AR002710A1 - Derivados de n-(3-benzofuranil)urea, un procedimiento para su preparacion, una composicion farmaceutica que los contiene, un procedimiento para preparardicha composicion farmaceutica y el uso de dichos derivados para la preparacion de medicamentos. - Google Patents

Derivados de n-(3-benzofuranil)urea, un procedimiento para su preparacion, una composicion farmaceutica que los contiene, un procedimiento para preparardicha composicion farmaceutica y el uso de dichos derivados para la preparacion de medicamentos.

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Publication number
AR002710A1
AR002710A1 ARP960101567A AR10156796A AR002710A1 AR 002710 A1 AR002710 A1 AR 002710A1 AR P960101567 A ARP960101567 A AR P960101567A AR 10156796 A AR10156796 A AR 10156796A AR 002710 A1 AR002710 A1 AR 002710A1
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AR
Argentina
Prior art keywords
alkyl
substituted
alkoxycarbonyl
derivatives
phenyl
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ARP960101567A
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English (en)
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Bayer Ag
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Publication of AR002710A1 publication Critical patent/AR002710A1/es

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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • A61P39/06Free radical scavengers or antioxidants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/86Benzo [b] furans; Hydrogenated benzo [b] furans with an oxygen atom directly attached in position 7
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
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  • Oncology (AREA)
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  • Communicable Diseases (AREA)
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  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
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  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
  • Cosmetics (AREA)

Abstract

Derivados de N-(3-benzofuranil)urea de la fórmula (I), donde A y D son acilo o alcoxicarbonilo o alquilo sustituido o nó por carboxilo oalcoxicarbonilo, fenoxilo o benzoilo, o son halógeno, -COOH, -CN, -NO2, -CF3, -O-CF3 o -OR5, -S(O)aR6, -(O-CH2-CO)b-NR7R8, -CO-NR9R10, -SO2-NR11R12 ó-NH-SO2R13, en la que R5, R6, R8, R9, R10, R11 y R12 son H, cicloalquilo de 3 a 6 miembros, bencilo o un heterociclo saturado o nó de 5 a 7 miembros quetiene hasta 3 heteroátomos de la serie formada por N, S y O y al que puede estar fusionado con fenilo y el cual está sustituido o nó por halógenos, -CN,-NO2 o por alquilo o es un alquilo, alquenilo o acilo, o es fenilo, el cual puede estar mono o di-sustituido, -NO2, halógeno, -COOH o ROOC- oR5 es ungrupo protector del -OH o alcoxicarbonilo, o alquilo sustituido por -COOH,-OH o acilo,alcoxicarbonilo, fenoxilo,benzoilo o por un heterociclo insaturado de 5 a7 miembros que tiene hasta 3 heteroátomos como N, S y/u O, ó R5 es SO2R14, en laque R14 es fenilo, -CF3 ó alquilo; a es 0,1, ó 2; b es 0 ó 1; R7 es H, oalquilo; R13 indica un arilo, -CF3 o alquilo; R1 es hidrógeno, alquilo, un grupo protector del amino o un grupo de fórmula -COR15, en la que R15 es OH, unROOC-, cicloalquilo, piridilo, pirrolidinilo o un alquilo, fenilo, los cuales pueden estar sustituidos, o L es oxígeno o azufre; R1 y R3 son H, uncicloalquilo, un alquilo, alcoxicarbonilo o alquenilo; o son benzoilo o arilo sustituidos o nó por halógeno, -CN, -NO2, -COO, alquilo, alcoxilo,alcoxicarbonilo o acilo; o juntos con el nitrógeno forman un heterociclo saturado de 5 a 7 miembros que puede tener un O adicional; y R4 es fenilo,sustituido por H, tiofenilo, cicloalquilo, halógeno, nitro, tetrazolilo, tiazolilo, furanilo, piridilo, -CF3, -CHF2, -CN,-COOH, R, RO-, ROOC- o RCO-
ARP960101567A 1995-03-06 1996-02-28 Derivados de n-(3-benzofuranil)urea, un procedimiento para su preparacion, una composicion farmaceutica que los contiene, un procedimiento para preparardicha composicion farmaceutica y el uso de dichos derivados para la preparacion de medicamentos. AR002710A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9504460.8A GB9504460D0 (en) 1995-03-06 1995-03-06 N-(3-Benzofuranyl)urea-derivatives

Publications (1)

Publication Number Publication Date
AR002710A1 true AR002710A1 (es) 1998-04-29

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ARP960101567A AR002710A1 (es) 1995-03-06 1996-02-28 Derivados de n-(3-benzofuranil)urea, un procedimiento para su preparacion, una composicion farmaceutica que los contiene, un procedimiento para preparardicha composicion farmaceutica y el uso de dichos derivados para la preparacion de medicamentos.

