CO4370145A1 - Derivados de n-(3-benzofuranil) urea - Google Patents
Derivados de n-(3-benzofuranil) ureaInfo
- Publication number
- CO4370145A1 CO4370145A1 CO96010870A CO96010870A CO4370145A1 CO 4370145 A1 CO4370145 A1 CO 4370145A1 CO 96010870 A CO96010870 A CO 96010870A CO 96010870 A CO96010870 A CO 96010870A CO 4370145 A1 CO4370145 A1 CO 4370145A1
- Authority
- CO
- Colombia
- Prior art keywords
- carbon
- atoms
- linear
- indicates
- branched chain
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/86—Benzo [b] furans; Hydrogenated benzo [b] furans with an oxygen atom directly attached in position 7
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Furan Compounds (AREA)
- Cosmetics (AREA)
Abstract
1. DERIVADOS DE N-(3-BENZOFURANIL)UREA DE FORMULA GENERAL (I) FIGURA 1 EN LA QUE A Y D SON IDENTICOS O DIFERENTES Y REPRESENTAN HI- DROGENO, UN ACILO O ALCOXICARBONILO DE CADENA LI- NEAL O RAMIFICADA QUE TIENEN CADA UNO HASTA 6 ATO- MOS DE CARBONO, O UN ALQUILO DE CADENA LINEAL O RAMIFICADA QUE TIENE HASTA 6 ATOMOS DE CARBONO, EL CUAL ESTA SUSTITUIDO OPCIONALMENTE POR CARBOXILO O ALCOXICARBONILO QUE TIENE HASTA 6 ATOMOS DE CARBO- NO, FENOXILO O BENZOILO, O REPRESENTAN UN HALOGE- NO, CARBOXILO, CIANO, NITRO, TRIFLUOROMETILO, TRI- FLUOROMETOXILO O UN GRUPO DE FORMULA -OR5,-S(O)aR6 , -(O-CH2-CO)b-NR7R8, -CO-NR9R10, -SO2-NR11R12 o NH-SO2R13, EN LA QUE R5, R6, R8, R9, R10, R11 Y R12 SON IDENTICOS O DI- FERENTES E INDICAN HIDROGENO, UN CICLOALQUILO QUE TIENE DE 3 A 6 ATOMOS DE CARBONO, BENCILO O UN HE- TEROCICLO SATURADO O INSATURADO DE 5 A 7 MIEMBROS QUE TIENE HASTA 3 HETEROATOMOS DE LA SERIE FORMADA POR N, S y O Y AL QUE PUEDE ESTAR FUSIONADO UN A- NILLO FENILO Y EL CUAL ESTA SUSTITUIDO OPCIONAL- MENTE POR SUSTITUYENTES IDENTICOS O DIFERENTES DE LA SERIE FORMADA HALOGENOS, CIANO, NITRO O POR UN ALQUILO DE CADENA LINEAL O RAMIFICADA QUE TIENE HASTA 6 ATOMOS DE CARBONO O INDICA UN ALQUILO, AL- QUENILO O ACILO DE CADENA LINEAL O RAMIFICADA QUE TIENE CADA UNO HASTA 8 ATOMOS DE CARBONO, O INDICA FENILO, EL CUAL ESTA MONOSUSTITUIDO O DISUSTITUIDO OPCIONALMENTE POR SUSTITUYENTES IDENTICOS O DIFE- RENTES DE LA SERIE FORMADA POR NITRO, HALOGENO, CARBOXILO O ALCOXICARBONILO DE CADENA LINEAL O RA- MIFICADA QUE TIENE HASTA 6 ATOMOS DE CARBONO, o R5 INDICA UN GRUPO PROTECTOR DEL HIDROXILO O UN ALCO- XICARBONILO DE CADENA LINEAL O RAMIFICADA DE HASTA 6 ATOMOS DE CARBONO, O INDICA UN ALQUILO DE CADENA LINEAL O RAMIFICADA QUE TIENE HASTA 8 ATOMOS DE CARBONO, EL CUAL ESTA SUSTITUIDO POR CARBOXILO, HIDROXILO O UN ACILO O ALCOXICARBONILO DE CADENA LINEAL O RAMIFICADA QUE TIENE CADA UNA HASTA 6 A- TOMOS DE CARBONO FENOXILO, BENZOILO O POR UN