ATE148114T1 - Fluor substituierte benzocycloheptapyridine, zusammensetzungen und verfahren zur verwendung derselben als antihistaminische verbindungen - Google Patents
Fluor substituierte benzocycloheptapyridine, zusammensetzungen und verfahren zur verwendung derselben als antihistaminische verbindungenInfo
- Publication number
- ATE148114T1 ATE148114T1 AT89309191T AT89309191T ATE148114T1 AT E148114 T1 ATE148114 T1 AT E148114T1 AT 89309191 T AT89309191 T AT 89309191T AT 89309191 T AT89309191 T AT 89309191T AT E148114 T1 ATE148114 T1 AT E148114T1
- Authority
- AT
- Austria
- Prior art keywords
- compounds
- anthistaminic
- benzocycloheptapyridines
- compositions
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/244,768 US4863931A (en) | 1988-09-15 | 1988-09-15 | Antihistaminic fluoro substituted benzocycloheptapyridines |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE148114T1 true ATE148114T1 (de) | 1997-02-15 |
Family
ID=22924039
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT89309191T ATE148114T1 (de) | 1988-09-15 | 1989-09-11 | Fluor substituierte benzocycloheptapyridine, zusammensetzungen und verfahren zur verwendung derselben als antihistaminische verbindungen |
Country Status (10)
Country | Link |
---|---|
US (1) | US4863931A (de) |
EP (2) | EP0359499B1 (de) |
JP (1) | JPH0631220B2 (de) |
AT (1) | ATE148114T1 (de) |
AU (1) | AU4337289A (de) |
DE (1) | DE68927697T2 (de) |
ES (1) | ES2096560T3 (de) |
GR (1) | GR3022966T3 (de) |
HK (1) | HK55797A (de) |
WO (1) | WO1990003375A2 (de) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4863931A (en) * | 1988-09-15 | 1989-09-05 | Schering Corporation | Antihistaminic fluoro substituted benzocycloheptapyridines |
KR920014799A (ko) * | 1991-01-18 | 1992-08-25 | 나오가따 다이도 | 신규벤조[5,6]시클로헵타[1,2-b]피리딘 유도체 및 이를 함유하는 항알레르기제 |
US6365588B1 (en) | 1993-10-15 | 2002-04-02 | Schering Corporation | Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
TW308594B (de) * | 1993-10-15 | 1997-06-21 | Schering Corp | |
US5721236A (en) * | 1993-10-15 | 1998-02-24 | Schering Corporation | Tricyclic carbamate compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
US6075025A (en) | 1993-10-15 | 2000-06-13 | Schering Corporation | Tricyclic carbamate compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
US5661152A (en) * | 1993-10-15 | 1997-08-26 | Schering Corporation | Tricyclic sulfonamide compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
US5719148A (en) * | 1993-10-15 | 1998-02-17 | Schering Corporation | Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases |
US5464840A (en) * | 1993-12-06 | 1995-11-07 | Schering Corporation | Tricyclic derivatives, compositions and methods of use |
US5939268A (en) * | 1994-07-26 | 1999-08-17 | The Scripps Research Institute | Combinatorial libraries of molecules and methods for producing same |
ES2080699B1 (es) * | 1994-07-27 | 1996-10-16 | Farmahispania S A | Nuevos derivados de 2-(1-etoxicarbonil-4-piperidiliden)metil)piridina y un procedimiento para su obtencion. |
ES2080700B1 (es) * | 1994-07-27 | 1996-10-16 | Farmihispania S A | Nuevo procedimiento para la obtencion de loratadina. |
US5700806A (en) * | 1995-03-24 | 1997-12-23 | Schering Corporation | Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
US5684013A (en) * | 1995-03-24 | 1997-11-04 | Schering Corporation | Tricyclic compounds useful for inhibition of g-protein function and for treatment of proliferative diseases |
US5891872A (en) * | 1995-04-07 | 1999-04-06 | Schering Corporation | Tricyclic compounds |
US5801175A (en) | 1995-04-07 | 1998-09-01 | Schering Corporation | Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
US5712280A (en) * | 1995-04-07 | 1998-01-27 | Schering Corporation | Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
JP3779349B2 (ja) * | 1995-04-24 | 2006-05-24 | 興和株式会社 | ピペリジン誘導体 |
AU705427B2 (en) * | 1995-05-08 | 1999-05-20 | Aventisub Ii Inc. | Alpha-(substituted alkylphenyl) -4-(hydroxydiphenylmethyl)-1-piperidine butanol derivatives, their preparation and their use as anti-histamines, anti-allergy agents and bronchodilators |
US5874442A (en) | 1995-12-22 | 1999-02-23 | Schering-Plough Corporation | Tricyclic amides useful for inhibition of G-protein function and for treatment of proliferative disease |
