MA31801B1 - Derives de 1,2,3-triazole destines a etre utilises comme inhibiteurs de la stearoyl-coa desaturase - Google Patents

Derives de 1,2,3-triazole destines a etre utilises comme inhibiteurs de la stearoyl-coa desaturase

Info

Publication number
MA31801B1
MA31801B1 MA32807A MA32807A MA31801B1 MA 31801 B1 MA31801 B1 MA 31801B1 MA 32807 A MA32807 A MA 32807A MA 32807 A MA32807 A MA 32807A MA 31801 B1 MA31801 B1 MA 31801B1
Authority
MA
Morocco
Prior art keywords
stearoyl
inhibitors
triazole derivatives
coa desaturase
relates
Prior art date
Application number
MA32807A
Other languages
Arabic (ar)
English (en)
Inventor
Anne Marie Jeanne Bouillot
Alain Laroze
Lionel Trottet
Original Assignee
Glaxosmithkline Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Llc filed Critical Glaxosmithkline Llc
Publication of MA31801B1 publication Critical patent/MA31801B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Psychiatry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Vascular Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)

Abstract

La présente invention porte sur des composés substitués du triazole représentés par la formule (i) et sur des sels pharmaceutiquement acceptables de ceux-ci, sur des compositions pharmaceutiques les contenant et sur leur utilisation en médecine. En particulier, l'invention porte sur des composés pour moduler l'activité de la scd.
MA32807A 2007-11-09 2010-04-30 Derives de 1,2,3-triazole destines a etre utilises comme inhibiteurs de la stearoyl-coa desaturase MA31801B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0722077.5A GB0722077D0 (en) 2007-11-09 2007-11-09 Compounds
PCT/EP2008/065104 WO2009060053A1 (fr) 2007-11-09 2008-11-07 Dérivés de 1,2,3-triazole destinés à être utilisés comme inhibiteurs de la stéaroyl-coa désaturase

Publications (1)

Publication Number Publication Date
MA31801B1 true MA31801B1 (fr) 2010-10-01

Family

ID=38858481

Family Applications (1)

Application Number Title Priority Date Filing Date
MA32807A MA31801B1 (fr) 2007-11-09 2010-04-30 Derives de 1,2,3-triazole destines a etre utilises comme inhibiteurs de la stearoyl-coa desaturase

Country Status (32)

Country Link
US (2) US8486977B2 (fr)
EP (2) EP2207770B1 (fr)
JP (1) JP5491407B2 (fr)
KR (1) KR101577080B1 (fr)
CN (1) CN101918376B (fr)
AT (1) ATE512140T1 (fr)
AU (1) AU2008324172B2 (fr)
BR (1) BRPI0820471A2 (fr)
CA (1) CA2705113C (fr)
CO (1) CO6270331A2 (fr)
CR (1) CR11482A (fr)
CY (2) CY1112233T1 (fr)
DK (2) DK2368887T3 (fr)
DO (1) DOP2010000137A (fr)
EA (1) EA016621B1 (fr)
ES (2) ES2366422T3 (fr)
GB (1) GB0722077D0 (fr)
HK (2) HK1141528A1 (fr)
HR (2) HRP20110552T1 (fr)
IL (1) IL205152A (fr)
MA (1) MA31801B1 (fr)
ME (1) ME01962B (fr)
MX (1) MX2010005187A (fr)
MY (1) MY163126A (fr)
NZ (1) NZ584725A (fr)
PL (2) PL2368887T3 (fr)
PT (2) PT2207770E (fr)
RS (2) RS53294B (fr)
SI (2) SI2207770T1 (fr)
UA (1) UA107324C2 (fr)
WO (1) WO2009060053A1 (fr)
ZA (1) ZA201002596B (fr)