HETE- ROCICLO INSATURADO DE 5 A 7 MIEMBROS QUE TIENE HASTA 3 HETEROATOMOS DE LA SERIE FORMADA POR N, S y/u O, EL CUAL ESTA SUSTITUIDO OPCIONALMENTE POR HALOGENOS, CIANO, NITRO O POR UN ALQUILO DE CADENA LINEAL O RAMIFICADA QUE TIENE HASTA 6 ATOMOS DE CARBONO o R5 INDICA UN GRUPO DE FORMULA SO2R14, EN LA QUE R14 INDICA FENILO, TRIFLUOROMETILO O UN ALQUILO DE CADENA LINEAL O RAMIFICADA QUE TIENE HASTA 4 ATO- MOS DE CARBONO, a INDICA UN NUMERO 0, 1 o 2, b INDICA UN NUMERO 0 o 1, R7 INDICA HIDROGENO O UN ALQUILO DE CADENA LINEAL O RAMIFICADA QUE TIENE HASTA 4 ATOMOS DE CARBONO, R13 INDICA UN ARILO QUE TIENE DE 6 A 10 ATOMOS DE CARBONO, TRIFLUOROMETILO O UN ALQUILO DE CADENA LINEAL O RAMIFICADA QUE TIENE HASTA 6 ATOMOS DE CARBONO, R1 REPRESENTA HIDROGENO, UN ALQUILO DE CADENA LI- NEAL O RAMIFICADA QUE TIENE HASTA 6 ATOMOS DE CARBONO, UN GRUPO PROTECTOR DEL AMINO O UN GRUPO DE FORMULA -CO-R15, EN LA QUE R15 INDICA HIDROXILO, UN ALCOXICARBONILO DE CADENA LINEAL O RAMIFICADA QUE TIENE HASTA 6 ATOMOS DE CARBONO, UN CICLOALQUILO QUE TIENE DE 3 A 6 ATOMOS DE CARBONO, PIRIDILO, PIRROLIDINILO O UN ALQUILO DE CADENA LINEAL O RAMIFICADA QUE TIENE HASTA 8 A- TOMOS DE CARBONO, EL CUAL ESTA SUSTITUIDO OPCIO- NALMENTE POR HALOGENO, CARBOXILO O UN ALCOXICARBO- NILO DE CADENA LINEAL O RAMIFICADA QUE TIENE HASTA 6 ATOMOS DE CARBONO, O INDICA FENILO, EL CUAL ESTA SUSTITUIDO OPCIONAL- MENTE POR HIDROXILO, CARBOXILO O UN ALCOXILO O AL- COXICARBONILO DE CADENA LINEAL O RAMIFICADA QUE TIENE CADA UNO HASTA 6 ATOMOS DE CARBONO, L REPRESENTA UN ATOMO DE OXIGENO O DE AZUFRE, R2 Y R3 SON IDENTICOS O DIFERENTES Y REPRESENTAN HIDROGENO, UN CICLOALQUILO QUE TIENE HASTA 6 ATO- MOS DE CARBONO, UN ALQUILO, ALCOXICARBONILO O AL- QUENILO DE CADENA LINEAL O RAMIFICADA, QUE TIENE CADA UNO HASTA 8 ATOMOS DE CARBONO, O REPRESENTAN BENZOILO O UN ARILO QUE TIENE DE 6 A 10 ATOMOS DE CARBONO, QUE ESTAN OPCIONALMENTE SUSTITUIDOS DE U- NA A TRES VECES POR SUSTITUYENTES IDENTICOS O DI- FERENTES DE LA SERIE FORMADA POR HALOGENO, CIANO, NITRO, CARBOXILO, ALQUILO, ALCOXILO, ALCOXICARBO- NILO O ACILO DE CADENA LINEAL O RAMIFICADA QUE TIENE CADA UNO HASTA 6 ATOMOS DE CARBONO, O R2 Y R3 JUNTO CON EL ATOMO DE NITROGENO FORMAN UN HETEROCICLO SATURADO DE 5 A 7 MIEMBROS QUE TIENE OPCIONALMENTE UN ATOMO DE O ADICIONAL, Y R4 REPRESENTA FENILO, EL CUAL ESTA SUSTITUIDO DE UNA A TRES VECES POR SUSTITUYENTES IDENTICOS O DI- FERENTES DE LA SERIE FORMADA POR HIDROXILO, TIOFE- NILO, CICLOALQUILO QUE TIENE DE 3 A 6 ATOMOS DE CARBONO, HALOGENO, NITRO, TETRAZOLILO, TIAZOLILO, FURANILO, PIRIDILO, TRIFLUOROMETILO, DIFLUOROMETI- LO, CIANO, CARBOXILO, ALQUILO, ALCOXILO, ALCOXI- CARBONILO O ACILO DE CADENA LINEAL O RAMIFICADA QUE TIENE CADA UNO HASTA 8 ATOMOS DE CARBONO, O EL FENILO ESTA SUSTITUIDO OPCIONALMENTE POR FENILO, EL CUAL ESTA OPCIONALMENTE MONOSUSTITUIDO O DISUS- TITUIDO POR HALOGENOS O POR UN GRUPO DE FORMULA -NR16R17, -SR18, SO2R19 o -O-SO2R20, EN LA QUE R16 Y R17 TIENEN EL SIGNIFICADO MENCIONADO ANTE- RIORMENTE PARA R7 Y R8 Y SON IDENTICOS O DIFEREN- TES A LOS ULTIMOS, o R16 INDICA HIDROGENO, Y R17 INDICA UN ACILO DE CADENA LINEAL O RAMIFICADA QUE TIENE HASTA 6 ATOMOS DE CARBONO, R18 INDICA HIDROGENO O UN ALQUILO DE CADENA LINEAL O RAMIFICADA QUE TIENE HASTA 6 ATOMOS DE CARBONO, R19 y R20 SON IDENTICOS O DIFERENTES Y REPRESENTAN UN ALQUILO DE CADENA LINEAL O RAMIFICADA QUE TIENE HASTA 6 ATOMOS DE CARBONO, BENCILO O FENILO, Y SA- LES DE LOS MISMOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9504460.8A GB9504460D0 (en) | 1995-03-06 | 1995-03-06 | N-(3-Benzofuranyl)urea-derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
CO4370145A1 true CO4370145A1 (es) | 1996-10-07 |
Family
ID=10770709
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO96010870A CO4370145A1 (es) | 1995-03-06 | 1996-03-06 | Derivados de n-(3-benzofuranil) urea |
Country Status (42)
Country | Link |
---|---|
US (2) | US6399657B1 (es) |
EP (1) | EP0731099B1 (es) |
JP (1) | JP3204901B2 (es) |
KR (2) | KR100405579B1 (es) |
CN (2) | CN1176651C (es) |
AR (1) | AR002710A1 (es) |
AT (1) | ATE193704T1 (es) |
BG (2) | BG100396A (es) |
BR (1) | BR9600930A (es) |
CA (1) | CA2170824A1 (es) |
CO (1) | CO4370145A1 (es) |
CZ (1) | CZ66796A3 (es) |
DE (1) | DE69608721T2 (es) |
DK (1) | DK0731099T3 (es) |
DZ (1) | DZ1998A1 (es) |
EE (1) | EE03921B1 (es) |
ES (1) | ES2147320T3 (es) |
FI (1) | FI960998A (es) |
GB (1) | GB9504460D0 (es) |
GR (1) | GR3034240T3 (es) |
HK (1) | HK1013285A1 (es) |
HR (1) | HRP960071B1 (es) |
HU (1) | HU222282B1 (es) |
IL (1) | IL117349A (es) |
MA (1) | MA23815A1 (es) |
MY (1) | MY117526A (es) |
NO (1) | NO313672B1 (es) |
NZ (1) | NZ286107A (es) |
PE (1) | PE43597A1 (es) |
PL (1) | PL189206B1 (es) |
PT (1) | PT731099E (es) |
RO (1) | RO116622B1 (es) |
RU (1) | RU2162845C2 (es) |
SI (1) | SI0731099T1 (es) |
SK (1) | SK281817B6 (es) |
SV (1) | SV1996000015A (es) |
TN (1) | TNSN96035A1 (es) |
TR (1) | TR199600177A2 (es) |
TW (1) | TW336934B (es) |
UA (1) | UA46714C2 (es) |
YU (1) | YU49359B (es) |
ZA (1) | ZA961774B (es) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9312853D0 (en) | 1993-06-22 | 1993-08-04 | Euro Celtique Sa | Chemical compounds |
US5922751A (en) | 1994-06-24 | 1999-07-13 | Euro-Celtique, S.A. | Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same |
