PT1150959E - Forma do celecoxib no estado sólido com biodisponibilidade acrescida - Google Patents

Forma do celecoxib no estado sólido com biodisponibilidade acrescida Download PDF

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Publication number
PT1150959E
PT1150959E PT00982255T PT00982255T PT1150959E PT 1150959 E PT1150959 E PT 1150959E PT 00982255 T PT00982255 T PT 00982255T PT 00982255 T PT00982255 T PT 00982255T PT 1150959 E PT1150959 E PT 1150959E
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Portugal
Prior art keywords
celecoxib
solid
state form
enhanced bioavailability
bioavailability
Prior art date
Application number
PT00982255T
Other languages
English (en)
Inventor
Michael J Hageman
Patricia J Miyake
Tugrul T Kararli
Xiaorong He
Lesley A Mackin
Brian R Rohrs
Kevin J Stefanski
Original Assignee
Pharmacia Corp
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Application filed by Pharmacia Corp filed Critical Pharmacia Corp
Publication of PT1150959E publication Critical patent/PT1150959E/pt

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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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PT00982255T 1999-12-08 2000-12-06 Forma do celecoxib no estado sólido com biodisponibilidade acrescida PT1150959E (pt)

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Families Citing this family (21)

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Publication number Priority date Publication date Assignee Title
ES2290157T3 (es) * 2000-07-20 2008-02-16 Lauras As Uso de inhibidores de cox-2 como inmunoestimulantes en el tratamiento de vih o sida.
DE60233874D1 (de) 2001-06-22 2009-11-12 Pfizer Prod Inc Pharmazeutische zusammensetzungen enthaltend dispersionen aus arzneistoffen und neutralen polymeren
US7790905B2 (en) 2002-02-15 2010-09-07 Mcneil-Ppc, Inc. Pharmaceutical propylene glycol solvate compositions
US7927613B2 (en) 2002-02-15 2011-04-19 University Of South Florida Pharmaceutical co-crystal compositions
WO2004061433A1 (en) * 2002-12-30 2004-07-22 Transform Pharmaceuticals, Inc. Pharmaceutical compositions with improved dissolution
US7446107B2 (en) 2002-02-15 2008-11-04 Transform Pharmaceuticals, Inc. Crystalline forms of conazoles and methods of making and using the same
JP4906233B2 (ja) 2002-03-01 2012-03-28 ユニバーシティー オブ サウス フロリダ 少なくとも１種の有効薬剤成分を含有する多構成要素固相
AU2003299482A1 (en) * 2002-05-13 2004-06-07 Pharmacia Corporation Stable amorphous celecoxib composite and process therefor
AU2003243354A1 (en) 2002-05-31 2003-12-19 Transform Pharmaceuticals, Inc. Novel conazole crystalline forms and related processes, pharmaceutical compositions and methods
MXPA05000232A (es) * 2002-06-21 2005-06-17 Transform Pharmaceuticals Inc Composiciones farmaceuticas con disolucion mejorada.
US20060052432A1 (en) * 2002-09-20 2006-03-09 Julius Remenar Pharmaceutical compositions with improved dissolution
EP1579198A1 (en) * 2002-12-30 2005-09-28 Transform Pharmaceuticals, Inc. Pharmaceutical compositions with improved dissolution
US8183290B2 (en) 2002-12-30 2012-05-22 Mcneil-Ppc, Inc. Pharmaceutically acceptable propylene glycol solvate of naproxen
WO2006000228A2 (en) * 2004-06-29 2006-01-05 Nycomed Danmark Aps Manufacturing of quick release pharmaceutical compositions of water insoluble drugs and pharmaceutical compositions obtained by the process of the invention
GB0423103D0 (en) * 2004-10-19 2004-11-17 Boots Healthcare Int Ltd Therapeutic agents
WO2006097459A1 (en) * 2005-03-14 2006-09-21 Nycomed Gmbh Method for preventing cardiovascular diseases
CN103462920A (zh) * 2012-06-06 2013-12-25 南京亿华药业有限公司 一种口服环加氧酶-2抑制剂塞来昔布的组合物
CN103524416B (zh) * 2013-10-29 2016-08-17 湖北华世通生物医药科技有限公司 一种塞来昔布新晶型a及其制备方法
CN103539739B (zh) * 2013-10-30 2016-02-10 中美华世通生物医药科技（武汉）有限公司 一种塞来昔布新晶型b及其制备方法
CN103508958A (zh) * 2013-10-30 2014-01-15 中美华世通生物医药科技（武汉）有限公司 一种塞来昔布新晶型c及其制备方法
KR101476096B1 (ko) * 2014-03-28 2014-12-24 대원제약주식회사 용해도가 향상된 쎄레콕시브의 약제학적 조성물

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5474995A (en) * 1993-06-24 1995-12-12 Merck Frosst Canada, Inc. Phenyl heterocycles as cox-2 inhibitors
KR100229343B1 (ko) * 1993-11-30 1999-11-01 윌리암스 로저 에이 염증치료용 치환 피라졸일벤젠술폰아미드
US5633272A (en) * 1995-02-13 1997-05-27 Talley; John J. Substituted isoxazoles for the treatment of inflammation
AU699593B2 (en) * 1995-02-13 1998-12-10 G.D. Searle & Co. Substituted isoxazoles for the treatment of inflammation
US5756529A (en) * 1995-09-29 1998-05-26 G.D. Searle & Co. Substituted pyrazolyl benzenesulfonamides for use in veterinary therapies
US5981576A (en) * 1995-10-13 1999-11-09 Merck Frosst Canada, Inc. (Methylsulfonyl)phenyl-2-(5H)-furanones as COX-2 inhibitors
EP0863134A1 (en) * 1997-03-07 1998-09-09 Merck Frosst Canada Inc. 2-(3,5-difluorophenyl)-3-(4-(methyl-sulfonyl)phenyl)-2-cyclopenten-1-one useful as an inhibitor of cyclooxygenase-2
US20070004655A9 (en) * 1998-04-27 2007-01-04 Murphy Gerald P Nr-cam gene, nucleic acids and nucleic acid products for therapeutic and diagnostic uses for tumors

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TWI276435B (en) 2007-03-21
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OA11831A (en) 2005-08-23
ZA200107149B (en) 2003-02-28
CO5251445A1 (es) 2003-02-28
KR20020002386A (ko) 2002-01-09
ES2236011T3 (es) 2005-07-16
HUP0200580A2 (hu) 2002-11-28
MY128366A (en) 2007-01-31
PE20010911A1 (es) 2001-09-10
KR100717570B1 (ko) 2007-05-15
SV2002000235A (es) 2002-06-13
BG105808A (en) 2002-09-30
CN1411447A (zh) 2003-04-16
BG65239B1 (bg) 2007-09-28
AU2041201A (en) 2001-06-18
WO2001041536A2 (en) 2001-06-14
ECSP003807A (es) 2005-07-06
AR030039A1 (es) 2003-08-13
PT1150960E (pt) 2005-06-30
ZA200107146B (en) 2002-08-29
MY128971A (en) 2007-03-30
CZ20012875A3 (cs) 2002-02-13
YU57801A (sh) 2005-07-19
CN1216869C (zh) 2005-08-31
HUP0200580A3 (en) 2002-12-28
AR027897A1 (es) 2003-04-16

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