BRPI0708291B8 - forma cristalina beta de sal de arginina de perindopril, processo para sua preparação, composições farmacêuticas que a contêm e seus usos - Google Patents

forma cristalina beta de sal de arginina de perindopril, processo para sua preparação, composições farmacêuticas que a contêm e seus usos

Info

Publication number
BRPI0708291B8
BRPI0708291B8 BRPI0708291A BRPI0708291A BRPI0708291B8 BR PI0708291 B8 BRPI0708291 B8 BR PI0708291B8 BR PI0708291 A BRPI0708291 A BR PI0708291A BR PI0708291 A BRPI0708291 A BR PI0708291A BR PI0708291 B8 BRPI0708291 B8 BR PI0708291B8
Authority
BR
Brazil
Prior art keywords
crystalline form
arginine salt
perindopril
preparation
beta crystalline
Prior art date
Application number
BRPI0708291A
Other languages
English (en)
Inventor
Coquerel Gérard
Souvie Jean-Claude
Lefebvre Löic
Authouart Pascale
Original Assignee
Les Laboratories Servier
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Les Laboratories Servier filed Critical Les Laboratories Servier
Publication of BRPI0708291A2 publication Critical patent/BRPI0708291A2/pt
Publication of BRPI0708291B1 publication Critical patent/BRPI0708291B1/pt
Publication of BRPI0708291B8 publication Critical patent/BRPI0708291B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

forma cristalina beta do de sal arginina do perindopril, o respectivo processo de preparo, e as composições farmacêuticas que a contêm. a presente invenção refere-se a forma cristalina 13 do composto de fórmula (i) caracterizada pelo fato de apresentar seu diagrama de difração x sobre pó. medicamentos.
BRPI0708291A 2006-02-28 2007-02-26 forma cristalina beta de sal de arginina de perindopril, processo para sua preparação, composições farmacêuticas que a contêm e seus usos BRPI0708291B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0601747A FR2897865B1 (fr) 2006-02-28 2006-02-28 Forme cristalline beta du sel d'arginine du perindopril, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR0601747 2006-02-28
PCT/FR2007/000334 WO2007099216A2 (fr) 2006-02-28 2007-02-26 FORME CRISTALLINE β DU SEL D'ARGININE DU PERINDOPRIL, SON PROCEDE DE PREPARATION, ET LES COMPOSITIONS PHARMACEUTIQUES QUI LA CONTIENNENT

Publications (3)

Publication Number Publication Date
BRPI0708291A2 BRPI0708291A2 (pt) 2011-05-24
BRPI0708291B1 BRPI0708291B1 (pt) 2021-02-02
BRPI0708291B8 true BRPI0708291B8 (pt) 2021-05-25

Family

ID=37198804

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0708291A BRPI0708291B8 (pt) 2006-02-28 2007-02-26 forma cristalina beta de sal de arginina de perindopril, processo para sua preparação, composições farmacêuticas que a contêm e seus usos

Country Status (31)