US5591776A (en) | 1994-06-24 | 1997-01-07 | Euro-Celtique, S.A. | Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV |
GB9504460D0 (en) * | 1995-03-06 | 1995-04-26 | Bayer Ag | N-(3-Benzofuranyl)urea-derivatives |
US6166041A (en) | 1995-10-11 | 2000-12-26 | Euro-Celtique, S.A. | 2-heteroaryl and 2-heterocyclic benzoxazoles as PDE IV inhibitors for the treatment of asthma |
GB9525262D0 (en) * | 1995-12-11 | 1996-02-07 | Bayer Ag | Heterocyclylcarbonyl substituted benzofuranyl-ureas |
US6075016A (en) | 1996-04-10 | 2000-06-13 | Euro-Celtique S.A. | 6,5-fused aromatic ring systems having enhanced phosphodiesterase IV inhibitory activity |
GB9614718D0 (en) * | 1996-07-12 | 1996-09-04 | Bayer Ag | 3-ureido-pyridofurans and -pyridothiophenes |
JPH10168095A (ja) | 1996-12-10 | 1998-06-23 | Cci Corp | 炎症性腸疾患予防および治療剤 |
JP2002529444A (ja) * | 1998-11-12 | 2002-09-10 | アリアド・ファーマシューティカルズ・インコーポレイテッド | 二環式シグナル伝達阻害剤、それを含む組成物とその用途 |
GB2350111A (en) * | 1999-05-17 | 2000-11-22 | Bayer Ag | Oligohydroxyl substituted 3-urea-benzofuran and pyridofuran derivatives |
GB2350112A (en) * | 1999-05-17 | 2000-11-22 | Bayer Ag | Pharmaceutically active cycloalkyl ketones |
GB2350110A (en) * | 1999-05-17 | 2000-11-22 | Bayer Ag | Pharmaceutically active benzofurans |
GB2350109A (en) * | 1999-05-17 | 2000-11-22 | Bayer Ag | Pharmaceutically active benzofuranyl sulfonates |
US7144885B2 (en) | 2002-02-22 | 2006-12-05 | Bayer Pharmaceuticals Corporation | Fused tricyclic heterocycles useful for treating hyper-proliferative disorders |
KR20040094720A (ko) * | 2002-02-22 | 2004-11-10 | 바이엘 파마슈티칼스 코포레이션 | 과다증식성 질환 치료에 유용한 접합 3환계 헤테로사이클 |
CA2506415A1 (en) * | 2002-11-19 | 2004-06-03 | Achillion Pharmaceuticals, Inc. | Substituted aryl thioureas and releated compounds; inhibitors of viral replication |
AU2003303678A1 (en) * | 2003-01-03 | 2004-08-10 | Genzyme Corporation | Urea derivatives and their use as anti-inflammatory agents |
TW200528459A (en) * | 2004-01-06 | 2005-09-01 | Achillion Pharmaceuticals Inc | Azabenzofuran substituted thioureas; inhibitors of viral replication |
TW200600492A (en) * | 2004-05-18 | 2006-01-01 | Achillion Pharmaceuticals Inc | Substituted aryl acylthioureas and related compounds; inhibitors of viral replication |
JPWO2006137350A1 (ja) * | 2005-06-22 | 2009-01-15 | キッセイ薬品工業株式会社 | 新規なフロピリジン誘導体、それを含有する医薬組成物およびそれらの用途 |
CN102772411A (zh) | 2006-07-05 | 2012-11-14 | 奈科明有限责任公司 | 用于治疗炎症性肺部疾病的HMG-CoA还原酶抑制剂与磷酸二酯酶4抑制剂的组合 |
WO2012123353A1 (en) | 2011-03-17 | 2012-09-20 | Algiax Pharmaceuticals Gmbh | Novel use of benzofuranylsulfonates |
WO2013156232A1 (en) * | 2012-04-16 | 2013-10-24 | Algiax Pharmaceuticals Gmbh | Use of benzofuranylsulfonates in neuropathic pain |