AU3924500A (en) * | 1999-03-29 | 2000-10-16 | Schering Corporation | Methods and compositions for treating allergic and related disorders using fluorinated descarboethoxyloratadine |
US6555139B2 (en) | 1999-06-28 | 2003-04-29 | Wockhardt Europe Limited | Preparation of micron-size pharmaceutical particles by microfluidization |
US6100274A (en) * | 1999-07-07 | 2000-08-08 | Schering Corporation | 8-chloro-6,11-dihydro-11- ](4-piperidylidine)-5H-benzo[5,6]cyclohepta[1,2-bpyridine oral compositions |
US6114346A (en) | 1999-10-22 | 2000-09-05 | Schering Corporation | Treating sleep disorders using desloratadine |
SK287684B6 (sk) * | 1999-12-20 | 2011-06-06 | Schering Corporation | Pevná orálna farmaceutická dávková forma s predĺženým uvoľňovaním |
WO2001045676A2 (en) | 1999-12-20 | 2001-06-28 | Schering Corporation | Extended release oral dosage composition |
US7405223B2 (en) | 2000-02-03 | 2008-07-29 | Schering Corporation | Treating allergic and inflammatory conditions |
US6720002B2 (en) | 2001-07-20 | 2004-04-13 | R.P. Scherer Technologies, Inc. | Antihistamine formulations for soft capsule dosage forms |
US20040001885A1 (en) * | 2002-06-27 | 2004-01-01 | Unchalee Kositprapa | Rapidly disintegrating antihistamine formulation |
ES2232332T3 (es) * | 2003-03-12 | 2007-08-16 | Teva Pharmaceutical Industries Ltd | Composiciones farmaceuticas estables de desloratadina. |
EP2023957A2 (de) * | 2006-06-07 | 2009-02-18 | Morton Grove Pharmaceuticals, Inc. | Orale flüssige loratadinformulierungen und verfahren |
US20090082385A1 (en) * | 2007-09-26 | 2009-03-26 | Protia, Llc | Deuterium-enriched desloratidine |
CA2690490C (en) | 2010-01-19 | 2012-06-26 | Accucaps Industries Limited | Pharmaceutical formulations of loratadine for encapsulation and combinations thereof |
CN112341433A (zh) * | 2020-11-16 | 2021-02-09 | 成都大学 | 一种氯雷他定的制备方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL132137C (de) * | 1963-04-24 | |||
US3717647A (en) * | 1971-04-09 | 1973-02-20 | Schering Corp | Alpha-nicotinoyl phenylacetonitriles |
US4282233B1 (en) * | 1980-06-19 | 2000-09-05 | Schering Corp | Antihistaminic 11-(4-piperidylidene)-5h-benzoÄ5,6Ü-cyclohepta-Ä1,2Ü-pyridines |
EP0208855B1 (de) * | 1985-05-13 | 1991-03-06 | Schering Corporation | Verfahren zur Herstellung von Piperidyliden-dihydrodibenzo(a,d)zykloheptenen und deren Azoderivate, so hergestellte Verbindungen und ihre Anwendung zur Vorbereitung von Heilmitteln |
US4731447A (en) * | 1985-05-13 | 1988-03-15 | Schering Corporation | Process for preparing piperidylidene dihydro-dibenzo(a,d)-cycloheptenes or aza-derivatives thereof |
US4826853A (en) * | 1986-10-31 | 1989-05-02 | Schering Corporation | 6,11-Dihydro-11-(N-substituted-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines and compositions and methods of use |
US4863931A (en) * | 1988-09-15 | 1989-09-05 | Schering Corporation | Antihistaminic fluoro substituted benzocycloheptapyridines |
-
1988
- 1988-09-15 US US07/244,768 patent/US4863931A/en not_active Expired - Lifetime
-
1989
- 1989-09-11 AU AU43372/89A patent/AU4337289A/en not_active Abandoned
- 1989-09-11 DE DE68927697T patent/DE68927697T2/de not_active Expired - Fee Related
- 1989-09-11 EP EP89309191A patent/EP0359499B1/de not_active Expired - Lifetime
- 1989-09-11 WO PCT/US1989/003819 patent/WO1990003375A2/en not_active Application Discontinuation
- 1989-09-11 ES ES89309191T patent/ES2096560T3/es not_active Expired - Lifetime
- 1989-09-11 AT AT89309191T patent/ATE148114T1/de not_active IP Right Cessation
- 1989-09-11 EP EP89911148A patent/EP0434759A1/de active Pending
- 1989-09-11 JP JP1510355A patent/JPH0631220B2/ja not_active Expired - Fee Related
-
1997
- 1997-03-28 GR GR970400643T patent/GR3022966T3/el unknown
- 1997-05-01 HK HK55797A patent/HK55797A/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
GR3022966T3 (en) | 1997-06-30 |
ES2096560T3 (es) | 1997-03-16 |
EP0359499A2 (de) | 1990-03-21 |
EP0359499B1 (de) | 1997-01-22 |
HK55797A (en) | 1997-05-09 |
WO1990003375A2 (en) | 1990-04-05 |
AU4337289A (en) | 1990-04-18 |
EP0359499A3 (de) | 1990-06-20 |
JPH0631220B2 (ja) | 1994-04-27 |
US4863931A (en) | 1989-09-05 |
DE68927697T2 (de) | 1997-06-12 |
JPH03502696A (ja) | 1991-06-20 |
WO1990003375A3 (en) | 1990-05-31 |
DE68927697D1 (de) | 1997-03-06 |
EP0434759A1 (de) | 1991-07-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
REN | Ceased due to non-payment of the annual fee |