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GB0722077D0 (en) * 2007-11-09 2007-12-19 Smithkline Beecham Corp Compounds
GB0722075D0 (en) * 2007-11-09 2007-12-19 Smithkline Beecham Corp Compounds
CN102159605B (zh) * 2008-09-15 2014-01-08 大金工业株式会社 水性聚合物分散组合物和表面处理剂
JP2012506386A (ja) * 2008-10-21 2012-03-15 メタボレックス， インコーポレイテッド アリールｇｐｒ１２０受容体アゴニストおよびその使用
FR2974089B1 (fr) * 2011-04-18 2014-04-25 Univ Nice Sophia Antipolis Derives de l'acadesine, produits et compositions les comprenant, leurs utilisations therapeutiques et leurs procedes de synthese.
WO2013134546A1 (fr) * 2012-03-07 2013-09-12 Mayo Foundation For Medical Education And Research Procédés et matériaux pour traiter le cancer
KR101676208B1 (ko) * 2012-09-17 2016-11-14 에프. 호프만-라 로슈 아게 트라이아졸 카복스아미드 유도체
IL227890A0 (en) * 2013-08-08 2014-01-30 Galderm Therapeutics Ltd Antiaging compounds containing bile acid and fatty acid conjugates
CA2975474C (fr) 2015-01-30 2023-06-13 Neurocrine Biosciences, Inc. Triazoles substitues et procedes associes
KR20180036318A (ko) * 2016-09-30 2018-04-09 경북대학교 산학협력단 2-아미노-2-(1-도데실-1h-1,2,3-트리아졸-4-일)프로판-1,3-디올 유도체를 유효성분으로 포함하는 퇴행성 신경질환 및 우울증 예방 또는 치료용 약학적 조성물
MA46589A (fr) 2016-10-24 2019-08-28 Yumanity Therapeutics Inc Composés et utilisations de ces derniers
JP2020514293A (ja) 2017-01-06 2020-05-21 ユマニティ セラピューティクス，インコーポレーテッド 神経障害を治療する方法
KR102292989B1 (ko) 2017-03-29 2021-08-26 재단법인 아산사회복지재단 S1pr4를 타겟으로 하는 비알코올성 지방간염 예방 또는 치료용 조성물
CA3083000A1 (fr) 2017-10-24 2019-05-02 Yumanity Therapeutics, Inc. Composes et utilisations de ces composes
JP2021522253A (ja) * 2018-04-25 2021-08-30 ユマニティ セラピューティクス，インコーポレーテッド 化合物及びその使用
KR102017324B1 (ko) * 2018-04-30 2019-09-02 경북대학교 산학협력단 신규한 asm 활성 직접 억제 화합물 2-아미노-2-(1,2,3-트리아졸-4-일)프로판-1,3-디올 유도체 및 이의 용도
CN114656414B (zh) * 2022-05-24 2022-08-23 常熟华虞环境科技有限公司 三氮唑改性二氧化钛光催化剂及其制备方法

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GB0722075D0 (en) 2007-11-09 2007-12-19 Smithkline Beecham Corp Compounds
GB0810913D0 (en) 2008-06-13 2008-07-23 Smithkline Beecham Corp Comppounds

Also Published As

Publication number Publication date
BRPI0820471A2 (pt) 2015-06-16
DK2207770T3 (da) 2011-09-12
ES2366422T3 (es) 2011-10-20
EP2207770A1 (fr) 2010-07-21
DOP2010000137A (es) 2010-08-15
CO6270331A2 (es) 2011-04-20
EA201070588A1 (ru) 2010-10-29
RS51918B (en) 2012-02-29
CY1112233T1 (el) 2015-12-09
HRP20110552T1 (hr) 2011-09-30
CA2705113A1 (fr) 2009-05-14
EP2207770B1 (fr) 2011-06-08
CN101918376B (zh) 2013-11-06
MY163126A (en) 2017-08-15
GB0722077D0 (en) 2007-12-19
WO2009060053A1 (fr) 2009-05-14
HRP20140346T1 (hr) 2014-05-09
KR101577080B1 (ko) 2015-12-11
PT2368887E (pt) 2014-05-15
ZA201002596B (en) 2010-12-29
NZ584725A (en) 2012-05-25
ATE512140T1 (de) 2011-06-15
DK2368887T3 (da) 2014-04-14
CA2705113C (fr) 2016-01-05
HK1160467A1 (en) 2012-08-17
EP2368887B8 (fr) 2014-04-16
AU2008324172B2 (en) 2012-03-15
HK1141528A1 (en) 2010-11-12
SI2368887T1 (sl) 2014-05-30
IL205152A0 (en) 2010-11-30
ME01962B (fr) 2012-02-29
JP5491407B2 (ja) 2014-05-14
CR11482A (es) 2010-07-09
US9051281B2 (en) 2015-06-09
US20130281499A1 (en) 2013-10-24
AU2008324172A1 (en) 2009-05-14
PL2207770T3 (pl) 2011-10-31
EA016621B1 (ru) 2012-06-29
RS53294B (en) 2014-08-29
US8486977B2 (en) 2013-07-16
UA107324C2 (uk) 2014-12-25
EP2368887A1 (fr) 2011-09-28
IL205152A (en) 2013-10-31
PT2207770E (pt) 2011-09-01
CN101918376A (zh) 2010-12-15
SI2207770T1 (sl) 2011-09-30
KR20100095574A (ko) 2010-08-31
JP2011503031A (ja) 2011-01-27
ES2457521T3 (es) 2014-04-28
EP2368887B1 (fr) 2014-02-26
MX2010005187A (es) 2010-05-27
CY1115058T1 (el) 2016-12-14
US20100297054A1 (en) 2010-11-25
PL2368887T3 (pl) 2014-07-31

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