EP3119744B1 (en) | 2014-03-18 | 2019-03-06 | Algiax Pharmaceuticals GmbH | 2-cyano-3-cyclopropyl-3-hydroxy-n-aryl-thioacrylamide derivatives |
EP3165224A1 (en) | 2015-11-09 | 2017-05-10 | Albert-Ludwigs-Universität Freiburg | Use of pde4 inhibitors for the prophylaxis and/or therapy of dyslipoproteinaemia and related disorders |
WO2017089347A1 (en) | 2015-11-25 | 2017-06-01 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods and pharmaceutical compositions for the treatment of braf inhibitor resistant melanomas |
JP6788966B2 (ja) * | 2015-12-24 | 2020-11-25 | 丸善製薬株式会社 | 化粧料 |
EP4020024A1 (en) | 2020-12-22 | 2022-06-29 | Paul Scherrer Institut | Method for producing high aspect ratio fan-shaped optics |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA824343B (en) * | 1981-07-01 | 1983-04-27 | Upjohn Co | Pyridinyl- and imidazolyl-benzofurane and benzothiophenes |
US4663347A (en) | 1983-10-31 | 1987-05-05 | Merck Frosst Canada, Inc. | Benzofuran 2-carboxylic acid esters useful as inhibitors of leukotriene biosynthesis |
US4933351A (en) * | 1983-10-31 | 1990-06-12 | Merck Frosst Canada, Inc. | Benzofuran 2-carbox amides useful as inhibitors of leukoriene biosynthesis |
EP0146243A1 (en) * | 1983-10-31 | 1985-06-26 | Merck Frosst Canada Inc. | Lipoxygenase inhibitors |
US4822803A (en) * | 1983-10-31 | 1989-04-18 | Merck Frosst Canada, Inc. | Benzofuran 2-carboxylic acid hydrazides useful as inhibitors of leukotriene biosynthesis |
US5087638A (en) * | 1984-06-20 | 1992-02-11 | Merck Frosst Canada, Inc. | Benzofuran derivatives |
GB9200623D0 (en) * | 1992-01-13 | 1992-03-11 | Bayer Ag | Benzofuranyl and thiophenyl-methylthio-alkanecarboxylic acid derivatives |
GB9309324D0 (en) * | 1993-05-06 | 1993-06-16 | Bayer Ag | Venzofuranyl-and-thiophenyl-alkanecarboxyclic acids derivatives |
GB9504460D0 (en) * | 1995-03-06 | 1995-04-26 | Bayer Ag | N-(3-Benzofuranyl)urea-derivatives |
-
1995
- 1995-03-06 GB GBGB9504460.8A patent/GB9504460D0/en active Pending
-
1996
- 1996-02-13 HR HR960071A patent/HRP960071B1/xx not_active IP Right Cessation
- 1996-02-22 ES ES96102650T patent/ES2147320T3/es not_active Expired - Lifetime
- 1996-02-22 PT PT96102650T patent/PT731099E/pt unknown
- 1996-02-22 DK DK96102650T patent/DK0731099T3/da active
- 1996-02-22 AT AT96102650T patent/ATE193704T1/de not_active IP Right Cessation
- 1996-02-22 DE DE69608721T patent/DE69608721T2/de not_active Expired - Fee Related
- 1996-02-22 SI SI9630186T patent/SI0731099T1/xx unknown
- 1996-02-22 EP EP96102650A patent/EP0731099B1/en not_active Expired - Lifetime
- 1996-02-28 AR ARP960101567A patent/AR002710A1/es unknown
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