ATE465992T1 - Beta-kristalline form von perindopril-arginin- salz, verfahren zu dessen herstellung und dieses enthaltende pharmazeutische zubereitungen - Google Patents
Beta-kristalline form von perindopril-arginin- salz, verfahren zu dessen herstellung und dieses enthaltende pharmazeutische zubereitungenInfo
- Publication number
- ATE465992T1 ATE465992T1 AT07731038T AT07731038T ATE465992T1 AT E465992 T1 ATE465992 T1 AT E465992T1 AT 07731038 T AT07731038 T AT 07731038T AT 07731038 T AT07731038 T AT 07731038T AT E465992 T1 ATE465992 T1 AT E465992T1
- Authority
- AT
- Austria
- Prior art keywords
- crystalline form
- arginine salt
- perindopril
- beta
- intensity
- Prior art date
Links
- RYCSJJXKEWBUTI-YDYAIEMNSA-N perindopril arginine Chemical class OC(=O)[C@@H](N)CCCNC(N)=N.C1CCC[C@H]2C[C@@H](C(O)=O)N(C(=O)[C@H](C)N[C@@H](CCC)C(=O)OCC)[C@H]21 RYCSJJXKEWBUTI-YDYAIEMNSA-N 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 abstract 2
- 238000002441 X-ray diffraction Methods 0.000 abstract 2
- 229910052802 copper Inorganic materials 0.000 abstract 2
- 239000010949 copper Substances 0.000 abstract 2
- 238000010586 diagram Methods 0.000 abstract 2
- 239000000843 powder Substances 0.000 abstract 2
- 239000005541 ACE inhibitor Substances 0.000 abstract 1
- 229940086440 Angiotensin I converting enzyme inhibitor Drugs 0.000 abstract 1
- 208000001953 Hypotension Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 208000021822 hypotensive Diseases 0.000 abstract 1
- 230000001077 hypotensive effect Effects 0.000 abstract 1
- 230000010534 mechanism of action Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0601747A FR2897865B1 (fr) | 2006-02-28 | 2006-02-28 | Forme cristalline beta du sel d'arginine du perindopril, son procede de preparation, et les compositions pharmaceutiques qui la contiennent |
| PCT/FR2007/000334 WO2007099216A2 (fr) | 2006-02-28 | 2007-02-26 | FORME CRISTALLINE β DU SEL D'ARGININE DU PERINDOPRIL, SON PROCEDE DE PREPARATION, ET LES COMPOSITIONS PHARMACEUTIQUES QUI LA CONTIENNENT |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE465992T1 true ATE465992T1 (de) | 2010-05-15 |
Family
ID=37198804
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07731038T ATE465992T1 (de) | 2006-02-28 | 2007-02-26 | Beta-kristalline form von perindopril-arginin- salz, verfahren zu dessen herstellung und dieses enthaltende pharmazeutische zubereitungen |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US7923569B2 (de) |
| EP (1) | EP2016051B1 (de) |
| JP (1) | JP5611524B2 (de) |
| KR (1) | KR20080106947A (de) |
| CN (1) | CN101389604B (de) |
| AT (1) | ATE465992T1 (de) |
| AU (1) | AU2007220434B2 (de) |
| BR (1) | BRPI0708291B8 (de) |
| CA (1) | CA2643803C (de) |
| CY (1) | CY1110082T1 (de) |
| DE (1) | DE602007006176D1 (de) |
| DK (1) | DK2016051T3 (de) |
| EA (1) | EA014715B1 (de) |
| ES (1) | ES2345291T3 (de) |
| FR (1) | FR2897865B1 (de) |
| GE (1) | GEP20135839B (de) |
| HR (1) | HRP20100357T1 (de) |
| MA (1) | MA30277B1 (de) |
| ME (1) | ME01805B (de) |
| MX (1) | MX2008010747A (de) |
| MY (1) | MY143557A (de) |
| NO (1) | NO341238B1 (de) |
| NZ (1) | NZ570366A (de) |
| PL (1) | PL2016051T3 (de) |
| PT (1) | PT2016051E (de) |
| RS (1) | RS51431B (de) |
| SI (1) | SI2016051T1 (de) |
| UA (1) | UA89904C2 (de) |
| WO (1) | WO2007099216A2 (de) |
| ZA (1) | ZA200807025B (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2897866B1 (fr) | 2006-02-28 | 2008-04-18 | Servier Lab | Forme cristalline alpha du sel d'arginine du perindopril, son procede de preparation, et les compositions pharmaceutiques qui la contiennent |
| US8686161B2 (en) | 2008-06-24 | 2014-04-01 | Mylan Laboratories Limited | Polymorphic forms of perindopril (L)-arginine and process for the preparation thereof |
| AU2013245523C1 (en) * | 2008-06-24 | 2017-09-07 | Tianish Laboratories Private Limited | Novel polymorphic forms of Perindopril (L)-Arginine and process for the preparation thereof |
| AU2009212902A1 (en) | 2008-09-03 | 2010-03-18 | Apotex Pharmachem Inc. | Amorphous form of an L-arginine salt of perindopril and processes of preparation thereof |