Country Link
US (1) US7923569B2 (pt)
EP (1) EP2016051B1 (pt)
JP (1) JP5611524B2 (pt)
KR (1) KR20080106947A (pt)
CN (1) CN101389604B (pt)
AT (1) ATE465992T1 (pt)
AU (1) AU2007220434B2 (pt)
BR (1) BRPI0708291B8 (pt)
CA (1) CA2643803C (pt)
CY (1) CY1110082T1 (pt)
DE (1) DE602007006176D1 (pt)
DK (1) DK2016051T3 (pt)
EA (1) EA014715B1 (pt)
ES (1) ES2345291T3 (pt)
FR (1) FR2897865B1 (pt)
GE (1) GEP20135839B (pt)
HK (1) HK1129668A1 (pt)
HR (1) HRP20100357T1 (pt)
MA (1) MA30277B1 (pt)
ME (1) ME01805B (pt)
MX (1) MX2008010747A (pt)
MY (1) MY143557A (pt)
NO (1) NO341238B1 (pt)
NZ (1) NZ570366A (pt)
PL (1) PL2016051T3 (pt)
PT (1) PT2016051E (pt)
RS (1) RS51431B (pt)
SI (1) SI2016051T1 (pt)
UA (1) UA89904C2 (pt)
WO (1) WO2007099216A2 (pt)
ZA (1) ZA200807025B (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2897866B1 (fr) 2006-02-28 2008-04-18 Servier Lab Forme cristalline alpha du sel d'arginine du perindopril, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
CA2919564A1 (en) * 2008-06-24 2009-12-30 Mylan Laboratories Limited Polymorphic form gamma of perindopril (l)-arginine and processes for the preparation thereof
AU2013245523C1 (en) * 2008-06-24 2017-09-07 Mylan Laboratories Ltd Novel polymorphic forms of Perindopril (L)-Arginine and process for the preparation thereof
AU2009212902A1 (en) 2008-09-03 2010-03-18 Apotex Pharmachem Inc. Amorphous form of an L-arginine salt of perindopril and processes of preparation thereof
FR2985512B1 (fr) * 2012-01-05 2014-06-20 Servier Lab Procede de preparation du sel de l-arginine du perindopril
FR2985511B1 (fr) * 2012-01-05 2014-01-03 Servier Lab Forme cristalline delta du sel d'arginine du perindopril, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
CN103172696B (zh) * 2012-12-19 2014-12-17 宁波美诺华药业股份有限公司 一种γ晶型的培哚普利精氨酸盐的制备方法
WO2016178591A2 (en) 2015-05-05 2016-11-10 Gene Predit, Sa Genetic markers and treatment of male obesity
FR3050380B1 (fr) 2016-04-20 2020-07-10 Les Laboratoires Servier Composition pharmaceutique comprenant un betabloquant, un inhibiteur de l'enzyme de conversion et un antihypertenseur ou un ains.
EP3842035A1 (en) 2019-12-23 2021-06-30 KRKA, d.d., Novo mesto Composition for the preparation of perindopril arginine granules, a method for their preparation and pharmaceutical composition comprising the granules
SI26268A (sl) 2021-11-18 2023-05-31 Zupet Rok Postopek za pripravo hidratirane oblike perindopril l-arginina

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2811318B1 (fr) * 2000-07-06 2002-08-23 Adir Nouvelle forme cristalline gamma du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR2811319B1 (fr) * 2000-07-06 2002-08-23 Adir Nouvelle forme cristalline beta du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR2811320B1 (fr) * 2000-07-06 2002-08-23 Adir Nouvelle forme cristalline alpha du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR2838648B1 (fr) * 2002-04-18 2004-05-21 Servier Lab Nouveau sel de perindopril et les compositions pharmaceutiques qui le contiennent
FR2841140B1 (fr) * 2002-06-24 2004-10-01 Servier Lab Microcapsules pour la liberation retardee et controlee du perindopril

Also Published As

Publication number Publication date
NO341238B1 (no) 2017-09-25
CN101389604B (zh) 2013-08-21
UA89904C2 (ru) 2010-03-10
HK1129668A1 (pt) 2009-12-04
MX2008010747A (es) 2008-09-01
PT2016051E (pt) 2010-05-13
CN101389604A (zh) 2009-03-18
ATE465992T1 (de) 2010-05-15
CA2643803A1 (fr) 2007-09-07
EA014715B1 (ru) 2011-02-28
AU2007220434B2 (en) 2010-10-14
JP2009529500A (ja) 2009-08-20
CY1110082T1 (el) 2015-01-14
AU2007220434A1 (en) 2007-09-07
EP2016051A2 (fr) 2009-01-21
MA30277B1 (fr) 2009-03-02
BRPI0708291A2 (pt) 2011-05-24
WO2007099216A3 (fr) 2007-10-25
ES2345291T3 (es) 2010-09-20
WO2007099216A2 (fr) 2007-09-07
ZA200807025B (en) 2009-11-25
GEP20135839B (en) 2013-06-10
EA200801772A1 (ru) 2009-02-27
FR2897865A1 (fr) 2007-08-31
CA2643803C (fr) 2017-08-08
ME01805B (me) 2011-04-30
RS51431B (en) 2011-04-30
KR20080106947A (ko) 2008-12-09
US20090186934A1 (en) 2009-07-23
PL2016051T3 (pl) 2010-08-31
NO20083506L (no) 2008-08-13
EP2016051B1 (fr) 2010-04-28
SI2016051T1 (sl) 2010-07-30
BRPI0708291B1 (pt) 2021-02-02
DE602007006176D1 (de) 2010-06-10
NZ570366A (en) 2011-05-27
MY143557A (en) 2011-05-31
US7923569B2 (en) 2011-04-12
FR2897865B1 (fr) 2008-04-18
DK2016051T3 (da) 2010-08-09
HRP20100357T1 (hr) 2010-07-31
JP5611524B2 (ja) 2014-10-22

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06T Formal requirements before examination [chapter 6.20 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 02/02/2021, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 26/02/2007 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF