
WO (1) | WO2001087835A1 (es) |
ZA (1) | ZA200210092B (es) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2811318B1 (fr) * | 2000-07-06 | 2002-08-23 | Adir | Nouvelle forme cristalline gamma du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent |
FR2811319B1 (fr) * | 2000-07-06 | 2002-08-23 | Adir | Nouvelle forme cristalline beta du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent |
FR2838648B1 (fr) * | 2002-04-18 | 2004-05-21 | Servier Lab | Nouveau sel de perindopril et les compositions pharmaceutiques qui le contiennent |
GB2395195A (en) | 2002-11-18 | 2004-05-19 | Cipla Ltd | Preparation of perindopril from carboxy-protected precursor, & perindopril monohydrates for use as angiotensin converting enzyme (ACE) inhibitors |
PL1636185T3 (pl) * | 2003-06-24 | 2012-12-31 | Servier Lab | Nowe formy krystaliczne peryndoprylu erbuminy |
WO2005037788A1 (en) | 2003-10-21 | 2005-04-28 | Lupin Ltd. | Novel method for preparation of crystalline perindopril erbumine |
SI21703A (en) | 2004-01-14 | 2005-08-31 | Lek Farmacevtska Druzba Dd | Inclusion complexes of perindopril, procedure of their preparation, pharmaceutical compositions containing these complexes and their application in treatment of hypertensia |
DK1729739T3 (en) * | 2004-03-29 | 2016-10-31 | Servier Lab | PROCESS FOR THE PREPARATION OF A solid pharmaceutical composition. |
US20050250706A1 (en) * | 2004-05-07 | 2005-11-10 | Glenmark Pharmaceuticals Limited | Processes for the preparation of alpha polymorph of perindopril erbumine |
WO2005108365A1 (en) * | 2004-05-07 | 2005-11-17 | Glenmark Pharmaceuticals Limited | Processes for the preparation of alpha polymorph of perindopril erbumine |
SI21800A (sl) * | 2004-05-14 | 2005-12-31 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Nov postopek sinteze perindoprila |
SI21881A (sl) | 2004-10-15 | 2006-04-30 | Diagen, Smartno Pri Ljubljani, D.O.O. | Nove kristalne oblike perindopril erbumin hidratov, postopek za njihovo pripravo in farmacevtske oblike, ki vsebujejo te spojine |
SG125975A1 (en) * | 2005-03-11 | 2006-10-30 | Servier Lab | New alpha crystalline form of perindopril tert-butylamine salt, a process for its preparation and pharmaceutical compositions containing it |
SG125976A1 (en) * | 2005-03-11 | 2006-10-30 | Servier Lab | New gama crystalline form of perindopril tert-butylamine salt, a process for its preparation and pharmaceutical compositions containing it |
JP2006290825A (ja) * | 2005-04-13 | 2006-10-26 | Shiono Chemical Co Ltd | アルファ型ペリンドプリルエルブミンの製造法 |
WO2007017894A2 (en) * | 2005-05-05 | 2007-02-15 | Arch Pharmalabs Limited | PREPARATION OF NOVEL CRYSTALLINE η(ETA) FORM OF PERINDOPRIL ERBUMINE |
US20070032661A1 (en) * | 2005-08-03 | 2007-02-08 | Glenmark Pharmaceuticals Limited | Process for the preparation of intermediates of perindopril |
US20090099370A1 (en) * | 2005-08-12 | 2009-04-16 | Sandoz Ag | Crystalline Form of Perindopril Erbumine |
CN101228179B (zh) * | 2005-08-12 | 2011-02-02 | 力奇制药公司 | 制备培哚普利特丁胺的方法 |
EP1815857A1 (en) | 2006-02-02 | 2007-08-08 | LEK Pharmaceuticals D.D. | A pharmaceutical composition comprising perindopril |
WO2007092758A2 (en) * | 2006-02-03 | 2007-08-16 | Dr. Reddy's Laboratories Ltd. | Crystalline forms of perindopril erbumine |
FR2897865B1 (fr) * | 2006-02-28 | 2008-04-18 | Servier Lab | Forme cristalline beta du sel d'arginine du perindopril, son procede de preparation, et les compositions pharmaceutiques qui la contiennent |
FR2897866B1 (fr) * | 2006-02-28 | 2008-04-18 | Servier Lab | Forme cristalline alpha du sel d'arginine du perindopril, son procede de preparation, et les compositions pharmaceutiques qui la contiennent |
EA007988B1 (ru) * | 2006-04-20 | 2007-02-27 | ИСМАГИЛОВ, Искандар Халиуллович | ξ-ЗЕТА ФОРМА ПЕРИНДОПРИЛ ЭРБУМИНА |
EP1964836A3 (en) * | 2006-11-06 | 2008-11-19 | IPCA Laboratories Limited | A process for the preparation of perindopril erbumine in alpha crystalline form |
GB0624084D0 (en) * | 2006-12-01 | 2007-01-10 | Selamine Ltd | Ramipril amino acid salts |
GB0624090D0 (en) * | 2006-12-01 | 2007-01-10 | Selamine Ltd | Ramipril amine salts |
GB0624087D0 (en) * | 2006-12-01 | 2007-01-10 | Selamine Ltd | Ramipril combination salt |
WO2008114270A1 (en) * | 2007-03-22 | 2008-09-25 | Aarti Healthcare Limited | Process for the preparation of perindopril erbumine salt and novel polymorph (s) thereof |
WO2008120241A2 (en) * | 2007-03-29 | 2008-10-09 | Ipca Laboratories Limited | Novel alcohol solvates of perindopril erbumine |
AU2013201812B2 (en) * | 2007-06-27 | 2015-04-02 | Les Laboratoires Servier | Salts of perindopril |
SI22543A (sl) * | 2007-06-27 | 2008-12-31 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Nove soli perindoprila |
SI23149A (sl) * | 2009-09-21 | 2011-03-31 | Silverstone Pharma | Nove benzatinske soli ACE inhibitorjev, postopek za njihovo pripravo in njihova uporaba za zdravljenje kardiovaskularnih bolezni |
PT105315B (pt) | 2010-09-29 | 2013-01-16 | Inst Superior Tecnico | Uma nova forma cristalina hidratada de erbumina de perindopril, métodos para a sua preparação e sua utilização em preparações farmacêuticas |
CN103822996A (zh) * | 2014-03-20 | 2014-05-28 | 东英(江苏)药业有限公司 | 一种培哚普利叔丁胺盐含量的测定方法 |
CN105395497B (zh) * | 2015-12-04 | 2019-06-18 | 杭州新诺华医药有限公司 | 一种稳定的α晶型培哚普利叔丁胺片及制备方法 |
EP3842035A1 (en) | 2019-12-23 | 2021-06-30 | KRKA, d.d., Novo mesto | Composition for the preparation of perindopril arginine granules, a method for their preparation and pharmaceutical composition comprising the granules |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2503155A2 (fr) * | 1980-10-02 | 1982-10-08 | Science Union & Cie | Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme |
FR2620744A1 (fr) * | 1987-09-17 | 1989-03-24 | Degremont | Procede de traitement par l'ozone de materiaux ligno-cellulosiques, notamment de pates a papier et reacteur pour la mise en oeuvre de ce procede |
FR2620703B1 (fr) * | 1987-09-17 | 1991-10-04 | Adir | Procede de synthese industrielle de l'acide perhydroindole carboxylique - 2(2s, 3as, 7as). application a la synthese de carboxyalkyl dipeptides |
FR2620709B1 (fr) * | 1987-09-17 | 1990-09-07 | Adir | Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese |
FR2771010B1 (fr) * | 1997-11-19 | 2003-08-15 | Adir | Utilisation d'une combinaison d'un inhibiteur de l'enzyme de conversion de l'angiotensine et d'un diuretique pour le traitement des desordres microcirculatoires |
FR2811319B1 (fr) * | 2000-07-06 | 2002-08-23 | Adir | Nouvelle forme cristalline beta du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent |
FR2811318B1 (fr) * | 2000-07-06 | 2002-08-23 | Adir | Nouvelle forme cristalline gamma du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent |
-
2000
- 2000-07-06 FR FR0008793A patent/FR2811320B1/fr not_active Expired - Fee Related
-
2001
- 2001-06-07 UA UA2003021020A patent/UA57188C2/uk unknown
- 2001-07-06 AT AT01954058T patent/ATE258918T1/de active
- 2001-07-06 OA OA1200200397A patent/OA12304A/en unknown
- 2001-07-06 ES ES01954058T patent/ES2214434T3/es not_active Expired - Lifetime
- 2001-07-06 EE EEP200300001A patent/EE05268B1/xx not_active IP Right Cessation
- 2001-07-06 AU AU2001276418A patent/AU2001276418B2/en not_active Ceased
- 2001-07-06 EP EP01954058A patent/EP1296947B1/fr not_active Revoked
- 2001-07-06 PL PL348492A patent/PL206359B1/pl unknown
- 2001-07-06 DE DE60101968T patent/DE60101968T2/de not_active Revoked
- 2001-07-06 MX MXPA02012949A patent/MXPA02012949A/es active IP Right Grant
- 2001-07-06 EA EA200300107A patent/EA005008B1/ru unknown
- 2001-07-06 NZ NZ523173A patent/NZ523173A/en not_active IP Right Cessation
- 2001-07-06 GE GE5075A patent/GEP20043361B/en unknown
- 2001-07-06 SK SK149-2003A patent/SK285714B6/sk not_active IP Right Cessation
- 2001-07-06 ME MEP-2008-673A patent/ME00443B/me unknown
- 2001-07-06 JP JP2001584232A patent/JP3602826B2/ja not_active Expired - Fee Related
- 2001-07-06 AP APAP/P/2002/002691A patent/AP1537A/en active
- 2001-07-06 AU AU7641801A patent/AU7641801A/xx active Pending
- 2001-07-06 CZ CZ20030357A patent/CZ297672B6/cs not_active IP Right Cessation
- 2001-07-06 CN CNB018123546A patent/CN1328259C/zh not_active Ceased
- 2001-07-06 US US10/312,961 patent/US20030186896A1/en not_active Abandoned
- 2001-07-06 AR ARP010103226A patent/AR034124A1/es unknown
- 2001-07-06 WO PCT/FR2001/002167 patent/WO2001087835A1/fr active IP Right Grant
- 2001-07-06 TR TR2004/00238T patent/TR200400238T4/xx unknown
- 2001-07-06 BR BR0112367-0A patent/BR0112367A/pt not_active Application Discontinuation
- 2001-07-06 RS YUP-1004/02A patent/RS50915B/sr unknown
- 2001-07-06 CA CA002415438A patent/CA2415438C/fr not_active Expired - Fee Related
- 2001-07-06 PT PT01954058T patent/PT1296947E/pt unknown
- 2001-07-06 KR KR10-2003-7000115A patent/KR100513570B1/ko not_active IP Right Cessation
- 2001-07-06 DK DK01954058T patent/DK1296947T3/da active
-
2002
- 2002-12-12 ZA ZA200210092A patent/ZA200210092B/xx unknown
-
2003
- 2003-01-03 NO NO20030024A patent/NO323447B1/no not_active IP Right Cessation
- 2003-02-05 BG BG107532A patent/BG64868B1/bg unknown
- 2003-02-06 HR HR20030077A patent/HRP20030077B1/xx not_active IP Right Cessation
- 2003-10-22 HK HK03107631A patent/HK1055425A1/xx not_active IP Right Cessation
-
2004
- 2004-03-03 US US10/792,355 patent/US20050059609A1/en not_active Abandoned
- 2004-07-13 JP JP2004206158A patent/JP5016185B2/ja not_active Expired - Fee Related
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