| FR2985512B1 (fr) * | 2012-01-05 | 2014-06-20 | Servier Lab | Procede de preparation du sel de l-arginine du perindopril |
| FR2985511B1 (fr) * | 2012-01-05 | 2014-01-03 | Servier Lab | Forme cristalline delta du sel d'arginine du perindopril, son procede de preparation, et les compositions pharmaceutiques qui la contiennent |
| CN103172696B (zh) * | 2012-12-19 | 2014-12-17 | 宁波美诺华药业股份有限公司 | 一种γ晶型的培哚普利精氨酸盐的制备方法 |
| WO2016178591A2 (en) | 2015-05-05 | 2016-11-10 | Gene Predit, Sa | Genetic markers and treatment of male obesity |
| PH12018502155B1 (en) | 2016-04-20 | 2024-03-27 | Servier Lab | Pharmaceutical composition comprising a beta blocker, a converting enzyme inhibitor and an antihypertensive or an nsaid |
| EP3842035A1 (de) | 2019-12-23 | 2021-06-30 | KRKA, d.d., Novo mesto | Zusammensetzung zur herstellung von perindopril-arginin-granulaten, verfahren zu ihrer herstellung und pharmazeutische zusammensetzung damit |
| SI26268A (sl) | 2021-11-18 | 2023-05-31 | Zupet Rok | Postopek za pripravo hidratirane oblike perindopril l-arginina |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2811319B1 (fr) * | 2000-07-06 | 2002-08-23 | Adir | Nouvelle forme cristalline beta du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent |
| FR2811320B1 (fr) * | 2000-07-06 | 2002-08-23 | Adir | Nouvelle forme cristalline alpha du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent |
| FR2811318B1 (fr) * | 2000-07-06 | 2002-08-23 | Adir | Nouvelle forme cristalline gamma du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent |
| FR2838648B1 (fr) * | 2002-04-18 | 2004-05-21 | Servier Lab | Nouveau sel de perindopril et les compositions pharmaceutiques qui le contiennent |
| FR2841140B1 (fr) * | 2002-06-24 | 2004-10-01 | Servier Lab | Microcapsules pour la liberation retardee et controlee du perindopril |
-
2006
- 2006-02-28 FR FR0601747A patent/FR2897865B1/fr not_active Expired - Fee Related
-
2007
- 2007-02-26 GE GEAP2007010917 patent/GEP20135839B/en unknown
- 2007-02-26 SI SI200730264T patent/SI2016051T1/sl unknown
- 2007-02-26 KR KR1020087023636A patent/KR20080106947A/ko not_active Ceased
- 2007-02-26 DE DE602007006176T patent/DE602007006176D1/de active Active
- 2007-02-26 HR HR20100357T patent/HRP20100357T1/hr unknown
- 2007-02-26 MY MYPI20082990A patent/MY143557A/en unknown
- 2007-02-26 AT AT07731038T patent/ATE465992T1/de active
- 2007-02-26 PL PL07731038T patent/PL2016051T3/pl unknown
- 2007-02-26 MX MX2008010747A patent/MX2008010747A/es active IP Right Grant
- 2007-02-26 DK DK07731038.1T patent/DK2016051T3/da active
- 2007-02-26 UA UAA200811434A patent/UA89904C2/ru unknown
- 2007-02-26 ES ES07731038T patent/ES2345291T3/es active Active
- 2007-02-26 US US12/224,415 patent/US7923569B2/en active Active
- 2007-02-26 JP JP2008556811A patent/JP5611524B2/ja not_active Expired - Fee Related
- 2007-02-26 ME MEP-2010-330A patent/ME01805B/me unknown
- 2007-02-26 PT PT07731038T patent/PT2016051E/pt unknown
- 2007-02-26 AU AU2007220434A patent/AU2007220434B2/en not_active Ceased
- 2007-02-26 BR BRPI0708291A patent/BRPI0708291B8/pt not_active IP Right Cessation
- 2007-02-26 EP EP07731038A patent/EP2016051B1/de active Active
- 2007-02-26 CN CN2007800061997A patent/CN101389604B/zh not_active Expired - Fee Related
- 2007-02-26 CA CA2643803A patent/CA2643803C/fr not_active Expired - Fee Related
- 2007-02-26 NZ NZ570366A patent/NZ570366A/en not_active IP Right Cessation
- 2007-02-26 WO PCT/FR2007/000334 patent/WO2007099216A2/fr not_active Ceased
- 2007-02-26 EA EA200801772A patent/EA014715B1/ru unknown
- 2007-02-26 RS RSP-2010/0330A patent/RS51431B/sr unknown
-
2008
- 2008-08-13 NO NO20083506A patent/NO341238B1/no unknown
- 2008-08-14 ZA ZA200807025A patent/ZA200807025B/xx unknown
- 2008-09-11 MA MA31233A patent/MA30277B1/fr unknown
-
2010
- 2010-06-14 CY CY20101100547T patent/CY1110082T1/el unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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