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US (2) US6399657B1 (es)
EP (1) EP0731099B1 (es)
JP (1) JP3204901B2 (es)
KR (2) KR100405579B1 (es)
CN (2) CN1134419A (es)
AR (1) AR002710A1 (es)
AT (1) ATE193704T1 (es)
BG (2) BG100396A (es)
BR (1) BR9600930A (es)
CA (1) CA2170824A1 (es)
CO (1) CO4370145A1 (es)
CZ (1) CZ66796A3 (es)
DE (1) DE69608721T2 (es)
DK (1) DK0731099T3 (es)
DZ (1) DZ1998A1 (es)
EE (1) EE03921B1 (es)
ES (1) ES2147320T3 (es)
FI (1) FI960998A (es)
GB (1) GB9504460D0 (es)
GR (1) GR3034240T3 (es)
HK (1) HK1013285A1 (es)
HR (1) HRP960071B1 (es)
HU (1) HU222282B1 (es)
IL (1) IL117349A (es)
MA (1) MA23815A1 (es)
MY (1) MY117526A (es)
NO (1) NO313672B1 (es)
NZ (1) NZ286107A (es)
PE (1) PE43597A1 (es)
PL (1) PL189206B1 (es)
PT (1) PT731099E (es)
RO (1) RO116622B1 (es)
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SI (1) SI0731099T1 (es)
SK (1) SK281817B6 (es)
SV (1) SV1996000015A (es)
TN (1) TNSN96035A1 (es)
TR (1) TR199600177A2 (es)
TW (1) TW336934B (es)
UA (1) UA46714C2 (es)
YU (1) YU49359B (es)
ZA (1) ZA961774B (es)

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BG100396A (bg) 1996-12-31
CN1134419A (zh) 1996-10-30
KR100405579B1 (ko) 2004-03-19
AU705667B2 (en) 1999-05-27
NO313672B1 (no) 2002-11-11
TW336934B (en) 1998-07-21
PT731099E (pt) 2000-11-30
EP0731099B1 (en) 2000-06-07
US6399657B1 (en) 2002-06-04
ZA961774B (en) 1996-09-17
UA46714C2 (uk) 2002-06-17
EE03921B1 (et) 2002-12-16
DK0731099T3 (da) 2000-09-25
HK1013285A1 (en) 1999-08-20
HU222282B1 (hu) 2003-05-28
DZ1998A1 (fr) 2002-07-20
BG62732B1 (bg) 2000-06-30
DE69608721T2 (de) 2000-10-05
YU49359B (sh) 2005-09-19
DE69608721D1 (de) 2000-07-13
ES2147320T3 (es) 2000-09-01
PL189206B1 (pl) 2005-07-29
NZ286107A (en) 1998-08-26
JPH08253466A (ja) 1996-10-01
JP3204901B2 (ja) 2001-09-04
CO4370145A1 (es) 1996-10-07
IL117349A (en) 2002-09-12
CN1176651C (zh) 2004-11-24
KR100438633B1 (ko) 2004-07-02
YU13396A (sh) 1999-06-15
NO960884D0 (no) 1996-03-05
HRP960071B1 (en) 2001-04-30
PL313070A1 (en) 1996-09-16
AU4582896A (en) 1996-09-19
CN1313284A (zh) 2001-09-19
GR3034240T3 (en) 2000-12-29
BR9600930A (pt) 1997-12-30
SV1996000015A (es) 1997-02-17
SK281817B6 (sk) 2001-08-06
HUP9600549A2 (en) 1997-07-28
FI960998A0 (fi) 1996-03-04
HRP960071A2 (en) 1997-12-31
SK29796A3 (en) 1996-10-02
TR199600177A2 (tr) 1996-10-21
GB9504460D0 (en) 1995-04-26
HU9600549D0 (en) 1996-04-29
MY117526A (en) 2004-07-31
KR960034194A (ko) 1996-10-22
MA23815A1 (fr) 1996-10-01
FI960998A (fi) 1996-09-07
TNSN96035A1 (fr) 2005-03-15
NO960884L (no) 1996-09-09
SI0731099T1 (en) 2000-08-31
PE43597A1 (es) 1997-12-26
US6677372B2 (en) 2004-01-13
CA2170824A1 (en) 1996-09-07
EP0731099A1 (en) 1996-09-11
RO116622B1 (ro) 2001-04-30
EE9600030A (et) 1996-10-15
IL117349A0 (en) 1996-07-23
US20030109578A1 (en) 2003-06-12
HUP9600549A3 (en) 1998-04-28
CZ66796A3 (en) 1996-09-11
ATE193704T1 (de) 2000-06-15
RU2162845C2 (ru) 2001-02-10

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